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Buch ; Konferenzbeitrag: New perspectives on Mary Elizabeth Braddon

Cox, Jessica

(DQR studies in literature ; 50)

2012

Veranstaltung/Kongress	Symposium on Braddon (2006.04.22, Swansea)
Verfasserangabe	ed. by Jessica Cox
Serientitel	DQR studies in literature ; 50
Schlagwörter	Domestic fiction, English/History and criticism ; Sensationalism in literature
Sprache	Englisch
Umfang	282 S.
Verlag	Rodopi
Erscheinungsort	Amsterdam u.a.
Dokumenttyp	Buch ; Konferenzbeitrag
ISBN	9789042035799 ; 9789401208543 ; 904203579X ; 9401208549
Datenquelle	Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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Artikel ; Online: Heterologous Expression of Secondary Metabolite Genes in

Shenouda, Mary L / Ambilika, Maria / Skellam, Elizabeth / Cox, Russell J

Journal of fungi (Basel, Switzerland)

2022 Band 8, Heft 4

Abstract: Trichoderma ... ...

Abstract	Trichoderma reesei
Sprache	Englisch
Erscheinungsdatum	2022-03-30
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof8040355
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Heterologous Expression of Secondary Metabolite Genes in Trichoderma reesei for Waste Valorization

Mary L. Shenouda / Maria Ambilika / Elizabeth Skellam / Russell J. Cox

Journal of Fungi, Vol 8, Iss 4, p

2022 Band 355

Abstract: Trichoderma reesei ( Hypocrea jecorina ) was developed as a microbial cell factory for the heterologous expression of fungal secondary metabolites. This was achieved by inactivation of sorbicillinoid biosynthesis and construction of vectors for the rapid ...

Abstract	Trichoderma reesei ( Hypocrea jecorina ) was developed as a microbial cell factory for the heterologous expression of fungal secondary metabolites. This was achieved by inactivation of sorbicillinoid biosynthesis and construction of vectors for the rapid cloning and expression of heterologous fungal biosynthetic genes. Two types of megasynth(et)ases were used to test the strain and vectors, namely a non-reducing polyketide synthase (nr-PKS, aspks1 ) from Acremonium strictum and a hybrid highly-reducing PKS non-ribosomal peptide synthetase (hr-PKS-NRPS, tenS + tenC ) from Beauveria bassiana . The resulting engineered T. reesei strains were able to produce the expected natural products 3-methylorcinaldehyde and pretenellin A on waste materials including potato, orange, banana and kiwi peels and barley straw. Developing T. reesei as a heterologous host for secondary metabolite production represents a new method for waste valorization by the direct conversion of waste biomass into secondary metabolites.
Schlagwörter	heterologous expression ; PKS-NRPS ; PKS ; waste valorization ; microbial cell factory ; Trichoderma reesei ; Biology (General) ; QH301-705.5
Thema/Rubrik (Code)	500
Sprache	Englisch
Erscheinungsdatum	2022-03-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Alcohol testing and alcohol involvement among violent deaths by state, 2014-2016.

Greene, Naomi / Tomedi, Laura E / Cox, Mary E / Mello, Elizabeth / Esser, Marissa B

Preventive medicine

2021 Band 148, Seite(n) 106527

Abstract: Blood alcohol concentration (BAC) testing rates vary across states, potentially biasing estimates of alcohol involvement in violent deaths. The National Violent Death Reporting System (NVDRS) collects information on violent deaths, including decedents' ... ...

Abstract	Blood alcohol concentration (BAC) testing rates vary across states, potentially biasing estimates of alcohol involvement in violent deaths. The National Violent Death Reporting System (NVDRS) collects information on violent deaths, including decedents' BACs. This study assessed characteristics of violent deaths by BAC testing status, and the proportion of decedents with a positive BAC or BAC ≥ 0.08 g/dL. NVDRS data from 2014 to 2016 (2014: 18 states; 2015: 27 states; 2016: 32 states) were analyzed to assess BAC testing (tested, not tested, unknown/missing) by state, decedent characteristics, and death investigation system (e.g., state medical examiner, coroners), in 2019. The proportion of violent deaths with a BAC > 0.0 or ≥ 0.08 g/dL was also assessed. Among 95,390 violent death decedents, 57.1% had a BAC test (range: 9.5% in Georgia to 95.8% in Utah), 2.3% were not tested, and 40.6% had an unknown/missing BAC testing status (range: 1.3% in Alaska to 78.0% in Georgia). Decedents who were 21-44 years, American Indian/Alaska Native or Hispanic, died by poisoning, died by undetermined intent, or were investigated by a state medical examiner were most likely to receive BAC testing. Among the violent deaths with a reported BAC, 41.1% had a positive BAC and 27.7% had a BAC ≥ 0.08 g/dL. About 2 in 5 violent deaths were missing data on alcohol testing. Increased testing and reporting of alcohol among violent deaths could inform the development and use of evidence-based prevention strategies (e.g., increasing alcohol taxes, regulating alcohol outlet density) for reducing violent deaths.
Mesh-Begriff(e)	Blood Alcohol Content ; Cause of Death ; Georgia ; Homicide ; Humans ; Population Surveillance ; Suicide ; United States/epidemiology ; Utah ; Violence
Chemische Substanzen	Blood Alcohol Content
Sprache	Englisch
Erscheinungsdatum	2021-03-18
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	184600-0
ISSN	1096-0260 ; 0091-7435
ISSN (online)	1096-0260
ISSN	0091-7435
DOI	10.1016/j.ypmed.2021.106527
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Characterization of a Long-Acting Site-Specific PEGylated Murine GM-CSF Analog and Analysis of Its Hematopoietic Properties in Normal and Cyclophosphamide-Treated Neutropenic Rats.

Cox, George N / Lee, Ji I / Rosendahl, Mary S / Chlipala, Elizabeth A / Doherty, Daniel H

The protein journal

2020 Band 39, Heft 2, Seite(n) 160–173

Abstract: Previously we reported that site-specific modification of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) A3C analog with polyethylene glycol (PEG) dramatically improved the pharmacokinetic properties of the protein in rats. However, ... ...

Abstract	Previously we reported that site-specific modification of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) A3C analog with polyethylene glycol (PEG) dramatically improved the pharmacokinetic properties of the protein in rats. However, we could not evaluate the hematological properties of the PEG-A3C protein in rats because human GM-CSF is inactive in rodents. To study the biological effects of PEGylated GM-CSF analogs in rodents we created a homologous site-specific PEGylated murine (mu) GM-CSF (T3C) protein. muGM-CSF and the T3C protein were expressed in Escherichia coli and purified by column chromatography. The purified T3C protein was covalently modified with a linear 20 kDa- or a branched 40 kDa-maleimide-PEG, and the monoPEGylated proteins purified by column chromatography. muGM-CSF, T3C and the two PEG-T3C proteins had comparable in vitro biological activities, as measured by stimulation of proliferation of the murine FDC-P1 cell line. The PEG-T3C proteins had 10- to 25-fold longer circulating half-lives than muGM-CSF and stimulated greater and longer lasting increases in neutrophils and white blood cells than muGM-CSF following a single intravenous or subcutaneous administration to rats. Treatment of rats made neutropenic with cyclophosphamide with the PEG-T3C proteins shortened the time for recovery of neutrophils to normal levels from 9 or 10 days to 5 or 6 days, whereas muGM-CSF showed no benefit versus vehicle solution. Acceleration of neutrophil recovery in cyclophosphamide-treated rats required a minimum of three PEG-T3C treatments over five days. The PEG-T3C proteins should prove useful for evaluating the potential therapeutic benefits of GM-CSF and long-acting GM-CSF proteins in rodent disease models.
Mesh-Begriff(e)	Animals ; Cell Line ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Granulocyte Colony-Stimulating Factor/pharmacokinetics ; Half-Life ; Hematopoiesis/drug effects ; Male ; Neutropenia/drug therapy ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/pharmacokinetics
Chemische Substanzen	Recombinant Proteins ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Polyethylene Glycols (3WJQ0SDW1A) ; pegylated granulocyte colony-stimulating factor (I4QL0KKG3K)
Sprache	Englisch
Erscheinungsdatum	2020-03-04
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2143071-8
ISSN	1875-8355 ; 1572-3887
ISSN (online)	1875-8355
ISSN	1572-3887
DOI	10.1007/s10930-020-09894-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Transcriptional profiles of pulmonary artery endothelial cells in pulmonary hypertension.

Singh, Navneet / Eickhoff, Carsten / Garcia-Agundez, Augusto / Bertone, Paul / Paudel, Sunita S / Tambe, Dhananjay T / Litzky, Leslie A / Cox-Flaherty, Katherine / Klinger, James R / Monaghan, Sean F / Mullin, Christopher J / Pereira, Mandy / Walsh, Thomas / Whittenhall, Mary / Stevens, Troy / Harrington, Elizabeth O / Ventetuolo, Corey E

Scientific reports

2023 Band 13, Heft 1, Seite(n) 22534

Abstract: Pulmonary arterial hypertension (PAH) is characterized by endothelial cell (EC) dysfunction. There are no data from living patients to inform whether differential gene expression of pulmonary artery ECs (PAECs) can discern disease subtypes, progression ... ...

Abstract	Pulmonary arterial hypertension (PAH) is characterized by endothelial cell (EC) dysfunction. There are no data from living patients to inform whether differential gene expression of pulmonary artery ECs (PAECs) can discern disease subtypes, progression and pathogenesis. We aimed to further validate our previously described method to propagate ECs from right heart catheter (RHC) balloon tips and to perform additional PAEC phenotyping. We performed bulk RNA sequencing of PAECs from RHC balloons. Using unsupervised dimensionality reduction and clustering we compared transcriptional signatures from PAH to controls and other forms of pulmonary hypertension. Select PAEC samples underwent single cell and population growth characterization and anoikis quantification. Fifty-four specimens were analyzed from 49 subjects. The transcriptome appeared stable over limited passages. Six genes involved in sex steroid signaling, metabolism, and oncogenesis were significantly upregulated in PAH subjects as compared to controls. Genes regulating BMP and Wnt signaling, oxidative stress and cellular metabolism were differentially expressed in PAH subjects. Changes in gene expression tracked with clinical events in PAH subjects with serial samples over time. Functional assays demonstrated enhanced replication competency and anoikis resistance. Our findings recapitulate fundamental biological processes of PAH and provide new evidence of a cancer-like phenotype in ECs from the central vasculature of PAH patients. This "cell biopsy" method may provide insight into patient and lung EC heterogeneity to advance precision medicine approaches in PAH.
Mesh-Begriff(e)	Humans ; Hypertension, Pulmonary/pathology ; Pulmonary Artery/pathology ; Endothelial Cells/metabolism ; Pulmonary Arterial Hypertension/pathology ; Familial Primary Pulmonary Hypertension/metabolism ; Vascular Diseases/pathology ; Wnt Signaling Pathway/genetics
Sprache	Englisch
Erscheinungsdatum	2023-12-18
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-48077-6
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Risk vs benefit in diabetes pharmacotherapy: a rational approach to choosing pharmacotherapy in type 2 diabetes.

Cox, Mary Elizabeth / Feinglos, Mark N

Current diabetes reports

2013 Band 13, Heft 3, Seite(n) 319–328

Abstract: Type 2 diabetes now affects more than 1 in 10 US adults and is a leading cause of morbidity, mortality, and healthcare expense. There are increasing numbers of available pharmacotherapies, with established agents as well as newer drugs developed from ... ...

Abstract	Type 2 diabetes now affects more than 1 in 10 US adults and is a leading cause of morbidity, mortality, and healthcare expense. There are increasing numbers of available pharmacotherapies, with established agents as well as newer drugs developed from hormones in the incretin pathway, among others. New data are accumulating continuously with respect to potential benefits of both long-standing and new agents, as well as risks identified through post-marketing surveillance. Here we review the commonly prescribed pharmacotherapy options with attention to recently published information and provide a rational approach to choice of therapy.
Mesh-Begriff(e)	Animals ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Glucagon-Like Peptide-1 Receptor ; Humans ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/therapeutic use ; Life Style ; Receptors, Glucagon/agonists ; Receptors, Glucagon/metabolism ; Risk Factors
Chemische Substanzen	Dipeptidyl-Peptidase IV Inhibitors ; GLP1R protein, human ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Receptors, Glucagon
Sprache	Englisch
Erscheinungsdatum	2013-03-19
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	2065167-3
ISSN	1539-0829 ; 1534-4827
ISSN (online)	1539-0829
ISSN	1534-4827
DOI	10.1007/s11892-013-0374-z
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Pharmacologic Treatment of Perinatal Depression.

Kimmel, Mary C / Cox, Elizabeth / Schiller, Crystal / Gettes, Edith / Meltzer-Brody, Samantha

Obstetrics and gynecology clinics of North America

2018 Band 45, Heft 3, Seite(n) 419–440

Abstract: This review provides information about medications used to treat perinatal depression, including guidance around when to use certain medications and when to consult a mental health provider. For each group of medications, including selective serotonin ... ...

Abstract	This review provides information about medications used to treat perinatal depression, including guidance around when to use certain medications and when to consult a mental health provider. For each group of medications, including selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, mirtazapine, bupropion, lithium, atypical antipsychotics, and lamotrigine, the risks and benefits of treatment during pregnancy and lactation are reviewed, and unique qualities of each medication. A treatment algorithm is included and a description of the Food and Drug Administration's approach to providing information about medications. The article also discusses hormone therapies and future directions for new pharmacologic treatments.
Mesh-Begriff(e)	Antidepressive Agents/adverse effects ; Antidepressive Agents/therapeutic use ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Clinical Decision-Making ; Contraindications ; Depression/drug therapy ; Female ; Humans ; Practice Patterns, Physicians'/statistics & numerical data ; Pregnancy ; Pregnancy Complications/drug therapy ; Pregnancy Complications/psychology ; Pregnant Women/psychology ; Prenatal Exposure Delayed Effects/prevention & control ; Psychotherapy ; Risk Assessment
Chemische Substanzen	Antidepressive Agents ; Antipsychotic Agents
Sprache	Englisch
Erscheinungsdatum	2018-08-09
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	1004315-9
ISSN	1558-0474 ; 0889-8545
ISSN (online)	1558-0474
ISSN	0889-8545
DOI	10.1016/j.ogc.2018.04.007
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A protocol for the Heart Matters stepped wedge cluster randomised trial: The effectiveness of heart attack education in regions at highest-risk.

Resuscitation plus

2023 Band 15, Seite(n) 100431

Abstract: Aim: To describe the Heart Matters (HM) trial which aims to evaluate the effectiveness of a community heart attack education intervention in high-risk areas in Victoria, Australia. These local government areas (LGAs) have high rates of acute coronary ... ...

Abstract	Aim: To describe the Heart Matters (HM) trial which aims to evaluate the effectiveness of a community heart attack education intervention in high-risk areas in Victoria, Australia. These local government areas (LGAs) have high rates of acute coronary syndrome (ACS), out-of-hospital cardiac arrest (OHCA), cardiovascular risk factors, and low rates of emergency medical service (EMS) use for ACS. Methods: The trial follows a stepped-wedge cluster randomised design, with eight clusters (high-risk LGAs) randomly assigned to transition from control to intervention every four months. Two pairs of LGAs will transition simultaneously due to their proximity. The intervention consists of a heart attack education program delivered by trained HM Coordinators, with additional support from opportunistic media and a geo-targeted social media campaign. The primary outcome measure is the proportion of residents from the eight LGAs who present to emergency departments by EMS during an ACS event. Secondary outcomes include prehospital delay time, rates of OHCA and heart attack awareness. The primary and secondary outcomes will be analysed at the patient/participant level using mixed-effects logistic regression models. A detailed program evaluation is also being conducted. The trial was registered on August 9, 2021 (NCT04995900). Results: The intervention was implemented between February 2022 and March 2023, and outcome data will be collected from administrative databases, registries, and surveys. Primary trial data is expected to be locked for analysis by October 31st 2023, with a follow-up planned until March 31st 2024. Conclusion: The results from this trial will provide high-level evidence the effectiveness of a community education intervention targeting regions at highest-risk of ACS and low EMS use.
Sprache	Englisch
Erscheinungsdatum	2023-07-25
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ISSN	2666-5204
ISSN (online)	2666-5204
DOI	10.1016/j.resplu.2023.100431
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Progress in Research Data Services

Andrew M Cox, Dr / Mary Anne Kennan, Dr / Elizabeth Josephine Lyon, Dr / Stephen Pinfield, Dr / Laura Sbaffi, Dr

International Journal of Digital Curation, Vol 14, Iss

2019 Band 1

Abstract: University libraries have played an important role in constructing an infrastructure of support for Research Data Management at an institutional level. This paper presents a comparative analysis of two international surveys of libraries about their ... ...

Abstract	University libraries have played an important role in constructing an infrastructure of support for Research Data Management at an institutional level. This paper presents a comparative analysis of two international surveys of libraries about their involvement in Research Data Services conducted in 2014 and 2018. The aim was to explore how services had developed over this time period, and to explore the drivers and barriers to change. In particular, there was an interest in how far the FAIR data principles had been adopted. Services in nearly every area were more developed in 2018 than before, but technical services remained less developed than advisory. Progress on institutional policy was also evident. However, priorities did not seem to have shifted significantly. Open ended answers suggested that funder policy, rather than researcher demand, remained the main driver of service development and that resources and skills gaps remained issues. While widely understood as an important reference point and standard, because of their relatively recent publication date, FAIR principles had not been widely adopted explicitly in policy.
Schlagwörter	Bibliography. Library science. Information resources ; Z
Thema/Rubrik (Code)	027
Sprache	Englisch
Erscheinungsdatum	2019-09-01T00:00:00Z
Verlag	University of Edinburgh
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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