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  1. Artikel ; Online: Deficiency of peripheral CLA

    Li, Jiachen / Sun, Feng / Zhu, Danxue / Hou, Yuke / Cheng, Gong / Wang, Ping / Jin, Xu / Zhou, Wenyan / Sun, Xiaolin / Li, Zhanguo / Liu, Tian

    Arthritis research & therapy

    2024  Band 26, Heft 1, Seite(n) 76

    Abstract: Background: Autoimmune responses have been suggested to involvement in patients with Behcet's syndrome (BS). There has been growing attention towards the roles of cutaneous lymphocyte antigen (CLA): Methods: We collected peripheral blood from a total ...

    Abstract Background: Autoimmune responses have been suggested to involvement in patients with Behcet's syndrome (BS). There has been growing attention towards the roles of cutaneous lymphocyte antigen (CLA)
    Methods: We collected peripheral blood from a total of 107 patients with BS and 114 healthy controls (HCs). The number of CLA
    Results: The absolute number and proportion of CLA
    Conclusion: CLA
    Mesh-Begriff(e) Humans ; Behcet Syndrome ; Clinical Relevance ; Oligosaccharides ; T-Lymphocytes, Regulatory ; Aneurysm ; Sialyl Lewis X Antigen/analogs & derivatives
    Chemische Substanzen 6-sulfo sialyl Lewis X ; Oligosaccharides ; Sialyl Lewis X Antigen
    Sprache Englisch
    Erscheinungsdatum 2024-03-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/s13075-024-03306-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Design, synthesis, antibacterial evaluation of isopropylamine linked with different substituted phenol and piperazine novel derivatives.

    Wang, Wen-Hang / Li, Zhu-Rui / Zhu, Dan-Xue / Chen, Jia-Yi / Zhou, Yue / Li, Cheng-Peng / Shao, Li-Hui / Qiu, Xue-Mei / Zhu, Mei / Long, Hai-Tao / Chen, Dan-Ping / Ouyang, Gui-Ping / Rong, Zi-Qiang / Wang, Zhen-Chao

    Pest management science

    2024  Band 80, Heft 6, Seite(n) 2710–2723

    Abstract: Background: Xanthomonas oryzae pv. oryzae (Xoo) is often considered one of the most destructive bacterial pathogens causing bacterial leaf blight (BLB), resulting in significant yield and cost losses in rice. In this study, a series of novel derivatives ...

    Abstract Background: Xanthomonas oryzae pv. oryzae (Xoo) is often considered one of the most destructive bacterial pathogens causing bacterial leaf blight (BLB), resulting in significant yield and cost losses in rice. In this study, a series of novel derivatives containing the isopropanolamine moiety linked to various substituted phenols and piperazines were designed, synthesized and screened.
    Results: Antibacterial activity results showed that most compounds had good inhibitory effects on Xoo, among which compound W2 (EC
    Conclusion: The present study offers a promising phenolic-piperazine-sopropanolamine compound as an innovative antibacterial strategy by specifically targeting the two-component system pathway and inducing upregulation of methyltransferase to effectively impact Xoo's pathogenicity. © 2024 Society of Chemical Industry.
    Mesh-Begriff(e) Xanthomonas/drug effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Phenols/pharmacology ; Phenols/chemistry ; Drug Design ; Piperazines/pharmacology ; Piperazines/chemistry ; Piperazines/chemical synthesis ; Oryza/microbiology ; Plant Diseases/microbiology
    Chemische Substanzen Anti-Bacterial Agents ; Phenols ; Piperazines
    Sprache Englisch
    Erscheinungsdatum 2024-02-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.7986
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Combination of scavenger receptor-A with anti-cyclic citrullinated peptide antibody for the diagnosis of rheumatoid arthritis.

    Wei, Chaonan / Wang, Ping / Zhang, Jian / Jiang, Xiang / Xie, Yang / Li, Yingni / Zhang, Wei / Du, Yan / Zheng, Xi / Fang, Xiangyu / Liu, Shuyan / Cao, Lulu / Yao, Ranran / Jin, Xu / Zhu, Danxue / Wu, Huaxiang / Wang, Yongfu / Li, Zhanguo / Hu, Fanlei

    Rheumatology (Oxford, England)

    2024  

    Abstract: Objectives: The routine biomarkers for rheumatoid arthritis (RA), including anticyclic citrullinated peptide antibody (anti-CCP), rheumatoid factor (RF), immunoglobulin M (IgM), erythrocyte sedimentation rate (ESR), and C-reaction protein (CRP) have ... ...

    Abstract Objectives: The routine biomarkers for rheumatoid arthritis (RA), including anticyclic citrullinated peptide antibody (anti-CCP), rheumatoid factor (RF), immunoglobulin M (IgM), erythrocyte sedimentation rate (ESR), and C-reaction protein (CRP) have limited sensitivity and specificity. Scavenger receptor-A (SR-A) is a novel RA biomarker identified by our group recently, especially for seronegative RA. Here, we performed a large-scale multicentre study to further assess the diagnostic value of SR-A in combination with other biomarkers for RA.
    Methods: The performance of SR-A in combination with other biomarkers for RA diagnosis was first revealed by a pilot study, and was further elucidated by a large-scale multicentre study. A total of 1129 individuals from 3 cohorts were recruited in the study, including RA patients, healthy controls, and patients with other common rheumatic diseases. Diagnostic properties were evaluated by the covariate-adjusted receiver-operating characteristic (AROC) curve, sensitivity, specificity and clinical association, respectively.
    Results: Large-scale multicentre analysis showed that SR-A and anti-CCP dual combination was the optimal method for RA diagnosis, increasing the sensitivity of anti-CCP by 13% (87% vs 74%) while maintaining a specificity of 90%. In early RA patients, SR-A and anti-CCP dual combination also showed promising diagnostic value, increasing the sensitivity of anti-CCP by 7% (79% vs 72%) while maintaining a specificity of 94%. Moreover, SR-A and anti-CCP dual combination was correlated with ESR, IgM, and autoantibodies of RA patients, further revealing its clinical significance.
    Conclusion: SR-A and anti-CCP dual combination could potentially improve early diagnosis of RA, thus improving the prognosis and reducing mortality.
    Sprache Englisch
    Erscheinungsdatum 2024-05-23
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keae297
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Soluble CD24 is an inflammatory biomarker in early and seronegative rheumatoid arthritis.

    Zheng, Xi / Wang, Ping / Song, Jing / Tang, Yundi / Xie, Yang / Jin, Xu / Zhu, Danxue / Fang, Xiangyu / Wei, Chaonan / Li, Ru / Hu, Fanlei / Li, Zhanguo

    Annals of medicine

    2023  Band 55, Heft 2, Seite(n) 2246370

    Abstract: Introduction: ...

    Abstract Introduction:
    Mesh-Begriff(e) Humans ; Arthritis, Rheumatoid/diagnosis ; Rheumatic Diseases ; Biomarkers ; Clinical Relevance ; Enzyme-Linked Immunosorbent Assay ; CD24 Antigen
    Chemische Substanzen Biomarkers ; CD24 protein, human ; CD24 Antigen
    Sprache Englisch
    Erscheinungsdatum 2023-08-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2246370
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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