Artikel ; Online: Tomographic evaluation of the effect of simvastatin topical use on alveolar bone microarchitecture, pain and swelling after mandibular third molar extraction: a randomized controlled trial.
2022 Band 26, Heft 4, Seite(n) 3533–3545
Abstract: Objectives: To evaluate the effect of a collagen sponge containing simvastatin on socket healing in terms of bone microarchitecture through tomographic analysis, pain, and swelling after impacted third molar extraction.: Materials and methods: In ... ...
Abstract | Objectives: To evaluate the effect of a collagen sponge containing simvastatin on socket healing in terms of bone microarchitecture through tomographic analysis, pain, and swelling after impacted third molar extraction. Materials and methods: In this single-blind, split-mouth, randomized clinical trial, 29 patients undergoing impacted third molar extraction were allocated into two groups: (i) test group, a collagen sponge containing simvastatin was inserted within the sockets; and (ii) control group, in which sockets retained the clot. Bone volume (BV), bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular spacing (Tb.Sp), and gray scale were evaluated using cone beam computed tomography (CBCT) acquired immediately postoperative and 3 months after surgery. Pain, swelling, and wound healing were evaluated using the 10-point visual analogue scale, three extra-oral reference measurements, and the Landry index. Results: In total, 22 participants remained in the study; no loss-to-follow-up was related to the intervention. BV and BV/TV were significantly higher at 3 months postoperatively in the test group compared with the control group and were correlated with greater bone trabeculation. Pain, edema, and the Landry index revealed a greater inflammatory response in the test group during early repair. Simvastatin contributed to bone healing, with no adverse effects or postoperative complications. Conclusions: The absorbable collagen sponge containing simvastatin improved BV, BV/TV, and trabecular bone, indicating the potential of this drug to induce the formation of autogenous bone. Clinical relevance: Intraosseous statins represent a promising, low-cost, and easy-to-use alternative for alveolar ridge preservation and bone regeneration. Trial registration: Brazilian Registry of Clinical Trials (REBEC), No. RBR-523N7R. |
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Mesh-Begriff(e) | Alveolar Bone Loss/surgery ; Alveolar Ridge Augmentation/methods ; Edema/drug therapy ; Humans ; Molar, Third/surgery ; Pain/etiology ; Simvastatin/pharmacology ; Simvastatin/therapeutic use ; Single-Blind Method ; Tooth Extraction/adverse effects ; Tooth Socket/diagnostic imaging ; Tooth Socket/surgery |
Chemische Substanzen | Simvastatin (AGG2FN16EV) |
Sprache | Englisch |
Erscheinungsdatum | 2022-01-22 |
Erscheinungsland | Germany |
Dokumenttyp | Journal Article ; Randomized Controlled Trial |
ZDB-ID | 1364490-7 |
ISSN | 1436-3771 ; 1432-6981 |
ISSN (online) | 1436-3771 |
ISSN | 1432-6981 |
DOI | 10.1007/s00784-021-04322-8 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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