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  1. Artikel ; Online: A Thermoresponsive injectable drug delivery system of chitosan/β-glycerophosphate with gellan gum/alginate microparticles.

    Carrêlo, H / Jiménez-Rosado, M / Vieira, Tânia / Da Rosa, Rafaela R / Perez-Puyana, Victor M / Silva, Jorge Carvalho / Romero, A / Borges, J P / Soares, Paula I P

    International journal of biological macromolecules

    2024  , Seite(n) 131981

    Abstract: The development of new Drug Delivery Systems (DDS) by incorporating microparticles within hydrogels can prolong the release rate of drugs and/or other bioactive agents. In this study, we combined gellan gum/alginate microparticles within a ... ...

    Abstract The development of new Drug Delivery Systems (DDS) by incorporating microparticles within hydrogels can prolong the release rate of drugs and/or other bioactive agents. In this study, we combined gellan gum/alginate microparticles within a thermoresponsive chitosan (Ch) hydrogel with β-Glycerophosphate (β-GP), designing the system to be in the sol state at 21 °C and in the gel state at 37 °C to enable the injectability of the system. The system was in the sol state between 10 °C and 21 °C. Higher concentrations of β-GP (0, 2, 3, 4, 5 w/v%) and microparticles (0, 2 and 5 w/v%) allowed a faster sol-gel transition with higher mechanical strength at 37 °C. However, the sol-gel transition was not instantaneous. The release profile of methylene blue (MB) from the microparticles was significantly affected by their incorporation in Ch/β-GP hydrogels, only allowing the release of 60-70 % of MB for 6 days, while the microparticles alone released all the MB in 48 h. The proposed system did not present cytotoxicity to VERO cell lines as a preliminary assay, with the Ch/β-GP/GG:Alg having >90 % of cellular viability. The proposed Ch/β-GP system proved to have a delaying effect on drug release and biocompatible properties, being a promising future DDS.
    Sprache Englisch
    Erscheinungsdatum 2024-05-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131981
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: The use of isoxazoline and isoxazole scaffolding in the design of novel thiourea and amide liquid-crystalline compounds.

    Gonçalves, Itamar L / da Rosa, Rafaela R / Eifler-Lima, Vera L / Merlo, Aloir A

    Beilstein journal of organic chemistry

    2020  Band 16, Seite(n) 175–184

    Abstract: A series of novel thiourea and amide liquid crystals containing 5-membered isoxazoline and isoxazole rings were synthetized and the liquid crystal properties studied. Thioureas were obtained using a condensation reaction of benzoyl chlorides, arylamines ... ...

    Abstract A series of novel thiourea and amide liquid crystals containing 5-membered isoxazoline and isoxazole rings were synthetized and the liquid crystal properties studied. Thioureas were obtained using a condensation reaction of benzoyl chlorides, arylamines and ammonium thiocyanate. The amides, on the other hand, were the byproduct of a quantitative reaction which used potassium cyanate as the starting material. Thiourea and amide derivatives were predominantly SmA mesophase inductors. A nematic mesophase was observed only for thioureas and amides containing an isoxazole ring. Additionaly, the liquid crystal behavior was also dependent on the relative position of nitrogen and oxygen atoms on the 5-membered heterocycle.
    Sprache Englisch
    Erscheinungsdatum 2020-02-06
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2192461-2
    ISSN 1860-5397
    ISSN 1860-5397
    DOI 10.3762/bjoc.16.20
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Assessing the Genotoxicity of Cellulose Nanomaterials in a Co-Culture of Human Lung Epithelial Cells and Monocyte-Derived Macrophages.

    Ventura, Célia / Pinto, Fátima / Lourenço, Ana Filipa / Pedrosa, Jorge F S / Fernandes, Susete N / da Rosa, Rafaela R / Godinho, Maria Helena / Ferreira, Paulo J T / Louro, Henriqueta / Silva, Maria João

    Bioengineering (Basel, Switzerland)

    2023  Band 10, Heft 8

    Abstract: Cellulose micro/nanomaterials (CMNMs) are innovative materials with a wide spectrum of industrial and biomedical applications. Although cellulose has been recognized as a safe material, the unique properties of its nanosized forms have raised concerns ... ...

    Abstract Cellulose micro/nanomaterials (CMNMs) are innovative materials with a wide spectrum of industrial and biomedical applications. Although cellulose has been recognized as a safe material, the unique properties of its nanosized forms have raised concerns about their safety for human health. Genotoxicity is an endpoint that must be assessed to ensure that no carcinogenic risks are associated with exposure to nanomaterials. In this study, we evaluated the genotoxicity of two types of cellulose micro/nanofibrils (CMF and CNF) and one sample of cellulose nanocrystals (CNC), obtained from industrial bleached
    Sprache Englisch
    Erscheinungsdatum 2023-08-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10080986
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Analysis of the In Vitro Toxicity of Nanocelluloses in Human Lung Cells as Compared to Multi-Walled Carbon Nanotubes.

    Pinto, Fátima / Lourenço, Ana Filipa / Pedrosa, Jorge F S / Gonçalves, Lídia / Ventura, Célia / Vital, Nádia / Bettencourt, Ana / Fernandes, Susete N / da Rosa, Rafaela R / Godinho, Maria Helena / Louro, Henriqueta / Ferreira, Paulo J T / Silva, Maria João

    Nanomaterials (Basel, Switzerland)

    2022  Band 12, Heft 9

    Abstract: Cellulose micro/nanomaterials (CMNM), comprising cellulose microfibrils (CMF), nanofibrils (CNF), and nanocrystals (CNC), are being recognized as promising bio-nanomaterials due to their natural and renewable source, attractive properties, and potential ... ...

    Abstract Cellulose micro/nanomaterials (CMNM), comprising cellulose microfibrils (CMF), nanofibrils (CNF), and nanocrystals (CNC), are being recognized as promising bio-nanomaterials due to their natural and renewable source, attractive properties, and potential for applications with industrial and economical value. Thus, it is crucial to investigate their potential toxicity before starting their production at a larger scale. The present study aimed at evaluating the cell internalization and in vitro cytotoxicity and genotoxicity of CMNM as compared to two multi-walled carbon nanotubes (MWCNT), NM-401 and NM-402, in A549 cells. The exposure to all studied NM, with the exception of CNC, resulted in evident cellular uptake, as analyzed by transmission electron microscopy. However, none of the CMNM induced cytotoxic effects, in contrast to the cytotoxicity observed for the MWCNT. Furthermore, no genotoxicity was observed for CNF, CNC, and NM-402 (cytokinesis-block micronucleus assay), while CMF and NM-401 were able to significantly raise micronucleus frequency. Only NM-402 was able to induce ROS formation, although it did not induce micronuclei. Thus, it is unlikely that the observed CMF and NM-401 genotoxicity is mediated by oxidative DNA damage. More studies targeting other genotoxicity endpoints and cellular and molecular events are underway to allow for a more comprehensive safety assessment of these nanocelluloses.
    Sprache Englisch
    Erscheinungsdatum 2022-04-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12091432
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Cellulose Nanocrystal Aqueous Colloidal Suspensions: Evidence of Density Inversion at the Isotropic-Liquid Crystal Phase Transition.

    da Rosa, Rafaela R / Silva, Pedro E S / Saraiva, Diogo V / Kumar, Anant / de Sousa, António P Mendes / Sebastião, Pedro / Fernandes, Susete N / Godinho, Maria Helena

    Advanced materials (Deerfield Beach, Fla.)

    2022  Band 34, Heft 28, Seite(n) e2108227

    Abstract: The colloidal suspensions of aqueous cellulose nanocrystals (CNCs) are known to form liquid crystalline (LC) systems above certain critical concentrations. From an isotropic phase, tactoid formation, growth, and sedimentation have been determined as the ... ...

    Abstract The colloidal suspensions of aqueous cellulose nanocrystals (CNCs) are known to form liquid crystalline (LC) systems above certain critical concentrations. From an isotropic phase, tactoid formation, growth, and sedimentation have been determined as the genesis of a high-density cholesteric phase, which, after drying, originates solid iridescent films. Herein, the coexistence of a liquid crystal upper phase and an isotropic bottom phase in CNC aqueous suspensions at the isotropic-nematic phase separation is reported. Furthermore, isotropic spindle-like domains are observed in the low-density LC phase and high-density LC phases are also prepared. The CNCs isolated from the low- and high-density LC phases are found to have similar average lengths, diameters, and surface charges. The existence of an LC low-density phase is explained by the presence of air dissolved in the water present within the CNCs. The air dissolves out when the water solidifies into ice and remains within the CNCs. The self-adjustment of the cellulose chain conformation enables the entrapment of air within the CNCs and CNC buoyancy in aqueous suspensions.
    Sprache Englisch
    Erscheinungsdatum 2022-06-06
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202108227
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Expeditious preparation of isoxazoles from Δ²-isoxazolines as advanced intermediates for functional materials

    Vilela, Guilherme D / da Rosa, Rafaela R / Schneider, Paulo H / Bechtold, Ivan H / Eccher, Juliana / Merlo, Aloir A

    Tetrahedron letters. 2011 Dec. 7, v. 52, no. 49

    2011  

    Abstract: A collection of isoxazoles derivatives has been efficiently synthesized in three steps. The oximation reaction of aldehydes followed by nitrile oxide [3+2] 1,3-dipolar cycloaddition and MnO₂-oxidation reaction furnished the title compounds which were ... ...

    Abstract A collection of isoxazoles derivatives has been efficiently synthesized in three steps. The oximation reaction of aldehydes followed by nitrile oxide [3+2] 1,3-dipolar cycloaddition and MnO₂-oxidation reaction furnished the title compounds which were purified by simple filtration on celite®.
    Schlagwörter aldehydes ; chemical reactions ; chemical structure ; filtration
    Sprache Englisch
    Erscheinungsverlauf 2011-1207
    Umfang p. 6569-6572.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2011.09.122
    Datenquelle NAL Katalog (AGRICOLA)

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