Artikel ; Online: Activation of TLR9 signaling suppresses the immunomodulating functions of CD55
2024 Band 15, Seite(n) 1337384
Abstract: Fibroblastic reticular cells (FRCs) are a subpopulation of stromal cells modulating the immune environments in health and disease. We have previously shown that activation of TLR9 signaling in FRC in fat-associated lymphoid clusters (FALC) regulate ... ...
Abstract | Fibroblastic reticular cells (FRCs) are a subpopulation of stromal cells modulating the immune environments in health and disease. We have previously shown that activation of TLR9 signaling in FRC in fat-associated lymphoid clusters (FALC) regulate peritoneal immunity via suppressing immune cell recruitment and peritoneal resident macrophage (PRM) retention. However, FRCs are heterogeneous across tissues and organs. The functions of each FRC subset and the regulation of TLR9 in distinct FRC subsets are unknown. Here, we confirmed that specific deletion of TLR9 in FRC improved bacterial clearance and survival during peritoneal infection. Furthermore, using single-cell RNA sequencing, we found two subsets of FRCs (CD55 |
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Mesh-Begriff(e) | Animals ; Toll-Like Receptor 9/metabolism ; Toll-Like Receptor 9/genetics ; Mice ; Peritonitis/immunology ; Peritonitis/metabolism ; Signal Transduction ; Fibroblasts/metabolism ; Fibroblasts/immunology ; Mice, Knockout ; Mice, Inbred C57BL ; Immunomodulation ; Male ; Humans ; Disease Models, Animal |
Chemische Substanzen | Toll-Like Receptor 9 ; Tlr9 protein, mouse |
Sprache | Englisch |
Erscheinungsdatum | 2024-05-17 |
Erscheinungsland | Switzerland |
Dokumenttyp | Journal Article |
ZDB-ID | 2606827-8 |
ISSN | 1664-3224 ; 1664-3224 |
ISSN (online) | 1664-3224 |
ISSN | 1664-3224 |
DOI | 10.3389/fimmu.2024.1337384 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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