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  1. Book ; Online ; Thesis: Epidemiologie ausgewählter Infektionen des Gastrointestinaltraktes in Deutschland

    Zimmermann, Lisa [Verfasser]

    Sekundärdatenanalysen zu bakteriell bedingten Leberabszessen und Clostridioides-difficile-Infektionen

    2023  

    Author's details Lisa Zimmermann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Leipzig
    Publishing place Leipzig
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Synthesis and Reactivity of Hetero-Pnictogen Diazonium Analogs Stabilized by Transition Metal Units.

    Zimmermann, Lisa / Riesinger, Christoph / Balázs, Gábor / Scheer, Manfred

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 61, Page(s) e202301974

    Abstract: The reactivity of the mixed dipnictogen complexes [{CpMo(CO) ...

    Abstract The reactivity of the mixed dipnictogen complexes [{CpMo(CO)
    Language English
    Publishing date 2023-09-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202301974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Conference proceedings: Das Matching von klinischen Studien- mit Versichertendaten: Ein innovativer Ansatz am Beispiel eines endovaskulären Dialyseshunts

    Zimmermann, Lisa

    2019  , Page(s) 19dkvf337

    Event/congress 18. Deutscher Kongress für Versorgungsforschung (DKVF); Berlin; Deutsches Netzwerk Versorgungsforschung; 2019
    Keywords Medizin, Gesundheit
    Publishing date 2019-10-02
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/19dkvf337
    Database German Medical Science

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  4. Article ; Online: Supramolecular compounds assembled from the heteroleptic tetrahedral complex [{CpMo(CO)

    Elsayed Moussa, Mehdi / Shelyganov, Pavel A / Seidl, Michael / Zimmermann, Lisa / Scheer, Manfred

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 35, Page(s) 4703–4706

    Abstract: The reaction of the tetrahedral complex [{CpMo(CO) ...

    Abstract The reaction of the tetrahedral complex [{CpMo(CO)
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc01001a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Validation and Application of Thresholds to Define Meaningful Change in Vasomotor Symptoms Frequency: Analysis of Pooled SKYLIGHT 1 and 2 Data.

    Morga, Antonia / Zimmermann, Lisa / Valluri, Udaya / Siddiqui, Emad / McLeod, Lori / Bender, Randall H

    Advances in therapy

    2024  

    Abstract: Introduction: Vasomotor symptoms (VMS), the characteristic symptoms of menopausal transition, are often the primary reason women seek treatment. Current treatment options for VMS include fezolinetant, a nonhormonal, selective neurokinin 3 receptor ... ...

    Abstract Introduction: Vasomotor symptoms (VMS), the characteristic symptoms of menopausal transition, are often the primary reason women seek treatment. Current treatment options for VMS include fezolinetant, a nonhormonal, selective neurokinin 3 receptor antagonist. This study aimed to define a clinically meaningful threshold for reduction of moderate-to-severe VMS in postmenopausal women treated with fezolinetant and then apply it in a responder analysis of the pooled trial data.
    Methods: This analysis pooled data from two identical phase 3, double-blind, placebo-controlled studies that randomized women with moderate-to-severe VMS to once-daily fezolinetant 30 mg, 45 mg, or placebo (SKYLIGHT 1 and 2). The frequency of VMS was collected daily using an electronic diary. Patients completed the Patient Global Impression of Change in VMS (PGI-C VMS) instrument, which assessed changes in hot flushes/night sweats at weeks 4 and 12 compared with baseline using a seven-point Likert scale. VMS frequency data were anchored to PGI-C VMS data; the anchor level for meaningful within-patient change in PGI-C VMS was "moderately better."
    Results: In the pooled population (N = 1022), the mean (standard deviation) estimated thresholds for a meaningful within-patient change in moderate-to-severe VMS frequency were - 5.73 (3.47) at week 4 and - 6.20 (5.18) at week 12. Applying the thresholds for meaningful within-patient change to responder analyses ("missing as non-responder" imputation method) indicated a favorable clinical benefit: greater proportions of responders were observed in the fezolinetant 30-mg and 45-mg groups compared with placebo at week 4 (odds ratio range 2.48-2.91; P < 0.001) and week 12 (odds ratio range 1.908-2.68; P < 0.001).
    Conclusion: PGI-C VMS is sensitive to change and correlates with VMS frequency: a reduction of approximately six VMS episodes per day from baseline to week 12 was meaningful at the individual patient level. Fezolinetant provides a meaningful clinical benefit for women with moderate-to-severe VMS associated with menopause and represents an important nonhormonal treatment option.
    Trial registration number: NCT04003155 and NCT04003142.
    Language English
    Publishing date 2024-05-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-024-02849-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2101: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Online ; Thesis: Bestimmung des Expressionsstatus von gezielt behandelbaren Proteinen im sinunasalen Schleimhautmelanom mittels eines Biopanels

    Zimmermann, Lisa [Verfasser]

    2018  

    Author's details Lisa Zimmermann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität Ulm
    Publishing place Ulm
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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    Inter-library loan at ZB MED

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  7. Book ; Online ; Thesis: Variability of radio and TeV emitting X-ray binary systems

    Zimmermann, Lisa

    the case of LS I +61303

    2013  

    Author's details vorgelegt von Lisa Zimmermann
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Bonn, 2013
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Online ; Thesis: Variability of radio and TeV emitting X-ray binary systems

    Zimmermann, Lisa

    the case of LS I +61303

    2013  

    Author's details vorgelegt von Lisa Zimmermann
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Bonn, 2013
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Adipogenic Activity of Chemicals Used in Plastic Consumer Products.

    Völker, Johannes / Ashcroft, Felicity / Vedøy, Åsa / Zimmermann, Lisa / Wagner, Martin

    Environmental science & technology

    2022  Volume 56, Issue 4, Page(s) 2487–2496

    Abstract: Bisphenols and phthalates, chemicals frequently used in plastic products, promote obesity in cell and animal models. However, these well-known metabolism-disrupting chemicals (MDCs) represent only a minute fraction of all compounds found in plastics. To ... ...

    Abstract Bisphenols and phthalates, chemicals frequently used in plastic products, promote obesity in cell and animal models. However, these well-known metabolism-disrupting chemicals (MDCs) represent only a minute fraction of all compounds found in plastics. To gain a comprehensive understanding of plastics as a source of exposure to MDCs, we characterized the chemicals present in 34 everyday products using nontarget high-resolution mass spectrometry and analyzed their joint adipogenic activities by high-content imaging. We detected 55,300 chemical features and tentatively identified 629 unique compounds, including 11 known MDCs. Importantly, the chemicals extracted from one-third of the products caused murine 3T3-L1 preadipocytes to proliferate, and differentiate into adipocytes, which were larger and contained more triglycerides than those treated with the reference compound rosiglitazone. Because the majority of plastic extracts did not activate the peroxisome proliferator-activated receptor γ and the glucocorticoid receptor, the adipogenic effects are mediated via other mechanisms and, thus, likely to be caused by unknown MDCs. Our study demonstrates that daily-use plastics contain potent mixtures of MDCs and can, therefore, be a relevant yet underestimated environmental factor contributing to obesity.
    MeSH term(s) 3T3-L1 Cells ; Adipocytes ; Adipogenesis ; Animals ; Mice ; Obesity ; PPAR gamma ; Plastics/pharmacology
    Chemical Substances PPAR gamma ; Plastics
    Language English
    Publishing date 2022-01-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.1c06316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Epidemiology of pyogenic liver abscesses in Germany: Analysis of incidence, risk factors and mortality rate based on routine data from statutory health insurance.

    Zimmermann, Lisa / Wendt, Sebastian / Lübbert, Christoph / Karlas, Thomas

    United European gastroenterology journal

    2021  Volume 9, Issue 9, Page(s) 1039–1047

    Abstract: Background: Pyogenic liver abscesses (PLAs) represent potentially life-threatening abdominal conditions that require immediate diagnosis and therapy. European and American incidence figures vary between one and 15 per 100,000 per year. Structured ... ...

    Abstract Background: Pyogenic liver abscesses (PLAs) represent potentially life-threatening abdominal conditions that require immediate diagnosis and therapy. European and American incidence figures vary between one and 15 per 100,000 per year. Structured epidemiological data for European countries are not available.
    Objective: To systematically characterize the epidemiology and clinical outcome of PLA in Germany.
    Methods: In representative statutory health insurance data from four million people in 2013-2019, the prevalence and incidence with clinical coding of International Statistical Classification of Diseases and Related Health Problems (ICD)-10 code K75.0 were selected (n = 1118). Furthermore, demographics, relevant comorbidities, hospitalizations, mortality and complications were determined within one year.
    Results: The incidence of PLA was approximately seven per 100,000. The average age at diagnosis was 66 years; 65% were male. Of these, biliary disease was documented in over 60% and infectious intestinal diseases were found in 21% within the same or previous calendar year. PLA patients had high comorbidity indices. Liver transplant status, malignancies of the liver and biliary system, liver cirrhosis and pancreatitis were strongly associated. Intensive care was documented in 27% of PLA cases. Nine percent died within 12 months, most with an underlying malignant disease.
    Conclusion: Pyogenic liver abscess is a rare disease with high morbidity. Predisposing and risk factors include intestinal and biliary diseases as well as hepatic malignancies. Further research should focus on PLA therapy within prospective surveys and controlled clinical trials.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biliary Tract Diseases/epidemiology ; Comorbidity ; Electronic Health Records ; Female ; Germany/epidemiology ; Humans ; Incidence ; Insurance, Health ; Intestinal Diseases/epidemiology ; Liver Abscess, Pyogenic/epidemiology ; Liver Abscess, Pyogenic/mortality ; Liver Cirrhosis/epidemiology ; Liver Transplantation ; Male ; Middle Aged ; Neoplasms/epidemiology ; Pancreatitis/epidemiology ; Risk Factors ; Young Adult
    Language English
    Publishing date 2021-07-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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