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  1. Artikel ; Online: Pseudohyperglycemia due to glucometer interference in galactosemia.

    Decru, Bram / Blanckaert, Hilde / Naulaers, Gunnar / Vanhole, Christine / Rymen, Daisy / Witters, Peter / Van Wambeke, Inge / Gillard, Pieter / Vermeersch, Pieter

    Clinical chemistry and laboratory medicine

    2023  Band 62, Heft 5, Seite(n) e107–e109

    Mesh-Begriff(e) Humans ; Galactosemias/diagnosis ; Blood Glucose Self-Monitoring ; Glucose ; Blood Glucose
    Chemische Substanzen Glucose (IY9XDZ35W2) ; Blood Glucose
    Sprache Englisch
    Erscheinungsdatum 2023-11-30
    Erscheinungsland Germany
    Dokumenttyp Letter
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2023-1304
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Corrigendum: IgG anti-spike antibodies and surrogate neutralizing antibody levels decline faster 3 to 10 months after BNT162b2 vaccination than after SARS-CoV-2 infection in healthcare workers.

    Decru, Bram / Van Elslande, Jan / Steels, Sophie / Van Pottelbergh, Gijs / Godderis, Lode / Van Holm, Bram / Bossuyt, Xavier / Van Weyenbergh, Johan / Maes, Piet / Vermeersch, Pieter

    Frontiers in immunology

    2022  Band 13, Seite(n) 1098285

    Abstract: This corrects the article DOI: 10.3389/fimmu.2022.909910.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2022.909910.].
    Sprache Englisch
    Erscheinungsdatum 2022-11-25
    Erscheinungsland Switzerland
    Dokumenttyp Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1098285
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  3. Artikel ; Online: IgG Anti-Spike Antibodies and Surrogate Neutralizing Antibody Levels Decline Faster 3 to 10 Months After BNT162b2 Vaccination Than After SARS-CoV-2 Infection in Healthcare Workers.

    Decru, Bram / Van Elslande, Jan / Steels, Sophie / Van Pottelbergh, Gijs / Godderis, Lode / Van Holm, Bram / Bossuyt, Xavier / Van Weyenbergh, Johan / Maes, Piet / Vermeersch, Pieter

    Frontiers in immunology

    2022  Band 13, Seite(n) 909910

    Abstract: Background: IgG anti-spike (S) antibodies arise after SARS-CoV-2 infection as well as vaccination. Levels of IgG anti-S are linked to neutralizing antibody titers and protection against (re)infection.: Methods: We measured IgG anti-S and surrogate ... ...

    Abstract Background: IgG anti-spike (S) antibodies arise after SARS-CoV-2 infection as well as vaccination. Levels of IgG anti-S are linked to neutralizing antibody titers and protection against (re)infection.
    Methods: We measured IgG anti-S and surrogate neutralizing antibody kinetics against Wild Type (WT) and 4 Variants of Concern (VOC) in health care workers (HCW) 3 and 10 months after natural infection ("infection", n=83) or vaccination (2 doses of BNT162b2) with ("hybrid immunity", n=17) or without prior SARS-CoV-2 infection ("vaccination", n=97).
    Results: The humoral immune response in the "vaccination" cohort was higher at 3 months, but lower at 10 months, compared to the "infection" cohort due to a faster decline. The "hybrid immunity" cohort had the highest antibody levels at 3 and 10 months with a slower decline compared to the "vaccination" cohort. Surrogate neutralizing antibody levels (expressed as %inhibition of ACE-2 binding) showed a linear relation with log10 of IgG anti-S against WT and four VOC. IgG anti-S corresponding to 90% inhibition ranged from 489 BAU/mL for WT to 1756 BAU/mL for Beta variant. Broad pseudoneutralization predicted live virus neutralization of Omicron BA.1 in 20 randomly selected high titer samples.
    Conclusions: Hybrid immunity resulted in the strongest humoral immune response. Antibodies induced by natural infection decreased more slowly than after vaccination, resulting in higher antibody levels at 10 months compared to vaccinated HCW without prior infection. There was a linear relationship between surrogate neutralizing activity and log10 IgG anti-S for WT and 4 VOC, although some VOC showed reduced sensitivity to pseudoneutralization.
    Mesh-Begriff(e) Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; Health Personnel ; Humans ; Immunoglobulin G ; SARS-CoV-2
    Chemische Substanzen Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; BNT162 Vaccine (N38TVC63NU)
    Sprache Englisch
    Erscheinungsdatum 2022-06-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.909910
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  4. Artikel ; Online: Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction.

    Adant, Isabelle / Bird, Matthew / Decru, Bram / Windmolders, Petra / Wallays, Marie / de Witte, Peter / Rymen, Daisy / Witters, Peter / Vermeersch, Pieter / Cassiman, David / Ghesquière, Bart

    Molecular metabolism

    2022  Band 63, Seite(n) 101537

    Abstract: Introduction: Primary mitochondrial diseases (PMD) are a large, heterogeneous group of genetic disorders affecting mitochondrial function, mostly by disrupting the oxidative phosphorylation (OXPHOS) system. Understanding the cellular metabolic re-wiring ...

    Abstract Introduction: Primary mitochondrial diseases (PMD) are a large, heterogeneous group of genetic disorders affecting mitochondrial function, mostly by disrupting the oxidative phosphorylation (OXPHOS) system. Understanding the cellular metabolic re-wiring occurring in PMD is crucial for the development of novel diagnostic tools and treatments, as PMD are often complex to diagnose and most of them currently have no effective therapy.
    Objectives: To characterize the cellular metabolic consequences of OXPHOS dysfunction and based on the metabolic signature, to design new diagnostic and therapeutic strategies.
    Methods: In vitro assays were performed in skin-derived fibroblasts obtained from patients with diverse PMD and validated in pharmacological models of OXPHOS dysfunction. Proliferation was assessed using the Incucyte technology. Steady-state glucose and glutamine tracing studies were performed with LC-MS quantification of cellular metabolites. The therapeutic potential of nutritional supplements was evaluated by assessing their effect on proliferation and on the metabolomics profile. Successful therapies were then tested in a in vivo lethal rotenone model in zebrafish.
    Results: OXPHOS dysfunction has a unique metabolic signature linked to an NAD+/NADH imbalance including depletion of TCA intermediates and aspartate, and increased levels of glycerol-3-phosphate. Supplementation with pyruvate and uridine fully rescues this altered metabolic profile and the subsequent proliferation deficit. Additionally, in zebrafish, the same nutritional treatment increases the survival after rotenone exposure.
    Conclusions: Our findings reinforce the importance of the NAD+/NADH imbalance following OXPHOS dysfunction in PMD and open the door to new diagnostic and therapeutic tools for PMD.
    Mesh-Begriff(e) Animals ; Metabolome ; Mitochondrial Diseases/metabolism ; NAD/metabolism ; Oxidative Phosphorylation ; Pyruvic Acid/metabolism ; Rotenone ; Uridine/metabolism ; Uridine/pharmacology ; Zebrafish/metabolism
    Chemische Substanzen Rotenone (03L9OT429T) ; NAD (0U46U6E8UK) ; Pyruvic Acid (8558G7RUTR) ; Uridine (WHI7HQ7H85)
    Sprache Englisch
    Erscheinungsdatum 2022-06-27
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2708735-9
    ISSN 2212-8778 ; 2212-8778
    ISSN (online) 2212-8778
    ISSN 2212-8778
    DOI 10.1016/j.molmet.2022.101537
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Comparison of the diagnostic performance with whole blood and plasma of four rapid antibody tests for SARS-CoV-2.

    Decru, Bram / Van Elslande, Jan / Weemaes, Matthias / Houben, Els / Empsen, Ine / André, Emmanuel / Van Ranst, Marc / Lagrou, Katrien / Vermeersch, Pieter

    Clinical chemistry and laboratory medicine

    2020  Band 58, Heft 10, Seite(n) e197–e199

    Mesh-Begriff(e) Adult ; Antibodies, Viral/blood ; Betacoronavirus/immunology ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/trends ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Female ; Humans ; Male ; Pandemics ; Plasma/chemistry ; Pneumonia, Viral/blood ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Sensitivity and Specificity
    Chemische Substanzen Antibodies, Viral
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-06
    Erscheinungsland Germany
    Dokumenttyp Letter
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2020-0817
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  6. Artikel ; Online: No SARS-CoV-2 carriage observed in children attending daycare centers during the intial weeks of the epidemic in Belgium.

    Desmet, Stefanie / Ekinci, Esra / Wouters, Ine / Decru, Bram / Beuselinck, Kurt / Malhotra-Kumar, Surbhi / Theeten, Heidi

    Journal of medical virology

    2020  Band 93, Heft 3, Seite(n) 1828–1831

    Abstract: To gain knowledge about the role of young children attending daycare in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic, a random sample of children (n = 84) aged between 6 and 30 months attending daycare in Belgium was studied ... ...

    Abstract To gain knowledge about the role of young children attending daycare in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic, a random sample of children (n = 84) aged between 6 and 30 months attending daycare in Belgium was studied shortly after the start of the epidemic (February 29th) and before the lockdown (March 18th) by performing in-house SARS-CoV-2 real-time polymerase chain reaction. No asymptomatic carriage of SARS-CoV-2 was detected, whereas common cold symptoms were common (51.2%). Our study shows that in Belgium, there was no sign of early introduction into daycare centers at the moment children being not yet isolated at home, although the virus was clearly circulating. It is clear that more evidence is needed to understand the actual role of young children in the transmission of SARS-CoV-2 and their infection risk when attending daycare.
    Mesh-Begriff(e) Belgium/epidemiology ; COVID-19/epidemiology ; Carrier State/diagnosis ; Carrier State/virology ; Child Day Care Centers/statistics & numerical data ; Child, Preschool ; Humans ; Infant ; Real-Time Polymerase Chain Reaction/methods ; SARS-CoV-2/genetics
    Sprache Englisch
    Erscheinungsdatum 2020-12-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26689
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction

    Isabelle Adant / Matthew Bird / Bram Decru / Petra Windmolders / Marie Wallays / Peter de Witte / Daisy Rymen / Peter Witters / Pieter Vermeersch / David Cassiman / Bart Ghesquière

    Molecular Metabolism, Vol 63, Iss , Pp 101537- (2022)

    2022  

    Abstract: Introduction: Primary mitochondrial diseases (PMD) are a large, heterogeneous group of genetic disorders affecting mitochondrial function, mostly by disrupting the oxidative phosphorylation (OXPHOS) system. Understanding the cellular metabolic re-wiring ... ...

    Abstract Introduction: Primary mitochondrial diseases (PMD) are a large, heterogeneous group of genetic disorders affecting mitochondrial function, mostly by disrupting the oxidative phosphorylation (OXPHOS) system. Understanding the cellular metabolic re-wiring occurring in PMD is crucial for the development of novel diagnostic tools and treatments, as PMD are often complex to diagnose and most of them currently have no effective therapy. Objectives: To characterize the cellular metabolic consequences of OXPHOS dysfunction and based on the metabolic signature, to design new diagnostic and therapeutic strategies. Methods: In vitro assays were performed in skin-derived fibroblasts obtained from patients with diverse PMD and validated in pharmacological models of OXPHOS dysfunction. Proliferation was assessed using the Incucyte technology. Steady-state glucose and glutamine tracing studies were performed with LC-MS quantification of cellular metabolites. The therapeutic potential of nutritional supplements was evaluated by assessing their effect on proliferation and on the metabolomics profile. Successful therapies were then tested in a in vivo lethal rotenone model in zebrafish. Results: OXPHOS dysfunction has a unique metabolic signature linked to an NAD+/NADH imbalance including depletion of TCA intermediates and aspartate, and increased levels of glycerol-3-phosphate. Supplementation with pyruvate and uridine fully rescues this altered metabolic profile and the subsequent proliferation deficit. Additionally, in zebrafish, the same nutritional treatment increases the survival after rotenone exposure. Conclusions: Our findings reinforce the importance of the NAD+/NADH imbalance following OXPHOS dysfunction in PMD and open the door to new diagnostic and therapeutic tools for PMD.
    Schlagwörter Primary mitochondrial disease ; OXPHOS ; Aspartic acid ; Treatment ; Pyruvate and uridine ; Internal medicine ; RC31-1245
    Thema/Rubrik (Code) 570 ; 610
    Sprache Englisch
    Erscheinungsdatum 2022-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel: Comparison of the diagnostic performance with whole blood and plasma of four rapid antibody tests for SARS-CoV-2

    Decru, Bram / Van Elslande, Jan / Weemaes, Matthias / Houben, Els / Empsen, Ine / André, Emmanuel / Van Ranst, Marc / Lagrou, Katrien / Vermeersch, Pieter

    Clin Chem Lab Med

    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #632974
    Datenquelle COVID19

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  9. Artikel ; Online: Comparison of the diagnostic performance with whole blood and plasma of four rapid antibody tests for SARS-CoV-2

    Decru, Bram / Van Elslande, Jan / Weemaes, Matthias / Houben, Els / Empsen, Ine / André, Emmanuel / Van Ranst, Marc / Lagrou, Katrien / Vermeersch, Pieter

    Clinical Chemistry and Laboratory Medicine (CCLM)

    2020  Band 58, Heft 10, Seite(n) e197–e199

    Schlagwörter Clinical Biochemistry ; Biochemistry, medical ; General Medicine ; covid19
    Verlag Walter de Gruyter GmbH
    Erscheinungsland de
    Dokumenttyp Artikel ; Online
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2020-0817
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: No SARS-CoV-2 carriage observed in children attending daycare centers during the first weeks of the epidemic in Belgium.

    Desmet, Stefanie / Ekinci, Esra / Wouters, Ine / Decru, Bram / Beuselinck, Kurt / Malhotra-Kumar, Surbhi / Theeten, Heidi

    medRxiv

    Abstract: To gain knowledge about the role of young children attending daycare in transmission risk of SARS-CoV-2, a random sample of children (n=84) aged between 6 and 30 months attending daycare in Belgium was studied shortly after the start of the epidemic ( ... ...

    Abstract To gain knowledge about the role of young children attending daycare in transmission risk of SARS-CoV-2, a random sample of children (n=84) aged between 6 and 30 months attending daycare in Belgium was studied shortly after the start of the epidemic (February 29th) and before the lockdown (March 18th). No asymptomatic carriage of SARS-CoV-2 was detected, whereas common cold symptoms were common (51.2%).
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-18
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2020.05.13.20095190
    Datenquelle COVID19

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