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  1. Book: System of ophthalmology / 8. Diseases of the outer eye, 2 / by Stewart Duke-Elder and Arthur George Leigh

    Duke-Elder, Stewart / Abrams, David / Wybar, Kenneth / Leigh, Arthur George / Perkins, Edward S. / Dobree, John H. / Scott, George I. / Macfaul, Peter A.

    1965  

    Author's details ed. by Steward Duke-Elder
    Collection System of ophthalmology
    Language English
    Size XIII S., S. 601 - 1242, XXXI S. : zahlr. Ill.
    Publisher Kimpton
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT010813005
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 6371 order for loan Magazin

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  2. Article: Soldier, physician executive, hematologist, and oncologist Major General Elder Granger, MD. Interview by George A. Dawson.

    Granger, Elder

    Journal of the National Medical Association

    2009  Volume 101, Issue 7, Page(s) 730–733

    MeSH term(s) African Americans ; Hematology ; Humans ; Medical Oncology ; Military Medicine ; Military Personnel ; Physician Executives ; United States
    Language English
    Publishing date 2009-07
    Publishing country United States
    Document type Interview ; Portraits
    ZDB-ID 419737-9
    ISSN 0027-9684
    ISSN 0027-9684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 150: Show issues Location:
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  3. Book: George Berkeley

    Ritchie, Arthur Davie / Davie, George Elder

    a reappraisal

    1967  

    Author's details by A. D. Ritchie. Ed. with a preface by G. E. Davie
    Language English
    Size XVIII, 189 S
    Publisher Univ. Press u.a.
    Publishing place Manchester u.a.
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article: The maddening business of King George III and porphyria.

    Warren, M J / Jay, M / Hunt, D M / Elder, G H / Röhl, J C

    Trends in biochemical sciences

    1996  Volume 21, Issue 6, Page(s) 229–234

    MeSH term(s) Ammonia-Lyases/genetics ; Ammonia-Lyases/metabolism ; England ; Famous Persons ; Heme/biosynthesis ; Heme/deficiency ; History, 18th Century ; History, 19th Century ; Humans ; Male ; Mental Disorders/etiology ; Mental Disorders/history ; Pedigree ; Porphyrias/diagnosis ; Porphyrias/genetics ; Porphyrias/history
    Chemical Substances Heme (42VZT0U6YR) ; Ammonia-Lyases (EC 4.3.1.-) ; porphobilinogenase (EC 5.-)
    Language English
    Publishing date 1996-06
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Melanocytic tumors of the skin

    Elder, David E. / Murphy, George F.

    (AFIP atlas of tumor pathology ; Ser. 4, Fasc. 12)

    2010  

    Author's details by David E. Elder ; George F. Murphy
    Series title AFIP atlas of tumor pathology ; Ser. 4, Fasc. 12
    Collection
    Language English
    Size XIV, 468 S. : zahlr. Ill.
    Publisher American Registry of Pathology
    Publishing place Washington, DC
    Publishing country United States
    Document type Book
    HBZ-ID HT016541124
    ISBN 1-933477-10-5 ; 978-1-933477-10-7
    Database Catalogue ZB MED Medicine, Health

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    Se 1357 -4,12- verfügbar in Königswinter Königswinter

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  6. Article: Peripheral Neuritis in Pregnancy.

    Elder, George

    Transactions. Edinburgh Obstetrical Society

    2018  Volume 21, Page(s) 242–250

    Language English
    Publishing date 2018-04-03
    Publishing country Scotland
    Document type Journal Article
    ISSN 0269-3402
    ISSN 0269-3402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Case of Cancrum Oris.

    Elder, George

    Transactions. Medico-Chirurgical Society of Edinburgh

    2018  Volume 12, Page(s) 259–262

    Language English
    Publishing date 2018-03-19
    Publishing country Scotland
    Document type Journal Article
    ISSN 0267-2790
    ISSN 0267-2790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The "Antiseptic" Treatment of Wounds, with Special Reference to Compound Fractures.

    Elder, George

    Glasgow medical journal

    2018  Volume 2, Issue 2, Page(s) 195–199

    Language English
    Publishing date 2018-11-14
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 414084-9
    ISSN 0367-4800
    ISSN 0367-4800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Inferring Compensatory Kinase Networks in Yeast using Prolog

    Elder, George A. / Bessant, Conrad

    2023  

    Abstract: Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in ... ...

    Abstract Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in humans. Therefore any insight in this model organism could potentially offer indications of mechanisms of action in the human kinome. The study utilises a Prolog-based approach, data from a yeast kinase deletions strains study and publicly available kinase-protein associations. Prolog, a programming language that is well-suited for symbolic reasoning is used to reason over the data and infer compensatory kinase networks. This approach is based on the idea that when a kinase is knocked out, other kinases may compensate for this loss of activity. Background knowledge on kinases targeting proteins is used to guide the analysis. This knowledge is used to infer the potential compensatory interactions between kinases based on the changes in phosphorylation observed in the phosphoproteomics data from the yeast study. The results demonstrate the effectiveness of the Prolog-based approach in analysing complex cell signalling mechanisms in yeast. The inferred compensatory kinase networks provide new insights into the regulation of cell signalling in yeast and may aid in the identification of potential therapeutic targets for modulating signalling pathways in yeast and other organisms.

    Comment: In Proceedings ICLP 2023, arXiv:2308.14898
    Keywords Quantitative Biology - Molecular Networks ; Computer Science - Symbolic Computation
    Subject code 570
    Publishing date 2023-08-30
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: From chemistry to genomics: A concise history of the porphyrias.

    Badminton, Michael N / Anderson, Karl E / Deybach, Jean-Charles / Harper, Pauline / Sandberg, Sverre / Elder, George H

    Liver international : official journal of the International Association for the Study of the Liver

    2024  

    Abstract: We describe developments in understanding of the porphyrias associated with each step in the haem biosynthesis pathway and the role of individuals whose contributions led to major advances over the past 150 years. The first case of erythropoietic ... ...

    Abstract We describe developments in understanding of the porphyrias associated with each step in the haem biosynthesis pathway and the role of individuals whose contributions led to major advances over the past 150 years. The first case of erythropoietic porphyria was reported in 1870, and the first with acute porphyria in 1889. Photosensitisation by porphyrin was confirmed by Meyer-Betz, who self-injected haematoporphyrin. Günther classified porphyrias into haematoporphyria acuta, acuta toxica, congenita and chronica. This was revised by Waldenström into porphyria congenita, acuta and cutanea tarda, with the latter describing those with late-onset skin lesions. Waldenström was the first to recognise porphobilinogen's association with acute porphyria, although its structure was not solved until 1953. Hans Fischer was awarded the Nobel prize in 1930 for solving the structure of porphyrins and the synthesis of haemin. After 1945, research by several groups elucidated the pathway of haem biosynthesis and its negative feedback regulation by haem. By 1961, following the work of Watson, Schmid, Rimington, Goldberg, Dean, Magnus and others, aided by the availability of modern techniques of porphyrin separation, six of the porphyrias were identified and classified as erythropoietic or hepatic. The seventh, 5-aminolaevulinate dehydratase deficiency porphyria, was described by Doss in 1979. The discovery of increased hepatic 5-aminolaevulinate synthase activity in acute porphyria led to development of haematin as a treatment for acute attacks. By 2000, all the haem biosynthesis genes were cloned, sequenced and assigned to chromosomes and disease-specific mutations identified in all inherited porphyrias. These advances have allowed definitive family studies and development of new treatments.
    Language English
    Publishing date 2024-05-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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