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  1. Buch: Peafowl

    Gardiner, Tom P.

    their conservation, breeding and management

    1996  

    Verfasserangabe T. P. Gardiner
    Schlagwörter Pfau ; Vogelhaltung ; Vogelzucht ; Kongopfau ; Vogelschutz
    Schlagwörter Vögel ; Pavo ; Afropavo congensis ; Blauer Pfau ; Pavo cristatus ; Vögelhaltung
    Umfang XV, 87 S. : zahlr. Ill., graph. Darst.
    Verlag World Pheasant Assoc
    Erscheinungsort Reading
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT007836366
    ISBN 0-906864-30-5 ; 978-0-906864-30-2
    Datenquelle Katalog ZB MED Ernährung, Umwelt, Agrar

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    Verfügbar in ZB MED Bonn

    SignaturLeihstatusStandort
    974/937 ausleihbar (Lesesaal) Freihandmagazin (U1)

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  2. Artikel ; Online: Comparative Assessment of Methane Emissions from Onshore LNG Facilities Measured Using Differential Absorption Lidar.

    Innocenti, Fabrizio / Robinson, Rod / Gardiner, Tom / Howes, Neil / Yarrow, Nigel

    Environmental science & technology

    2023  Band 57, Heft 8, Seite(n) 3301–3310

    Abstract: This study provides results from measurements of methane emissions from three onshore LNG liquefaction facilities and two regasification facilities across different regions using the Differential Absorption Lidar (DIAL) technique. The measurement ... ...

    Abstract This study provides results from measurements of methane emissions from three onshore LNG liquefaction facilities and two regasification facilities across different regions using the Differential Absorption Lidar (DIAL) technique. The measurement approach was to quantify, at each facility, emissions from the key functional elements (FEs), defined as spatially separable areas related to different identified processes. The DIAL technique enabled quantification of emissions at the FE level, allowing emission factors (EFs) to be determined for each FE using activity data. The comprehensive data set presented here should not be used for annualization, however shows the potential of what could be achieved with a larger sample size in terms of potential methane reduction and improving inventory accuracy. Among the benefits in obtaining data with this level of granularity is the possibility to compare the emissions of similar FEs on different plants including FEs present in both liquefaction and regasification facilities. Emissions from noncontinuous sources and superemitters can also be identified and quantified enabling more accurate inventory reporting and targeted maintenance and repair. Site throughput during the measurement periods was used to characterize total site EF; on average the methane losses were 0.018% and 0.070% of throughput at the regasification and liquefaction facilities, respectively.
    Mesh-Begriff(e) Methane/analysis ; Air Pollutants/analysis ; Natural Gas/analysis
    Chemische Substanzen Methane (OP0UW79H66) ; Air Pollutants ; Natural Gas
    Sprache Englisch
    Erscheinungsdatum 2023-02-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.2c05446
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Pericyte and Vascular Smooth Muscle Death in Diabetic Retinopathy Involves Autophagy

    Tom A. Gardiner / Alan W. Stitt

    International Journal of Translational Medicine, Vol 2, Iss 3, Pp 26-

    2022  Band 40

    Abstract: Diabetic retinopathy (DR) is the most common complication of diabetes and a major cause of vision loss worldwide. The premature death of the microvascular mural cells represents both a pathological hallmark of vasodegeneration in DR and a basis for ... ...

    Abstract Diabetic retinopathy (DR) is the most common complication of diabetes and a major cause of vision loss worldwide. The premature death of the microvascular mural cells represents both a pathological hallmark of vasodegeneration in DR and a basis for therapeutic intervention to halt progression to the sight-threatening stages. Recent studies suggest that retinal microvascular mural cells, classed as pericytes in the capillaries and vascular smooth muscle cells in the larger vessels (VSMC), may undergo autophagy-dependent cell death during DR. The present investigation was undertaken to assess electron microscopic evidence for involvement of autophagy in mediation of cell death in the mural cells of the retinal vasculature, in eyes from human diabetic donors and diabetic dogs. All specimens examined showed widespread evidence of autophagosomes in processes of viable pericytes and VSMCs, and the membranous remnants of excessive autophagic activity in their “ghost cell” remnants within the vascular walls. Autophagy was termed “excessive” when it occupied the greater part of the cytoplasm in mural cell processes. This was notable in specimens from short-term diabetic donors with no evidence of basement-membrane thickening or mural cell loss, in which regions of mural cell cytoplasm filled with autophagic bodies appeared to be undergoing cytoplasmic cleavage. No equivalent evidence of autophagy was detected in the adjacent endothelial cells of the retinal vessels. We conclude that increased autophagy in the retinal pericytes and VSMCs is linked to the diabetic milieu, and over time may also act as a trigger for mural cell loss and progressive vasodegeneration.
    Schlagwörter retina ; diabetic retinopathy ; pericytes ; vascular smooth muscle ; autophagy ; Computer applications to medicine. Medical informatics ; R858-859.7
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Uncertainty Assessment of Differential Absorption Lidar Measurements of Industrial Emissions Concentrations

    Fabrizio Innocenti / Tom Gardiner / Rod Robinson

    Remote Sensing, Vol 14, Iss 4291, p

    2022  Band 4291

    Abstract: Differential absorption lidar (DIAL) has been shown to be a very effective technique for the location and quantification of emissions of pollutants and greenhouse gases at industrial facilities. Several field trials have demonstrated the DIAL system ... ...

    Abstract Differential absorption lidar (DIAL) has been shown to be a very effective technique for the location and quantification of emissions of pollutants and greenhouse gases at industrial facilities. Several field trials have demonstrated the DIAL system performances and contributed to the development of the DIAL methodology, which is the basis of the protocols described in the European Standard EN 17628. While numerous papers have focused on different aspects of DIAL uncertainties, a rigorous propagation of the uncertainties in the DIAL equation has not been found. In this study, all the uncertainty sources contributing to a DIAL concentration measurement are assessed and the impact they have on the calculation of the mass emission rate. We derive the equations for both a DIAL system path-concentration integral and concentration uncertainties. The results from a methane measurement are presented, showing that for a signal to noise ratio on the backscattered lidar signals of 500, the path-concentration integral standard uncertainty is 2.3 ppb km and the concentration standard uncertainty is 92 ppb over a sampling spacing of 45 m. An equation is also presented enabling calculation of the contribution of the concentration uncertainty to the mass emission rate uncertainty.
    Schlagwörter DIAL ; industrial pollutants ; GHG ; methane ; uncertainty ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: BH4 supplementation reduces retinal cell death in ischaemic retinopathy.

    Edgar, Kevin S / Cunning, Ciara / Gardiner, Tom A / McDonald, Denise M

    Scientific reports

    2023  Band 13, Heft 1, Seite(n) 21292

    Abstract: Dysregulation of nitric oxide (NO) production can cause ischaemic retinal injury and result in blindness. How this dysregulation occurs is poorly understood but thought to be due to an impairment in NO synthase function (NOS) and nitro-oxidative stress. ... ...

    Abstract Dysregulation of nitric oxide (NO) production can cause ischaemic retinal injury and result in blindness. How this dysregulation occurs is poorly understood but thought to be due to an impairment in NO synthase function (NOS) and nitro-oxidative stress. Here we investigated the possibility of correcting this defective NOS activity by supplementation with the cofactor tetrahydrobiopterin, BH
    Mesh-Begriff(e) Mice ; Animals ; Biopterins/metabolism ; Retinal Diseases/drug therapy ; Nitric Oxide/metabolism ; Cell Death ; Dietary Supplements ; Ischemia/drug therapy
    Chemische Substanzen Biopterins ; Nitric Oxide (31C4KY9ESH)
    Sprache Englisch
    Erscheinungsdatum 2023-12-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-48167-5
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  6. Artikel ; Online: Radiation and Diabetic Retinopathy

    Tom A. Gardiner / Desmond B. Archer / Giuliana Silvestri / Winfried M. Amoaku

    International Journal of Translational Medicine, Vol 3, Iss 11, Pp 120-

    A Dark Synergy

    2023  Band 159

    Abstract: Exacerbation of the vascular pathology in radiation retinopathy as a result of pre-existing diabetes has been recognized for many years, as reflected by clinical reports and a few early experimental studies. However, the underlying pathogenetic ... ...

    Abstract Exacerbation of the vascular pathology in radiation retinopathy as a result of pre-existing diabetes has been recognized for many years, as reflected by clinical reports and a few early experimental studies. However, the underlying pathogenetic mechanisms for the synergistic interaction of radiation retinopathy (RR) and diabetic retinopathy (DR) have not been compared and evaluated for insight on this phenomenon. The present work draws attention to the roles of reactive oxygen species (ROS) and reactive nitrogen species (RNS) as common mediators of both conditions and sources of ongoing cellular injury in the radiation-induced bystander effect (RIBE) and the senescence-associated secretory phenotype (SASP). Chronic hyperglycemia-mediated oxidative stress and depleted antioxidant defense in diabetes, together with impaired DNA damage sensing and repair mechanisms, were identified as the primary elements contributing to the increased severity of RR in diabetic patients. We conclude that apart from strategic genetic mutations affecting the DNA damage response (DDR), diabetes represents the most significant common risk factor for vascular injury as a side effect of radiotherapy.
    Schlagwörter retina ; retinal vasculature ; ionizing radiation ; diabetes ; radiation retinopathy ; diabetic retinopathy ; Computer applications to medicine. Medical informatics ; R858-859.7
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: BH4 supplementation reduces retinal cell death in ischaemic retinopathy

    Kevin S. Edgar / Ciara Cunning / Tom A. Gardiner / Denise M. McDonald

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Band 19

    Abstract: Abstract Dysregulation of nitric oxide (NO) production can cause ischaemic retinal injury and result in blindness. How this dysregulation occurs is poorly understood but thought to be due to an impairment in NO synthase function (NOS) and nitro-oxidative ...

    Abstract Abstract Dysregulation of nitric oxide (NO) production can cause ischaemic retinal injury and result in blindness. How this dysregulation occurs is poorly understood but thought to be due to an impairment in NO synthase function (NOS) and nitro-oxidative stress. Here we investigated the possibility of correcting this defective NOS activity by supplementation with the cofactor tetrahydrobiopterin, BH4. Retinal ischaemia was examined using the oxygen-induced retinopathy model and BH4 deficient Hph-1 mice used to establish the relationship between NOS activity and BH4. Mice were treated with the stable BH4 precursor sepiapterin at the onset of hypoxia and their retinas assessed 48 h later. HPLC analysis confirmed elevated BH4 levels in all sepiapterin supplemented groups and increased NOS activity. Sepiapterin treatment caused a significant decrease in neuronal cell death in the inner nuclear layer that was most notable in WT animals and was associated with significantly diminished superoxide and local peroxynitrite formation. Interestingly, sepiapterin also increased inflammatory cytokine levels but not microglia cell number. BH4 supplementation by sepiapterin improved both redox state and neuronal survival during retinal ischaemia, in spite of a paradoxical increase in inflammatory cytokines. This implicates nitro-oxidative stress in retinal neurones as the cytotoxic element in ischaemia, rather than enhanced pro-inflammatory signalling.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel: Uncertainty Assessment of Differential Absorption Lidar Measurements of Industrial Emissions Concentrations

    Innocenti, Fabrizio / Gardiner, Tom / Robinson, Rod

    Remote Sensing. 2022 Aug. 31, v. 14, no. 17

    2022  

    Abstract: Differential absorption lidar (DIAL) has been shown to be a very effective technique for the location and quantification of emissions of pollutants and greenhouse gases at industrial facilities. Several field trials have demonstrated the DIAL system ... ...

    Abstract Differential absorption lidar (DIAL) has been shown to be a very effective technique for the location and quantification of emissions of pollutants and greenhouse gases at industrial facilities. Several field trials have demonstrated the DIAL system performances and contributed to the development of the DIAL methodology, which is the basis of the protocols described in the European Standard EN 17628. While numerous papers have focused on different aspects of DIAL uncertainties, a rigorous propagation of the uncertainties in the DIAL equation has not been found. In this study, all the uncertainty sources contributing to a DIAL concentration measurement are assessed and the impact they have on the calculation of the mass emission rate. We derive the equations for both a DIAL system path-concentration integral and concentration uncertainties. The results from a methane measurement are presented, showing that for a signal to noise ratio on the backscattered lidar signals of 500, the path-concentration integral standard uncertainty is 2.3 ppb km and the concentration standard uncertainty is 92 ppb over a sampling spacing of 45 m. An equation is also presented enabling calculation of the contribution of the concentration uncertainty to the mass emission rate uncertainty.
    Schlagwörter absorption ; equations ; greenhouses ; lidar ; methane ; signal-to-noise ratio ; uncertainty
    Sprache Englisch
    Erscheinungsverlauf 2022-0831
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs14174291
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Safe Sampling Volume determinations of 12 volatile organic compounds on Carboxen 1003, Carbopack-X & Tenax-TA.

    Butterfield, David M / Lipscombe, Robert P / Gardiner, Tom D

    Journal of chromatography. A

    2020  Band 1626, Seite(n) 461369

    Abstract: Pumped sorbent tube sampling is a well established method for the sampling of volatile organic compounds (VOCs) and semi volatile organic compounds (SVOCs) in ambient, indoor and workplace ... ...

    Abstract Pumped sorbent tube sampling is a well established method for the sampling of volatile organic compounds (VOCs) and semi volatile organic compounds (SVOCs) in ambient, indoor and workplace atmospheres
    Mesh-Begriff(e) Adsorption ; Air Pollution, Indoor/analysis ; Aldehydes/chemistry ; Chromatography, Gas/methods ; Environmental Monitoring ; Furans/chemistry ; Polymers/chemistry ; Volatile Organic Compounds/analysis ; Volatile Organic Compounds/chemistry
    Chemische Substanzen Aldehydes ; Furans ; Polymers ; Volatile Organic Compounds ; tenax (24938-68-9) ; isovalerylaldehyde (69931RWI96) ; furan (UC0XV6A8N9)
    Sprache Englisch
    Erscheinungsdatum 2020-06-24
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2020.461369
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  10. Artikel ; Online: Racial and ethnic health disparities in healthcare settings.

    Gardiner, Tom / Abraham, Sonya / Clymer, Olivia / Rao, Mala / Gnani, Shamini

    BMJ (Clinical research ed.)

    2021  Band 372, Seite(n) n605

    Mesh-Begriff(e) COVID-19/epidemiology ; COVID-19/ethnology ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; Clinical Trials as Topic/statistics & numerical data ; Community Participation/statistics & numerical data ; Continental Population Groups/statistics & numerical data ; Culturally Competent Care/organization & administration ; Culturally Competent Care/statistics & numerical data ; Ethnic Groups/statistics & numerical data ; Health Services Research/organization & administration ; Health Services Research/statistics & numerical data ; Health Status Disparities ; Healthcare Disparities/ethnology ; Humans ; Minority Groups/statistics & numerical data ; Patient Selection ; United Kingdom/epidemiology
    Chemische Substanzen COVID-19 Vaccines
    Sprache Englisch
    Erscheinungsdatum 2021-03-08
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n605
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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