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  1. Artikel ; Online: Chronic Nonbacterial Osteomyelitis in Inflammatory Bowel Disease

    Ariadni Tzaneti / Elli Athanasopoulou / Smaragdi Fessatou / Lampros Fotis

    Life, Vol 13, Iss 12, p

    2023  Band 2347

    Abstract: Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a rare autoinflammatory bone disease primarily affecting children and adolescents. This review presents a comprehensive analysis of the ... ...

    Abstract Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a rare autoinflammatory bone disease primarily affecting children and adolescents. This review presents a comprehensive analysis of the intricate relationship between CNO and inflammatory bowel disease (IBD), shedding light on shared pathophysiological mechanisms and clinical management. A thorough literature review was conducted, encompassing 24 case reports involving 40 patients. The demographic distribution of patients revealed a near-equal gender ratio, with a median age of diagnosis at 12 years. The diagnosis patterns showed a higher proportion of CNO as the initial diagnosis, while Crohn’s disease was more prevalent than ulcerative colitis. The time interval between the clinical presentations varied, ranging from simultaneous detection to a substantial 15-year gap. Treatment modalities included nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, aminosalicylates, and biologic agents, such as infliximab, often overlapping in their use and suggesting shared pathophysiological pathways. Both conditions displayed systemic manifestations, and patients often responded well to immunosuppressive medications. The pathophysiology of CNO involves a genetic predisposition, cytokine dysregulation, and osteoclast activation. Dysregulated innate immunity results in immune cell infiltration into bones, causing sterile bone lesions. Notably, emerging evidence hints at a potential link between the microbiome and CNO. In contrast, IBD results from imbalanced mucosal immune responses to the intestinal microbiota. Polymorphisms in the promotor region of IL-10, common cytokines, immune cells, and genetic markers indicate shared immunological and genetic factors between CNO and IBD. Both conditions also involve extraintestinal symptoms. This analysis underscores the need for clinical awareness of the co-occurrence of CNO and IBD, especially among pediatric patients. A deepened understanding of the connections ...
    Schlagwörter CRMO ; Crohn’s disease ; inflammatory bowel disease ; osteomyelitis ; pediatrics ; ulcerative colitis ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel: Chronic Nonbacterial Osteomyelitis in Inflammatory Bowel Disease.

    Tzaneti, Ariadni / Athanasopoulou, Elli / Fessatou, Smaragdi / Fotis, Lampros

    Life (Basel, Switzerland)

    2023  Band 13, Heft 12

    Abstract: Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a rare autoinflammatory bone disease primarily affecting children and adolescents. This review presents a comprehensive analysis of the ... ...

    Abstract Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a rare autoinflammatory bone disease primarily affecting children and adolescents. This review presents a comprehensive analysis of the intricate relationship between CNO and inflammatory bowel disease (IBD), shedding light on shared pathophysiological mechanisms and clinical management. A thorough literature review was conducted, encompassing 24 case reports involving 40 patients. The demographic distribution of patients revealed a near-equal gender ratio, with a median age of diagnosis at 12 years. The diagnosis patterns showed a higher proportion of CNO as the initial diagnosis, while Crohn's disease was more prevalent than ulcerative colitis. The time interval between the clinical presentations varied, ranging from simultaneous detection to a substantial 15-year gap. Treatment modalities included nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, aminosalicylates, and biologic agents, such as infliximab, often overlapping in their use and suggesting shared pathophysiological pathways. Both conditions displayed systemic manifestations, and patients often responded well to immunosuppressive medications. The pathophysiology of CNO involves a genetic predisposition, cytokine dysregulation, and osteoclast activation. Dysregulated innate immunity results in immune cell infiltration into bones, causing sterile bone lesions. Notably, emerging evidence hints at a potential link between the microbiome and CNO. In contrast, IBD results from imbalanced mucosal immune responses to the intestinal microbiota. Polymorphisms in the promotor region of IL-10, common cytokines, immune cells, and genetic markers indicate shared immunological and genetic factors between CNO and IBD. Both conditions also involve extraintestinal symptoms. This analysis underscores the need for clinical awareness of the co-occurrence of CNO and IBD, especially among pediatric patients. A deepened understanding of the connections between these seemingly distinct diseases could lead to more effective management and improved patient outcomes.
    Sprache Englisch
    Erscheinungsdatum 2023-12-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13122347
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Arthritis Remission With Partial Cartilage Restoration in a 9 y/o Female With Hip Chondrolysis Following Treatment With Adalimumab.

    Fotis, Lampros / Kanellopoulos, Anastasios / Papakonstantinou, Olympia

    Modern rheumatology case reports

    2022  

    Abstract: Hip chondrolysis is observed primarily or secondary to other diseases and is a rare but yet debilitating disease, characterized by loss of cartilage of the femoral epiphysis and significant restriction of motion. We present the case of a 9-year-old ... ...

    Abstract Hip chondrolysis is observed primarily or secondary to other diseases and is a rare but yet debilitating disease, characterized by loss of cartilage of the femoral epiphysis and significant restriction of motion. We present the case of a 9-year-old female diagnosed with hip chondrolysis associated with probable juvenile psoriatic arthritis. Avoidance of weight bearing activities and treatment with corticosteroids, methotrexate, and adalimumab followed by aquatic therapy resulted in clinical and radiographic improvement as well as partial cartilage regeneration.
    Sprache Englisch
    Erscheinungsdatum 2022-03-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2472-5625
    ISSN (online) 2472-5625
    DOI 10.1093/mrcr/rxac024
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  4. Artikel ; Online: Tailored treatment strategies and future directions in systemic lupus erythematosus.

    Nikolopoulos, Dionysis / Fotis, Lampros / Gioti, Ourania / Fanouriakis, Antonis

    Rheumatology international

    2022  Band 42, Heft 8, Seite(n) 1307–1319

    Abstract: Systemic lupus erythematosus (SLE) represents a diagnostic and therapeutic challenge for physicians due to its protean manifestations and unpredictable course. The disease may manifest as multisystemic or organ-dominant and severity at presentation may ... ...

    Abstract Systemic lupus erythematosus (SLE) represents a diagnostic and therapeutic challenge for physicians due to its protean manifestations and unpredictable course. The disease may manifest as multisystemic or organ-dominant and severity at presentation may vary according to age at onset (childhood-, adult- or late-onset SLE). Different manifestations may respond variably to different immunosuppressive medications and, even within the same organ-system, the severity of inflammation may vary from mild to organ-threatening. Current "state-of-the-art" in SLE treatment aims at remission or low disease activity in all organ systems. Apart from hydroxychloroquine and glucocorticoids (which should be used with caution), the choice of the appropriate immunosuppressive agent should be individualized and depend on the prevailing manifestation, severity stratification and patient childbearing potential. In this review, we provide an overview of therapeutic options for the various organ manifestations and severity patterns of the disease, different phenotypes (such as multisystem versus organ-dominant disease), as well as specific considerations, including lupus with antiphospholipid antibodies, childhood and late-onset disease, as well as treatment options during pregnancy and lactation.
    Mesh-Begriff(e) Antibodies, Antiphospholipid ; Female ; Glucocorticoids/therapeutic use ; Humans ; Hydroxychloroquine/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy
    Chemische Substanzen Antibodies, Antiphospholipid ; Glucocorticoids ; Immunosuppressive Agents ; Hydroxychloroquine (4QWG6N8QKH)
    Sprache Englisch
    Erscheinungsdatum 2022-04-21
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-022-05133-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Erythromelalgia in an Adolescent Female.

    Mamatsi, Eleftheria / Giorgi, Melpomeni / Dinopoulos, Argirios / Papaevangelou, Vasiliki / Fotis, Lampros

    Mediterranean journal of rheumatology

    2022  Band 33, Heft 2, Seite(n) 256–258

    Abstract: Erythromelalgia is a disabling syndrome of paroxysmal vasodilation affecting the feet, hands and face characterised by patient's cooling behaviour to achieve symptom relief. It can be primary or secondary and although a rare disorder it has been ... ...

    Abstract Erythromelalgia is a disabling syndrome of paroxysmal vasodilation affecting the feet, hands and face characterised by patient's cooling behaviour to achieve symptom relief. It can be primary or secondary and although a rare disorder it has been described in children and adolescents. We describe the case of a 14-year-old female diagnosed with primary erythromelalgia successfully treated with aspirin, amitriptyline, and carbamazepine.
    Sprache Englisch
    Erscheinungsdatum 2022-06-30
    Erscheinungsland Greece
    Dokumenttyp Case Reports
    ZDB-ID 3019943-8
    ISSN 2529-198X ; 2459-3516
    ISSN (online) 2529-198X
    ISSN 2459-3516
    DOI 10.31138/mjr.33.2.256
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  6. Artikel: Janus Kinase Inhibitors and Interstitial Lung Disease Associated With Pediatric Rheumatic Diseases: An Unexplored Field.

    Sapountzi, Evdoxia / Fotis, Lampros / Kotanidou, Eleni / Fidani, Liana / Galli-Tsinopoulou, Assimina

    Cureus

    2023  Band 15, Heft 12, Seite(n) e50928

    Abstract: Rheumatic diseases are often complicated by lung disease, commonly presenting as interstitial lung disease (ILD), with potentially detrimental consequences for patient survival. Although less frequent in pediatric patients, pulmonary involvement may be ... ...

    Abstract Rheumatic diseases are often complicated by lung disease, commonly presenting as interstitial lung disease (ILD), with potentially detrimental consequences for patient survival. Although less frequent in pediatric patients, pulmonary involvement may be observed in almost all childhood-onset rheumatic conditions. The development of biological disease-modifying anti-rheumatic drugs has significantly improved clinical outcomes. However, disease remission is not always complete or long-lasting, and treatment may need to be discontinued due to adverse effects. A novel class of drugs, namely Janus kinase inhibitors (JAKis), has been proposed to provide a significant survival benefit for patients with rheumatic diseases. Despite the ample literature on the efficacy and safety of JAKis in rheumatic disease, only a few studies have investigated the effectiveness of these drugs in patients with pulmonary involvement, and only two case reports have presented results in pediatric patients. We provide an overview of the rationale for using JAKis in ILDs associated with rheumatic disease and summarize the main studies evaluating their efficacy in both adult and pediatric patients. The present review highlights the need for controlled long-term studies to assess the efficacy and safety of JAKis in pediatric rheumatic disease complicated by lung disease.
    Sprache Englisch
    Erscheinungsdatum 2023-12-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.50928
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  7. Artikel ; Online: Facial necrotic ulcerative lesions in an adolescent female with granulomatosis with polyangiitis (GPA).

    Fotis, Lampros / Prountzos, Spyridon / Giannouli, Georgia / Papaevangelou, Vassiliki

    Clinical rheumatology

    2020  Band 39, Heft 11, Seite(n) 3519–3520

    Mesh-Begriff(e) Adolescent ; Antibodies, Antineutrophil Cytoplasmic ; Female ; Granulomatosis with Polyangiitis/complications ; Humans ; Necrosis
    Chemische Substanzen Antibodies, Antineutrophil Cytoplasmic
    Sprache Englisch
    Erscheinungsdatum 2020-07-01
    Erscheinungsland Germany
    Dokumenttyp Editorial
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-020-05264-4
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  8. Artikel ; Online: Colchicine-Induced Macrophage Activation Syndrome in an Adolescent Female Patient With PSTPIP1-Associated Myeloid-Related Proteinemia Inflammatory Syndrome.

    Fotis, Lampros / Kekkou, Kassiani / Papaevangelou, Vassiliki / Fessatou, Smaragdi

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2020  Band 27, Heft 8S, Seite(n) S409–S410

    Mesh-Begriff(e) Adaptor Proteins, Signal Transducing/genetics ; Adolescent ; Colchicine/adverse effects ; Cytoskeletal Proteins/genetics ; Female ; Humans ; Macrophage Activation Syndrome/chemically induced ; Macrophage Activation Syndrome/diagnosis ; Metal Metabolism, Inborn Errors/genetics
    Chemische Substanzen Adaptor Proteins, Signal Transducing ; Cytoskeletal Proteins ; PSTPIP1 protein, human ; Colchicine (SML2Y3J35T)
    Sprache Englisch
    Erscheinungsdatum 2020-11-05
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000001407
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  9. Artikel: Whole-body magnetic resonance imaging findings and patterns of chronic nonbacterial osteomyelitis in a series of Greek pediatric patients.

    Papakonstantinou, Olympia / Prountzos, Spyridon / Karavasilis, Eustratios / Atsali, Erato / Bizimi, Vasiliki / Alexopoulou, Efthymia / Fotis, Lampros

    Acta radiologica open

    2022  Band 11, Heft 6, Seite(n) 20584601221106701

    Abstract: Background: Chronic nonbacterial osteomyelitis (CNO) is a pediatric autoinflammatory disorder presenting with sterile inflammatory bone lesions. Whole-body MRI (WBMRI) has most recently emerged for disease assessment, but data are limited.: Purpose: ... ...

    Abstract Background: Chronic nonbacterial osteomyelitis (CNO) is a pediatric autoinflammatory disorder presenting with sterile inflammatory bone lesions. Whole-body MRI (WBMRI) has most recently emerged for disease assessment, but data are limited.
    Purpose: The purpose is to evaluate the imaging findings and patterns of CNO on WBMRI in a series of Greek pediatric patients.
    Material and methods: Whole-body magnetic resonance imaging studies of all children with documented CNO, performed in a single tertiary center, were retrospectively reviewed. WBMRI included coronal T1 and short-tau inversion recovery (STIR), whole spine sagittal STIR, and ankle/foot sagittal STIR images. High signal intensity lesions on STIR images corresponding to bone marrow edema were recorded. The SPSS v.20 statistical package was used for descriptive statistics.
    Results: Twenty children were included (mean age: 12, range: 6-16 years) with 1-31 lesions (mean: 11.8) on WBMRI. Two children had unifocal disease localized at the clavicle, three paucifocal (1-4 lesions), and 15 multifocal bone involvement. All but two children presented with ankle pain and exhibited lesions at the bones of the ankle joint (90%) followed by the knee (50%) and pelvis (10%). The tibia was the most frequently affected bone (70%) followed by calcaneus (60%), fibula (50%), femur (45%), talus, and metatarsals (45%). No lesions in the cervical, thoracic, lumbar spine, and mandible were documented. Only small sacral lesions were seen in 25% of patients with the extensive peripheral disease. Bilateral metaphyseal and epiphyseal involvement with transphyseal extension were common, but the periosteal reaction and well-defined lesion margins were rare.
    Conclusion: Frequent involvement of the foot and ankle and paucity of substantial spinal involvement were seen in Greek pediatric patients with CNO.
    Sprache Englisch
    Erscheinungsdatum 2022-06-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2818429-4
    ISSN 2058-4601
    ISSN 2058-4601
    DOI 10.1177/20584601221106701
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  10. Artikel ; Online: Takayasu arteritis in an adolescent with Crohn's disease.

    Fotis, Lampros / Kourti, Afroditi / Prountzos, Spyridon / Alexopoulou, Efthymia / Papaevangelou, Vasiliki / Fessatou, Smaragdi

    Rheumatology international

    2021  Band 42, Heft 3, Seite(n) 563–570

    Abstract: Crohn's disease (CD) and Takayasu arteritis (TA) are two distinct clinical entities. Τhe likelihood of both diseases coexisting is low, and although CD co-occurs with all types of vasculitis, TA is the most common subtype. Herein, the case of a 15-year- ... ...

    Abstract Crohn's disease (CD) and Takayasu arteritis (TA) are two distinct clinical entities. Τhe likelihood of both diseases coexisting is low, and although CD co-occurs with all types of vasculitis, TA is the most common subtype. Herein, the case of a 15-year-old female, diagnosed with TA following an initial diagnosis of CD, is reported. A review of the literature, including a systemic review of the case reports and case series of children and adolescents up to the age of 21, with both CD and TA, follows the case description. In total, 28 cases of TA and CD were retrieved. The median age of patients was 14.8 years, they were mostly females (72%) and the median time between the two diagnoses was 3.7 years. In the majority of cases, CD was diagnosed first and TA followed. Computed tomography angiography and magnetic resonance angiography were the preferred imaging modalities to assist diagnosis.
    Mesh-Begriff(e) Adolescent ; Child ; Crohn Disease/complications ; Crohn Disease/diagnostic imaging ; Crohn Disease/pathology ; Female ; Humans ; Magnetic Resonance Imaging ; Takayasu Arteritis/complications ; Takayasu Arteritis/diagnostic imaging ; Takayasu Arteritis/pathology ; Tomography, X-Ray Computed
    Sprache Englisch
    Erscheinungsdatum 2021-04-27
    Erscheinungsland Germany
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-021-04869-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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