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  1. Artikel ; Online: A New Approach for the Synthesis of N -Arylamides Starting from Benzonitriles

    Pradip Debnath

    Chemistry Proceedings, Vol 8, Iss 27, p

    2021  Band 27

    Abstract: N -Arylamides are a ubiquitous component of a broad range of natural products and biologically active compounds. In this paper, a new synthetic protocol for the preparation of N -arylamides was developed via the hypervalent iodine-mediated aza -Hofmann- ... ...

    Abstract N -Arylamides are a ubiquitous component of a broad range of natural products and biologically active compounds. In this paper, a new synthetic protocol for the preparation of N -arylamides was developed via the hypervalent iodine-mediated aza -Hofmann-type rearrangement of amidines. The reaction proceeded smoothly at 100 °C in the presence of PhINTs in toluene solvent. The requisite amidine substrates were prepared from amines and nitriles by applying the Pinner reaction approach. Considering the easy access of amidines from nitriles, the overall process is the conversion of nitriles to acetanilide and N -arylamides. As an application of the protocol, the preparation of paracetamol from 4-cyanophenol is also described.
    Schlagwörter N -arylamides ; nitriles ; amidines ; paracetamol ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: A Review on Mathematical Modeling of Different Biological Methods of Hydrogen Production

    Priyakrishna Yumnam / Pradip Debnath

    Hydrogen, Vol 4, Iss 4, Pp 881-

    2023  Band 916

    Abstract: In this paper, we present an updated review on the mathematical modeling of different biological methods of hydrogen production. The presented mathematical modeling and methods range from inception to the current state-of-the-art developments in hydrogen ...

    Abstract In this paper, we present an updated review on the mathematical modeling of different biological methods of hydrogen production. The presented mathematical modeling and methods range from inception to the current state-of-the-art developments in hydrogen production using biological methods. A comparative study was performed along with indications for future research and shortcomings of earlier research. This review will be helpful for all researchers working on different methods of hydrogen production. However, we only covered biological methods such as biophotolysis, fermentation and microbial electrolysis cells, and this list is not exhaustive of all other methods of hydrogen production.
    Schlagwörter biological ; biophotolysis ; fermentation ; microbial electrolysis ; mathematical modeling ; hydrogen production ; Science (General) ; Q1-390
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: TBHP-mediated oxidative synthesis of substituted pyrimido[4,5-

    Debnath, Pradip

    RSC advances

    2019  Band 9, Heft 51, Seite(n) 29831–29839

    Abstract: An efficient and operationally simple protocol has been demonstrated for the synthesis of 1,3,5,7-tetrasubstituted pyrimido[4,5- ...

    Abstract An efficient and operationally simple protocol has been demonstrated for the synthesis of 1,3,5,7-tetrasubstituted pyrimido[4,5-
    Sprache Englisch
    Erscheinungsdatum 2019-09-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c9ra06625j
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Therapeutic role of traditionally used Indian medicinal plants and spices in combating COVID-19 pandemic situation.

    Nath, Moumita / Debnath, Pradip

    Journal of biomolecular structure & dynamics

    2022  Band 41, Heft 12, Seite(n) 5894–5913

    Abstract: The coronavirus disease (COVID-19) caused by SARS-CoV-2 is a big challenge and burning issue to the scientific community and doctors worldwide. Globally, COVID-19 has created a health disaster and adversely affects the economic growth. Although some ... ...

    Abstract The coronavirus disease (COVID-19) caused by SARS-CoV-2 is a big challenge and burning issue to the scientific community and doctors worldwide. Globally, COVID-19 has created a health disaster and adversely affects the economic growth. Although some vaccines have already emerged, no therapeutic medication has yet been approved by FDA for the treatment of COVID-19 patients. Traditionally, we have been using different medicinal plants like neem, tulsi, tea, and many spices like garlic, ginger, turmeric, black seed, onion, etc. for the treatment of flu-like diseases. In this paper, we are highlighting the recent research progress in the identification of natural products from the Indian medicinal plants and spices that have potential inhibition properties against SARS-CoV-2. This study will provide an initiative to stimulate further research by providing useful guidance to the medicinal chemists for designing new protease inhibitors effective against SARS-CoV-2 in future.Communicated by Ramaswamy H. Sarma.
    Mesh-Begriff(e) Humans ; Spices ; Pandemics ; Plants, Medicinal ; COVID-19/epidemiology ; SARS-CoV-2 ; Biological Products ; Protease Inhibitors ; Molecular Docking Simulation
    Chemische Substanzen holy basil leaf extract (SCJ765569P) ; Biological Products ; Protease Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2022-06-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2022.2093793
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Carvacrol

    Sudhan Debnath / Bimal Debnath / Pradip Debnath

    Chemistry Proceedings, Vol 12, Iss 11, p

    A PL pro Inhibitor of SARS-CoV-2 Is a Natural Weapon for COVID-19

    2022  Band 11

    Abstract: The outbreak of SARS-CoV-2 created the biggest crisis to human health and has adversely affected economic growth worldwide. Several vaccines emerged from manufacturers to combat COVID-19. Unfortunately, no therapeutic medication has yet been approved by ... ...

    Abstract The outbreak of SARS-CoV-2 created the biggest crisis to human health and has adversely affected economic growth worldwide. Several vaccines emerged from manufacturers to combat COVID-19. Unfortunately, no therapeutic medication has yet been approved by the FDA for the treatment of this disease. Many researchers have performed in silico studies for the identification of potential SARS-CoV-2 inhibitors from the molecules present in Indian medicinal plants and spices. In this paper, we have performed a structure-based virtual screening (VS) of 120 compounds derived from Nigella sativa (NS) against M pro , PL pro , and spike proteins of SARS-CoV-2. Strong binding interactions of M pro occurred with hits NS-40 and NS-84, whereas hits NS-72D and NS-95D showed strong binding interactions with spike proteins. Interestingly, four promising hits (i.e., NS-21, NS-40, carvacrol (NS_08), and menthol) exhibited good binding interactions with both M pro and spike proteins. Carvacrol, a monoterpenoid phenol possessing several biological activities, showed a favourable binding affinity towards the papain-like protease of SARS-CoV-2. This small molecule may be used as a natural weapon to combat COVID-19.
    Schlagwörter carvacrol ; black seed ; SARS-CoV-2 ; COVID-19 ; natural product ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: TBHP-mediated oxidative synthesis of substituted pyrimido[4,5-d]pyrimidines from N-uracil amidines and methylarenes under metal free conditions

    Debnath, Pradip

    RSC advances. 2019 Sept. 20, v. 9, no. 51

    2019  

    Abstract: An efficient and operationally simple protocol has been demonstrated for the synthesis of 1,3,5,7-tetrasubstituted pyrimido[4,5-d]pyrimidines via TBHP-mediated direct oxidative coupling of N-uracil amidines and methylarenes under metal-free conditions. ... ...

    Abstract An efficient and operationally simple protocol has been demonstrated for the synthesis of 1,3,5,7-tetrasubstituted pyrimido[4,5-d]pyrimidines via TBHP-mediated direct oxidative coupling of N-uracil amidines and methylarenes under metal-free conditions. Due to the inherent stability of methylarenes compared to aldehydes, the presented synthetic protocol is adaptable to a broad substrate scope, is operationally simple, has no need for stringent protection in the whole preparation process, and has the potential to prepare valuable products that are currently inaccessible or challenging to prepare using conventional methods. It is a significantly important complement to the conventional synthetic methods. The reaction possesses an efficient tandem oxidation–imination–cyclization process.
    Schlagwörter aldehydes ; amidines ; pyrimidines
    Sprache Englisch
    Erscheinungsverlauf 2019-0920
    Umfang p. 29831-29839.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    ISSN 2046-2069
    DOI 10.1039/c9ra06625j
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: Potentiality of

    Sen, Debanjan / Bhaumik, Samhita / Debnath, Pradip / Debnath, Sudhan

    Journal of biomolecular structure & dynamics

    2021  Band 40, Heft 16, Seite(n) 7517–7534

    Abstract: Coronavirus disease 2019 (COVID-19) has created a global human health crisis and economic setbacks. Lack of specific therapeutics and limited treatment options against COVID-19 has become a new challenge to identify potential hits in order to develop new ...

    Abstract Coronavirus disease 2019 (COVID-19) has created a global human health crisis and economic setbacks. Lack of specific therapeutics and limited treatment options against COVID-19 has become a new challenge to identify potential hits in order to develop new therapeutics. One of the crucial life cycle enzymes of SARS-CoV-2 is main protease (M
    Mesh-Begriff(e) COVID-19/drug therapy ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/chemistry ; Drug Design ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Moringa oleifera/metabolism ; Protease Inhibitors/chemistry ; SARS-CoV-2 ; Viral Nonstructural Proteins/chemistry
    Chemische Substanzen Protease Inhibitors ; Viral Nonstructural Proteins ; Cysteine Endopeptidases (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Sprache Englisch
    Erscheinungsdatum 2021-03-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2021.1898475
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2093: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Artikel: In Silico Identification of Potential Inhibitors of ADP-Ribose Phosphatase of SARS-CoV-2 nsP3 by Combining E-Pharmacophore- and Receptor-Based Virtual Screening of Database.

    Debnath, Pradip / Debnath, Bimal / Bhaumik, Samhita / Debnath, Sudhan

    ChemistrySelect

    2020  Band 5, Heft 30, Seite(n) 9388–9398

    Abstract: The recently emerged 2019 Novel Coronavirus (SARS-CoV-2) and associated COVID-19 disease cause serious or even fatal respiratory tract infection. Observing the spread, illness and death caused by COVID-19, the World Health Organization (WHO) declared ... ...

    Abstract The recently emerged 2019 Novel Coronavirus (SARS-CoV-2) and associated COVID-19 disease cause serious or even fatal respiratory tract infection. Observing the spread, illness and death caused by COVID-19, the World Health Organization (WHO) declared COVID-19 a pandemic. To date, there is no approved therapeutics or effective treatment available to combat the outbreak. This urgent situation is pressing the world to respond with development of novel vaccine or a small molecule therapeutics for SARS-CoV-2. In line with these efforts, the structure of several proteins of SARS-CoV-2 has been rapidly resolved and made publicly available to facilitate global efforts to develop novel drug candidates. In this paper, we aim to find out the small molecule inhibitors for ADP-ribose phosphatase of SARS-CoV-2. In order to identify potential inhibitors, we applied sequential E-pharmacophore and structure-based virtual screening (VS) of MolPort database containing 113687 number of commercially available natural compounds using Glide module. Six potential inhibitors having admirable XP glide score range from -11.009 to -14.684 kcal/mol and good binding affinity towards active sites were identified. All the molecules are commercially available for further characterization and development by scientific community. The
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ISSN 2365-6549
    ISSN 2365-6549
    DOI 10.1002/slct.202001419
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  9. Artikel ; Online: Identification of potential edible mushroom as SARS-CoV-2 main protease inhibitor using rational drug designing approach.

    Sen, Debanjan / Debnath, Bimal / Debnath, Pradip / Debnath, Sudhan / Zaki, Magdi E A / Masand, Vijay H

    Scientific reports

    2022  Band 12, Heft 1, Seite(n) 1503

    Abstract: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is highly pathogenic to humans and has created health care threats worldwide. This urgent situation has focused the researchers worldwide towards the development of novel vaccine or small ... ...

    Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is highly pathogenic to humans and has created health care threats worldwide. This urgent situation has focused the researchers worldwide towards the development of novel vaccine or small molecule therapeutics for SARS-CoV-2. Although several vaccines have already been discovered and are in use for the masses, no therapeutic medication has yet been approved by FDA for the treatment of COVID-19. Keeping this in view, in the present study, we have identified promising hits against the main protease (M
    Mesh-Begriff(e) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Basidiomycota/chemistry ; Benzofurans/pharmacology ; Benzofurans/therapeutic use ; COVID-19/drug therapy ; Coronavirus 3C Proteases/antagonists & inhibitors ; Molecular Dynamics Simulation ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; Terphenyl Compounds/pharmacology ; Terphenyl Compounds/therapeutic use
    Chemische Substanzen Antiviral Agents ; Benzofurans ; Protease Inhibitors ; Terphenyl Compounds ; kynapcin 12 ; kynapcin-24 ; kynapcin-28 ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Sprache Englisch
    Erscheinungsdatum 2022-01-27
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-05349-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Exploring antioxidative, cytotoxic and neuropharmacological insights into

    Sarkar, Kishore Kumar / Mitra, Trina / Aktaruzzaman, Md / Abid, Md Ahsan / Rahman, Md Asibur / Debnath, Pradip / Sadhu, Samir Kumar

    Heliyon

    2024  Band 10, Heft 5, Seite(n) e27001

    Abstract: Background study: The aim of this research was to examine possible antioxidant, cytotoxic and neurological activity of methanol and n-hexane extracts of : Methods: In-vitro: Results: MBOL displayed substantial antioxidative activities in various ... ...

    Abstract Background study: The aim of this research was to examine possible antioxidant, cytotoxic and neurological activity of methanol and n-hexane extracts of
    Methods: In-vitro
    Results: MBOL displayed substantial antioxidative activities in various established assays compared to NBOL. In brine shrimp lethality bioassay, both MBOL and NBOL revealed cytotoxic activity in a concentration-dependent approach. Again, in Elevated Plus Maze test, 200 and 400 mg/kg of NBOL and MBOL demonstrated significant anxiolytic activities evident from time spent in open arms. In addition, maximum number of head dipping was demonstrated by MBOL at 400 mg/kg (53.90 ± 1.16) in Hole Board test. NBOL and MBOL at both doses significantly diminished the magnitude of movements from the 2nd to 5th observation periods in Open Field test. Furthermore, in Hole Cross test, MBOL remarkably dwindled the locomotor activity at 120 min and 180 min (3.60 ± 0.40 and 2.40 ± 0.51) at 400 mg/kg. Finally,
    Conclusion: Therefore, the present study's findings advocate the traditional usage of this plant and recommend both MBOL and NBOL as as a potential source of therapeutic candidate for the management of neurological disorders.
    Sprache Englisch
    Erscheinungsdatum 2024-02-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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