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  1. Artikel ; Online: Assessing the Effects of Healthy and Neuropathological Aging on Personality with the Iowa Scales of Personality Change.

    Zirbes, Christian / Jones, Andrew / Manzel, Kenneth / Denburg, Natalie / Barrash, Joseph

    Developmental neuropsychology

    2021  Band 46, Heft 5, Seite(n) 393–408

    Abstract: Personality changes in older adults with brain disease may be confounded by effects of normal aging. In this cross-sectional study, ratings with the Iowa Scales of Personality Change for 62 healthy older adults (OA-H, aged 60+) were compared to matched ... ...

    Abstract Personality changes in older adults with brain disease may be confounded by effects of normal aging. In this cross-sectional study, ratings with the Iowa Scales of Personality Change for 62 healthy older adults (OA-H, aged 60+) were compared to matched older adults with brain diseases (OA-BD). OA-H did not show any significant personality changes from middle age to older adulthood. However, between 10% and 20% of OA-H developed a disturbance in
    Mesh-Begriff(e) Aged ; Aging ; Cross-Sectional Studies ; Humans ; Iowa ; Middle Aged ; Personality ; Personality Disorders/diagnosis
    Sprache Englisch
    Erscheinungsdatum 2021-07-20
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632665-1
    ISSN 1532-6942 ; 8756-5641
    ISSN (online) 1532-6942
    ISSN 8756-5641
    DOI 10.1080/87565641.2021.1956500
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Pancreatic enzymes digest obstructive meconium from cystic fibrosis pig intestines.

    Gangadharan Nambiar, Gopinathan / Gonzalez Szachowicz, Sussette / Zirbes, Christian F / Hill, Jared J / Powers, Linda S / Meyerholz, David K / Thornell, Ian M / Stoltz, David A / Fischer, Anthony J

    Frontiers in pediatrics

    2024  Band 12, Seite(n) 1387171

    Abstract: Introduction: Meconium ileus (MI) is a life-threatening obstruction of the intestines affecting ∼15% of newborns with cystic fibrosis (CF). Current medical treatments for MI often fail, requiring surgical intervention. MI typically occurs in newborns ... ...

    Abstract Introduction: Meconium ileus (MI) is a life-threatening obstruction of the intestines affecting ∼15% of newborns with cystic fibrosis (CF). Current medical treatments for MI often fail, requiring surgical intervention. MI typically occurs in newborns with pancreatic insufficiency from CF. Meconium contains mucin glycoprotein, a potential substrate for pancreatic enzymes or mucolytics. Our study aim was to determine whether pancreatic enzymes in combination with mucolytic treatments dissolve obstructive meconium using the CF pig model.
    Methods: We collected meconium from CF pigs at birth and submerged it in solutions with and without pancreatic enzymes, including normal saline, 7% hypertonic saline, and the reducing agents N-acetylcysteine (NAC) and dithiothreitol (DTT). We digested meconium at 37 °C with agitation, and measured meconium pigment release by spectrophotometry and residual meconium solids by filtration.
    Results and discussion: In CF pigs, meconium appeared as a solid pigmented mass obstructing the ileum. Meconium microscopically contained mucus glycoprotein, cellular debris, and bile pigments. Meconium fragments released pigments with maximal absorption at 405 nm after submersion in saline over approximately 8 h. Pancreatic enzymes significantly increased pigment release and decreased residual meconium solids. DTT did not improve meconium digestion and the acidic reducing agent NAC worsened digestion. Pancreatic enzymes digested CF meconium best at neutral pH in isotonic saline. We conclude that pancreatic enzymes digest obstructive meconium from CF pigs, while hydrating or reducing agents alone were less effective. This work suggests a potential role for pancreatic enzymes in relieving obstruction due to MI in newborns with CF.
    Sprache Englisch
    Erscheinungsdatum 2024-04-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2024.1387171
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Parallel Evolution of Linezolid Resistant

    Pitcher, Nicholas J / Feder, Andries / Bolden, Nicholas / Zirbes, Christian F / Pamatmat, Anthony J / Boyken, Linda / Hill, Jared J / Thurman, Andrew L / Reeb, Valérie C / Porterfield, Harry S / Moustafa, Ahmed M / Planet, Paul J / Fischer, Anthony J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Background: Linezolid is an antibiotic used to treat serious : Objectives: The goals of this study were to determine the incidence of linezolid resistance in CF and identify molecular mechanisms for linezolid resistance.: Methods: We identified ... ...

    Abstract Background: Linezolid is an antibiotic used to treat serious
    Objectives: The goals of this study were to determine the incidence of linezolid resistance in CF and identify molecular mechanisms for linezolid resistance.
    Methods: We identified patients with
    Main results: Between 2008 and 2018, 111 patients received linezolid and 4 of these patients cultured linezolid resistant
    Conclusions: Linezolid resistance evolved in 4 of 111 patients in this study. Linezolid resistance occurred by multiple genetic mechanisms. All resistant strains developed in ST5 or ST105 MRSA backgrounds.
    Key point: Linezolid resistance arises through multiple genetic mechanisms and could be facilitated by mutator phenotypes. Linezolid resistance was transient, possibly due to growth disadvantage.
    Sprache Englisch
    Erscheinungsdatum 2023-05-02
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.05.02.539145
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Parallel evolution of linezolid-resistant

    Pitcher, Nicholas J / Feder, Andries / Bolden, Nicholas / Zirbes, Christian F / Pamatmat, Anthony J / Boyken, Linda / Hill, Jared J / Bartels, Alyssa R / Thurman, Andrew L / Reeb, Valerie C / Porterfield, Harry S / Moustafa, Ahmed M / Planet, Paul J / Fischer, Anthony J

    Microbiology spectrum

    2023  , Seite(n) e0208423

    Abstract: Linezolid is an antibiotic used to treat ... ...

    Abstract Linezolid is an antibiotic used to treat serious
    Sprache Englisch
    Erscheinungsdatum 2023-09-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02084-23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Staphylococcus aureus detection from CF respiratory samples is improved using alternative media.

    Zirbes, Christian F / Pitcher, Nicholas J / Davis, Joseph C / Bartels, Alyssa R / Krogh, Justin D / Teresi, Mary / Farber, Tyler / Milavetz, Francesca / Pamatmat, Anthony J / Rozen, Alexis L / Reinhardt, Lindsey D / Boyken, Linda / Singh, Sachinkumar B / Twait, Erik / Reeb, Valérie C / Ford, Bradley A / Fischer, Anthony J

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2022  Band 21, Heft 5, Seite(n) 888–889

    Mesh-Begriff(e) Anti-Bacterial Agents/therapeutic use ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/drug therapy ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2022-04-29
    Erscheinungsland Netherlands
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2022.04.017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: MRSA strains with distinct accessory genes predominate at different ages in cystic fibrosis.

    Porterfield, Harry S / Maakestad, Lucas J / LaMarche, Mason M / Thurman, Andrew L / Kienenberger, Zoe E / Pitcher, Nicholas J / Hansen, Alexis R / Zirbes, Christian F / Boyken, Linda / Muyskens, Bethany L / Pezzulo, Alejandro A / Singh, Sachinkumar B / Twait, Erik / Ford, Bradley / Diekema, Daniel J / Reeb, Valérie / Fischer, Anthony J

    Pediatric pulmonology

    2021  Band 56, Heft 9, Seite(n) 2868–2878

    Abstract: Rationale: Methicillin resistant Staphylococcus aureus (MRSA) is prevalent and consequential in cystic fibrosis (CF). Whole genome sequencing (WGS) could reveal genomic differences in MRSA associated with poorer outcomes or detect MRSA transmission.: ... ...

    Abstract Rationale: Methicillin resistant Staphylococcus aureus (MRSA) is prevalent and consequential in cystic fibrosis (CF). Whole genome sequencing (WGS) could reveal genomic differences in MRSA associated with poorer outcomes or detect MRSA transmission.
    Objectives: To identify MRSA genes associated with low lung function and potential MRSA transmission in CF.
    Methods: We collected 97 MRSA isolates from 74 individuals with CF from 2017 and performed short-read WGS. We determined sequence type (ST) and the phylogenetic relationship between isolates. We aligned accessory genes from 25 reference genomes to genome assemblies, classified isolates by accessory gene content, and correlated the accessory genome to clinical outcomes.
    Results: The most prevalent ST were ST5 (N = 55), ST8 (N = 15), and ST105 (N = 14). Closely related MRSA strains were shared by family members with CF, but rarely between unrelated individuals. Three clusters of MRSA were identified by accessory genome content. Cluster A, including ST5 and ST105, was highly prevalent at all ages. Cluster B, including ST8, was more limited to younger patients. Cluster C included 6 distantly related strains. Patients 20 years old and younger infected with Cluster A had lower forced expiratory volume in the first second (FEV
    Conclusions: In this CF cohort, we identified MRSA subtypes that predominate at different ages and differ by accessory gene content. The most prevalent cluster of MRSA, including ST5 and ST105, was associated with lower FEV
    Mesh-Begriff(e) Adolescent ; Cystic Fibrosis/epidemiology ; Cystic Fibrosis/microbiology ; Humans ; Methicillin-Resistant Staphylococcus aureus/genetics ; Phylogeny ; Staphylococcal Infections/epidemiology ; Whole Genome Sequencing ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2021-07-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25559
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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