Artikel ; Online: Safety pharmacology and subchronic toxicity of jinqing granules in rats.
BMC veterinary research
2017 Band 13, Heft 1, Seite(n) 179
Abstract: Background: Jinqing granules which are made of a mixture extract that contains Radix Tinosporae ... pharmacology experiments, Jinqing granules had no evident adverse effects on the central nervous ... cardiovascular, or respiratory systems. In subchronic toxicity study, 2-8 g/kg of Jinqing granules induced no ...
| Abstract | Background: Jinqing granules which are made of a mixture extract that contains Radix Tinosporae and Canarii fructus in proportions according to a longstanding formula have a good effect on the prevention and treatment of gastric ulcer disease. It has not been through safety through systematic toxicological studies, however. To provide basis for clinical application, we performed safety pharmacology and subchronic toxicity experiments in specific pathogen-free Sprague-Dawley rats. Results: In safety pharmacology experiments, Jinqing granules had no evident adverse effects on the central nervous, cardiovascular, or respiratory systems. In subchronic toxicity study, 2-8 g/kg of Jinqing granules induced no evident adverse effects on Clinical signs, body weight changes, food and water intake, death daily, indicators of urine, hematological assay, serum biochemistry, organ coefficient and histopathological examination. However, the 16 g/kg dose was associated with slightly slowed weight growth, decreased number of sperm in seminiferous tubules and increased values of serum aspartate aminotransferase and bilirubin. During the 30-day feeding test, 3 rats that received the 16 g/kg dose died, but the deaths were most likely due to trauma of oral gavage, not to drug toxicity. Conclusion: Jinqing granules given to Sprague-Dawley rats orally for 30 days at a dose of 8 g/kg or less appears safe, but higher doses were not proven safe. The significance of these observations with respect to animal usage of Jinqing granules deserves thorough investigation. |
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| Mesh-Begriff(e) | Animals ; Burseraceae/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/toxicity ; Female ; Male ; Rats ; Rats, Sprague-Dawley ; Tinospora/chemistry |
| Chemische Substanzen | Drugs, Chinese Herbal ; jinqing |
| Sprache | Englisch |
| Erscheinungsdatum | 2017-06-17 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ISSN | 1746-6148 |
| ISSN (online) | 1746-6148 |
| DOI | 10.1186/s12917-017-1095-3 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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