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  1. Artikel ; Online: Flurofamide Prevention and Treatment of

    Fleming, Derek / Patel, Robin

    Microbiology spectrum

    2022  Band 10, Heft 5, Seite(n) e0192722

    Abstract: Hyperammonemia (HA) syndrome caused by respiratory infection with ammonia ( ... ...

    Abstract Hyperammonemia (HA) syndrome caused by respiratory infection with ammonia (NH
    Mesh-Begriff(e) Mice ; Animals ; Ureaplasma ; Hyperammonemia/drug therapy ; Hyperammonemia/prevention & control ; Hyperammonemia/complications ; Urease/pharmacology ; Ammonia/pharmacology ; Ureaplasma Infections/complications ; Ureaplasma Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Urea/pharmacology
    Chemische Substanzen flurofamide (599XHU06GH) ; Urease (EC 3.5.1.5) ; Ammonia (7664-41-7) ; Anti-Bacterial Agents ; Urea (8W8T17847W)
    Sprache Englisch
    Erscheinungsdatum 2022-08-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01927-22
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Evaluation of Treatment of Methicillin-Resistant

    Islam Anoy, Md Monzurul / Kim, Won-Jun / Gelston, Suzanne / Fleming, Derek / Patel, Robin / Beyenal, Haluk

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Chronic wound infections can be difficult to treat and may lead to impaired healing and worsened patient outcomes. Novel treatment strategies are needed. This study evaluated effects of intermittently produced ... ...

    Abstract Chronic wound infections can be difficult to treat and may lead to impaired healing and worsened patient outcomes. Novel treatment strategies are needed. This study evaluated effects of intermittently produced H
    Sprache Englisch
    Erscheinungsdatum 2024-03-27
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.03.22.586337
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Evaluation of treatment of methicillin-resistant

    Anoy, Md Monzurul Islam / Kim, Won-Jun / Gelston, Suzanne / Fleming, Derek / Patel, Robin / Beyenal, Haluk

    Antimicrobial agents and chemotherapy

    2024  , Seite(n) e0172223

    Abstract: Chronic wound infections can be difficult to treat and may lead to impaired healing and worsened patient outcomes. Novel treatment strategies are needed. This study evaluated the effects of intermittently produced hydrogen peroxide ( ... ...

    Abstract Chronic wound infections can be difficult to treat and may lead to impaired healing and worsened patient outcomes. Novel treatment strategies are needed. This study evaluated the effects of intermittently produced hydrogen peroxide (H
    Sprache Englisch
    Erscheinungsdatum 2024-05-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01722-23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Development of shunt valves used for treating hydrocephalus: comparison with endoscopy treatment.

    Fleming, Charles H / Ritter, Ann M / Bruce, Derek A

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2023  Band 39, Heft 10, Seite(n) 2709–2717

    Abstract: The pathophysiology of hydrocephalus is not clearly defined. Thus, treatment will remain empirical until a fuller understanding of the various forms of hydrocephalus is achieved. Valve-controlled shunting has been the mainstay of therapy since the late ... ...

    Abstract The pathophysiology of hydrocephalus is not clearly defined. Thus, treatment will remain empirical until a fuller understanding of the various forms of hydrocephalus is achieved. Valve-controlled shunting has been the mainstay of therapy since the late 1950s. Initially, shunting occurred from the ventricular system to the atrium. In the 1970s, VA shunts were replaced by ventriculoperitoneal shunts as the primary location for the distal end. Multiple types of one-way valve systems have been developed in the pursuit of draining the appropriate amount of CSF that avoids either overdrainage or underdrainage while preserving normal brain development and cognition. These valves are reviewed and compared as to their function. Other locations for the distal end of the shunting system are reviewed to include pleural space and gallbladder. The lumbar subarachnoid space as the proximal location for a shunt is also reviewed. The only other surgical alternative for treating hydrocephalus is endoscopic third ventriculostomy. Since 2000, approximately 50% of children with hydrocephalus have been shown to be candidates for ETV. The benefits are the lack of need for an artificial shunt system and thus lower rates of infection and over time fewer reoperations. Future progress is dependent on improved shunt valve systems that are affordable worldwide and ready availability of ETV in developing countries. Anatomic and molecular causes of hydrocephalus need to be defined so that medications or genetic modifications become available for potential cure of hydrocephalus.
    Mesh-Begriff(e) Child ; Humans ; Infant ; Third Ventricle/surgery ; Hydrocephalus/etiology ; Ventriculostomy/adverse effects ; Brain/surgery ; Endoscopy ; Ventriculoperitoneal Shunt/adverse effects ; Cerebrospinal Fluid Shunts/adverse effects ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2023-06-24
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-023-06049-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: DUAL ACTION ELECTROCHEMICAL BANDAGE OPERATED by a PROGRAMMABLE MULTIMODAL WEARABLE POTENTIOSTAT.

    Bozyel, Ibrahim / Fleming, Derek / Kim, Won-Jun / Rosen, Peter F / Gelston, Suzanne / Ozdemir, Dilara / Ay, Suat U / Patel, Robin / Beyenal, Haluk

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Electrochemical bandages (e-bandages) can be applied to biofilm-infected wounds to generate reactive oxygen species, such as hypochlorous acid (HOCl) or hydrogen peroxide ( ... ...

    Abstract Electrochemical bandages (e-bandages) can be applied to biofilm-infected wounds to generate reactive oxygen species, such as hypochlorous acid (HOCl) or hydrogen peroxide (H
    Sprache Englisch
    Erscheinungsdatum 2024-03-27
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.03.22.586346
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Contribution of Uremia to

    Fleming, Derek / Cunningham, Scott A / Patel, Robin

    Microbiology spectrum

    2022  Band 10, Heft 1, Seite(n) e0194221

    Abstract: Lung transplant recipients (LTRs) are vulnerable to hyperammonemia syndrome (HS) in the early postoperative period, a condition typically unresponsive to nonantibiotic interventions. HS in LTRs is strongly correlated with Ureaplasma infection of the ... ...

    Abstract Lung transplant recipients (LTRs) are vulnerable to hyperammonemia syndrome (HS) in the early postoperative period, a condition typically unresponsive to nonantibiotic interventions. HS in LTRs is strongly correlated with Ureaplasma infection of the respiratory tract, although it is not well understood what makes LTRs preferentially susceptible to HS compared to other immunocompromised hosts. Ureaplasma species harbor highly active ureases, and postoperative LTRs commonly experience uremia. We hypothesized that uremia could be a potentiating comorbidity, providing increased substrate for ureaplasmal ureases. Using a novel dialyzed flow system, the ammonia-producing capacities of four isolates of Ureaplasma parvum and six isolates of Ureaplasma urealyticum in media formulations relating to normal and uremic host conditions were tested. For all isolates, growth under simulated uremic conditions resulted in increased ammonia production over 24 h, despite similar endpoint bacterial quantities. Further, transcripts of
    Mesh-Begriff(e) Ammonia/metabolism ; Animals ; Humans ; Hyperammonemia/complications ; Hyperammonemia/microbiology ; Immunocompromised Host ; Lung ; Lung Transplantation ; Mice ; Transplant Recipients ; Ureaplasma ; Ureaplasma urealyticum/isolation & purification ; Uremia/complications ; Uremia/microbiology ; Urinary Tract
    Chemische Substanzen Ammonia (7664-41-7)
    Sprache Englisch
    Erscheinungsdatum 2022-02-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01942-21
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Dealing With Surrogate Conflict: A Student's Perspective.

    Su, Derek / Fleming, David A

    Southern medical journal

    2019  Band 112, Heft 6, Seite(n) 315–317

    Mesh-Begriff(e) Advance Care Planning ; Conflict, Psychological ; Decision Making/ethics ; Humans ; Negotiating/methods ; Patient Preference ; Proxy
    Sprache Englisch
    Erscheinungsdatum 2019-06-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.14423/SMJ.0000000000000981
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: HOCl-producing Electrochemical Bandage is Active in Murine Polymicrobial Wound Infection.

    Fleming, Derek / Bozyel, Ibrahim / Koscianski, Christina A / Ozdemir, Dilara / Karau, Melissa J / Cuello, Luz / Anoy, Md Monzurul Islam / Gelston, Suzanne / Schuetz, Audrey N / Greenwood-Quaintance, Kerryl E / Mandrekar, Jayawant N / Beyenal, Haluk / Patel, Robin

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Wound infections, exacerbated by the prevalence of antibiotic-resistant bacterial pathogens, necessitate innovative antimicrobial approaches. Polymicrobial infections, often ... ...

    Abstract Wound infections, exacerbated by the prevalence of antibiotic-resistant bacterial pathogens, necessitate innovative antimicrobial approaches. Polymicrobial infections, often involving
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.03.19.585100
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A novel bioreactor for the stable growth of Ureaplasma parvum and Ureaplasma urealyticum.

    Fleming, Derek / Karau, Melissa / Patel, Robin

    Journal of microbiological methods

    2020  Band 181, Seite(n) 106131

    Abstract: Ureaplasma species, including Ureaplasma parvum and Ureaplasma urealyticum, are challenging to culture and maintain. Here, we describe a novel bioreactor for growing high-titer liquid Ureaplasma cultures in a stable manner. ...

    Abstract Ureaplasma species, including Ureaplasma parvum and Ureaplasma urealyticum, are challenging to culture and maintain. Here, we describe a novel bioreactor for growing high-titer liquid Ureaplasma cultures in a stable manner.
    Mesh-Begriff(e) Bioreactors/microbiology ; Humans ; Ureaplasma/growth & development ; Ureaplasma Infections/microbiology ; Ureaplasma urealyticum/growth & development
    Sprache Englisch
    Erscheinungsdatum 2020-12-30
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604916-3
    ISSN 1872-8359 ; 0167-7012
    ISSN (online) 1872-8359
    ISSN 0167-7012
    DOI 10.1016/j.mimet.2020.106131
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: HOCl-producing electrochemical bandage for treating

    Fleming, Derek / Bozyel, Ibrahim / Ozdemir, Dilara / Otero, Judith Alvarez / Karau, Melissa J / Anoy, Md Monzurul Islam / Koscianski, Christina / Schuetz, Audrey N / Greenwood-Quaintance, Kerryl E / Mandrekar, Jayawant N / Beyenal, Haluk / Patel, Robin

    Antimicrobial agents and chemotherapy

    2024  Band 68, Heft 2, Seite(n) e0121623

    Abstract: The growing threat of antibiotic-resistant bacterial pathogens necessitates the development of alternative antimicrobial approaches. This is particularly true for chronic wound infections, which commonly harbor biofilm-dwelling bacteria. A novel ... ...

    Abstract The growing threat of antibiotic-resistant bacterial pathogens necessitates the development of alternative antimicrobial approaches. This is particularly true for chronic wound infections, which commonly harbor biofilm-dwelling bacteria. A novel electrochemical bandage (e-bandage) delivering low-levels of hypochlorous acid (HOCl) was evaluated against
    Mesh-Begriff(e) Animals ; Mice ; Pseudomonas aeruginosa ; Hypochlorous Acid ; Amikacin ; Pseudomonas Infections/microbiology ; Wound Infection/microbiology ; Bandages ; Anti-Bacterial Agents ; Biofilms
    Chemische Substanzen Hypochlorous Acid (712K4CDC10) ; Amikacin (84319SGC3C) ; Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2024-01-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01216-23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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