Artikel ; Online: Hibiscus acid from Hibiscus sabdariffa (Malvaceae) has a vasorelaxant effect on the rat aorta.
2019 Band 134, Seite(n) 5–13
Abstract: Hibiscus sabdariffa (Malvaceae) is a plant that is widely recognised for its antihypertensive properties; however the constituent(s) responsible for this biological activity are presently unknown. The aim of this study was to identify the potential ... ...
| Abstract | Hibiscus sabdariffa (Malvaceae) is a plant that is widely recognised for its antihypertensive properties; however the constituent(s) responsible for this biological activity are presently unknown. The aim of this study was to identify the potential compounds that are responsible for the vasorelaxant activity of H. sabdariffa. Thereafter, the mechanisms involved in producing the vasorelaxation were investigated. The plant was extracted consecutively with hexane, ethyl acetate and methanol. The methanolic extract was subjected to bioassay-guided fractionation in order to isolate pure compounds that possessed vasorelaxant activity. The vascular effects of the pure compounds were studied on the rat aorta in vitro using myography techniques. Hibiscus acid produced a concentration-dependent relaxation of the rat aorta pre-contracted with either phenylephrine (3 μM) or KCl (60 mM), irrespective of the presence of the endothelium. When the tissue was pre-contracted with phenylephrine, the concentration required to produce 50% relaxation (IC |
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| Mesh-Begriff(e) | Animals ; Aorta/drug effects ; Calcium/analysis ; Calcium Channels, L-Type/physiology ; Citrates/pharmacology ; Female ; Hibiscus/chemistry ; In Vitro Techniques ; Male ; Nigeria ; Plant Extracts/pharmacology ; Rats ; Rats, Sprague-Dawley ; Vasodilation ; Vasodilator Agents/pharmacology |
| Chemische Substanzen | Calcium Channels, L-Type ; Citrates ; Plant Extracts ; Vasodilator Agents ; hydroxycitric acid (8W94T9026R) ; Calcium (SY7Q814VUP) |
| Sprache | Englisch |
| Erscheinungsdatum | 2019-01-25 |
| Erscheinungsland | Netherlands |
| Dokumenttyp | Journal Article |
| ZDB-ID | 412385-2 |
| ISSN | 1873-6971 ; 0367-326X |
| ISSN (online) | 1873-6971 |
| ISSN | 0367-326X |
| DOI | 10.1016/j.fitote.2019.01.012 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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