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  1. Artikel: STEAM: Using the Arts to Train Well-Rounded and Creative Scientists.

    Segarra, Verónica A / Natalizio, Barbara / Falkenberg, Cibele V / Pulford, Stephanie / Holmes, Raquell M

    Journal of microbiology & biology education

    2018  Band 19, Heft 1

    Abstract: While the demand for a strong STEM workforce continues to grow, there are challenges that threaten our ability to recruit, train, and retain such a workforce in a way that is effective and sustainable and fosters innovation. One way in which we are ... ...

    Abstract While the demand for a strong STEM workforce continues to grow, there are challenges that threaten our ability to recruit, train, and retain such a workforce in a way that is effective and sustainable and fosters innovation. One way in which we are meeting this challenge is through the use of the arts in the training of scientists. In this Perspectives article, we review the use of the arts in science education and its benefits in both K-12 and postsecondary education. We also review the use of STEAM (science, technology, engineering, arts, and mathematics) programs in science outreach and the development of professional scientists.
    Sprache Englisch
    Erscheinungsdatum 2018-04-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1935-7877
    ISSN 1935-7877
    DOI 10.1128/jmbe.v19i1.1360
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: STEAM

    Verónica A. Segarra / Barbara Natalizio / Cibele V. Falkenberg / Stephanie Pulford / Raquell M. Holmes

    Journal of Microbiology & Biology Education, Vol 19, Iss

    Using the Arts to Train Well-Rounded and Creative Scientists

    2018  Band 1

    Abstract: While the demand for a strong STEM workforce continues to grow, there are challenges that threaten our ability to recruit, train, and retain such a workforce in a way that is effective and sustainable and fosters innovation. One way in which we are ... ...

    Abstract While the demand for a strong STEM workforce continues to grow, there are challenges that threaten our ability to recruit, train, and retain such a workforce in a way that is effective and sustainable and fosters innovation. One way in which we are meeting this challenge is through the use of the arts in the training of scientists. In this Perspectives article, we review the use of the arts in science education and its benefits in both K–12 and postsecondary education. We also review the use of STEAM (science, technology, engineering, arts, and mathematics) programs in science outreach and the development of professional scientists.
    Schlagwörter Special aspects of education ; LC8-6691 ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2018-03-01T00:00:00Z
    Verlag American Society for Microbiology
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: STEAM

    Verónica A. Segarra / Barbara Natalizio / Cibele V. Falkenberg / Stephanie Pulford / Raquell M. Holmes

    Journal of Microbiology & Biology Education, Vol 19, Iss

    Using the Arts to Train Well-Rounded and Creative Scientists

    2018  Band 1

    Abstract: While the demand for a strong STEM workforce continues to grow, there are challenges that threaten our ability to recruit, train, and retain such a workforce in a way that is effective and sustainable and fosters innovation. One way in which we are ... ...

    Abstract While the demand for a strong STEM workforce continues to grow, there are challenges that threaten our ability to recruit, train, and retain such a workforce in a way that is effective and sustainable and fosters innovation. One way in which we are meeting this challenge is through the use of the arts in the training of scientists. In this Perspectives article, we review the use of the arts in science education and its benefits in both K–12 and postsecondary education. We also review the use of STEAM (science, technology, engineering, arts, and mathematics) programs in science outreach and the development of professional scientists.
    Schlagwörter Diversity ; inclusion ; improvisational learning ; science pedagogy ; classroom science communication ; STEAM ; Special aspects of education ; LC8-6691 ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2018-05-01T00:00:00Z
    Verlag American Society for Microbiology
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: A biophysical model for integration of electrical, osmotic, and pH regulation in the human bronchial epithelium.

    Falkenberg, Cibele V / Jakobsson, Eric

    Biophysical journal

    2010  Band 98, Heft 8, Seite(n) 1476–1485

    Abstract: A dynamical biophysical model for the functioning of an epithelium is presented. This model integrates the electrical and osmotic behaviors of the epithelium, taking into account intracellular conditions. The specific tissue modeled is the human ... ...

    Abstract A dynamical biophysical model for the functioning of an epithelium is presented. This model integrates the electrical and osmotic behaviors of the epithelium, taking into account intracellular conditions. The specific tissue modeled is the human bronchial epithelium, which is of particular interest, as it is the location of the most common lethal symptoms of cystic fibrosis. The model is implemented in a modular form to facilitate future application of the code to other epithelial tissue by inputting different transporters, channels, and geometric parameters. The model includes pH regulation as an integral component of overall regulation of epithelial function, through the interdependence of pH, bicarbonate concentration, and current. The procedures for specification, the validation of the model, and parametric studies are presented using available experimental data of cultured human bronchial epithelium. Parametric studies are performed to elucidate a), the contribution of basolateral chloride channels to the short-circuit current functional form, and b), the role that regulation of basolateral potassium conductance plays in epithelial function.
    Mesh-Begriff(e) Biophysical Phenomena ; Bronchi/physiology ; Computer Simulation ; Electricity ; Epithelium/physiology ; Humans ; Hydrogen-Ion Concentration ; Membrane Potentials/physiology ; Models, Biological ; Osmosis/physiology
    Sprache Englisch
    Erscheinungsdatum 2010-04-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2009.11.045
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 235: Hefte anzeigen Standort:
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  5. Artikel ; Online: Pleomorphic ensembles: formation of large clusters composed of weakly interacting multivalent molecules.

    Falkenberg, Cibele V / Blinov, Michael L / Loew, Leslie M

    Biophysical journal

    2013  Band 105, Heft 11, Seite(n) 2451–2460

    Abstract: Molecular interactions of importance to cell biology are subject to sol-gel transitions: large clusters of weakly interacting multivalent molecules (gel phase) are produced at a critical concentration of monomers. Examples include cell-cell and cell- ... ...

    Abstract Molecular interactions of importance to cell biology are subject to sol-gel transitions: large clusters of weakly interacting multivalent molecules (gel phase) are produced at a critical concentration of monomers. Examples include cell-cell and cell-matrix adhesions, nucleoprotein bodies, and cell signaling platforms. We use the term pleomorphic ensembles (PEs) to describe these clusters, because they have dynamic compositions and sizes and have rapid turnover of their molecular constituents; this plasticity can be highly responsive to cellular signals. The classical polymer physical chemistry theory developed by Flory and Stockmayer provides a brilliant framework for treating multivalent interactions for simple idealized systems. But the complexity and variability of PEs challenges existing modeling approaches. Here we describe and validate a computational algorithm that extends the Flory-Stockmayer formalism to overcome the limitations of analytic theories. We divide the problem by deterministically calculating the fraction of bound sites for each type of binding site, followed by the stochastic assignment of the bonds to a finite number of molecules. The method allows for high valency within many different kinds of interacting molecules and site types, permits simulation of steady-state distributions, as well as assembly kinetics, and can treat cooperative binding within one of the interacting molecules. We then apply our method to the analysis of interactions in the nephrin-Nck-N-Wasp signaling system, demonstrating how multivalent layered scaffolds produce PEs at low monomer concentrations despite weak binding interactions. We show how the experimental data for this system are most consistent with synergistic cooperative interactions between Nck and N-Wasp.
    Mesh-Begriff(e) Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/metabolism ; Algorithms ; Animals ; Biopolymers/chemistry ; Gels/chemistry ; Humans ; Kinetics ; Membrane Proteins/chemistry ; Membrane Proteins/metabolism ; Models, Biological ; Oncogene Proteins/chemistry ; Oncogene Proteins/metabolism ; Protein Binding ; Wiskott-Aldrich Syndrome Protein Family/chemistry ; Wiskott-Aldrich Syndrome Protein Family/metabolism
    Chemische Substanzen Adaptor Proteins, Signal Transducing ; Biopolymers ; Gels ; Membrane Proteins ; Nck protein ; Oncogene Proteins ; Wiskott-Aldrich Syndrome Protein Family ; nephrin
    Sprache Englisch
    Erscheinungsdatum 2013-12-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2013.10.016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Pleomorphic Ensembles: Formation of Large Clusters Composed of Weakly Interacting Multivalent Molecules

    Falkenberg, Cibele V / Blinov, Michael L / Loew, Leslie M

    Biophysical journal. 2013 Dec. 3, v. 105, no. 11

    2013  

    Abstract: Molecular interactions of importance to cell biology are subject to sol-gel transitions: large clusters of weakly interacting multivalent molecules (gel phase) are produced at a critical concentration of monomers. Examples include cell-cell and cell- ... ...

    Abstract Molecular interactions of importance to cell biology are subject to sol-gel transitions: large clusters of weakly interacting multivalent molecules (gel phase) are produced at a critical concentration of monomers. Examples include cell-cell and cell-matrix adhesions, nucleoprotein bodies, and cell signaling platforms. We use the term pleomorphic ensembles (PEs) to describe these clusters, because they have dynamic compositions and sizes and have rapid turnover of their molecular constituents; this plasticity can be highly responsive to cellular signals. The classical polymer physical chemistry theory developed by Flory and Stockmayer provides a brilliant framework for treating multivalent interactions for simple idealized systems. But the complexity and variability of PEs challenges existing modeling approaches. Here we describe and validate a computational algorithm that extends the Flory-Stockmayer formalism to overcome the limitations of analytic theories. We divide the problem by deterministically calculating the fraction of bound sites for each type of binding site, followed by the stochastic assignment of the bonds to a finite number of molecules. The method allows for high valency within many different kinds of interacting molecules and site types, permits simulation of steady-state distributions, as well as assembly kinetics, and can treat cooperative binding within one of the interacting molecules. We then apply our method to the analysis of interactions in the nephrin-Nck-N-Wasp signaling system, demonstrating how multivalent layered scaffolds produce PEs at low monomer concentrations despite weak binding interactions. We show how the experimental data for this system are most consistent with synergistic cooperative interactions between Nck and N-Wasp.
    Schlagwörter algorithms ; binding sites ; cell biology ; gels ; models ; polymers
    Sprache Englisch
    Erscheinungsverlauf 2013-1203
    Umfang p. 2451-2460.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2013.10.016
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

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  7. Artikel ; Online: Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability.

    Cibele V Falkenberg / Evren U Azeloglu / Mark Stothers / Thomas J Deerinck / Yibang Chen / John C He / Mark H Ellisman / James C Hone / Ravi Iyengar / Leslie M Loew

    PLoS Computational Biology, Vol 13, Iss 3, p e

    2017  Band 1005433

    Abstract: Kidney podocytes' function depends on fingerlike projections (foot processes) that interdigitate with those from neighboring cells to form the glomerular filtration barrier. The integrity of the barrier depends on spatial control of dynamics of actin ... ...

    Abstract Kidney podocytes' function depends on fingerlike projections (foot processes) that interdigitate with those from neighboring cells to form the glomerular filtration barrier. The integrity of the barrier depends on spatial control of dynamics of actin cytoskeleton in the foot processes. We determined how imbalances in regulation of actin cytoskeletal dynamics could result in pathological morphology. We obtained 3-D electron microscopy images of podocytes and used quantitative features to build dynamical models to investigate how regulation of actin dynamics within foot processes controls local morphology. We find that imbalances in regulation of actin bundling lead to chaotic spatial patterns that could impair the foot process morphology. Simulation results are consistent with experimental observations for cytoskeletal reconfiguration through dysregulated RhoA or Rac1, and they predict compensatory mechanisms for biochemical stability. We conclude that podocyte morphology, optimized for filtration, is intrinsically fragile, whereby local transient biochemical imbalances may lead to permanent morphological changes associated with pathophysiology.
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 612
    Sprache Englisch
    Erscheinungsdatum 2017-03-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: (mit Forschungsdaten) Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability.

    Falkenberg, Cibele V / Azeloglu, Evren U / Stothers, Mark / Deerinck, Thomas J / Chen, Yibang / He, John C / Ellisman, Mark H / Hone, James C / Iyengar, Ravi / Loew, Leslie M

    PLoS computational biology

    2017  Band 13, Heft 3, Seite(n) e1005433

    Abstract: Kidney podocytes' function depends on fingerlike projections (foot processes) that interdigitate with those from neighboring cells to form the glomerular filtration barrier. The integrity of the barrier depends on spatial control of dynamics of actin ... ...

    Abstract Kidney podocytes' function depends on fingerlike projections (foot processes) that interdigitate with those from neighboring cells to form the glomerular filtration barrier. The integrity of the barrier depends on spatial control of dynamics of actin cytoskeleton in the foot processes. We determined how imbalances in regulation of actin cytoskeletal dynamics could result in pathological morphology. We obtained 3-D electron microscopy images of podocytes and used quantitative features to build dynamical models to investigate how regulation of actin dynamics within foot processes controls local morphology. We find that imbalances in regulation of actin bundling lead to chaotic spatial patterns that could impair the foot process morphology. Simulation results are consistent with experimental observations for cytoskeletal reconfiguration through dysregulated RhoA or Rac1, and they predict compensatory mechanisms for biochemical stability. We conclude that podocyte morphology, optimized for filtration, is intrinsically fragile, whereby local transient biochemical imbalances may lead to permanent morphological changes associated with pathophysiology.
    Mesh-Begriff(e) Actin Cytoskeleton/pathology ; Actin Cytoskeleton/physiology ; Cell Polarity ; Cell Size ; Cell Surface Extensions/pathology ; Cell Surface Extensions/physiology ; Cells, Cultured ; Computer Simulation ; Humans ; Models, Biological ; Nonlinear Dynamics ; Podocytes/pathology ; Podocytes/physiology ; Spatio-Temporal Analysis
    Sprache Englisch
    Erscheinungsdatum 2017-03-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1005433
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Pleomorphic Ensembles: Formation of Large Clusters Composed of Weakly Interacting Multivalent Molecules

    Falkenberg, Cibele V. / Blinov, Michael L. / Loew, Leslie M.

    Biophysical journal

    Band v. 105,, Heft no. 1

    Abstract: Molecular interactions of importance to cell biology are subject to sol-gel transitions: large clusters of weakly interacting multivalent molecules (gel phase) are produced at a critical concentration of monomers. Examples include cell-cell and cell- ... ...

    Abstract Molecular interactions of importance to cell biology are subject to sol-gel transitions: large clusters of weakly interacting multivalent molecules (gel phase) are produced at a critical concentration of monomers. Examples include cell-cell and cell-matrix adhesions, nucleoprotein bodies, and cell signaling platforms. We use the term pleomorphic ensembles (PEs) to describe these clusters, because they have dynamic compositions and sizes and have rapid turnover of their molecular constituents; this plasticity can be highly responsive to cellular signals. The classical polymer physical chemistry theory developed by Flory and Stockmayer provides a brilliant framework for treating multivalent interactions for simple idealized systems. But the complexity and variability of PEs challenges existing modeling approaches. Here we describe and validate a computational algorithm that extends the Flory-Stockmayer formalism to overcome the limitations of analytic theories. We divide the problem by deterministically calculating the fraction of bound sites for each type of binding site, followed by the stochastic assignment of the bonds to a finite number of molecules. The method allows for high valency within many different kinds of interacting molecules and site types, permits simulation of steady-state distributions, as well as assembly kinetics, and can treat cooperative binding within one of the interacting molecules. We then apply our method to the analysis of interactions in the nephrin-Nck-N-Wasp signaling system, demonstrating how multivalent layered scaffolds produce PEs at low monomer concentrations despite weak binding interactions. We show how the experimental data for this system are most consistent with synergistic cooperative interactions between Nck and N-Wasp.
    Schlagwörter models ; cell biology ; binding sites ; algorithms ; polymers ; gels
    Sprache Englisch
    Dokumenttyp Artikel
    ISSN 0006-3495
    Datenquelle AGRIS - International Information System for the Agricultural Sciences and Technology

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