Article ; Online: The pancreatic and extrapancreatic manifestations of IgG4-related disease.
Diagnostic and interventional radiology (Ankara, Turkey)
2018 Volume 24, Issue 2, Page(s) 83–88
Abstract: The association between immunoglobulin IgG4 and autoimmune pancreatitis was first shown in 2001. Since then many previously established fibrosclerotic diseases demonstrating synchronous or metachronous multiorgan involvement have been included within the ...
| Abstract | The association between immunoglobulin IgG4 and autoimmune pancreatitis was first shown in 2001. Since then many previously established fibrosclerotic diseases demonstrating synchronous or metachronous multiorgan involvement have been included within the ambit of IgG4-related disease. Diagnostic criteria have been proposed involving 1) serum IgG4 level elevated beyond 135 mg/dL, 2) IgG4+ to IgG+ plasma cell ratio > 40% and >10 IgG4+ cells per high power field of biopsy sample and 3) a constellation of imaging features which involve a variety of organ systems. We present a pictorial essay demonstrating the spectrum of imaging findings for IgG4-related disease, including dacryosialadenitis, variety of renal lesions, tumefactive thickening of the extraocular muscles and orbital nerve, sclerosing cholangitis, and type I pancreatitis. Imaging plays an important role in diagnosis, screening for multiorgan involvement, and follow-up of the disease. |
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| MeSH term(s) | Autoimmune Diseases/diagnostic imaging ; Autoimmune Diseases/pathology ; Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/diagnostic imaging ; Cholangitis, Sclerosing/pathology ; Dacryocystitis/complications ; Dacryocystitis/diagnostic imaging ; Dacryocystitis/pathology ; Diffusion Magnetic Resonance Imaging/methods ; Humans ; Immunoglobulin G/blood ; Kidney/diagnostic imaging ; Kidney/immunology ; Kidney/pathology ; Lung/diagnostic imaging ; Lung/immunology ; Lung/pathology ; Orbit/diagnostic imaging ; Orbit/innervation ; Orbit/pathology ; Pancreas/diagnostic imaging ; Pancreas/immunology ; Pancreas/pathology ; Pancreatitis/complications ; Pancreatitis/diagnostic imaging ; Pancreatitis/immunology ; Pancreatitis/pathology ; Sialadenitis/complications ; Sialadenitis/diagnostic imaging ; Sialadenitis/pathology ; Vascular Diseases/complications ; Vascular Diseases/diagnostic imaging ; Vascular Diseases/immunology ; Vascular Diseases/pathology |
| Chemical Substances | Immunoglobulin G |
| Language | English |
| Publishing date | 2018-02-21 |
| Publishing country | Turkey |
| Document type | Journal Article |
| ZDB-ID | 2184145-7 |
| ISSN | 1305-3612 ; 1305-3825 |
| ISSN (online) | 1305-3612 |
| ISSN | 1305-3825 |
| DOI | 10.5152/dir.2018.17319 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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