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Artikel ; Online: Author Correction: Withania somnifera (L.) Dunal whole-plant extract demonstrates acceptable non-clinical safety in rat 28-day subacute toxicity evaluation under GLP-compliance.

Balkrishna, Acharya / Sinha, Sandeep / Srivastava, Jyotish / Varshney, Anurag

2024 Band 14, Heft 1, Seite(n) 10748

Sprache	Englisch
Erscheinungsdatum	2024-05-10
Erscheinungsland	England
Dokumenttyp	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-61198-w
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Twenty-eight days of repeated dose sub-acute toxicological evaluation of polyherbal Ayurvedic medicine BPGrit in Sprague-Dawley rats.

Balkrishna, Acharya / Sinha, Sandeep / Bhattacharya, Kunal / Varshney, Anurag

Journal of applied toxicology : JAT

2024

Abstract: A pre-clinical toxicological evaluation of herbal medicines is necessary to identify any underlying health-associated side effects, if any. BPGrit is an Ayurveda-based medicine prescribed for treating hypertensive conditions. High-performance liquid ... ...

Abstract	A pre-clinical toxicological evaluation of herbal medicines is necessary to identify any underlying health-associated side effects, if any. BPGrit is an Ayurveda-based medicine prescribed for treating hypertensive conditions. High-performance liquid chromatography-based analysis revealed the presence of gallic acid, ellagic acid, coumarin, cinnamic acid, guggulsterone E, and guggulsterone Z in BPGrit. For sub-acute toxicity analysis of BPGrit, male and female Sprague-Dawley rats were given repeated oral gavage at 100, 300, and 1000 mg/kg body weight/day dosages for 28 days, followed by a 14-day recovery phase. No incidences of mortality, morbidity, or abnormal clinical signs were observed in BPGrit-treated rats throughout the study period. Also, the body weight and food consumption habits of the experimental animals did not change during the study duration. Hematological, biochemical, and histopathological analysis did not indicate any abnormal changes occurring in the BPGrit-treated rats up to the highest tested dose of 1000 mg/kg body weight/day. Finally, the study established the "no-observed-adverse-effect level" for BPGrit at >1000 mg/kg body weight/day in Sprague-Dawley rats.
Sprache	Englisch
Erscheinungsdatum	2024-05-13
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	604625-3
ISSN	1099-1263 ; 0260-437X
ISSN (online)	1099-1263
ISSN	0260-437X
DOI	10.1002/jat.4625
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Enhancement of Wheat (Triticum aestivum L.) Growth and Yield Attributes in a Subtropical Humid Climate through Treated Ganga Sludge-based Organic Fertilizers.

Balkrishna, Acharya / Sharma, Nidhi / Gautam, Ajay / Arya, Vedpriya / Khelwade, Vikram

Recent advances in food, nutrition & agriculture

2024

Abstract: Background: Sewage sludge is a by-product of urbanization that poses environmental and health challenges. However, it can also be a valuable source of organic matter and nutrients for agriculture.: Method: This study aimed to assess the potential of ... ...

Abstract	Background: Sewage sludge is a by-product of urbanization that poses environmental and health challenges. However, it can also be a valuable source of organic matter and nutrients for agriculture. Method: This study aimed to assess the potential of five types of organic fertilizers derived from treated Ganga sludge on the growth of wheat plants. The Patanjali Organic Research Institute has developed five types of granulated organic fertilizer from the stabilized Ganga sludge. Results: The results showed that the organic fertilizers significantly improved the wheat performance in terms of plant height, biomass accumulation, chlorophyll content, leaf area and other yield parameters. Furthermore, the fertilizers ameliorated soil physicochemical attributes and augmented the availability of macro- and micronutrients. Importantly, levels of heavy metals in soil and wheat grains remained within permissible limits, affirming the safety and appropriateness of these fertilizers for wheat cultivation. Conclusion: This study underscores the efficient utilization of treated Ganga sludge as a valuable organic fertilizer source, proposing a sustainable and ecologically sound approach for sewage sludge management and enhancement of agricultural productivity.
Sprache	Englisch
Erscheinungsdatum	2024-01-26
Erscheinungsland	United Arab Emirates
Dokumenttyp	Journal Article
ISSN	2772-5758
ISSN (online)	2772-5758
DOI	10.2174/012772574X280744240103044354
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: OECD-407 Driven 28-day-repeated-dose non-clinical safety evaluation of

Balkrishna, Acharya / Haldar, Swati / Varshney, Anurag

Frontiers in pharmacology

2023 Band 14, Seite(n) 1095083

Abstract: Introduction: ...

Abstract	Introduction:
Sprache	Englisch
Erscheinungsdatum	2023-05-18
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1095083
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Neuroprotection by Polyherbal Medicine Divya-Medha-Vati Against Scopolamine-Induced Cognitive Impairment Through Modulation of Oxidative Stress, Acetylcholine Activity, and Cell Signaling.

Balkrishna, Acharya / Bhattacharya, Kunal / Shukla, Sunil / Varshney, Anurag

Molecular neurobiology

2023 Band 61, Heft 3, Seite(n) 1363–1382

Abstract: Alzheimer disease is associated with cognitive impairments and neuronal damages. In this study, Scopolamine, a model drug used for the generation of Alzheimer-like symptoms induced cognitive dysfunction in C57BL/6 mice. It also elevated acetylcholine ... ...

Abstract	Alzheimer disease is associated with cognitive impairments and neuronal damages. In this study, Scopolamine, a model drug used for the generation of Alzheimer-like symptoms induced cognitive dysfunction in C57BL/6 mice. It also elevated acetylcholine esterase (AcHE) activity, and reduced antioxidant (superoxide dismutase and catalase) activity in cortex tissue. Scop reduced neuronal density and increased pyknotic neurons in hippocampus tissue. In mouse neuroblastoma (Neuro2a) cells, Scop triggered a dose-dependent loss of cell viability and neurite outgrowth reduction. Scop-treated Neuro2a cells showed oxidative stress and reduction in mRNA expression for brain-derived neurotrophic factor (BDNF), nerve growth factor-1 (NGF-1), and Synapsin-1 (SYN-1) genes. Mice treated with Divya-Medha-Vati (DMV), an Ayurvedic polyherbal medicine showed protection against Scop-induced cognitive impairment (Morris Water Maze Escape Latency, and Elevated Plus Maze Transfer Latency). DMV protected against Scop-induced AcHE activity, and loss of antioxidant activities in the mice brain cortex while sustaining neuronal density in the hippocampus region. In the Neuro2a cells, DMV reduced Scop-induced loss of cell viability and neurite outgrowth loss. DMV protected the cells against induction of oxidative stress and promoted mRNA expression of BDNF, NGF-1, and SYN-1 genes. Phytochemical profiling of DMV showed the presence of Withanolide A, Withanolide B, Bacopaside II, Jujubogenin, Apigenin, Gallic acid, Caffeic acid, and Quercetin that are associated with antioxidant and neurostimulatory activities. In conclusion, the study showed that Divya-Medha-Vati was capable of promoting neuronal health and inhibiting Alzheimer-like cognitive dysfunction through enhanced antioxidant activities and modulation of neuronal activities.
Mesh-Begriff(e)	Mice ; Animals ; Scopolamine ; Acetylcholine/metabolism ; Antioxidants/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Nerve Growth Factor/metabolism ; Neuroprotection ; Alzheimer Disease/metabolism ; Mice, Inbred C57BL ; Oxidative Stress ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/metabolism ; Signal Transduction ; Hippocampus/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Maze Learning ; Acetylcholinesterase/metabolism ; Memory Disorders/metabolism
Chemische Substanzen	Scopolamine (DL48G20X8X) ; Acetylcholine (N9YNS0M02X) ; Antioxidants ; Brain-Derived Neurotrophic Factor ; Nerve Growth Factor (9061-61-4) ; RNA, Messenger ; Acetylcholinesterase (EC 3.1.1.7)
Sprache	Englisch
Erscheinungsdatum	2023-09-14
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-023-03601-7
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Unveiling Role of MicroRNAs in Metastasizing Triple Negative Breast Cancer: From Therapeutics to Delivery.

Balkrishna, Acharya / Mittal, Rashmi / Arya, Vedpriya

Current drug targets

2023 Band 24, Heft 6, Seite(n) 509–520

Abstract: Triple negative breast cancers are malignant, heterogeneous tumors with high histological grades, increased reoccurrence, and cancer-related death rates. TNBC metastasis to the brain, lungs, liver, and lymph nodes is a complex process regulated by ... ...

Abstract	Triple negative breast cancers are malignant, heterogeneous tumors with high histological grades, increased reoccurrence, and cancer-related death rates. TNBC metastasis to the brain, lungs, liver, and lymph nodes is a complex process regulated by epithelial to mesenchymal transition, intravasation, extravasation, stem cell niche, and migration. Aberrant expression of miRNAs, also known as a transcriptional regulators of genes, may function as oncogenes or tumor suppressors. In this review, we systematically elucidated the biogenesis and tumor suppressor role of miRNA in targeting distant metastasis of TNBC cells and the above-mentioned underlying mechanisms involved in complicating the disease. Apart from their therapeutic implications, the emerging roles of miRNAs as prognostic markers have also been discussed. To overcome delivery bottlenecks, RNA nanoparticles, nano-diamonds, exosomes, and mesoporous silica nanoparticle-mediated delivery of miRNAs have been contemplated. Altogether, the present review article uncovers the potential role of miRNA in antagonizing distant metastasis of TNBC cells, and highlights their clinical significance as prognostic markers and possible drug delivery strategies to enhance the likely outcome of miRNA-based therapy against the disease.
Mesh-Begriff(e)	Humans ; MicroRNAs/therapeutic use ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Epithelial-Mesenchymal Transition/genetics ; Drug Delivery Systems
Chemische Substanzen	MicroRNAs
Sprache	Englisch
Erscheinungsdatum	2023-03-06
Erscheinungsland	United Arab Emirates
Dokumenttyp	Review ; Journal Article
ZDB-ID	2064859-5
ISSN	1873-5592 ; 1389-4501
ISSN (online)	1873-5592
ISSN	1389-4501
DOI	10.2174/1389450124666230308154551
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Tumor Suppressive Role of MicroRNAs in Triple Negative Breast Cancer.

Balkrishna, Acharya / Mittal, Rashmi / Arya, Vedpriya

Current pharmaceutical design

2023 Band 29, Heft 42, Seite(n) 3357–3367

Abstract: Triple-negative breast cancers are highly aggressive, a heterogeneous form of breast cancer with a high re-occurrence rate that further lacks an efficient treatment strategy and prognostic marker. The tumor microenvironment of the disease comprises ... ...

Abstract	Triple-negative breast cancers are highly aggressive, a heterogeneous form of breast cancer with a high re-occurrence rate that further lacks an efficient treatment strategy and prognostic marker. The tumor microenvironment of the disease comprises cancer-associated fibroblasts, cancer stem cells, immunological molecules, epithelial-mesenchymal transition, and a metastatic microenvironment that contributes to disease progression and metastasis to distant sites. Emerging evidence indicated that miRNA clusters would be of clinical utility as they exert an oncogenic or tumor suppressor role in TNBC. The present review article aims to highlight the therapeutic significance of miRNA in targeting the above-mentioned signaling cascades and modulating the intracellular crosstalk in the tumor microenvironment of TNBC. Prognostic implications of miRNAs to depict disease-free survival, distant metastasis-free survival, relapse-free survival, and overall survival outcome were also unveiled.
Mesh-Begriff(e)	Humans ; Cell Line, Tumor ; Disease Progression ; Epithelial-Mesenchymal Transition/genetics ; MicroRNAs/genetics ; Neoplasm Recurrence, Local ; Prognosis ; Triple Negative Breast Neoplasms/genetics ; Tumor Microenvironment ; Female
Chemische Substanzen	MicroRNAs
Sprache	Englisch
Erscheinungsdatum	2023-12-01
Erscheinungsland	United Arab Emirates
Dokumenttyp	Review ; Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/0113816128272489231124095922
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Herbo-Mineral Medicine, Lithom Exhibits Anti-Nephrolithiasis Activity in Rat Model of Hyperoxaluria by Attenuating Calcium Oxalate Crystal Formation and Oxidative Stress.

Balkrishna, Acharya / Sinha, Sandeep / Manik, Moumita / Pandey, Anupam / Maity, Madhulina / Dev, Rishabh / Varshney, Anurag

Discovery medicine

2024 Band 36, Heft 183, Seite(n) 799–815

Abstract: Background: Calcium oxalate monohydrate (COM) forms the most common type of kidney stones observed in clinics, elevated levels of urinary oxalate being the principal risk factor for such an etiology. The objective of the present study was to evaluate ... ...

Abstract	Background: Calcium oxalate monohydrate (COM) forms the most common type of kidney stones observed in clinics, elevated levels of urinary oxalate being the principal risk factor for such an etiology. The objective of the present study was to evaluate the anti-nephrolithiatic effect of herbo-mineral formulation, Lithom. Methods: The Results: The presence of Lithom during COM crystals synthesis significantly reduced the average crystal area, feret's diameter, and area-perimeter ratio, in a dose-dependent manner. SEM analysis revealed that COM crystals synthesized in the presence of 100 and 300 μg/mL of Lithom exhibited a veritable morphological transition from irregular polygons with sharp edges to smoothened smaller cuboid polygons. UHPLC analysis of Lithom revealed the presence of Trigonelline, Bergenin, Xanthosine, Adenosine, Bohoervinone B, Vanillic acid, and Ellagic acid as key phytoconstituents. In EG-induced SD rats, the Lithom-treated group showed a decrease in elevated urinary oxalate levels, oxidative stress, and renal inflammation. Von Kossa staining of kidney tissue also exhibited a marked reduction in crystal depositions in Lithom-treated groups. Conclusion: Taken together, Lithom could be a potential clinical-therapeutic alternative for management of nephrolithiasis.
Mesh-Begriff(e)	Animals ; Calcium Oxalate/metabolism ; Calcium Oxalate/chemistry ; Hyperoxaluria/chemically induced ; Hyperoxaluria/metabolism ; Oxidative Stress/drug effects ; Rats, Sprague-Dawley ; Rats ; Disease Models, Animal ; Nephrolithiasis/chemically induced ; Nephrolithiasis/metabolism ; Nephrolithiasis/pathology ; Male ; Crystallization ; Ethylene Glycol/toxicity ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use
Chemische Substanzen	Calcium Oxalate (2612HC57YE) ; Ethylene Glycol (FC72KVT52F) ; Plant Extracts
Sprache	Englisch
Erscheinungsdatum	2024-04-25
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2415544-5
ISSN	1944-7930 ; 1944-7930
ISSN (online)	1944-7930
ISSN	1944-7930
DOI	10.24976/Discov.Med.202436183.75
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Livogrit prevents Amiodarone-induced toxicity in experimental model of human liver (HepG2) cells and

Balkrishna, Acharya / Gohel, Vivek / Pathak, Nishit / Bhattacharya, Kunal / Dev, Rishabh / Varshney, Anurag

Drug and chemical toxicology

2024 , Seite(n) 1–17

Abstract: Treatment with cationic amphiphilic drugs like Amiodarone leads to development of phospholipidosis, a type of lysosomal storage disorder characterized by excessive deposition of phospholipids. Such disorder in liver enhances accumulation of drugs and its ...

Abstract	Treatment with cationic amphiphilic drugs like Amiodarone leads to development of phospholipidosis, a type of lysosomal storage disorder characterized by excessive deposition of phospholipids. Such disorder in liver enhances accumulation of drugs and its metabolites, and dysregulates lipid profiles, which subsequently leads to hepatotoxicity. In the present study, we assessed pharmacological effects of herbal medicine, Livogrit, against hepatic phospholipidosis-induced toxicity. Human liver (HepG2) cells and
Sprache	Englisch
Erscheinungsdatum	2024-03-01
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	548368-2
ISSN	1525-6014 ; 0148-0545
ISSN (online)	1525-6014
ISSN	0148-0545
DOI	10.1080/01480545.2024.2320189
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Exploring the potential of Mustard (Brassica spp.) seeds through 'Kolhu' traditional method of extraction and novel identification of an anti-cancer dipeptide, Aurantiamide acetate (Asperglaucide) on ultra-performance liquid chromatography-mass spectrometry coupled with quadrupole time-of-flight (UPLC/MS-QToF) analytical platform.

Balkrishna, Acharya / Verma, Sudeep / Priya Rani, M / Nain, Pardeep / Varshney, Anurag

Food chemistry

2024 Band 446, Seite(n) 138870

Abstract: Mustard (Brassica spp.) is one of the world's oldest condiments in the food basket, which holds a significant place in the global culinary landscape due to historical prominence and perceived health benefits. This study explores the extraction of oils ... ...

Abstract	Mustard (Brassica spp.) is one of the world's oldest condiments in the food basket, which holds a significant place in the global culinary landscape due to historical prominence and perceived health benefits. This study explores the extraction of oils from Mustard seeds by employing traditional 'Kolhu' method, modern supercritical fluid, and solvent extraction techniques. This study, for the first-time, identified Aurantiamide acetate, a potent anti-cancer dipeptide in Mustard seeds using ultra-performance liquid chromatography-mass spectrometry coupled with quadrupole time-of-flight (UPLC/MS-QToF) analytical platform. The analytical methodology was meticulously validated encompassing optimal parameters such as limit of detection, limit of quantification, precision, accuracy, linearity and robustness, within the range. Interestingly, 'Kolhu' method of oil extraction exhibited better yield of Aurantiamide acetate, suggesting superior efficiency of traditional methods. This study accentuates the importance of classical extraction methods, used traditionally, and emphasizes that naturally occurring substances indeed could be harnessed for better health.
Mesh-Begriff(e)	Chromatography, High Pressure Liquid/methods ; Tandem Mass Spectrometry/methods ; Mustard Plant ; Liquid Chromatography-Mass Spectrometry ; Dipeptides ; Seeds
Chemische Substanzen	N-benzoylphenylalanylphenylalinol acetate (56121-42-7) ; Dipeptides
Sprache	Englisch
Erscheinungsdatum	2024-02-28
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138870
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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