Artikel ; Online: Clinical and pathological significance of proliferation index and p53 expression in gastric adenocarcinoma.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
2021 Band 26, Heft 4, Seite(n) 1466–1478
Abstract: Purpose: The purpose of our work was to investigate the association between proliferative index [proIDX] and expression index p53 (p53IDX) with the clinical and pathological characteristics of gastric adenocarcinoma.: Methods: The biopsy material of ... ...
| Abstract | Purpose: The purpose of our work was to investigate the association between proliferative index [proIDX] and expression index p53 (p53IDX) with the clinical and pathological characteristics of gastric adenocarcinoma. Methods: The biopsy material of 90 patients operated on for gastric cancer was routinely processed in paraffin and archived. After the histopathological report was made, two study groups were formed, the first group (n=45) comprised biopsies with intestinal carcinoma and the second (n=45) biopsies of diffuse gastric cancer. In both cases, the control group consisted of biopsies of surrounding non-tumor tissue The routine Hematoxylin-Eosin and immunohistochemical ABC method with anti-Ki67 and anti-p53 antibodies was applied at sections 3-5 μm thick. The expression of Ki67 and p53 was quantified stereometrically. For statistical analysis SPSS (19.0) was used. Results: Significantly higher Ki67 expression was found in both types of adenocarcinoma compared to the control group, as well as significant association of proIDX with most of testing parameters. Expression of p53 was significantly higher in the intestinal type compared to the diffuse type and the control group and was significantly associated with age and histological grade. Diffuse type particulary showed, significant association of p53IDX with most of the histological parameters tested. Conclusion: Our results point a highly significant correlation of the Ki67 and p53 expression with indicators of gastric adenocarcinoma progression, which may help to identify patients with an aggressive gastric adenocarcinoma phenotype. |
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| Mesh-Begriff(e) | Adenocarcinoma/chemistry ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Cell Proliferation ; Female ; Humans ; Male ; Middle Aged ; Stomach Neoplasms/chemistry ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Tumor Suppressor Protein p53/analysis ; Tumor Suppressor Protein p53/biosynthesis | |||||
| Chemische Substanzen | Tumor Suppressor Protein p53 | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2021-10-22 | |||||
| Erscheinungsland | Cyprus | |||||
| Dokumenttyp | Journal Article | |||||
| ZDB-ID | 2040386-0 | |||||
| ISSN | 2241-6293 ; 1107-0625 | |||||
| ISSN (online) | 2241-6293 | |||||
| ISSN | 1107-0625 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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