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  1. Artikel: Animal models of inflammatory bowel disease: category and evaluation indexes.

    Wen, Changlin / Chen, Dan / Zhong, Rao / Peng, Xi

    Gastroenterology report

    2024  Band 12, Seite(n) goae021

    Abstract: Inflammatory bowel disease (IBD) research often relies on animal models to study the etiology, pathophysiology, and management of IBD. Among these models, rats and mice are frequently employed due to their practicality and genetic manipulability. However, ...

    Abstract Inflammatory bowel disease (IBD) research often relies on animal models to study the etiology, pathophysiology, and management of IBD. Among these models, rats and mice are frequently employed due to their practicality and genetic manipulability. However, for studies aiming to closely mimic human pathology, non-human primates such as monkeys and dogs offer valuable physiological parallels. Guinea pigs, while less commonly used, present unique advantages for investigating the intricate interplay between neurological and immunological factors in IBD. Additionally, New Zealand rabbits excel in endoscopic biopsy techniques, providing insights into mucosal inflammation and healing processes. Pigs, with their physiological similarities to humans, serve as ideal models for exploring the complex relationships between nutrition, metabolism, and immunity in IBD. Beyond mammals, non-mammalian organisms including zebrafish,
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2710871-5
    ISSN 2052-0034
    ISSN 2052-0034
    DOI 10.1093/gastro/goae021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Zinc and Inflammatory Bowel Disease: From Clinical Study to Animal Experiment.

    Peng, Xi / Yang, Yingxiang / Zhong, Rao / Yang, Yuexuan / Yan, Fang / Liang, Na / Yuan, Shibin

    Biological trace element research

    2024  

    Abstract: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract (GI) with a high incidence rate globally, and IBD patients are often accompanied by zinc deficiency. This review aims to summarize the potential therapeutic ... ...

    Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract (GI) with a high incidence rate globally, and IBD patients are often accompanied by zinc deficiency. This review aims to summarize the potential therapeutic value of zinc supplementation in IBD clinical patients and animal models. Zinc supplementation can relieve the severity of IBD especially in patients with zinc deficiency. The clinical severity of IBD were mainly evaluated through some scoring methods involving clinical performance, endoscopic observation, blood biochemistry, and pathologic biopsy. Through conducting animal experiments, it has been found that zinc plays an important role in alleviating clinical symptoms and improving pathological lesions. In both clinical observation and animal experiment of IBD, the therapeutic mechanisms of zinc interventions have been found to be related to immunomodulation, intestinal epithelial repair, and gut microbiota's balance. Furthermore, the antioxidant activity of zinc was clarified in animal experiment. Appropriate zinc supplementation is beneficial for IBD therapy, and the present evidence highlights that alleviating zinc-deficient status can effectively improve the severity of clinical symptoms in IBD patients and animal models.
    Sprache Englisch
    Erscheinungsdatum 2024-05-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-024-04193-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Dietary Zinc Ameliorates TNBS-Induced Colitis in Mice Associated with Regulation of Th1/Th2/Th17 Balance and NF-κB/NLRP3 Signaling Pathway.

    Wen, Changlin / Wang, Jiayu / Sun, Zhenhua / Zhong, Rao / Li, Mengjie / Shen, Xuemei / Ye, Qiaobo / Qin, Kaihua / Peng, Xi

    Biological trace element research

    2023  Band 202, Heft 2, Seite(n) 659–670

    Abstract: Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are chronic relapsing inflammatory gastrointestinal tract diseases of uncertain origin, which are frequently associated with zinc deficiency. Animal models have a ... ...

    Abstract Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are chronic relapsing inflammatory gastrointestinal tract diseases of uncertain origin, which are frequently associated with zinc deficiency. Animal models have a considerable value in elucidating the process of IBD. In this study, 50 male C57BL/6 J mice were randomly assigned to five groups: control group (Con), 2,4,6-trinitrobenzenesulfonic acid (TNBS) group, and three zinc supplementation groups, namely 160 ppm group, 400 ppm group, and 1000 ppm group. The results showed that supplementation of dietary zinc with zinc oxide could effectively relieve the severity of ulcerative colitis induced by TNBS in mice. We demonstrate that the protective mechanism involves the immunomodulation of dietary zinc by increasing CD3
    Mesh-Begriff(e) Mice ; Male ; Animals ; NF-kappa B/metabolism ; Colitis, Ulcerative ; NLR Family, Pyrin Domain-Containing 3 Protein ; Th17 Cells/metabolism ; Zinc Oxide/pharmacology ; Mice, Inbred C57BL ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/prevention & control ; Inflammatory Bowel Diseases ; Signal Transduction ; Zinc/adverse effects ; Disease Models, Animal
    Chemische Substanzen NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Zinc Oxide (SOI2LOH54Z) ; Zinc (J41CSQ7QDS)
    Sprache Englisch
    Erscheinungsdatum 2023-05-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-023-03715-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2323: Hefte anzeigen Standort:
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  4. Artikel ; Online: Adult midgut malrotation: multi-detector computed tomography (MDCT) findings of 14 cases.

    Yang, Bin / Chen, Wen-Hui / Zhang, Xiao-Feng / Luo, Zhong-Rao

    Japanese journal of radiology

    2013  Band 31, Heft 5, Seite(n) 328–335

    Abstract: Purpose: To describe MDCT findings in adult patients of midgut malrotation and to correlate the types of adult midgut malrotation with its complications.: Materials and methods: CT scans were performed on 14 adult patients with midgut malrotation. ... ...

    Abstract Purpose: To describe MDCT findings in adult patients of midgut malrotation and to correlate the types of adult midgut malrotation with its complications.
    Materials and methods: CT scans were performed on 14 adult patients with midgut malrotation. The images were reviewed retrospectively by one radiologist. Abnormal intestinal location, mesenteric vascular arrangement, extraintestinal anomalies and complications were evaluated and correlated with patterns of adult midgut malrotation.
    Results: The 14 cases of adult midgut malrotation revealed the following CT findings: intestinal malposition (n = 14), abnormally oriented mesenteric vessels (n = 8), extraintestinal anomalies (n = 14). These cases were classified into six types: complete nonrotation (n = 3), nonrotated duodenum and partially rotated colon (n = 6), isolated nonrotation of the duodenum (n = 2), partial rotation of the duodenum and colon (n = 1), partially rotated duodenum (n = 1) and isolated colonic partial rotation (n = 1). Four of these patients had accompanying complications, including volvulus (n = 2), right paraduodenal hernia (n = 1) and gastroduodenal intussusception (n = 1), respectively.
    Conclusion: Imaging features of adult midgut malrotation are characteristic. Adult midgut malrotation has various manifestations, and types of midgut malrotation may be closely related to their complications.
    Mesh-Begriff(e) Abnormalities, Multiple/diagnostic imaging ; Adult ; Aged ; Duodenum/abnormalities ; Duodenum/diagnostic imaging ; Female ; Hernia/diagnostic imaging ; Humans ; Intestines/abnormalities ; Intestines/diagnostic imaging ; Intussusception/diagnostic imaging ; Male ; Middle Aged ; Multidetector Computed Tomography ; Retrospective Studies ; Rotation
    Sprache Englisch
    Erscheinungsdatum 2013-03-09
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2488907-6
    ISSN 1867-108X ; 1867-1071
    ISSN (online) 1867-108X
    ISSN 1867-1071
    DOI 10.1007/s11604-013-0194-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2249: Hefte anzeigen Standort:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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