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  1. Artikel ; Online: Effects of frankincense on experimentally induced renal stones in rats.

    Al-Marhoon, Mohamed S / Al-Harrasi, Ahmed / Siddiqui, Khurram / Ashique, Mohammed / Ali, Haytham / Ali, Badreldin H

    BJUI compass

    2023  Band 4, Heft 4, Seite(n) 437–445

    Abstract: Objectives: Frankincense (Luban) is a resin obtained from trees of genus : Materials and methods: A rat model of urolithiasis induced by : Results: The lithogenic effects of HLP, such as an increase in urine oxalate and cystine, an increase in ... ...

    Abstract Objectives: Frankincense (Luban) is a resin obtained from trees of genus
    Materials and methods: A rat model of urolithiasis induced by
    Results: The lithogenic effects of HLP, such as an increase in urine oxalate and cystine, an increase in plasma uric acid and an increase in kidney levels of calcium and oxalate, have all been best significantly reversed by the Luban dose of 150 mg/kg/day. The histological changes of HLP on the kidney tissue including calcium oxalate crystal formation, cystic dilatation, high degree of tubular necrosis, inflammatory changes, atrophy and fibrosis have also been ameliorated by Luban dose of 150 mg/kg/day.
    Conclusion: Luban has shown a significant improvement in the treatment and prevention of experimentally induced renal stones, particularly at a dose of 150 mg/kg/day. Further studies on the effect of Luban in other animal models and humans with urolithiasis are warranted.
    Sprache Englisch
    Erscheinungsdatum 2023-02-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2688-4526
    ISSN (online) 2688-4526
    DOI 10.1002/bco2.227
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Clinicopathological Features, Treatment, and Outcome of Omani Patients with Metastatic Prostate Cancer.

    Kumar, Shiyam / Burney, Ikram A / Kunju, Joseph / Al-Marhoon, Mohammed Salim / Siddiqui, Khurrum Mutahir

    Oman medical journal

    2022  Band 37, Heft 1, Seite(n) e333

    Abstract: ... gathered until April 2019 or until the patient's death for progression-free survival (PFS) and overall ...

    Abstract Objectives: Prostate cancer (PCa) is the third most common cancer worldwide, with its incidence rising in the Middle East. There is a paucity of data about the clinicopathological features and outcomes of metastatic prostate cancer (mPCa) from the Middle East. We report the outcomes of mPCa from Oman.
    Methods: We recruited consecutive men diagnosed with mPCa and treated at Sultan Qaboos University Hospital in Oman between January 2006 and December 2017. Information about demographics, clinical, laboratory, pathological, and radiological features at presentation, treatment, and survival outcomes was collected. Data were gathered until April 2019 or until the patient's death for progression-free survival (PFS) and overall survival (OS), whichever came first. Survival rates were estimated using the Kaplan-Meier method. Univariate and multivariate analysis and Cox regression analyses were performed to study factors affecting the PFS and the OS.
    Results: Of the 239 men diagnosed with PCa over the study period, 62 were diagnosed with mPCa. The median age was 71 (range = 57-92) years. The majority of patients (61.3%) had a Gleason score ≥ 8. Median prostate-specific antigen (PSA) level was 100.0. Bone was the most common site of metastatic disease (90.3%). The majority of patients with the hormone-sensitive disease were treated with testosterone suppression only, while abiraterone, enzalutamide, and docetaxel were added for treating metastatic castration-resistant mPCa (mCRPC). After a median follow-up of 34.5 months, the median PFS was 17 months, while the median OS was 43 months. Median survival post mCRPC was 17 months.
    Conclusions: Omani patients with mPCa present with high PSA and Gleason score and with widespread metastatic disease burden. Treatments offered are according to internationally accepted standards and have comparable PFS and OS as reported elsewhere.
    Sprache Englisch
    Erscheinungsdatum 2022-01-31
    Erscheinungsland Oman
    Dokumenttyp Journal Article
    ZDB-ID 2571431-4
    ISSN 2070-5204 ; 1999-768X
    ISSN (online) 2070-5204
    ISSN 1999-768X
    DOI 10.5001/omj.2021.117
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Staghorn calculus in a horseshoe kidney.

    Al-Marhoon, Mohammed S

    Sultan Qaboos University medical journal

    2012  Band 12, Heft 4, Seite(n) 534–536

    Sprache Englisch
    Erscheinungsdatum 2012-11-20
    Erscheinungsland Oman
    Dokumenttyp Journal Article
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-051X
    ISSN (online) 2075-0528
    ISSN 2075-051X
    DOI 10.12816/0003185
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  4. Artikel: The role of biopsy in incidental renal tumours.

    Al-Marhoon, Mohammed S

    Arab journal of urology

    2011  Band 9, Heft 1, Seite(n) 11–15

    Abstract: Purpose: Historically, the biopsy of renal masses was not advocated, and to date there remains some controversy on the role of biopsy for renal masses in making treatment decisions. With the widespread use of imaging methods, the incidental diagnosis of ...

    Abstract Purpose: Historically, the biopsy of renal masses was not advocated, and to date there remains some controversy on the role of biopsy for renal masses in making treatment decisions. With the widespread use of imaging methods, the incidental diagnosis of renal masses has increased, necessitating renal biopsies to better plan the management of these tumours. Here I review previous reports to define the role of biopsy in incidental renal tumours.
    Methods: Data were obtained from English-language studies listed in PubMed on the use of renal biopsy for evaluating incidental solid small renal tumours.
    Results: The biopsy of small renal tumours is increasingly accepted due to: the increase in the incidence of small renal tumours; the finding that a significant number of these tumours are benign; the availability of new management options, such as ablative therapy and surveillance strategies; that imaging alone is unable to predict the biological behaviour of these tumours; and advances in the pathological evaluation of the biopsies. The biopsy procedure has an acceptable complication rate but is not free of limitations. The current recommendations for the use of renal biopsy in small renal tumours are: to help in differentiating benign from malignant renal tumours; before or during ablative therapies and during the follow-up after ablative therapies, for defining treatment success or failure; and to exclude nonrenal cell primary tumours (metastasis and lymphoma) or benign conditions (abscess), which may not require surgery.
    Conclusions: The biopsy of small renal tumours is a safe and accurate procedure, and can help in the planning of definitive patient management.
    Sprache Englisch
    Erscheinungsdatum 2011-05-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2631788-6
    ISSN 2090-598X
    ISSN 2090-598X
    DOI 10.1016/j.aju.2011.03.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Small Incidental Renal Masses in Adults: Review of the literature.

    Al-Marhoon, Mohammed S

    Sultan Qaboos University medical journal

    2010  Band 10, Heft 2, Seite(n) 196–202

    Abstract: Incidental renal tumours are becoming an important clinical problem that many physicians will need to deal with. A good knowledge of the nature of these tumours and how to manage them is therefore needed. The aim of this paper is to review the literature ...

    Abstract Incidental renal tumours are becoming an important clinical problem that many physicians will need to deal with. A good knowledge of the nature of these tumours and how to manage them is therefore needed. The aim of this paper is to review the literature about incidental renal tumours in adults. Many incidentally discovered small renal tumours (<4 cm) are benign and of low stage, grade and progression potential. The preferred management in young fit patients is open or laparoscopic nephron-sparing surgery. Treatment alternatives include needle-ablative therapies and surveillance in elderly unfit patients. Tumour renal biopsy is encouraged prior to needle-ablative therapy and surveillance. Awareness about incidental renal masses and their management is essential for treating doctors.
    Sprache Englisch
    Erscheinungsdatum 2010-07-19
    Erscheinungsland Oman
    Dokumenttyp Journal Article
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-0528
    ISSN (online) 2075-0528
    ISSN 2075-0528
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Clinicopathological Features, Treatment, and Outcome of Omani Patients with Metastatic Prostate Cancer

    Shiyam Kumar / Ikram A. Burney / Joseph Kunju / Mohammed Salim Al-Marhoon / Khurrum Mutahir Siddiqui

    Oman Medical Journal, Vol 37, Iss 1, Pp e333-e

    2022  Band 333

    Abstract: ... gathered until April 2019 or until the patient’s death for progression-free survival (PFS) and overall ...

    Abstract Objectives: Prostate cancer (PCa) is the third most common cancer worldwide, with its incidence rising in the Middle East. There is a paucity of data about the clinicopathological features and outcomes of metastatic prostate cancer (mPCa) from the Middle East. We report the outcomes of mPCa from Oman. Methods: We recruited consecutive men diagnosed with mPCa and treated at Sultan Qaboos University Hospital in Oman between January 2006 and December 2017. Information about demographics, clinical, laboratory, pathological, and radiological features at presentation, treatment, and survival outcomes was collected. Data were gathered until April 2019 or until the patient’s death for progression-free survival (PFS) and overall survival (OS), whichever came first. Survival rates were estimated using the Kaplan-Meier method. Univariate and multivariate analysis and Cox regression analyses were performed to study factors affecting the PFS and the OS. Results: Of the 239 men diagnosed with PCa over the study period, 62 were diagnosed with mPCa. The median age was 71 (range = 57–92) years. The majority of patients (61.3%) had a Gleason score ≥ 8. Median prostate-specific antigen (PSA) level was 100.0. Bone was the most common site of metastatic disease (90.3%). The majority of patients with the hormone-sensitive disease were treated with testosterone suppression only, while abiraterone, enzalutamide, and docetaxel were added for treating metastatic castration-resistant mPCa (mCRPC). After a median follow-up of 34.5 months, the median PFS was 17 months, while the median OS was 43 months. Median survival post mCRPC was 17 months. Conclusions: Omani patients with mPCa present with high PSA and Gleason score and with widespread metastatic disease burden. Treatments offered are according to internationally accepted standards and have comparable PFS and OS as reported elsewhere.
    Schlagwörter prostate-specific antigen ; prostatic neoplasms ; castration-resistant ; progression-free survival ; survival rate ; arabs ; oman ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Oman Medical Specialty Board
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Is there a role for Helicobacter pylori infection in urological diseases?

    Al-Marhoon, Mohammed S

    Urology journal

    2008  Band 5, Heft 3, Seite(n) 139–143

    Abstract: Introduction: Helicobacter pylori (H pylori) infection is a focus of attention nowadays. It has been found to cause gastrointestinal disorders and also extra-intestinal disorders. The aim of this paper is to explore the role of H pylori in urological ... ...

    Abstract Introduction: Helicobacter pylori (H pylori) infection is a focus of attention nowadays. It has been found to cause gastrointestinal disorders and also extra-intestinal disorders. The aim of this paper is to explore the role of H pylori in urological diseases and to keep urologists up to date in this subject.
    Materials and methods: Medline and PubMed were searched from 1950 to December 2007 for the following combined terms: Helicobacter pylori together with urology, urological diseases, kidney, kidney cancer, ureter, bladder, bladder cancer, prostate, prostate cancer, benign prostatic hyperplasia, urethra, seminal vesicle, testis, and testicular cancer.
    Results: Accumulating evidence is appearing in the literature relating H pylori infection to urological diseases. The most obvious is the implication of H pylori in inducing chronic cystitis leading to bladder lymphoma. In addition, some epidemiological studies have shown significant associations between infective chronic prostatitis and prostatic carcinoma.
    Conclusion: A simple hypothetical model relating H pylori infection to prostate and bladder diseases is proposed to stimulate the collaborative work between the urologists and scientists to explore this field which is underinvestigated to date. If H pylori is found to have a significant role in urological diseases, prevention of bladder and prostate cancers by eradication of H pylori infection may become a reality like what happened in the treatment of peptic ulcer disease and gastric cancer.
    Mesh-Begriff(e) Helicobacter Infections/complications ; Helicobacter pylori ; Humans ; Male ; Prostatic Diseases/microbiology ; Prostatic Diseases/pathology ; Prostatic Diseases/prevention & control ; Urologic Diseases/microbiology ; Urologic Diseases/pathology ; Urologic Diseases/prevention & control
    Sprache Englisch
    Erscheinungsdatum 2008
    Erscheinungsland Iran
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2251940-3
    ISSN 1735-546X ; 1735-1308
    ISSN (online) 1735-546X
    ISSN 1735-1308
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Staghorn Calculus in a Horseshoe Kidney

    Mohammed S. Al-Marhoon

    Sultan Qaboos University Medical Journal , Vol 12, Iss 4, Pp 534-

    2012  Band 536

    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2012-11-01T00:00:00Z
    Verlag Sultan Qaboos University
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Staghorn Calculus in a Horseshoe Kidney

    Mohammed S. Al-Marhoon

    Sultan Qaboos University Medical Journal, Vol 12, Iss 4, Pp 534-

    2012  Band 536

    Abstract: ... ...

    Abstract NA
    Schlagwörter na ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2012-11-01T00:00:00Z
    Verlag Sultan Qaboos University
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Complications and outcomes of JJ stenting of the ureter in urological practice: A single-centre experience.

    Al-Marhoon, Mohammed S / Shareef, Omar / Venkiteswaran, Krishna P

    Arab journal of urology

    2012  Band 10, Heft 4, Seite(n) 372–377

    Abstract: Objective: To determine the factors affecting the development of complications and the outcomes of JJ stenting.: Patients and methods: The study included 220 patients (133 males and 87 females, mean age 39.5 years, SD 15.4) who had self-retaining JJ ... ...

    Abstract Objective: To determine the factors affecting the development of complications and the outcomes of JJ stenting.
    Patients and methods: The study included 220 patients (133 males and 87 females, mean age 39.5 years, SD 15.4) who had self-retaining JJ ureteric stents placed while in the authors' institution. Univariate and multivariate analyses were used to identify the significant variables affecting the development of complications and outcome of stenting (condition 'improved' or 'not improved').
    Results: Using a modified Clavien classification, there were grade I, II, IIIa, IIIb complications in 67 (30.4%), 39 (17.7%), two (0.9%) and 23 (10.5%) patients, respectively, and none of grades IVa, IVb and V. Loin pain (10.9%) and urinary tract infection (10.9%) were the most common complications, followed by dysuria (7.7%). There were significant complications requiring treatment in 29% of patients, and 71.4% of patients improved after stenting. On multivariate analysis the significant independent factor affecting the complication rate was the stent length (P = 0.016), and the significant independent factor affecting the 'improved' outcome was age (P = 0.014).
    Conclusion: Longer stents are associated with increased complication rates, and the older the patient the more likely they are to have a poor outcome after stenting. Future prospective multicentre studies with more patients are needed to confirm the present conclusions.
    Sprache Englisch
    Erscheinungsdatum 2012-10-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2631788-6
    ISSN 2090-598X
    ISSN 2090-598X
    DOI 10.1016/j.aju.2012.08.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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