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  1. Article ; Online: Comparison of LIRADS 5 Image Guided Core Biopsy Derived From Formalin Fixed and Frozen Tissue Cores for Radiogenomics and Radioproteomics Analysis in Well, Moderate and Poorly Differentiated Hepatocellular Carcinoma.

    Simonian, Margaret / Lu, David S K / Whitelegge, Julian / Cohn, Whitaker / Ahuja, Preeti / Hsu, William / Raman, Steven S

    Global medicine and therapeutics

    2024  Volume 6

    Abstract: The aim of this pilot study is to evaluate and compare the quality of the genomics and proteomics data obtained from paired Formalin Fixed Paraffin Embedded (FFPE) and frozen (FF) tissue percutaneous core biopsies of Liver Imaging Reporting and Data ... ...

    Abstract The aim of this pilot study is to evaluate and compare the quality of the genomics and proteomics data obtained from paired Formalin Fixed Paraffin Embedded (FFPE) and frozen (FF) tissue percutaneous core biopsies of Liver Imaging Reporting and Data System 5 (LIRADS 5) hepatocellular carcinoma (HCC) of varying histological grades. The preliminary data identified differentially expressed proteins and genes in poor, moderate and well differentiated HCC biopsies, with a greater efficacy in fresh frozen samples. The data offered valuable insights into the characteristics and suitability of samples for future studies.
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ISSN 2516-7065
    ISSN (online) 2516-7065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Protein Tyrosine Phosphatases: A new paradigm in an old signaling system?

    Welsh, Colin L / Pandey, Preeti / Ahuja, Lalima G

    Advances in cancer research

    2021  Volume 152, Page(s) 263–303

    Abstract: Protein Tyrosine Phosphatases reverse cellular signals initiated by growth factors receptors and other tyrosine kinases by dephosphorylating phosphotyrosine on target proteins. The activity of these enzymes is crucial for maintaining cell homeostasis, ... ...

    Abstract Protein Tyrosine Phosphatases reverse cellular signals initiated by growth factors receptors and other tyrosine kinases by dephosphorylating phosphotyrosine on target proteins. The activity of these enzymes is crucial for maintaining cell homeostasis, yet these enzymes have been often dismissed as humble house-keeping proteins. Understandably, mutations and changes in expression patterns of Protein Tyrosine Phosphatases are implicated in tumorigenesis and various carcinomas. The conserved nature of their catalytic domains makes drug discovery a challenging pursuit. In this review, we focus on describing the various classes of Protein Tyrosine Phosphatases and their catalytic domains. We also summarize their role in cancer and neurodegenerative diseases using specific members as the model system. Finally, we explain the dichotomy in the biological role of catalytically active vs the pseudoenzyme forms of Protein Tyrosine Phosphatases in the context of their membrane bound receptor forms. This chapter aims to provide a current understanding of these proteins, in the background of their foundational past research.
    MeSH term(s) Humans ; Neoplasms ; Phosphorylation ; Protein Tyrosine Phosphatases/genetics ; Protein Tyrosine Phosphatases/metabolism ; Protein-Tyrosine Kinases ; Signal Transduction
    Chemical Substances Protein-Tyrosine Kinases (EC 2.7.10.1) ; Protein Tyrosine Phosphatases (EC 3.1.3.48)
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 127-2
    ISSN 2162-5557 ; 0065-230X
    ISSN (online) 2162-5557
    ISSN 0065-230X
    DOI 10.1016/bs.acr.2021.06.001
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  3. Article ; Online: Awareness data on cervical cancer among females of rural and urban areas of Haryana, India.

    Yadav, Ritu / Chauhan, Meenakshi B / Yadav, Chetna / Ranga, Shalu / Ahuja, Parul / Tanwar, Mukesh / Balhara, Nikita / Kadian, Lokesh / Chauhan, Preeti / Tanwar, Neha / Ahlawat, Chavi

    Data in brief

    2024  Volume 53, Page(s) 110168

    Abstract: A cross-sectional study was done to assess the degree of current awareness and behaviors about cervical cancer among females in urban and rural areas of North India. This survey was conducted on one thousand females (500 rural and 500 urban). A well- ... ...

    Abstract A cross-sectional study was done to assess the degree of current awareness and behaviors about cervical cancer among females in urban and rural areas of North India. This survey was conducted on one thousand females (500 rural and 500 urban). A well-structured questionnaire was designed to collect information about participants' knowledge on cancer of cervix uteri such as age, height and weight measurements, marital status, menstrual status, personal hygiene, age at menarche, sexual history, pregnancy and abortion history, use of contraceptive pills for birth-control, smoking, alcohol consumption, and other relevant information. The data was collected by conducting face-to-face interviews after obtaining the verbal consent of the participants. The data has the potential to reduce disease burden by spreading awareness about symptoms and risk factors of cervical cancer as well as implementation of effective early screening strategies.
    Language English
    Publishing date 2024-02-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2024.110168
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  4. Article ; Online: Characterization and immunogenicity assessment of MERS-CoV pre-fusion spike trimeric oligomers as vaccine immunogen.

    Ahuja, Rahul / Vishwakarma, Preeti / Raj, Sneha / Kumar, Varun / Khatri, Ritika / Lohiya, Bharat / Saxena, Shikha / Kaur, Gurleen / Singh, Gagandeep / Asthana, Shailendra / Ahmed, Shubbir / Samal, Sweety

    Human vaccines & immunotherapeutics

    2024  Volume 20, Issue 1, Page(s) 2351664

    Abstract: Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal beta-coronavirus that emerged in 2012. The virus is part of the WHO blueprint priority list with a concerning fatality rate of 35%. Scientific efforts are ongoing for the development of ... ...

    Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal beta-coronavirus that emerged in 2012. The virus is part of the WHO blueprint priority list with a concerning fatality rate of 35%. Scientific efforts are ongoing for the development of vaccines, anti-viral and biotherapeutics, which are majorly directed toward the structural spike protein. However, the ongoing effort is challenging due to conformational instability of the spike protein and the evasion strategy posed by the MERS-CoV. In this study, we have expressed and purified the MERS-CoV pre-fusion spike protein in the Expi293F mammalian expression system. The purified protein was extensively characterized for its biochemical and biophysical properties. Thermal stability analysis showed a melting temperature of 58°C and the protein resisted major structural changes at elevated temperature as revealed by fluorescence spectroscopy and circular dichroism. Immunological assessment of the MERS-CoV spike immunogen in BALB/c mice with AddaVax
    MeSH term(s) Middle East Respiratory Syndrome Coronavirus/immunology ; Animals ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Mice, Inbred BALB C ; Antibodies, Viral/immunology ; Antibodies, Viral/blood ; Viral Vaccines/immunology ; Mice ; Female ; Coronavirus Infections/prevention & control ; Coronavirus Infections/immunology ; Immunogenicity, Vaccine ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/blood ; Adjuvants, Immunologic/administration & dosage ; Adjuvants, Vaccine ; Humans
    Language English
    Publishing date 2024-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2024.2351664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Anaesthetic management of a child with Lesch Nyhan syndrome.

    Banerjee, Shraya / Sinha, Sunil K / Varshney, Preeti G / Ahuja, Pragya

    Indian journal of anaesthesia

    2019  Volume 63, Issue 12, Page(s) 1051–1052

    Language English
    Publishing date 2019-12-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 412570-8
    ISSN 0019-5049
    ISSN 0019-5049
    DOI 10.4103/ija.IJA_602_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Analysis of cell division in cardiomyocytes during development and disease

    Ahuja, Preeti

    2006  

    Author's details by Preeti Ahuja
    Language English
    Size Online-Ressource (145 Bl), Ill
    Publisher ETH
    Publishing place Zürich
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Diss., Naturwissenschaften, Eidgenössische Technische Hochschule ETH Zürich, Nr. 16518--Zürich, 1651
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article ; Online: 3-T Multiparametric MRI Followed by In-Bore MR-Guided Biopsy for Detecting Clinically Significant Prostate Cancer After Prior Negative Transrectal Ultrasound-Guided Biopsy.

    Hosseiny, Melina / Shakeri, Sepideh / Felker, Ely R / Lu, David / Sayre, James / Ahuja, Preeti / Raman, Steven S

    AJR. American journal of roentgenology

    2020  Volume 215, Issue 3, Page(s) 660–666

    Abstract: OBJECTIVE. ...

    Abstract OBJECTIVE.
    MeSH term(s) Aged ; Humans ; Image-Guided Biopsy ; Magnetic Resonance Imaging, Interventional ; Male ; Middle Aged ; Multiparametric Magnetic Resonance Imaging/methods ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Retrospective Studies ; Ultrasonography, Interventional
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.19.22455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Utility of Labile Plasma Iron Assay in Thalassemia Major Patients.

    Tripathi, Preeti / Pati, H P / Mahapatra, Manoranjan / Tyagi, Seema / Ahuja, Ankur / Saxena, Renu

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2019  Volume 35, Issue 2, Page(s) 272–277

    Abstract: Labile plasma iron (LPI) levels are proposed as marker of iron overload in thalassemia patients and are also known to be the earliest parameter to indicate efficacy of chelation therapy. It was a prospective study in 35 patients of thalassemia major. ... ...

    Abstract Labile plasma iron (LPI) levels are proposed as marker of iron overload in thalassemia patients and are also known to be the earliest parameter to indicate efficacy of chelation therapy. It was a prospective study in 35 patients of thalassemia major. Patients were recruited in two groups-group A (n = 13) patients not on chelation therapy and group B (n = 22) patients who were on regular oral chelation therapy. Ten age and gender matched healthy controls were also studied. For all patients, ferritin levels and LPI levels were measured at baseline, 6 months and 12 months. For group B patients paired samples for LPI were taken (before and 2 h after chelator). LPI levels were found to be significantly higher in group B patients versus group A patients versus normal healthy controls at all time-points. (
    Language English
    Publishing date 2019-02-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-019-01104-x
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  9. Article ; Online: A UNIQUE TYPE OF ENDOSPERM IN

    VENUGOPAL Nagulan / AHUJA Preeti / LALCHHANHIMI

    Journal of Plant Development , Vol 20, Iss 1, Pp 45-

    2013  Volume 50

    Abstract: Panax wangianus S. C. Sun (Araliaceae) is a critically endangered, medicinal plant of north-east India. The objective of this research was to study post-fertilization changes in embryo-sac of P. wangianus. A characteristic feature has been observed in ... ...

    Abstract Panax wangianus S. C. Sun (Araliaceae) is a critically endangered, medicinal plant of north-east India. The objective of this research was to study post-fertilization changes in embryo-sac of P. wangianus. A characteristic feature has been observed in the endosperm in P. wangianus in which both the nuclear and cellular endosperm remains together in the mature seeds. The embryo is present in the nuclear part of endosperm so that it can draw the nutrition easily. The embryo probably exerts some physical and physiological forces that prevent the nuclear endosperm to become cellular.
    Keywords Panax wangianus S. C. Sun ; medicinal plant ; North-East India ; post-fertilization changes ; Plant culture ; SB1-1110 ; Agriculture ; S ; Botany ; QK1-989 ; Science ; Q
    Language English
    Publishing date 2013-12-01T00:00:00Z
    Publisher Alexandru Ioan Cuza University of Iasi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Can ADC be used as a surrogate marker of response to therapy in intestinal tuberculosis?

    Mathur, Preeti / Sharma, Raju / Kandasamy, Devasenathipathy / Kedia, Saurabh / Gamanagatti, Shivanand / Ahuja, Vineet

    Abdominal radiology (New York)

    2019  Volume 44, Issue 9, Page(s) 3006–3018

    Abstract: Purpose: To evaluate the utility of Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) in assessing treatment response in patients of intestinal tuberculosis (ITB).: Method and materials: MR Enterography (MRE) was done for ... ...

    Abstract Purpose: To evaluate the utility of Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) in assessing treatment response in patients of intestinal tuberculosis (ITB).
    Method and materials: MR Enterography (MRE) was done for patients with suspicion of ITB and 19 patients with pre- and post-treatment imaging were included in the analysis. MRE included T1W, T2W, post-contrast T1W, and DWI sequences. DWI was done using b values-0, 400 and 800 s/mm
    Results: Thirty-one bowel segments were evaluated at baseline and after treatment in 19 patients. Prior to therapy, restricted diffusion was seen in 29/31 (93.5%) segments. After treatment, patients with either complete or partial response (27/31 segments, 15 patients) showed significant rise in mean ADC values from 1.1 ± 0.37 × 10
    Conclusion: ADC values show good correlation with treatment response in ITB and can be used for objectively quantifying it.
    MeSH term(s) Adolescent ; Adult ; Antitubercular Agents/therapeutic use ; Biomarkers ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Humans ; Intestines/diagnostic imaging ; Male ; Middle Aged ; Treatment Outcome ; Tuberculosis, Gastrointestinal/diagnostic imaging ; Tuberculosis, Gastrointestinal/drug therapy ; Young Adult
    Chemical Substances Antitubercular Agents ; Biomarkers
    Language English
    Publishing date 2019-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-019-02090-4
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