Artikel ; Online: Rationale and Design of the Groningen Intervention Study for the Preservation of Cardiac Function with Sodium Thiosulfate after St-segment Elevation Myocardial Infarction (GIPS-IV) trial.
2021 Band 243, Seite(n) 167–176
Abstract: Background: Ischemia and subsequent reperfusion cause myocardial injury in patients presenting with ST-segment elevation myocardial infarction (STEMI). Hydrogen sulfide (H: Study design: The Groningen Intervention study for the Preservation of ... ...
| Abstract | Background: Ischemia and subsequent reperfusion cause myocardial injury in patients presenting with ST-segment elevation myocardial infarction (STEMI). Hydrogen sulfide (H Study design: The Groningen Intervention study for the Preservation of cardiac function with STS after STEMI (GIPS-IV) trial (NCT02899364) is a double-blind, randomized, placebo-controlled, multicenter trial, which will enroll 380 patients with a first STEMI. Patients receive STS 12.5 grams intravenously or matching placebo in addition to standard care immediately at arrival at the catheterization laboratory after providing consent. A second dose is administered 6 hours later at the coronary care unit. The primary endpoint is myocardial infarct size as quantified by cardiac magnetic resonance imaging 4 months after randomization. Secondary endpoints include the effect of STS on peak CK-MB during admission and left ventricular ejection fraction and NT-proBNP levels at 4 months follow-up. Patients will be followed-up for 2 years to assess clinical endpoints. Conclusions: The GIPS-IV trial is the first study to determine the effect of a H |
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| Mesh-Begriff(e) | Humans ; Myocardial Infarction ; Percutaneous Coronary Intervention ; ST Elevation Myocardial Infarction/drug therapy ; Stroke Volume ; Thiosulfates ; Treatment Outcome ; Ventricular Function, Left | |||||
| Chemische Substanzen | Thiosulfates ; sodium thiosulfate (HX1032V43M) | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2021-09-15 | |||||
| Erscheinungsland | United States | |||||
| Dokumenttyp | Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 80026-0 | |||||
| ISSN | 1097-6744 ; 0002-8703 | |||||
| ISSN (online) | 1097-6744 | |||||
| ISSN | 0002-8703 | |||||
| DOI | 10.1016/j.ahj.2021.08.012 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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