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Artikel ; Online: Intracochlear Trauma and Local Ossification Patterns Differ Between Straight and Precurved Cochlear Implant Electrodes.

Geerardyn, Alexander / Zhu, MengYu / Verhaert, Nicolas / Quesnel, Alicia M

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

2024 Band 45, Heft 3, Seite(n) 245–255

Abstract: Hypothesis: Trauma to the osseous spiral lamina (OSL) or spiral ligament (SL) during cochlear implant (CI) insertion segregates with electrode type and induces localized intracochlear ossification and fibrosis.: Background: The goal of atraumatic CI ... ...

Abstract	Hypothesis: Trauma to the osseous spiral lamina (OSL) or spiral ligament (SL) during cochlear implant (CI) insertion segregates with electrode type and induces localized intracochlear ossification and fibrosis. Background: The goal of atraumatic CI insertion is to preserve intracochlear structures, limit reactive intracochlear tissue formation, and preserve residual hearing. Previous qualitative studies hypothesized a localized effect of trauma on intracochlear tissue formation; however, quantitative studies failed to confirm this. Methods: Insertional trauma beyond the immediate insertion site was histologically assessed in 21 human temporal bones with a CI. Three-dimensional reconstructions were generated and virtually resectioned perpendicular to the cochlear spiral at high resolution. The cochlear volume occupied by ossification or fibrosis was determined at the midpoint of the trauma and compared with regions proximal and distal to this point. Results: Seven cases, all implanted with precurved electrodes, showed an OSL fracture beyond the immediate insertion site. Significantly more intracochlear ossification was observed at the midpoint of the OSL fracture, compared with the -26 to -18 degrees proximal and 28 to 56 degrees distal to the center. No such pattern was observed for fibrosis. In the 12 cases with a perforation of the SL (9 straight and 3 precurved electrodes), no localized pattern of ossification or fibrosis was observed around these perforations. Conclusion: OSL fractures were observed exclusively with precurved electrodes in this study and may serve as a nidus for localized intracochlear ossification. Perforation of the SL, in contrast, predominantly occurred with straight electrodes and was not associated with localized ossification.
Mesh-Begriff(e)	Humans ; Cochlear Implants/adverse effects ; Osteogenesis ; Electrodes, Implanted/adverse effects ; Cochlear Implantation/adverse effects ; Cochlear Implantation/methods ; Cochlea/diagnostic imaging ; Cochlea/surgery ; Cochlea/injuries ; Temporal Bone/diagnostic imaging ; Temporal Bone/surgery ; Temporal Bone/pathology ; Fibrosis
Sprache	Englisch
Erscheinungsdatum	2024-01-17
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2036790-9
ISSN	1537-4505 ; 1531-7129
ISSN (online)	1537-4505
ISSN	1531-7129
DOI	10.1097/MAO.0000000000004102
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effects of Voltage and Treatment Time of Pulsed Electric Field on Electroporation in Rhizoctonia solani.

Feng, Xuebin / Zhu, Xueru / Zhu, Mengyu / Qian, Yan / Li, Hua

Current microbiology

2024 Band 81, Heft 2, Seite(n) 58

Abstract: The pulsed electric field (PEF) of μs duration can induce electroporation by causing permanent damage to the membrane, leading to cell death. The microbe was treated by a homemade PEF generator instrument. The sterilization effect of PEF on the ... ...

Abstract	The pulsed electric field (PEF) of μs duration can induce electroporation by causing permanent damage to the membrane, leading to cell death. The microbe was treated by a homemade PEF generator instrument. The sterilization effect of PEF on the Rhizoctonia solani was observed by scanning electron microscope (SEM) and transmission electron microscope (TEM), and the leakage of the intracellular contents was measured with a conductometer and an ultraviolet spectrophotometer. The increases in the electrical conductivity and the optical density (OD) value indicated that the cell membrane was damaged, and the intracellular contents overflowed. As a result, according to our experimental conditions, the optimum condition was the high-pulsed electric voltage of 26 kV, and the treatment time was 4 min. It could be concluded that the PEF could damage the cell membrane, and the ratio of electroporation reached 100%, which provides a new method of killing R. solani efficiently.
Mesh-Begriff(e)	Electroporation ; Rhizoctonia ; Electricity ; Cell Membrane
Sprache	Englisch
Erscheinungsdatum	2024-01-10
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-023-03564-x
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A Review on the Anticancer Activity of Carbazole-based Tricyclic Compounds.

Zhang, Hua / Zhang, Wen / Zhu, Mengyu / Awadasseid, Annoor

Current medicinal chemistry

2023

Abstract: Cancers are a huge threat to human life and health. Every year, many people suffer and die from various cancers, and numerous resources have been used to combat cancer. Due to several disadvantages of anticancer agents, such as drug-induced side effects, ...

Abstract	Cancers are a huge threat to human life and health. Every year, many people suffer and die from various cancers, and numerous resources have been used to combat cancer. Due to several disadvantages of anticancer agents, such as drug-induced side effects, drug resistance, etc., there are still wide gaps in their ability to conquer cancer. Therefore, there is an urgent need to discover and develop many novel chemotypes to suppress cancer. In this review, we mainly focus on the anticancer potency of two representative sorts of carbazole-based compounds: carboline derivatives and diazacarbazole derivatives. Diazacarbazole derivatives, which have not been fully explored yet, might bring us a new vision and a valuable opportunity for overcoming the enormous hurdle we are now facing in the cancer campaign. We also provide several synthetic approaches for constructing the critical skeletons of the carbazole-based tricyclic compounds.
Sprache	Englisch
Erscheinungsdatum	2023-08-25
Erscheinungsland	United Arab Emirates
Dokumenttyp	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867331666230825104254
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Multi-Access Edge Computing (MEC) Based on MIMO: A Survey.

Zhu, Mengyu / Gao, Shaoshuai / Tu, Guofang / Chen, Deyuan

Sensors (Basel, Switzerland)

2023 Band 23, Heft 8

Abstract: With the rapid development of wireless communication technology and the emergence of intelligent applications, higher requirements have been put forward for data communication and computing capacity. Multi-access edge computing (MEC) can handle highly ... ...

Abstract	With the rapid development of wireless communication technology and the emergence of intelligent applications, higher requirements have been put forward for data communication and computing capacity. Multi-access edge computing (MEC) can handle highly demanding applications by users by sinking the services and computing capabilities of the cloud to the edge of the cell. Meanwhile, the multiple input multiple output (MIMO) technology based on large-scale antenna arrays can achieve an order-of-magnitude improvement in system capacity. The introduction of MIMO into MEC takes full advantage of the energy and spectral efficiency of MIMO technology, providing a new computing paradigm for time-sensitive applications. In parallel, it can accommodate more users and cope with the inevitable trend of continuous data traffic explosion. In this paper, the state-of-the-art research status in this field is investigated, summarized and analyzed. Specifically, we first summarize a multi-base station cooperative mMIMO-MEC model that can easily be expanded to adapt to different MIMO-MEC application scenarios. Subsequently, we comprehensively analyze the current works, compare them to each other and summarize them, mainly from four aspects: research scenarios, application scenarios, evaluation indicators and research issues, and research algorithms. Finally, some open research challenges are identified and discussed, and these indicate the direction for future research on MIMO-MEC.
Sprache	Englisch
Erscheinungsdatum	2023-04-11
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23083883
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Alkaloids in Uncaria rhynchophylla improves AD pathology by restraining CD4

Kuang, Ying / Zhu, Mengyu / Gu, Hongting / Tao, Yue / Huang, Hao / Chen, Lei

Journal of ethnopharmacology

2024 Band 331, Seite(n) 118273

Abstract: Ethnopharmacological relevance: Uncaria rhynchophylla (Miq.) Miq.ex Havil. was a classical medicinal plant exhibiting the properties of extinguishing wind, arresting convulsions, clearing heat and pacifying the liver. Clinically, it could be utilized ... ...

Abstract	Ethnopharmacological relevance: Uncaria rhynchophylla (Miq.) Miq.ex Havil. was a classical medicinal plant exhibiting the properties of extinguishing wind, arresting convulsions, clearing heat and pacifying the liver. Clinically, it could be utilized for the treatment of central nervous system-related diseases, such as Alzheimer's disease. U. rhynchophylla (UR) and its major ingredient alkaloid compounds (URA) have been proved to exert significant neuroprotective effects. However, the potential mechanism aren't fully understood. Aim of the study: This study systematically examined the therapeutic effects of URA on AD pathology in APP-PS1 mice, and revealed the potential mechanism of action. Materials and methods: The cognitive ability was evaluated by morris water maze test in APP-PS1 mice. The H&E staining was used to observe the tissue pathological changes. The ELISA kits were used to detect the level of inflammatory factors. The flow cytometry was used to analyze the percentage of CD4 Results: URA treatment improved AD pathology effectively as demonstrated by enhanced cognitive ability, decreased Aβ deposit and Tau phosphorylation, as well as reduced neuron apoptosis. Also, the neuroinflammation was significantly alleviated as evidenced by decreased IFN-γ, IL-17 and increased IL-10, TGF-β. Notably, URA treatment down-regulated the percentage of Teffs (Th1 and Th17) in spleen, and reduced the infiltration of Teffs and microglia in brain. Meanwhile, the Treg cell was up-regulated both in spleen and brain. In vitro, URA was capable of attenuating the spleen lymphocyte proliferation and release of inflammatory factors provoked by ConA. Interestingly, glycolysis was inhibited by URA treatment as evidenced by the decrease in Lactic Acid production and expression of HK2 and GLUT1 via regulating PI3K/Akt/mTOR signaling pathway in ConA-induced naive T cell. Conclusion: This study proved that URA could improve AD pathology which was possibly attributable to the restraints of CD4
Mesh-Begriff(e)	Animals ; Uncaria/chemistry ; Glycolysis/drug effects ; Mice ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; CD4-Positive T-Lymphocytes/drug effects ; Alkaloids/pharmacology ; Male ; Neuroinflammatory Diseases/drug therapy ; Mice, Transgenic ; Disease Models, Animal ; Mice, Inbred C57BL ; Neuroprotective Agents/pharmacology ; Signal Transduction/drug effects
Chemische Substanzen	Alkaloids ; Neuroprotective Agents
Sprache	Englisch
Erscheinungsdatum	2024-05-03
Erscheinungsland	Ireland
Dokumenttyp	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118273
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Computer-aided rational design strategy based on protein surface charge to improve the thermal stability of a novel esterase from Geobacillus jurassicus.

Song, Runfei / Zhang, Jin / Zhu, Mengyu / Lin, Lin / Wei, Wei / Wei, Dongzhi

Biotechnology letters

2024 Band 46, Heft 3, Seite(n) 443–458

Abstract: Objectives: Although Geobacillus are significant thermophilic bacteria source, there are no reports of thermostable esterase gene in Geobacillus jurassicus or rational design strategies to increase the thermal stability of esterases.: Results: Gene ... ...

Abstract	Objectives: Although Geobacillus are significant thermophilic bacteria source, there are no reports of thermostable esterase gene in Geobacillus jurassicus or rational design strategies to increase the thermal stability of esterases. Results: Gene gju768 showed a highest similarity of 15.20% to esterases from Geobacillus sp. with detail enzymatic properties. Using a combination of Gibbs Unfolding Free Energy (∆∆G) calculator and the distance from the mutation site to the catalytic site (Ds Conclusion: Cloning of gene gju768 and rational design based on surface charge engineering contributed to the identification of thermostable esterase from Geobacillus sp. and the exploration of evolutionary strategies for thermal stability.
Mesh-Begriff(e)	Geobacillus/enzymology ; Geobacillus/genetics ; Esterases/genetics ; Esterases/chemistry ; Esterases/metabolism ; Enzyme Stability ; Bacterial Proteins/genetics ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Computer-Aided Design ; Cloning, Molecular
Chemische Substanzen	Esterases (EC 3.1.-) ; Bacterial Proteins
Sprache	Englisch
Erscheinungsdatum	2024-03-25
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	423853-9
ISSN	1573-6776 ; 0141-5492
ISSN (online)	1573-6776
ISSN	0141-5492
DOI	10.1007/s10529-024-03473-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Rutin modified selenium nanoparticles reduces cell oxidative damage induced by H

Zhu, Mengyu / Zhang, Yang / Zhang, Chi / Chen, Lei / Kuang, Ying

Journal of biomaterials applications

2023 Band 38, Heft 1, Seite(n) 109–121

Abstract: Oxidative damage of neurons is one of the key pathological markers of Alzheimer's disease (AD), which eventually leads to neuronal apoptosis and loss. Nuclear factor E2-related factor 2 (Nrf2) is a key regulator of antioxidant response and is considered ... ...

Abstract	Oxidative damage of neurons is one of the key pathological markers of Alzheimer's disease (AD), which eventually leads to neuronal apoptosis and loss. Nuclear factor E2-related factor 2 (Nrf2) is a key regulator of antioxidant response and is considered to be an important therapeutic target for neurodegenerative diseases. In this study, the selenated derivative of antioxidant rutin (Se-Rutin) was synthesized with sodium selenate (Na
Mesh-Begriff(e)	Rats ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Selenium/pharmacology ; Reactive Oxygen Species/metabolism ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/pharmacology ; Hydrogen Peroxide ; Rutin/pharmacology ; Oxidative Stress ; Signal Transduction ; Alzheimer Disease ; Nanoparticles ; Apoptosis
Chemische Substanzen	Antioxidants ; Selenium (H6241UJ22B) ; Reactive Oxygen Species ; NF-E2-Related Factor 2 ; Hydrogen Peroxide (BBX060AN9V) ; Rutin (5G06TVY3R7)
Sprache	Englisch
Erscheinungsdatum	2023-06-07
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639283-0
ISSN	1530-8022 ; 0885-3282
ISSN (online)	1530-8022
ISSN	0885-3282
DOI	10.1177/08853282231182765
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Surgical Considerations in Inner Ear Gene Therapy from Human Temporal Bone Anatomy.

Brown, Alyssa / Zhu, MengYu / Rohani, Alireza / Ladak, Hanif / Agrawal, Sumit K / Stankovic, Konstantina M / Welling, D Bradley

The Laryngoscope

2024 Band 134, Heft 6, Seite(n) 2879–2888

Abstract: Objective(s): Recently directed methods of inner ear drug delivery underscore the necessity for understanding critical anatomical dimensions. This study examines anatomical measurements of the human middle and inner ear relevant for inner ear drug ... ...

Abstract	Objective(s): Recently directed methods of inner ear drug delivery underscore the necessity for understanding critical anatomical dimensions. This study examines anatomical measurements of the human middle and inner ear relevant for inner ear drug delivery studied with three different imaging modalities. Methods: Post-mortem human temporal bones were analyzed using human temporal bone histopathology (N = 24), micro computerized tomography (μCT; N = 4), and synchrotron radiation phase-contrast imaging (SR-PCI; N = 7). Nine measurements involving the oval and round windows were performed when relevant anatomical structures were visualized for subsequent age-controlled analysis, and comparisons were made between imaging methods. Results: Combined human temporal bone histopathology showed the mean distance to the saccule from the center of the stapes footplate (FP) was 2.07 ± 0.357 mm and the minimum distance was 1.23 mm. The mean distance from the round window membrane (RWM) to the osseous spiral lamina (OSL) was 1.75 ± 0.199 mm and the minimum distance was 1.43 mm. Instruments inserted up to 1 mm past the center of the FP are unlikely to cause saccular damage, provided there are no endolymphatic hydrops. Similarly, instruments inserted up to 1 mm through the RWM in the trajectory toward the OSL are unlikely to cause OSL damage. Conclusion: The combined analyses of inner-ear dimensions of age-controlled groups and imaging modalities demonstrate critical dimensions of importance to consider when inserting delivery vehicles into the human cochlea. Level of evidence: N/A Laryngoscope, 134:2879-2888, 2024.
Mesh-Begriff(e)	Humans ; Temporal Bone/diagnostic imaging ; Temporal Bone/anatomy & histology ; Ear, Inner/diagnostic imaging ; Ear, Inner/anatomy & histology ; X-Ray Microtomography/methods ; Genetic Therapy/methods ; Cadaver ; Middle Aged ; Male ; Female ; Synchrotrons ; Aged
Sprache	Englisch
Erscheinungsdatum	2024-01-10
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.31259
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Enhanced Thermostability of

Zhu, Mengyu / Zhai, Wenxin / Song, Runfei / Lin, Lin / Wei, Wei / Wei, Dongzhi

Journal of agricultural and food chemistry

2023 Band 71, Heft 48, Seite(n) 18928–18942

Abstract: α-Amylase (EC 3.2.1.1) ... ...

Abstract	α-Amylase (EC 3.2.1.1) from
Mesh-Begriff(e)	alpha-Amylases/chemistry ; Geobacillus stearothermophilus/genetics ; Zea mays/genetics ; Zea mays/metabolism ; Starch ; Bread ; Quality Improvement ; Enzyme Stability ; Disulfides/chemistry ; Temperature
Chemische Substanzen	alpha-Amylases (EC 3.2.1.1) ; Starch (9005-25-8) ; Disulfides
Sprache	Englisch
Erscheinungsdatum	2023-11-21
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c06761
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Correction to "Enhanced Thermostability of

Zhu, Mengyu / Zhai, Wenxin / Song, Runfei / Lin, Lin / Wei, Wei / Wei, Dongzhi

Journal of agricultural and food chemistry

2023 Band 72, Heft 1, Seite(n) 950–951

Sprache	Englisch
Erscheinungsdatum	2023-12-25
Erscheinungsland	United States
Dokumenttyp	Published Erratum
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c09375
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