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  1. Buch ; Online: Molecular Advances in Diagnosis and Treatment of CNS Tumors

    Chen, Liam / Lin, Ming-Tseh / Zhang, Zhaohui / Zhang, Zhaohui

    2020  

    Schlagwörter Medicine ; Oncology ; brain tumor ; glioblastoma ; glioma ; astrocytic ; molecular biomarker ; therapy
    Umfang 1 electronic resource (283 pages)
    Verlag Frontiers Media SA
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT021230941
    ISBN 9782889661640 ; 2889661644
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Reply to: Inspiratory muscle training for COVID-19: Benefits appear promising but findings remain uncertain.

    Chen, Yusha / Liu, Xuefeng / Zhaohui, Tong

    Journal of medical virology

    2024  Band 96, Heft 2, Seite(n) e29441

    Mesh-Begriff(e) Humans ; COVID-19 ; Counseling ; Muscles
    Sprache Englisch
    Erscheinungsdatum 2024-02-02
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29441
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: NaRbB

    Zhao, Huanhuan / Xu, Die / Chen, Zhaohui

    Inorganic chemistry

    2024  Band 63, Heft 18, Seite(n) 8476–8483

    Abstract: Two deep ultraviolet (DUV) hydroxylated-alkali-metal borates, ... ...

    Abstract Two deep ultraviolet (DUV) hydroxylated-alkali-metal borates, NaRbB
    Sprache Englisch
    Erscheinungsdatum 2024-04-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.4c01030
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Buch: Modern computational approaches to traditional Chinese medicine

    Wu, Zhaohui / Chen, Hua-jun / Jiang, Xiaohong

    (Elsevier insights)

    2012  

    Verfasserangabe Zhaohui Wu ; Huajun Chen ; Xiaohong Jiang
    Serientitel Elsevier insights
    Schlagwörter Medicine, Chinese ; Medicine, Chinese--Data processing
    Sprache Englisch
    Umfang XV, 233 S. : Ill., graph. Darst., 24 cm
    Verlag Elsevier
    Erscheinungsort Amsterdam
    Erscheinungsland Niederlande
    Dokumenttyp Buch
    Anmerkung Formerly CIP Uk. - Includes bibliographical references
    HBZ-ID HT018109072
    ISBN 978-0-12-398510-1 ; 0-12-398510-2
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  5. Artikel ; Online: Research trends on the gastrointestinal stromal tumor: A bibliometric analysis.

    Xu, Yang / Lyu, JianBo / Xu, Zhaohui / Chen, Xin

    Asian journal of surgery

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-05-14
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.05.038
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Cool Skin Effect as Seen from a New Generation Geostationary Satellite Himawari-8

    Yueqi Zhang / Zhaohui Chen

    Remote Sensing, Vol 15, Iss 4408, p

    2023  Band 4408

    Abstract: The cool skin effect refers to the phenomenon where the surface skin temperature of the ocean is always slightly cooler than the temperature of the water directly underneath due to the ubiquitous cooling processes at the ocean surface, especially in the ... ...

    Abstract The cool skin effect refers to the phenomenon where the surface skin temperature of the ocean is always slightly cooler than the temperature of the water directly underneath due to the ubiquitous cooling processes at the ocean surface, especially in the absence of solar radiation. The cool skin effect plays a critical role in the estimation of heat, momentum, and gas exchange between the air and the sea. However, the scarcity of observational data greatly hinders the accurate assessment of the cool skin effect. Here, the matchup data from the new generation geostationary satellite Himawari-8 and in situ sea surface temperature (SST) observations are used to evaluate the performance and dependence on the cool skin effect in the low/mid-latitude oceans. Results show that the intensity of the cool skin effect as revealed by Himawari-8 (−0.16 K) is found to be relatively weaker than previously published cool skin models based on in situ concurrent observations. A considerable amount of warm skin signals has been detected in the high-latitude oceans (e.g., Southern Ocean) under the circumstances of positive air–sea temperature difference and high wind, which may be the main cause of discrepancies with previous thoughts on the cool skin effect.
    Schlagwörter cool skin effect ; geostationary satellite ; carbon dioxide flux ; air–sea interaction ; Science ; Q
    Thema/Rubrik (Code) 551
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Dynamic characteristics of soil heavy metals and microbial communities under moss cover at different successional stages in a manganese mining area.

    Pengpeng, Chen / Zhihui, Wang / Zhaohui, Zhang

    Environmental geochemistry and health

    2023  Band 45, Heft 11, Seite(n) 7711–7726

    Abstract: The mining and smelting of manganese ores and the accumulation of slag not only pollute the environment and increase the threat to biodiversity, but also adversely affect the health of human and other organisms. Therefore, it's important to study the ... ...

    Abstract The mining and smelting of manganese ores and the accumulation of slag not only pollute the environment and increase the threat to biodiversity, but also adversely affect the health of human and other organisms. Therefore, it's important to study the restoration of manganese mining area. Since mosses play an irreplaceable role in the ecological restoration of mine sites, this study is carried out in a slag heap area that has been in continuous operation for about 50 years, and spatial variation is used instead of temporal variation to study the diversity of moss plants, the characteristics of soil heavy metal changes under moss cover, and the characteristics of bacterial communities in manganese mine sites at different time scales. A total of 20 moss taxa from 8 genera and 5 families are recorded, the dominant families are Bryaceae (50%) and Pottiaceae (25%), with the development of succession, the alpha-diversity index of mosses increases with the development of succession. The study area has a relatively high level of heavy metal contamination, the heavy metals Mn, V, Cu and Ni are significantly affected by succession in the Manganese mining area, and the soil heavy metal content generally shows a decreasing trend with the development of succession. Actinobacteriota, Proteobacteria, Chloroflexi Acidobacteriota and Gemmatimonadota are the dominant soil bacterial phyla in manganese mining areas (relative abundance > 10%), the composition of soil bacteria at different successional stages at the phylum level was the same, but the abundance of each bacterial community differed. The soil bacterial community in the manganese mining area is significantly affected by soil heavy metals.
    Mesh-Begriff(e) Humans ; Manganese/analysis ; Soil ; Soil Pollutants/toxicity ; Soil Pollutants/analysis ; Metals, Heavy/toxicity ; Metals, Heavy/analysis ; Mining ; Microbiota ; Bacteria ; Bryophyta ; Bryopsida ; China ; Environmental Monitoring
    Chemische Substanzen Manganese (42Z2K6ZL8P) ; Soil ; Soil Pollutants ; Metals, Heavy
    Sprache Englisch
    Erscheinungsdatum 2023-07-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 52039-1
    ISSN 1573-2983 ; 0142-7245 ; 0269-4042
    ISSN (online) 1573-2983
    ISSN 0142-7245 ; 0269-4042
    DOI 10.1007/s10653-023-01681-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment.

    Chen, Yilin / Ye, Zi / Chen, Haixu / Li, Zhaohui

    International journal of nanomedicine

    2024  Band 19, Seite(n) 4021–4040

    Abstract: Cataract is a leading cause of blindness globally, and its surgical treatment poses a significant burden on global healthcare. Pharmacologic therapies, including antioxidants and protein aggregation reversal agents, have attracted great attention in the ... ...

    Abstract Cataract is a leading cause of blindness globally, and its surgical treatment poses a significant burden on global healthcare. Pharmacologic therapies, including antioxidants and protein aggregation reversal agents, have attracted great attention in the treatment of cataracts in recent years. Due to the anatomical and physiological barriers of the eye, the effectiveness of traditional eye drops for delivering drugs topically to the lens is hindered. The advancements in nanomedicine present novel and promising strategies for addressing challenges in drug delivery to the lens, including the development of nanoparticle formulations that can improve drug penetration into the anterior segment and enable sustained release of medications. This review introduces various cutting-edge drug delivery systems for cataract treatment, highlighting their physicochemical properties and surface engineering for optimal design, thus providing impetus for further innovative research and potential clinical applications of anti-cataract drugs.
    Mesh-Begriff(e) Humans ; Cataract/drug therapy ; Nanomedicine/methods ; Drug Delivery Systems/methods ; Nanoparticles/chemistry ; Animals ; Lens, Crystalline/drug effects ; Cataract Extraction ; Nanoparticle Drug Delivery System/chemistry ; Ophthalmic Solutions/chemistry ; Ophthalmic Solutions/pharmacokinetics ; Ophthalmic Solutions/administration & dosage
    Chemische Substanzen Nanoparticle Drug Delivery System ; Ophthalmic Solutions
    Sprache Englisch
    Erscheinungsdatum 2024-05-06
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2364941-0
    ISSN 1178-2013 ; 1176-9114
    ISSN (online) 1178-2013
    ISSN 1176-9114
    DOI 10.2147/IJN.S463679
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: NRF2 Controls the Competitive Fitness of Squamous Epithelial Cells in the Mouse Esophagus.

    Xiong, Zhaohui / Chen, Xiaoxin

    Cellular and molecular gastroenterology and hepatology

    2022  Band 15, Heft 1, Seite(n) 275–276

    Mesh-Begriff(e) Mice ; Animals ; NF-E2-Related Factor 2 ; Epithelial Cells/pathology ; Esophagus/pathology
    Chemische Substanzen NF-E2-Related Factor 2
    Sprache Englisch
    Erscheinungsdatum 2022-11-06
    Erscheinungsland United States
    Dokumenttyp Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2022.10.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: AHNAK2 Promotes the Progression of Pancreatic Ductal Adenocarcinoma by Maintaining the Stability of c-MET.

    Chen, Zhaohui / Miao, Pengbiao / Lin, Hongcao / Lu, Yanan

    Cancer management and research

    2024  Band 16, Seite(n) 431–444

    Abstract: Purpose: Pancreatic ductal adenocarcinoma (PDAC) is extremely malignant and rapidly progresses. The overall response rate of PDAC to current treatment methods is still unsatisfactory. Thus, identifying novel targets and clarifying the underlying ... ...

    Abstract Purpose: Pancreatic ductal adenocarcinoma (PDAC) is extremely malignant and rapidly progresses. The overall response rate of PDAC to current treatment methods is still unsatisfactory. Thus, identifying novel targets and clarifying the underlying mechanisms associated with PDAC progression may potentially offer additional treatment strategies. AHNAK2 is aberrantly expressed in a variety of tumors and exerts pro-tumorigenic effects. However, the biological role of AHNAK2 in PDAC remains poorly understood.
    Methods: The expression of AHNAK2 in PDAC and paired non-tumor tissues was detected by immunohistochemistry (IHC) and quantitative real-time polymerase chain reaction (qRT-PCR). Lentivirus knockdown was performed to investigate the impact of AHNAK2 on the biological function of pancreatic cancer cells. The subcutaneous cell-derived xenograft (CDX) model and the KPC spontaneous mouse model with AHNAK2 silencing were used to observe the effects of AHNAK2 on tumor growth and prognosis. The expression of c-MET at protein level in response to HGF treatment was assessed using western blot.
    Results: Our results demonstrated that AHNAK2 was highly expressed in PDAC clinical samples and associated with poor prognosis. Knockdown of AHNAK2 significantly inhibited the proliferation, migration, and invasion of pancreatic cancer cells. AHNAK2 knockdown or knockout resulted in tumor growth suppression and prolonged survival in mice with PDAC. In addition, AHNAK2 and c-MET expression levels showed a significant positive correlation at the post-transcriptional level. Mechanistically, AHNAK2 promoted tumor progression by preventing c-MET degradation and persistently activating the HGF/c-MET signaling pathway.
    Conclusion: Overall, our study revealed that AHNAK2 plays an important role in PDAC progression by modulating the c-MET signaling pathway, and targeting AHNAK2 may be an effective therapeutic strategy for PDAC.
    Sprache Englisch
    Erscheinungsdatum 2024-05-08
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S451486
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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