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Buch ; Dissertation / Habilitation: Effects of interferons on palatal wound healing

1999

Verfasserangabe	door Anne Maria Henrica Cornelissen
Sprache	Englisch
Umfang	143 S. : Ill.
Erscheinungsland	Niederlande
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Nijmegen, Kath. Univ., Diss., 1999
Anmerkung	Zsfassung in niederländ. Sprache
HBZ-ID	HT012776859
ISBN	90-901-3468-9 ; 978-90-901-3468-0
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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Artikel: Fibroblast Growth Factor 23 and Outcome Prediction in Patients with Acute Myocardial Infarction.

Cornelissen, Anne / Florescu, Roberta / Kneizeh, Kinan / Cornelissen, Christian / Liehn, Elisa / Brandenburg, Vincent / Schuh, Alexander

Journal of clinical medicine

2022 Band 11, Heft 3

Abstract: 1) Background: Fibroblast growth factor 23 (FGF23) is associated with mortality in patients with heart failure (HF); however, less is known about mortality associations in patients with myocardial infarction (MI). (2) Methods: FGF23 was assessed in 180 ... ...

Abstract	(1) Background: Fibroblast growth factor 23 (FGF23) is associated with mortality in patients with heart failure (HF); however, less is known about mortality associations in patients with myocardial infarction (MI). (2) Methods: FGF23 was assessed in 180 patients with acute MI, 99 of whom presented with concomitant acute HF. Patients were followed up for one year, and outcome estimates by FGF23 were compared to GRACE score estimates. (3) Results: Log-transformed serum levels of intact FGF23 (logFGF23) did not differ between MI patients with and without HF, and no difference in logFGF23 was observed between 14 MI patients who died and those who survived. However, when only MI patients with concomitant HF were considered, logFGF23 was significantly higher among non-survivors compared to that in survivors. While logFGF23 was not associated with the outcome in the entire cohort, logFGF23 was fairly predictive for one-year mortality in patients with concomitant HF (AUC 0.78; 95%CI 0.61-0.95), where it outperformed GRACE score estimates (AUC 0.70; 95%CI 0.46-0.94). (4) Conclusions: FGF23 was associated with one-year mortality only in MI patients who concomitantly presented with HF, surpassing the predictive ability of GRACE score estimates. No associations were observed in patients without HF despite similar FGF23 levels at admission. Further studies are warranted to investigate whether FGF23 is causal for dismal outcome of HF.
Sprache	Englisch
Erscheinungsdatum	2022-01-25
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11030601
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Fibroblast Growth Factor 23 and Outcome Prediction in Patients with Acute Myocardial Infarction

Anne Cornelissen / Roberta Florescu / Kinan Kneizeh / Christian Cornelissen / Elisa Liehn / Vincent Brandenburg / Alexander Schuh

Journal of Clinical Medicine, Vol 11, Iss 601, p

2022 Band 601

Abstract	(1) Background: Fibroblast growth factor 23 (FGF23) is associated with mortality in patients with heart failure (HF); however, less is known about mortality associations in patients with myocardial infarction (MI). (2) Methods: FGF23 was assessed in 180 patients with acute MI, 99 of whom presented with concomitant acute HF. Patients were followed up for one year, and outcome estimates by FGF23 were compared to GRACE score estimates. (3) Results: Log-transformed serum levels of intact FGF23 (logFGF23) did not differ between MI patients with and without HF, and no difference in logFGF23 was observed between 14 MI patients who died and those who survived. However, when only MI patients with concomitant HF were considered, logFGF23 was significantly higher among non-survivors compared to that in survivors. While logFGF23 was not associated with the outcome in the entire cohort, logFGF23 was fairly predictive for one-year mortality in patients with concomitant HF (AUC 0.78; 95%CI 0.61–0.95), where it outperformed GRACE score estimates (AUC 0.70; 95%CI 0.46–0.94). (4) Conclusions: FGF23 was associated with one-year mortality only in MI patients who concomitantly presented with HF, surpassing the predictive ability of GRACE score estimates. No associations were observed in patients without HF despite similar FGF23 levels at admission. Further studies are warranted to investigate whether FGF23 is causal for dismal outcome of HF.
Schlagwörter	fibroblast growth factor 23 ; myocardial infarction ; HF ; GRACE score ; outcome prediction ; Medicine ; R
Sprache	Englisch
Erscheinungsdatum	2022-01-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Intact fibroblast growth factor 23 levels and outcome prediction in patients with acute heart failure.

Cornelissen, Anne / Florescu, Roberta / Kneizeh, Kinan / Cornelissen, Christian / Brandenburg, Vincent / Liehn, Elisa / Schuh, Alexander

Scientific reports

2021 Band 11, Heft 1, Seite(n) 15507

Abstract: Elevated fibroblast growth factor 23 (FGF23) levels are associated with adverse outcome in populations with cardiovascular disease and chronic kidney failure. It is unclear if FGF23 has significance in prognosis estimation in patients with acute heart ... ...

Abstract	Elevated fibroblast growth factor 23 (FGF23) levels are associated with adverse outcome in populations with cardiovascular disease and chronic kidney failure. It is unclear if FGF23 has significance in prognosis estimation in patients with acute heart failure (HF) when compared to traditional risk estimation tools. Serum levels of intact FGF23 were assessed in 139 patients admitted to the Intermediate Care Unit of a tertiary hospital for acute HF. Patients were followed-up for one year. After exclusion of patients who were lost to follow-up, data outliers, and patients with sampling errors, the final study cohort comprised 133 patients. The Seattle Heart Failure (SHF) Model was used to estimate one-year survival. FGF23 levels correlated with HF severity and were strongly associated with one-year mortality. Associations between one-year outcome and FGF23, assessed on day 1 after admission, were still evident after multivariable adjustment (OR 15.07; 95%CI 1.75-129.79; p = 0.014). FGF23 levels predicted the one-year outcome with similar accuracy as the SHF Model, both if assessed on day 1 and on day 2 after admission (FGF23d1: AUC 0.784; 95%CI 0.669-0.899; FGF23d2: AUC 0.766; 95%CI 0.631-0.901; SHF: AUC 0.771; 95%CI 0.651-0.891). The assessment of FGF23 in patients with acute HF might help identify high-risk patients that are more prone to complications, need a closer follow-up and more aggressive treatment.
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Female ; Fibroblast Growth Factors/blood ; Heart Failure/blood ; Heart Failure/pathology ; Humans ; Male ; Middle Aged ; Prognosis ; Risk Factors
Chemische Substanzen	Biomarkers ; Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 23 (7Q7P4S7RRE)
Sprache	Englisch
Erscheinungsdatum	2021-07-30
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-94780-7
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The effects of stenting on coronary endothelium from a molecular biological view: Time for improvement?

Cornelissen, Anne / Vogt, Felix Jan

Journal of cellular and molecular medicine

2018 Band 23, Heft 1, Seite(n) 39–46

Abstract: Coronary artery stenting following balloon angioplasty represents the gold standard in revascularization of coronary artery stenoses. However, stent deployment as well as percutaneous transluminal coronary angioplasty (PTCA) alone causes severe injury of ...

Abstract	Coronary artery stenting following balloon angioplasty represents the gold standard in revascularization of coronary artery stenoses. However, stent deployment as well as percutaneous transluminal coronary angioplasty (PTCA) alone causes severe injury of vascular endothelium. The damaged endothelium is intrinsically repaired by locally derived endothelial cells and by circulating endothelial progenitor cells from the blood, leading to re-population of the denuded regions within several weeks to months. However, the process of re-endothelialization is often incomplete or dysfunctional, promoting in-stent thrombosis and restenosis. The molecular and biomechanical mechanisms that influence the process of re-endothelialization in stented segments are incompletely understood. Once the endothelium is restored, endothelial function might still be impaired. Several strategies have been followed to improve endothelial function after coronary stenting. In this review, the effects of stenting on coronary endothelium are outlined and current and future strategies to improve endothelial function after stent deployment are discussed.
Mesh-Begriff(e)	Angioplasty, Balloon, Coronary/methods ; Animals ; Cell Proliferation ; Constriction, Pathologic/physiopathology ; Constriction, Pathologic/surgery ; Coronary Stenosis/physiopathology ; Coronary Stenosis/surgery ; Endothelial Cells/cytology ; Endothelial Cells/physiology ; Endothelium, Vascular/physiopathology ; Humans ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/physiology ; Stents
Sprache	Englisch
Erscheinungsdatum	2018-10-23
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.13936
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Intact fibroblast growth factor 23 levels and outcome prediction in patients with acute heart failure

Anne Cornelissen / Roberta Florescu / Kinan Kneizeh / Christian Cornelissen / Vincent Brandenburg / Elisa Liehn / Alexander Schuh

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Band 10

Abstract: Abstract Elevated fibroblast growth factor 23 (FGF23) levels are associated with adverse outcome in populations with cardiovascular disease and chronic kidney failure. It is unclear if FGF23 has significance in prognosis estimation in patients with acute ...

Abstract	Abstract Elevated fibroblast growth factor 23 (FGF23) levels are associated with adverse outcome in populations with cardiovascular disease and chronic kidney failure. It is unclear if FGF23 has significance in prognosis estimation in patients with acute heart failure (HF) when compared to traditional risk estimation tools. Serum levels of intact FGF23 were assessed in 139 patients admitted to the Intermediate Care Unit of a tertiary hospital for acute HF. Patients were followed-up for one year. After exclusion of patients who were lost to follow-up, data outliers, and patients with sampling errors, the final study cohort comprised 133 patients. The Seattle Heart Failure (SHF) Model was used to estimate one-year survival. FGF23 levels correlated with HF severity and were strongly associated with one-year mortality. Associations between one-year outcome and FGF23, assessed on day 1 after admission, were still evident after multivariable adjustment (OR 15.07; 95%CI 1.75–129.79; p = 0.014). FGF23 levels predicted the one-year outcome with similar accuracy as the SHF Model, both if assessed on day 1 and on day 2 after admission (FGF23d1: AUC 0.784; 95%CI 0.669–0.899; FGF23d2: AUC 0.766; 95%CI 0.631–0.901; SHF: AUC 0.771; 95%CI 0.651–0.891). The assessment of FGF23 in patients with acute HF might help identify high-risk patients that are more prone to complications, need a closer follow-up and more aggressive treatment.
Schlagwörter	Medicine ; R ; Science ; Q
Thema/Rubrik (Code)	610 ; 616
Sprache	Englisch
Erscheinungsdatum	2021-07-01T00:00:00Z
Verlag	Nature Portfolio
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Multivariate genome-wide associations for immune traits in two maternal pig lines.

Roth, Katharina / Pröll-Cornelissen, Maren Julia / Henne, Hubert / Appel, Anne Kathrin / Schellander, Karl / Tholen, Ernst / Große-Brinkhaus, Christine

BMC genomics

2023 Band 24, Heft 1, Seite(n) 492

Abstract: Background: Immune traits are considered to serve as potential biomarkers for pig's health. Medium to high heritabilities have been observed for some of the immune traits suggesting genetic variability of these phenotypes. Consideration of previously ... ...

Abstract	Background: Immune traits are considered to serve as potential biomarkers for pig's health. Medium to high heritabilities have been observed for some of the immune traits suggesting genetic variability of these phenotypes. Consideration of previously established genetic correlations between immune traits can be used to identify pleiotropic genetic markers. Therefore, genome-wide association study (GWAS) approaches are required to explore the joint genetic foundation for health biomarkers. Usually, GWAS explores phenotypes in a univariate (uv), trait-by-trait manner. Besides two uv GWAS methods, four multivariate (mv) GWAS approaches were applied on combinations out of 22 immune traits for Landrace (LR) and Large White (LW) pig lines. Results: In total 433 (LR: 351, LW: 82) associations were identified with the uv approach implemented in PLINK and a Bayesian linear regression uv approach (BIMBAM) software. Single Nucleotide Polymorphisms (SNPs) that were identified with both uv approaches (n = 32) were mostly associated with immune traits such as haptoglobin, red blood cell characteristics and cytokines, and were located in protein-coding genes. Mv GWAS approaches detected 647 associations for different mv immune trait combinations which were summarized to 133 Quantitative Trait Loci (QTL). SNPs for different trait combinations (n = 66) were detected with more than one mv method. Most of these SNPs are associated with red blood cell related immune trait combinations. Functional annotation of these QTL revealed 453 immune-relevant protein-coding genes. With uv methods shared markers were not observed between the breeds, whereas mv approaches were able to detect two conjoint SNPs for LR and LW. Due to unmapped positions for these markers, their functional annotation was not clarified. Conclusions: This study evaluated the joint genetic background of immune traits in LR and LW piglets through the application of various uv and mv GWAS approaches. In comparison to uv methods, mv methodologies identified more significant associations, which might reflect the pleiotropic background of the immune system more accurately. In genetic research of complex traits, the SNP effects are generally small. Furthermore, one genetic variant can affect several correlated immune traits at the same time, termed pleiotropy. As mv GWAS methods consider strong dependencies among traits, the power to detect SNPs can be boosted. Both methods revealed immune-relevant potential candidate genes. Our results indicate that one single test is not able to detect all the different types of genetic effects in the most powerful manner and therefore, the methods should be applied complementary.
Mesh-Begriff(e)	Swine/genetics ; Animals ; Genome-Wide Association Study ; Bayes Theorem ; Phenotype ; Cytokines ; Erythrocytes
Chemische Substanzen	Cytokines
Sprache	Englisch
Erscheinungsdatum	2023-08-28
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-023-09594-w
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Making Novel Genetic Associations With Carotid Intima-Media Thickness Using the UK Biobank.

Guo, Liang / Cornelissen, Anne / Sakamoto, Atsushi / Finn, Aloke V

Arteriosclerosis, thrombosis, and vascular biology

2020 Band 40, Heft 2, Seite(n) 297–300

Mesh-Begriff(e)	Biological Specimen Banks ; Carotid Artery Diseases ; Carotid Intima-Media Thickness ; Female ; Humans ; Male ; Obesity ; United Kingdom
Sprache	Englisch
Erscheinungsdatum	2020-01-22
Erscheinungsland	United States
Dokumenttyp	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.119.313784
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Comparison of thrombogenicity in different types of drug-eluting stents during transition from DAPT to SAPT.

Kawai, Kenji / Sato, Yu / Cornelissen, Anne / Kolodgie, Frank D / Cheng, Qi / Kawakami, Rika / Konishi, Takao / Perkins, Laura E L / Virmani, Renu / Finn, Aloke V

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2024

Abstract: Background: During the transition from dual antiplatelet therapy (DAPT) to single antiplatelet therapy (SAPT), previous studies have raised concerns about a rebound effect. We compared platelet and inflammatory cell adhesion on different types of stents ...

Abstract	Background: During the transition from dual antiplatelet therapy (DAPT) to single antiplatelet therapy (SAPT), previous studies have raised concerns about a rebound effect. We compared platelet and inflammatory cell adhesion on different types of stents in the setting of clopidogrel presence and withdrawal. Methods: In Experiment 1, three pigs were administered with DAPT, that is, clopidogrel and acetylsalicylic acid (ASA), for 7 days. Each animal underwent an extracorporeal carotid arteriovenous shunt model implanted with fluoropolymer-coated everolimus-eluting stent (FP-EES), biodegradable-polymer sirolimus-eluting stent (BP-SES), and biodegradable-polymer everolimus-eluting stents (BP-EES). In Experiment 2, two pigs were administered DAPT, clopidogrel was then withdrawn at day 7, and SAPT with ASA was continued for next 21 days. Then flow-loop experiments with the drawn blood from each time point were performed for FP-EES, BioLinx-polymer zotarolimus-eluting stents (BL-ZES), and BP-EES. The rebound effect was defined as the statistical increase of inflammation and platelet adhesion assessed with immunohistochemistry on the stent-strut level basis from baseline to day-14 or 28. Results: Both experiments showed platelet adhesion value was highest in BP-EES, while the least in FP-EES during DAPT therapy. There was no increase in platelet or inflammatory cell adhesion above baseline values (i.e., no therapy) due to the cessation of clopidogrel on the stent-strut level. Monocyte adhesion was the least for FP-EES with the same trend observed for neutrophil adhesion. Conclusions: No evidence of rebound effect was seen after the transition from DAPT to SAPT. FP-EES demonstrated the most favorable antithrombotic and anti-inflammatory profile regardless of the different experimental designs.
Sprache	Englisch
Erscheinungsdatum	2024-05-20
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.31083
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online ; Dissertation / Habilitation: Vascular Composite Graft

Cornelissen, Anne

Entwicklung einer kleinlumigen Gefäßprothese auf der Basis einer Fibringelmatrix ; Optimierung von Gussverfahren, Bioreaktor und Kulturbedingungen

2012

Verfasserangabe	vorgelegt von Anne Cornelissen, geb. Glitz
Sprache	Deutsch
Umfang	Online-Ressource
Dokumenttyp	Buch ; Online ; Dissertation / Habilitation
Dissertation / Habilitation	Techn. Hochsch., Diss.--Aachen, 2011
Datenquelle	Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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