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  1. Artikel ; Online: Reservoir Characteristics and Formation Model of the Bauxite Gas Reservoir: The Benxi Formation in the LX Block, Northeast of Ordos Basin, China.

    Yu, Shanshan / Zhao, Zhigang / Zhu, Yanhe / Zhu, Xiaomin / Lai, Jin / Li, Dan / Wang, Xiaolin

    ACS omega

    2024  Band 9, Heft 16, Seite(n) 18127–18136

    Abstract: Recently, horizontal well L47-1CH in the Longdong area of the southwestern Ordos Basin made a significant breakthrough in bauxite natural gas exploration, changing the traditional geological understanding that bauxite could not form effective reservoirs. ...

    Abstract Recently, horizontal well L47-1CH in the Longdong area of the southwestern Ordos Basin made a significant breakthrough in bauxite natural gas exploration, changing the traditional geological understanding that bauxite could not form effective reservoirs. To further explore the exploration and development potential of bauxite natural gas reservoirs in the northeast of the Ordos Basin, it is urgent to carry out basic geological studies. This paper discusses the sedimentary environment, reservoir characteristics, and formation patterns of the bauxite gas reservoirs in the LX Block using trace elements, thin sections, X-ray diffraction, scanning electron microscopy, conventional physical properties, constant pressure mercury, etc. Then, the distribution pattern of bauxite was studied according to the restoration of the karst paleogeomorphology, and the formation model of bauxite was ultimately established. The results show that bauxite developed a clear triple-segment structure vertically, characterized by rich iron at the bottom, high aluminum at the middle, and low iron at the top. The mineral composition of the bauxite section mainly includes diaspore, iron minerals, titanium minerals, and birnessite. The types of pores mainly include intra- and intergranular dissolved pores, matrix-dissolved pores, intercrystalline pores, and microfractures. The porosity ranges from 1.51 to 9.90%, with a relatively good sorting and connectivity of the pore and throat. The bauxite was formed in a hot and humid climate, deposited in a shallow-water tidal flat and lagoon sedimentary environment with oxygen depleted, and experienced oscillatory regression during the deposition process. The thickness of bauxite is significantly controlled by karst paleogeomorphology, and it is mainly distributed at the negative terrain positions of karat pits and karst terraces. The above results can provide a geological basis for the exploration and development of bauxite in the Ordos Basin and similar basins worldwide.
    Sprache Englisch
    Erscheinungsdatum 2024-04-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c10097
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Hydrogel microrobots for biomedical applications.

    Song, Wenping / Li, Leike / Liu, Xuejia / Zhu, Yanhe / Yu, Shimin / Wang, Haocheng / Wang, Lin

    Frontiers in chemistry

    2024  Band 12, Seite(n) 1416314

    Abstract: Recent years have witnessed a surge in the application of microrobots within the medical sector, with hydrogel microrobots standing out due to their distinctive advantages. These microrobots, characterized by their exceptional biocompatibility, ... ...

    Abstract Recent years have witnessed a surge in the application of microrobots within the medical sector, with hydrogel microrobots standing out due to their distinctive advantages. These microrobots, characterized by their exceptional biocompatibility, adjustable physico-mechanical attributes, and acute sensitivity to biological environments, have emerged as pivotal tools in advancing medical applications such as targeted drug delivery, wound healing enhancement, bio-imaging, and precise surgical interventions. The capability of hydrogel microrobots to navigate and perform tasks within complex biological systems significantly enhances the precision, efficiency, and safety of therapeutic procedures. Firstly, this paper delves into the material classification and properties of hydrogel microrobots and compares the advantages of different hydrogel materials. Furthermore, it offers a comprehensive review of the principal categories and recent innovations in the synthesis, actuation mechanisms, and biomedical application of hydrogel-based microrobots. Finally, the manuscript identifies prevailing obstacles and future directions in hydrogel microrobot research, aiming to furnish insights that could propel advancements in this field.
    Sprache Englisch
    Erscheinungsdatum 2024-05-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2024.1416314
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Reinforcement learning based variable damping control of wearable robotic limbs for maintaining astronaut pose during extravehicular activity.

    Zhao, Sikai / Zheng, Tianjiao / Sui, Dongbao / Zhao, Jie / Zhu, Yanhe

    Frontiers in neurorobotics

    2023  Band 17, Seite(n) 1093718

    Abstract: As astronauts perform on-orbit servicing of extravehicular activity (EVA) without the help of the space station's robotic arms, it will be rather difficult and labor-consuming to maintain the appropriate position in case of impact. In order to solve this ...

    Abstract As astronauts perform on-orbit servicing of extravehicular activity (EVA) without the help of the space station's robotic arms, it will be rather difficult and labor-consuming to maintain the appropriate position in case of impact. In order to solve this problem, we propose the development of a wearable robotic limb system for astronaut assistance and a variable damping control method for maintaining the astronaut's position. The requirements of the astronaut's impact-resisting ability during EVA were analyzed, including the capabilities of deviation resistance, fast return, oscillation resistance, and accurate return. To meet these needs, the system of the astronaut with robotic limbs was modeled and simplified. In combination with this simplified model and a reinforcement learning algorithm, a variable damping controller for the end of the robotic limb was obtained, which can regulate the dynamic performance of the robot end to resist oscillation after impact. A weightless simulation environment for the astronaut with robotic limbs was constructed. The simulation results demonstrate that the proposed method can meet the recommended requirements for maintaining an astronaut's position during EVA. No matter how the damping coefficient was set, the fixed damping control method failed to meet all four requirements at the same time. In comparison to the fixed damping control method, the variable damping controller proposed in this paper fully satisfied all the impact-resisting requirements by itself. It could prevent excessive deviation from the original position and was able to achieve a fast return to the starting point. The maximum deviation displacement was reduced by 39.3% and the recovery time was cut by 17.7%. Besides, it also had the ability to prevent reciprocating oscillation and return to the original position accurately.
    Sprache Englisch
    Erscheinungsdatum 2023-02-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2453002-5
    ISSN 1662-5218
    ISSN 1662-5218
    DOI 10.3389/fnbot.2023.1093718
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A Graph-Based Hybrid Reconfiguration Deformation Planning for Modular Robots.

    Wei, Ruopeng / Liu, Yubin / Dong, Huijuan / Zhu, Yanhe / Zhao, Jie

    Sensors (Basel, Switzerland)

    2023  Band 23, Heft 18

    Abstract: The self-reconfigurable modular robotic system is a class of robots that can alter its configuration by rearranging the connectivity of their component modular units. The reconfiguration deformation planning problem is to find a sequence of ... ...

    Abstract The self-reconfigurable modular robotic system is a class of robots that can alter its configuration by rearranging the connectivity of their component modular units. The reconfiguration deformation planning problem is to find a sequence of reconfiguration actions to transform one reconfiguration into another. In this paper, a hybrid reconfiguration deformation planning algorithm for modular robots is presented to enable reconfiguration between initial and goal configurations. A hybrid algorithm is developed to decompose the configuration into subconfigurations with maximum commonality and implement distributed dynamic mapping of free vertices. The module mapping relationship between the initial and target configurations is then utilized to generate reconfiguration actions. Simulation and experiment results verify the effectiveness of the proposed algorithm.
    Sprache Englisch
    Erscheinungsdatum 2023-09-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23187892
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Sema3A alleviates viral myocarditis by modulating SIRT1 to regulate cardiomyocyte mitophagy

    Lin, Lin / Wei, Jin / Zhu, Canzhan / Hao, Guanghua / Xue, Jiahong / Zhu, Yanhe / Wu, Ruiyun

    Environmental Toxicology. 2023 June, v. 38, no. 6 p.1305-1317

    2023  

    Abstract: Viral myocarditis (VMC) is a common myocardial inflammatory disease characterized by inflammatory cell infiltration and cardiomyocyte necrosis. Sema3A was reported to reduce cardiac inflammation and improve cardiac function after myocardial infarction, ... ...

    Abstract Viral myocarditis (VMC) is a common myocardial inflammatory disease characterized by inflammatory cell infiltration and cardiomyocyte necrosis. Sema3A was reported to reduce cardiac inflammation and improve cardiac function after myocardial infarction, but its role in VMC remains to be explored. Here, a VMC mouse model was established by infection with CVB3, and Sema3A was overexpressed in vivo by intraventricular injection of an adenovirus‐mediated Sema3A expression vector (Ad‐Sema3A). We found that Sema3A overexpression attenuated CVB3‐induced cardiac dysfunction and tissue inflammation. And Sema3A also reduced macrophage accumulation and NLRP3 inflammasome activation in the myocardium of VMC mice. In vitro, LPS was used to stimulate primary splenic macrophages to mimic the macrophage activation state in vivo. Activated macrophages were co‐cultured with primary mouse cardiomyocytes to evaluate macrophage infiltration‐induced cardiomyocyte damage. Ectopic expression of Sema3A in cardiomyocytes effectively protected cardiomyocytes from activated macrophage‐induced inflammation, apoptosis, and ROS accumulation. Mechanistically, cardiomyocyte‐expressed Sema3A mitigated macrophage infiltration‐caused cardiomyocyte dysfunction by promoting cardiomyocyte mitophagy and hindering NLRP3 inflammasome activation. Furthermore, NAM (a SIRT1 inhibitor) reversed the protective effect of Sema3A against activated macrophage‐induced cardiomyocyte dysfunction by suppressing cardiomyocyte mitophagy. In conclusion, Sema3A promoted cardiomyocyte mitophagy and suppressed inflammasome activation by regulating SIRT1, thereby attenuating macrophage infiltration‐induced cardiomyocyte injury in VMC.
    Schlagwörter apoptosis ; cardiac output ; cardiomyocytes ; coculture ; ecotoxicology ; genetic vectors ; inflammasomes ; inflammation ; macrophage activation ; macrophages ; mice ; mitophagy ; models ; myocardial infarction ; myocarditis ; necrosis ; protective effect
    Sprache Englisch
    Erscheinungsverlauf 2023-06
    Umfang p. 1305-1317.
    Erscheinungsort John Wiley & Sons, Inc.
    Dokumenttyp Artikel ; Online
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23765
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel ; Online: A Mouth and Tongue Interactive Device to Control Wearable Robotic Limbs in Tasks where Human Limbs Are Occupied.

    Jing, Hongwei / Zheng, Tianjiao / Zhang, Qinghua / Liu, Benshan / Sun, Kerui / Li, Lele / Zhao, Jie / Zhu, Yanhe

    Biosensors

    2024  Band 14, Heft 5

    Abstract: The Wearable Robotic Limb (WRL) is a type of robotic arm worn on the human body, aiming to enhance the wearer's operational capabilities. However, proposing additional methods to control and perceive the WRL when human limbs are heavily occupied with ... ...

    Abstract The Wearable Robotic Limb (WRL) is a type of robotic arm worn on the human body, aiming to enhance the wearer's operational capabilities. However, proposing additional methods to control and perceive the WRL when human limbs are heavily occupied with primary tasks presents a challenge. Existing interactive methods, such as voice, gaze, and electromyography (EMG), have limitations in control precision and convenience. To address this, we have developed an interactive device that utilizes the mouth and tongue. This device is lightweight and compact, allowing wearers to achieve continuous motion and contact force control of the WRL. By using a tongue controller and mouth gas pressure sensor, wearers can control the WRL while also receiving sensitive contact feedback through changes in mouth pressure. To facilitate bidirectional interaction between the wearer and the WRL, we have devised an algorithm that divides WRL control into motion and force-position hybrid modes. In order to evaluate the performance of the device, we conducted an experiment with ten participants tasked with completing a pin-hole assembly task with the assistance of the WRL system. The results show that the device enables continuous control of the position and contact force of the WRL, with users perceiving feedback through mouth airflow resistance. However, the experiment also revealed some shortcomings of the device, including user fatigue and its impact on breathing. After experimental investigation, it was observed that fatigue levels can decrease with training. Experimental studies have revealed that fatigue levels can decrease with training. Furthermore, the limitations of the device have shown potential for improvement through structural enhancements. Overall, our mouth and tongue interactive device shows promising potential in controlling the WRL during tasks where human limbs are occupied.
    Mesh-Begriff(e) Humans ; Wearable Electronic Devices ; Robotics ; Tongue ; Mouth ; Male ; Adult ; Electromyography
    Sprache Englisch
    Erscheinungsdatum 2024-04-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios14050213
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Symmetrical Efficient Gait Planning Based on Constrained Direct Collocation.

    Chen, Boyang / Zang, Xizhe / Zhang, Yue / Gao, Liang / Zhu, Yanhe / Zhao, Jie

    Micromachines

    2023  Band 14, Heft 2

    Abstract: Biped locomotion provides more mobility and effectiveness compared with other methods. Animals have evolved efficient walking patterns that are pursued by biped robot researchers. Current researchers have observed that symmetry is a critical criterion to ...

    Abstract Biped locomotion provides more mobility and effectiveness compared with other methods. Animals have evolved efficient walking patterns that are pursued by biped robot researchers. Current researchers have observed that symmetry is a critical criterion to achieve efficient natural walking and usually realize symmetrical gait patterns through morphological characteristics using simplified dynamic models or artificial priors of the center of mass (CoM). However, few considerations of symmetry and energy consumption are introduced at the joint level, resulting in inefficient leg motion. In this paper, we propose a full-order biped gait planner in which the symmetry requirement, energy efficiency, and trajectory smoothness can all be involved at the joint level, and CoM motion is automatically determined without any morphological prior. In order to achieve a symmetrical and efficient walking pattern, we first investigated the characteristic of a completely symmetrical gait, and a group of nearly linear slacked constraints was designed for three phases of planning. Then a Constrained Direct Collocation (DIRCON)-based full-order biped gait planner with a weighted cost function for energy consumption and trajectory smoothness is proposed. A dynamic simulation with our newly designed robot model was performed in CoppliaSim to test the planner. Physical comparison experiments on a real robot device finally validated the symmetry characteristic and energy efficiency of the generated gait. In addition, a detailed presentation of the real biped robot is also provided.
    Sprache Englisch
    Erscheinungsdatum 2023-02-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14020417
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Calcitriol Suppressed Isoproterenol-induced Proliferation of Cardiac Fibroblasts via Integrin β3/FAK/Akt Pathway.

    Wang, Xin-Feng / Li, Qian / Sun, Xia / Zheng, Li-Ming / Cheng, Shao-Li / Zhu, Yan-He

    Current medical science

    2023  Band 43, Heft 1, Seite(n) 48–57

    Abstract: Objective: Cardiac fibroblasts (CFs) proliferation and extracellular matrix deposition are important features of cardiac fibrosis. Various studies have indicated that vitamin D displays an anti-fibrotic property in chronic heart diseases. This study ... ...

    Abstract Objective: Cardiac fibroblasts (CFs) proliferation and extracellular matrix deposition are important features of cardiac fibrosis. Various studies have indicated that vitamin D displays an anti-fibrotic property in chronic heart diseases. This study explored the role of vitamin D in the growth of CFs via an integrin signaling pathway.
    Methods: MTT and 5-ethynyl-2'-deoxyuridine assays were performed to determine cell viability. Western blotting was performed to detect the expression of proliferating cell nuclear antigen (PCNA) and integrin signaling pathway. The fibronectin was observed by ELISA. Immunohistochemical staining was employed to evaluate the expression of integrin β3.
    Results: The PCNA expression in the CFs was enhanced after isoproterenol (ISO) stimulation accompanied by an elevated expression of integrin beta-3 (β3). The blockade of the integrin β3 with a specific integrin β3 antibody reduced the PCNA expression induced by the ISO. Decreasing the integrin β3 by siRNA reduced the ISO-triggered phosphorylation of FAK and Akt. Both the FAK inhibitor and Akt inhibitor suppressed the PCNA expression induced by the ISO in the CFs. Calcitriol (CAL), an active form of vitamin D, attenuated the ISO-induced CFs proliferation by downregulating the integrin β3 expression, and phosphorylation of FAK and Akt. Moreover, CAL reduced the increased levels of fibronectin and hydroxyproline in the CFs culture medium triggered by the ISO. The administration of calcitriol decreased the integrin β3 expression in the ISO-induced myocardial injury model.
    Conclusion: These findings revealed a novel role for CAL in suppressing the CFs growth by the downregulation of the integrin β3/FAK/Akt pathway.
    Mesh-Begriff(e) Humans ; Calcitriol/metabolism ; Calcitriol/pharmacology ; Fibronectins/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Isoproterenol ; Proliferating Cell Nuclear Antigen/metabolism ; Integrin beta3/genetics ; Integrin beta3/metabolism ; Vitamins ; Cell Proliferation ; Fibroblasts/metabolism
    Chemische Substanzen Calcitriol (FXC9231JVH) ; Fibronectins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Isoproterenol (L628TT009W) ; Proliferating Cell Nuclear Antigen ; Integrin beta3 ; Vitamins
    Sprache Englisch
    Erscheinungsdatum 2023-01-21
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-022-2681-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Sema3A alleviates viral myocarditis by modulating SIRT1 to regulate cardiomyocyte mitophagy.

    Lin, Lin / Wei, Jin / Zhu, Canzhan / Hao, Guanghua / Xue, Jiahong / Zhu, Yanhe / Wu, Ruiyun

    Environmental toxicology

    2023  Band 38, Heft 6, Seite(n) 1305–1317

    Abstract: Viral myocarditis (VMC) is a common myocardial inflammatory disease characterized by inflammatory cell infiltration and cardiomyocyte necrosis. Sema3A was reported to reduce cardiac inflammation and improve cardiac function after myocardial infarction, ... ...

    Abstract Viral myocarditis (VMC) is a common myocardial inflammatory disease characterized by inflammatory cell infiltration and cardiomyocyte necrosis. Sema3A was reported to reduce cardiac inflammation and improve cardiac function after myocardial infarction, but its role in VMC remains to be explored. Here, a VMC mouse model was established by infection with CVB3, and Sema3A was overexpressed in vivo by intraventricular injection of an adenovirus-mediated Sema3A expression vector (Ad-Sema3A). We found that Sema3A overexpression attenuated CVB3-induced cardiac dysfunction and tissue inflammation. And Sema3A also reduced macrophage accumulation and NLRP3 inflammasome activation in the myocardium of VMC mice. In vitro, LPS was used to stimulate primary splenic macrophages to mimic the macrophage activation state in vivo. Activated macrophages were co-cultured with primary mouse cardiomyocytes to evaluate macrophage infiltration-induced cardiomyocyte damage. Ectopic expression of Sema3A in cardiomyocytes effectively protected cardiomyocytes from activated macrophage-induced inflammation, apoptosis, and ROS accumulation. Mechanistically, cardiomyocyte-expressed Sema3A mitigated macrophage infiltration-caused cardiomyocyte dysfunction by promoting cardiomyocyte mitophagy and hindering NLRP3 inflammasome activation. Furthermore, NAM (a SIRT1 inhibitor) reversed the protective effect of Sema3A against activated macrophage-induced cardiomyocyte dysfunction by suppressing cardiomyocyte mitophagy. In conclusion, Sema3A promoted cardiomyocyte mitophagy and suppressed inflammasome activation by regulating SIRT1, thereby attenuating macrophage infiltration-induced cardiomyocyte injury in VMC.
    Mesh-Begriff(e) Animals ; Mice ; Myocarditis ; Myocytes, Cardiac/metabolism ; Semaphorin-3A/metabolism ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Mitophagy ; Coxsackievirus Infections/metabolism ; Inflammation/metabolism
    Chemische Substanzen Semaphorin-3A ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Sirtuin 1 (EC 3.5.1.-) ; Sirt1 protein, mouse (EC 3.5.1.-)
    Sprache Englisch
    Erscheinungsdatum 2023-03-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23765
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Swimming Performance of the Frog-Inspired Soft Robot.

    Fan, Jizhuang / Wang, Shuqi / Yu, Qingguo / Zhu, Yanhe

    Soft robotics

    2020  Band 7, Heft 5, Seite(n) 615–626

    Abstract: This article presents a frog-inspired swimming soft robot whose joints are articulated pneumatic soft actuators. The soft actuator is designed and prepared by studying the biological structure and limb movement characteristics of frogs. A schematic limb ... ...

    Abstract This article presents a frog-inspired swimming soft robot whose joints are articulated pneumatic soft actuators. The soft actuator is designed and prepared by studying the biological structure and limb movement characteristics of frogs. A schematic limb motion diagram of the robot is established based on the kinematic model, and the design scheme is determined by a combined control system. The torso size is 0.175 × 0.100 × 0.060 m, which realizes frog-inspired swimming robot miniaturization. The experimental results show that the average propulsion speed during linear motion is 0.075 m/s, and the average turning speed is 15°/s. The rationality of the robot structural design and correctness of the control system are verified by prototype experiments.
    Mesh-Begriff(e) Animals ; Anura ; Biomechanical Phenomena ; Equipment Design ; Motion ; Robotics ; Swimming
    Sprache Englisch
    Erscheinungsdatum 2020-05-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2169-5180
    ISSN (online) 2169-5180
    DOI 10.1089/soro.2019.0094
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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