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  1. Artikel ; Online: Remdesivir: A giant step, or a tiptoe?

    Dickinson, Gordon M

    Clinics in dermatology

    2020  Band 38, Heft 6, Seite(n) 773–774

    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2020.05.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A research note on the benefit of patient and public involvement in research: The experience of prostate cancer patients regarding information in radiotherapy.

    Gordon, L / Dickinson, A / Offredy, M / Smiddy, J

    Radiography (London, England : 1995)

    2017  Band 23, Heft 2, Seite(n) 167–170

    Abstract: Aim: To explore the inclusion of patient and public involvement (PPI) in a qualitative study on the experiences of men with prostate cancer regarding information in radiotherapy.: Method: The application of PPI to one doctoral research study is ... ...

    Abstract Aim: To explore the inclusion of patient and public involvement (PPI) in a qualitative study on the experiences of men with prostate cancer regarding information in radiotherapy.
    Method: The application of PPI to one doctoral research study is explored with respect to two perspectives: firstly, involvement of a patient reference group who informed the research design and materials, and secondly, the involvement of a public involvement in research group (PIRg) in advising the researcher during the design process.
    Discussion: PPI is recognised as an important component of contemporary health research. PPI is becoming a common and essential requirement for high quality research projects and yet literature exploring or reporting the involvement and influence of PPI is sparse. Consideration is given to the national PPI landscape that has shaped public involvement in health research.
    Conclusion: The contribution of PPI to this study appears to have been beneficial to the development and evaluation of the study design, the self-worth of the reference group participants and demonstrates that the value of PPI in health research should not be underestimated.
    Mesh-Begriff(e) Biomedical Research ; Community Participation ; Cooperative Behavior ; Humans ; Male ; Patient Participation ; Prostatic Neoplasms/radiotherapy ; Qualitative Research ; Research Design
    Sprache Englisch
    Erscheinungsdatum 2017-02-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1289102-2
    ISSN 1532-2831 ; 1078-8174
    ISSN (online) 1532-2831
    ISSN 1078-8174
    DOI 10.1016/j.radi.2017.02.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: The early use of Pasteur's rabies vaccine in the United States.

    Hoenig, Leonard J / Jackson, Alan C / Dickinson, Gordon M

    Vaccine

    2018  Band 36, Heft 30, Seite(n) 4578–4581

    Abstract: Louis Pasteur's vaccine against rabies was introduced in France during 1885. A year later it became available within the United States. This article tells the story of the first use of the Pasteur vaccine in America and describes the early history of the ...

    Abstract Louis Pasteur's vaccine against rabies was introduced in France during 1885. A year later it became available within the United States. This article tells the story of the first use of the Pasteur vaccine in America and describes the early history of the vaccine's production and distribution across the country by Pasteur Institutes established for this purpose. Highlights of Pasteur's landmark studies on rabies are presented: research which pioneered the field of virology and the use of immunization to prevent infectious diseases.
    Mesh-Begriff(e) History, 19th Century ; Humans ; Rabies/prevention & control ; Rabies Vaccines/history ; Rabies Vaccines/therapeutic use ; United States
    Chemische Substanzen Rabies Vaccines
    Sprache Englisch
    Erscheinungsdatum 2018-06-18
    Erscheinungsland Netherlands
    Dokumenttyp Historical Article ; Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2018.05.016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A Highly Unusual V1 Region of Env in an Elite Controller of HIV Infection.

    Silver, Zachary A / Dickinson, Gordon M / Seaman, Michael S / Desrosiers, Ronald C

    Journal of virology

    2019  Band 93, Heft 10

    Abstract: HIV elite controllers represent a remarkable minority of patients who maintain normal ... ...

    Abstract HIV elite controllers represent a remarkable minority of patients who maintain normal CD4
    Mesh-Begriff(e) Amino Acid Sequence ; Antibodies, Monoclonal/metabolism ; Antibodies, Neutralizing/immunology ; Epitopes/immunology ; Glycosylation ; HIV Antibodies/immunology ; HIV Envelope Protein gp120/genetics ; HIV Envelope Protein gp120/immunology ; HIV Envelope Protein gp120/metabolism ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/immunology ; HIV-1/pathogenicity ; Humans ; Immune Evasion/immunology ; Neutralization Tests ; Peptide Fragments/genetics ; Peptide Fragments/immunology ; Polysaccharides/metabolism ; env Gene Products, Human Immunodeficiency Virus/genetics ; env Gene Products, Human Immunodeficiency Virus/immunology
    Chemische Substanzen Antibodies, Monoclonal ; Antibodies, Neutralizing ; Epitopes ; HIV Antibodies ; HIV Envelope Protein gp120 ; HIV envelope protein gp120 (135-148) ; Peptide Fragments ; Polysaccharides ; env Gene Products, Human Immunodeficiency Virus
    Sprache Englisch
    Erscheinungsdatum 2019-05-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00094-19
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Information in radiotherapy for men with localised prostate cancer: An integrative review.

    Gordon, Lynne / Dickinson, Angela / Offredy, Maxine

    European journal of cancer care

    2019  Band 28, Heft 3, Seite(n) e13085

    Abstract: Introduction: Men with prostate cancer may receive radiotherapy as part of their management. They encounter a range of information related to radiotherapy, and a crucial role for therapeutic radiographers and other healthcare practitioners is ensuring ... ...

    Abstract Introduction: Men with prostate cancer may receive radiotherapy as part of their management. They encounter a range of information related to radiotherapy, and a crucial role for therapeutic radiographers and other healthcare practitioners is ensuring patients receive appropriate information related to their treatment. This integrative review aims to identify, synthesise and analyse literature reporting experiences of men with localised prostate cancer related to information in radiotherapy.
    Methods: A systematic literature search encompassing database and hand searches was carried out between February and March 2017 with date limits of 2000-2017 applied. Initially, 4,954 articles were identified. Systematic screening and detailed examination identified that 33 met the inclusion criteria. Data were synthesised and analysed thematically.
    Results: Few studies explicitly addressed the issue of information in radiotherapy for men with localised prostate cancer. Themes that emerged and were explored are information needs, information regarding adverse effects, information and time, information preferences, satisfaction with information related to radiotherapy and patient experience related to radiotherapy information.
    Conclusion: This review suggests that although several aspects related to information for men with localised prostate cancer have been documented, few were explored in detail with respect to radiotherapy indicating that further research in this area is warranted.
    Mesh-Begriff(e) Brachytherapy ; Humans ; Male ; Needs Assessment ; Patient Education as Topic ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Radiotherapy, Intensity-Modulated
    Sprache Englisch
    Erscheinungsdatum 2019-05-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1303114-4
    ISSN 1365-2354 ; 0961-5423 ; 1360-5801
    ISSN (online) 1365-2354
    ISSN 0961-5423 ; 1360-5801
    DOI 10.1111/ecc.13085
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies.

    Silver, Zachary A / Antonopoulos, Aristotelis / Haslam, Stuart M / Dell, Anne / Dickinson, Gordon M / Seaman, Michael S / Desrosiers, Ronald C

    Cell reports

    2020  Band 30, Heft 6, Seite(n) 1862–1869.e4

    Abstract: Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on Env. ... ...

    Abstract Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on Env. Here we show that a subset of patient-derived HIV-1 isolates contain O-linked carbohydrate on the variable 1 (V1) domain of Env gp120. We demonstrate the presence of this O-glycosylation both on virions and on gp120 expressed as a secreted protein. Further, we establish that these O-linked glycans can confer a more than 1,000-fold decrease in neutralization sensitivity (IC
    Mesh-Begriff(e) Broadly Neutralizing Antibodies/metabolism ; HIV Antibodies/immunology ; HIV-1/immunology ; Humans
    Chemische Substanzen Broadly Neutralizing Antibodies ; HIV Antibodies
    Sprache Englisch
    Erscheinungsdatum 2020-02-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2020.01.056
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies

    Zachary A. Silver / Aristotelis Antonopoulos / Stuart M. Haslam / Anne Dell / Gordon M. Dickinson / Michael S. Seaman / Ronald C. Desrosiers

    Cell Reports, Vol 30, Iss 6, Pp 1862-1869.e

    2020  Band 4

    Abstract: Summary: Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on ...

    Abstract Summary: Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on Env. Here we show that a subset of patient-derived HIV-1 isolates contain O-linked carbohydrate on the variable 1 (V1) domain of Env gp120. We demonstrate the presence of this O-glycosylation both on virions and on gp120 expressed as a secreted protein. Further, we establish that these O-linked glycans can confer a more than 1,000-fold decrease in neutralization sensitivity (IC50) to V3-glycan broadly neutralizing antibodies. These findings uncover a structural modification to the HIV-1 Env and suggest a functional role in promoting viral escape from one category of broadly neutralizing antibodies. : Silver et al. demonstrate that certain HIV-1 isolates possess O-linked carbohydrate on their Envelope glycoprotein. These sugars allow the virus to evade V3-glycan broadly neutralizing antibodies. This work identifies a post-translational modification to the HIV-1 Envelope and sheds light on its role in shielding against the host antibody response. Keywords: HIV-1, Envelope, gp120, V1 domain, O-glycosylation, broadly neutralizing antibodies, immune evasion, escape mechanism
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2020-02-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel: The early use of Pasteur’s rabies vaccine in the United States

    Hoenig, Leonard J / Dickinson, Gordon M / Jackson, Alan C

    Elsevier Ltd Vaccine. 2018 July 16, v. 36, no. 30

    2018  

    Abstract: Louis Pasteur’s vaccine against rabies was introduced in France during 1885. A year later it became available within the United States. This article tells the story of the first use of the Pasteur vaccine in America and describes the early history of the ...

    Abstract Louis Pasteur’s vaccine against rabies was introduced in France during 1885. A year later it became available within the United States. This article tells the story of the first use of the Pasteur vaccine in America and describes the early history of the vaccine’s production and distribution across the country by Pasteur Institutes established for this purpose. Highlights of Pasteur’s landmark studies on rabies are presented: research which pioneered the field of virology and the use of immunization to prevent infectious diseases.
    Schlagwörter immunization ; rabies ; Rabies virus ; vaccines ; virology ; United States
    Sprache Englisch
    Erscheinungsverlauf 2018-0716
    Umfang p. 4578-4581.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2018.05.016
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Acute crystalline arthritis in an artificial knee.

    Hunte, Tai C / Bernstein, Henry M / Dickinson, Gordon M

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2012  Band 18, Heft 4, Seite(n) 203–204

    Mesh-Begriff(e) Acute Disease ; Anti-Bacterial Agents/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Arthroplasty, Replacement, Knee ; Calcium Pyrophosphate/isolation & purification ; Chondrocalcinosis/diagnosis ; Chondrocalcinosis/etiology ; Chondrocalcinosis/therapy ; Debridement ; Humans ; Indomethacin/therapeutic use ; Inflammation/etiology ; Male ; Middle Aged ; Pneumonia/complications ; Pneumonia/drug therapy ; Postoperative Complications ; Synovial Fluid/chemistry ; Vancomycin/therapeutic use
    Chemische Substanzen Anti-Bacterial Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Vancomycin (6Q205EH1VU) ; Calcium Pyrophosphate (X69NU20D19) ; Indomethacin (XXE1CET956)
    Sprache Englisch
    Erscheinungsdatum 2012-06
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0b013e318258b582
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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