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Artikel ; Online: Neuroprotective Effect of Nerve Growth Factor Loaded in Porous Silicon Nanostructures in an Alzheimer's Disease Model and Potential Delivery to the Brain.

Zilony-Hanin, Neta / Rosenberg, Michal / Richman, Michal / Yehuda, Ronen / Schori, Hadas / Motiei, Menachem / Rahimipour, Shai / Groisman, Alexander / Segal, Ester / Shefi, Orit

Small (Weinheim an der Bergstrasse, Germany)

2019  Band 15, Heft 45, Seite(n) e1904203

Abstract: Nerve growth factor (NGF) plays a vital role in reducing the loss of cholinergic neurons in Alzheimer's disease (AD). However, its delivery to the brain remains a challenge. Herein, NGF is loaded into degradable oxidized porous silicon ( ... ...

Abstract Nerve growth factor (NGF) plays a vital role in reducing the loss of cholinergic neurons in Alzheimer's disease (AD). However, its delivery to the brain remains a challenge. Herein, NGF is loaded into degradable oxidized porous silicon (PSiO
Mesh-Begriff(e) Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Animals ; Brain/metabolism ; Cell Survival/drug effects ; Mice ; Microscopy, Confocal ; Microscopy, Fluorescence ; Nanostructures/chemistry ; Nanostructures/therapeutic use ; Nerve Growth Factor/chemistry ; Nerve Growth Factor/pharmacokinetics ; Nerve Growth Factor/therapeutic use ; PC12 Cells ; Porosity ; Rats ; Silicon/chemistry ; X-Ray Microtomography
Chemische Substanzen Nerve Growth Factor (9061-61-4) ; Silicon (Z4152N8IUI)
Sprache Englisch
Erscheinungsdatum 2019-09-04
Erscheinungsland Germany
Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
ISSN 1613-6829
ISSN (online) 1613-6829
DOI 10.1002/smll.201904203
Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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