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  1. Artikel ; Online: Diet-Derived Antioxidants: The Special Case of Ergothioneine.

    Halliwell, Barry / Tang, Richard M Y / Cheah, Irwin K

    Annual review of food science and technology

    2023  Band 14, Seite(n) 323–345

    Abstract: This article reviews what is presently known about the biological roles of the diet-derived compound ergothioneine (ET). ET seems important to humans because it is rapidly taken up from the diet by a transporter largely or completely specific for ET, and ...

    Abstract This article reviews what is presently known about the biological roles of the diet-derived compound ergothioneine (ET). ET seems important to humans because it is rapidly taken up from the diet by a transporter largely or completely specific for ET, and once taken up it is retained within the body for weeks or months. The various possible functions of ET in vivo are explored. Much emphasis has been placed on the antioxidant properties of ET, but although these are well established in vitro, the evidence that antioxidant activity is the principal function of ET in vivo is weak. ET is not unique in this: The evidence for the antioxidant roles of vitamin C and polyphenols such as the flavonoids in vivo is also weak. By contrast, α-tocopherol has demonstrated in vivo antioxidant effects in humans.
    Mesh-Begriff(e) Humans ; Antioxidants ; Ergothioneine ; Diet
    Chemische Substanzen Antioxidants ; Ergothioneine (BDZ3DQM98W)
    Sprache Englisch
    Erscheinungsdatum 2023-01-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516759-5
    ISSN 1941-1421 ; 1941-1413
    ISSN (online) 1941-1421
    ISSN 1941-1413
    DOI 10.1146/annurev-food-060822-122236
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Ergothioneine, recent developments.

    Cheah, Irwin K / Halliwell, Barry

    Redox biology

    2021  Band 42, Seite(n) 101868

    Abstract: There has been a recent surge of interest in the unique low molecular weight dietary thiol/thione, ergothioneine. This compound can accumulate at high levels in the body from diet and may play important physiological roles in human health and development, ...

    Abstract There has been a recent surge of interest in the unique low molecular weight dietary thiol/thione, ergothioneine. This compound can accumulate at high levels in the body from diet and may play important physiological roles in human health and development, and possibly in prevention and treatment of disease. Blood levels of ergothioneine decline with age and onset of various diseases. Here we highlight recent advances in our knowledge of ergothioneine.
    Mesh-Begriff(e) Antioxidants ; Diet ; Ergothioneine ; Humans
    Chemische Substanzen Antioxidants ; Ergothioneine (BDZ3DQM98W)
    Sprache Englisch
    Erscheinungsdatum 2021-01-26
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2021.101868
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Ergothioneine, recent developments

    Irwin K. Cheah / Barry Halliwell

    Redox Biology, Vol 42, Iss , Pp 101868- (2021)

    2021  

    Abstract: There has been a recent surge of interest in the unique low molecular weight dietary thiol/thione, ergothioneine. This compound can accumulate at high levels in the body from diet and may play important physiological roles in human health and development, ...

    Abstract There has been a recent surge of interest in the unique low molecular weight dietary thiol/thione, ergothioneine. This compound can accumulate at high levels in the body from diet and may play important physiological roles in human health and development, and possibly in prevention and treatment of disease. Blood levels of ergothioneine decline with age and onset of various diseases. Here we highlight recent advances in our knowledge of ergothioneine.
    Schlagwörter Ergothioneine ; OCTN1 ; Antioxidant ; Thiol/thione ; Mushroom ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-06-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

    Cheah, Irwin K / Halliwell, Barry

    Antioxidants (Basel, Switzerland)

    2020  Band 9, Heft 7

    Abstract: Infection with SARS-CoV-2 causes the coronavirus infectious disease 2019 (COVID-19), a pandemic that has, at present, infected more than 11 million people globally. Some COVID-19 patients develop a severe and critical illness, spurred on by excessive ... ...

    Abstract Infection with SARS-CoV-2 causes the coronavirus infectious disease 2019 (COVID-19), a pandemic that has, at present, infected more than 11 million people globally. Some COVID-19 patients develop a severe and critical illness, spurred on by excessive inflammation that can lead to respiratory or multiorgan failure. Numerous studies have established the unique array of cytoprotective properties of the dietary amino acid ergothioneine. Based on studies in a range of in vitro and in vivo models, ergothioneine has exhibited the ability to modulate inflammation, scavenge free radicals, protect against acute respiratory distress syndrome, prevent endothelial dysfunction, protect against ischemia and reperfusion injury, protect against neuronal damage, counteract iron dysregulation, hinder lung and liver fibrosis, and mitigate damage to the lungs, kidneys, liver, gastrointestinal tract, and testis, amongst many others. When compiled, this evidence suggests that ergothioneine has a potential application in the treatment of the underlying pathology of COVID-19. We propose that ergothioneine could be used as a therapeutic to reduce the severity and mortality of COVID-19, especially in the elderly and those with underlying health conditions. This review presents evidence to support that proposal.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9070595
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Protection against Doxorubicin-Induced Cardiotoxicity by Ergothioneine.

    Cheah, Irwin K / Tang, Richard M Y / Wang, Xiaoyuan / Sachaphibulkij, Karishma / Chong, Suet Yen / Lim, Lina H K / Wang, Jiong-Wei / Halliwell, Barry

    Antioxidants (Basel, Switzerland)

    2023  Band 12, Heft 2

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2023-01-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12020320
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

    Irwin K. Cheah / Barry Halliwell

    Antioxidants, Vol 9, Iss 595, p

    2020  Band 595

    Abstract: Infection with SARS-CoV-2 causes the coronavirus infectious disease 2019 (COVID-19), a pandemic that has, at present, infected more than 11 million people globally. Some COVID-19 patients develop a severe and critical illness, spurred on by excessive ... ...

    Abstract Infection with SARS-CoV-2 causes the coronavirus infectious disease 2019 (COVID-19), a pandemic that has, at present, infected more than 11 million people globally. Some COVID-19 patients develop a severe and critical illness, spurred on by excessive inflammation that can lead to respiratory or multiorgan failure. Numerous studies have established the unique array of cytoprotective properties of the dietary amino acid ergothioneine. Based on studies in a range of in vitro and in vivo models, ergothioneine has exhibited the ability to modulate inflammation, scavenge free radicals, protect against acute respiratory distress syndrome, prevent endothelial dysfunction, protect against ischemia and reperfusion injury, protect against neuronal damage, counteract iron dysregulation, hinder lung and liver fibrosis, and mitigate damage to the lungs, kidneys, liver, gastrointestinal tract, and testis, amongst many others. When compiled, this evidence suggests that ergothioneine has a potential application in the treatment of the underlying pathology of COVID-19. We propose that ergothioneine could be used as a therapeutic to reduce the severity and mortality of COVID-19, especially in the elderly and those with underlying health conditions. This review presents evidence to support that proposal.
    Schlagwörter ergothioneine ; COVID-19 ; antioxidant ; coronavirus ; SARS ; inflammation ; cytokine ; NETs ; Therapeutics. Pharmacology ; RM1-950 ; covid19
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Superior Photoprotection of Cyanine Dyes with Thio-imidazole Amino Acids.

    Gidi, Yasser / Ramos-Sanchez, Jorge / Lovell, Terri C / Glembockyte, Viktorija / Cheah, Irwin K / Schnermann, Martin J / Halliwell, Barry / Cosa, Gonzalo

    Journal of the American Chemical Society

    2023  Band 145, Heft 36, Seite(n) 19571–19577

    Abstract: Preventing fluorophore photobleaching and unwanted blinking is crucial for single-molecule fluorescence (SMF) studies. Reductants achieve ... ...

    Abstract Preventing fluorophore photobleaching and unwanted blinking is crucial for single-molecule fluorescence (SMF) studies. Reductants achieve photoprotection
    Mesh-Begriff(e) Amino Acids ; Fluorescent Dyes ; Imidazoles ; Ergothioneine ; Ionophores ; Quinolines
    Chemische Substanzen Amino Acids ; Fluorescent Dyes ; Imidazoles ; Ergothioneine (BDZ3DQM98W) ; Ionophores ; Quinolines
    Sprache Englisch
    Erscheinungsdatum 2023-09-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c03058
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Bonn

    Z 4' 55/32: Hefte anzeigen
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  8. Artikel: Could ergothioneine aid in the treatment of coronavirus patients?

    Cheah, Irwin K. / Halliwell, Barry

    Antioxidants

    Abstract: Infection with SARS-CoV-2 causes the coronavirus infectious disease 2019 (COVID-19), a pandemic that has, at present, infected more than 11 million people globally. Some COVID-19 patients develop a severe and critical illness, spurred on by excessive ... ...

    Abstract Infection with SARS-CoV-2 causes the coronavirus infectious disease 2019 (COVID-19), a pandemic that has, at present, infected more than 11 million people globally. Some COVID-19 patients develop a severe and critical illness, spurred on by excessive inflammation that can lead to respiratory or multiorgan failure. Numerous studies have established the unique array of cytoprotective properties of the dietary amino acid ergothioneine. Based on studies in a range of in vitro and in vivo models, ergothioneine has exhibited the ability to modulate inflammation, scavenge free radicals, protect against acute respiratory distress syndrome, prevent endothelial dysfunction, protect against ischemia and reperfusion injury, protect against neuronal damage, counteract iron dysregulation, hinder lung and liver fibrosis, and mitigate damage to the lungs, kidneys, liver, gastrointestinal tract, and testis, amongst many others. When compiled, this evidence suggests that ergothioneine has a potential application in the treatment of the underlying pathology of COVID-19. We propose that ergothioneine could be used as a therapeutic to reduce the severity and mortality of COVID-19, especially in the elderly and those with underlying health conditions. This review presents evidence to support that proposal.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #638724
    Datenquelle COVID19

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  9. Artikel ; Online: Does Lactobacillus reuteri influence ergothioneine levels in the human body?

    Cheah, Irwin K / Lee, Jovan Z / Tang, Richard M Y / Koh, Pei Wen / Halliwell, Barry

    FEBS letters

    2022  Band 596, Heft 10, Seite(n) 1241–1251

    Abstract: The dietary thione-thiol, ergothioneine (ET), accumulates in human and animal tissues and may play important roles in disease prevention. ET biosynthesis has only been described in fungi and certain bacteria, and humans and animals are widely assumed to ... ...

    Abstract The dietary thione-thiol, ergothioneine (ET), accumulates in human and animal tissues and may play important roles in disease prevention. ET biosynthesis has only been described in fungi and certain bacteria, and humans and animals are widely assumed to accumulate ET solely from diet. However, a recent study suggested that Lactobacillus/Limosilactobacillus reuteri, a commensal gut bacterium, may produce ET, thereby protecting the host against social defeat stress and sleep disturbances. Upon our further investigation, no evidence of ET biosynthesis was observed in L. reuteri when a heavy-labelled histidine precursor was administered. Instead, we discovered that L. reuteri avidly accumulates ET. This observation may indicate a possible mechanism by which the gut microbiota could influence tissue levels of ET in the host.
    Mesh-Begriff(e) Animals ; Bacteria ; Diet ; Ergothioneine ; Gastrointestinal Microbiome ; Human Body ; Humans ; Lactobacillus reuteri ; Probiotics
    Chemische Substanzen Ergothioneine (BDZ3DQM98W)
    Sprache Englisch
    Erscheinungsdatum 2022-05-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14364
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 282: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Artikel ; Online: Blood-based biomarkers of cerebral small vessel disease.

    Wu, Liu-Yun / Chai, Yuek Ling / Cheah, Irwin K / Chia, Rachel S L / Hilal, Saima / Arumugam, Thiruma V / Chen, Christopher P / Lai, Mitchell K P

    Ageing research reviews

    2024  Band 95, Seite(n) 102247

    Abstract: Age-associated cerebral small vessel disease (CSVD) represents a clinically heterogenous condition, arising from diverse microvascular mechanisms. These lead to chronic cerebrovascular dysfunction and carry a substantial risk of subsequent stroke and ... ...

    Abstract Age-associated cerebral small vessel disease (CSVD) represents a clinically heterogenous condition, arising from diverse microvascular mechanisms. These lead to chronic cerebrovascular dysfunction and carry a substantial risk of subsequent stroke and vascular cognitive impairment in aging populations. Owing to advances in neuroimaging, in vivo visualization of cerebral vasculature abnormities and detection of CSVD, including lacunes, microinfarcts, microbleeds and white matter lesions, is now possible, but remains a resource-, skills- and time-intensive approach. As a result, there has been a recent proliferation of blood-based biomarker studies for CSVD aimed at developing accessible screening tools for early detection and risk stratification. However, a good understanding of the pathophysiological processes underpinning CSVD is needed to identify and assess clinically useful biomarkers. Here, we provide an overview of processes associated with CSVD pathogenesis, including endothelial injury and dysfunction, neuroinflammation, oxidative stress, perivascular neuronal damage as well as cardiovascular dysfunction. Then, we review clinical studies of the key biomolecules involved in the aforementioned processes. Lastly, we outline future trends and directions for CSVD biomarker discovery and clinical validation.
    Mesh-Begriff(e) Humans ; Stroke/complications ; Neuroimaging/adverse effects ; Cognitive Dysfunction ; Biomarkers ; Cerebral Small Vessel Diseases/diagnostic imaging ; Magnetic Resonance Imaging
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2024-02-27
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2024.102247
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5579: Hefte anzeigen Standort:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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