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  1. AU=Georgiev Tsvetoslav
  2. AU="Donahue, James M"
  3. AU="Aierken, Kaibinuer"
  4. AU=Shafiabadi Hassani Neda
  5. AU="Makoto Taiji"
  6. AU="Frierson, Henry F"
  7. AU="Laursen, Sisse H"
  8. AU=Ribeiro Ribeiro Andre Luis
  9. AU="Young, Jason"
  10. AU="F Rustad, Cecilie"
  11. AU="Merve Kayhan"
  12. AU="Rondini, Ermanno"
  13. AU="Koprivová Herotová, Tereza"
  14. AU="Schmidt, Ellen M"
  15. AU="Sandya R Kesoju"
  16. AU="Goss, Dale M"
  17. AU="Jeanes, Christopher"
  18. AU="Jeyanathan, Jeyamalar"
  19. AU="Tara Kenny"
  20. AU="Harrison, Clare"
  21. AU=Cao Jing
  22. AU="Amado-Rodríguez, Laura"
  23. AU="Di Centa, Isabelle"
  24. AU="Park, Kwon N"
  25. AU="Obayashi, Kenichi"
  26. AU="Gharib, Heba Said Abdel-Rahman"
  27. AU="Piqueras-Flores, Jesus"
  28. AU="Tejal Shah"
  29. AU="Dasgupta, A."
  30. AU="Asad M. Iqbal"
  31. AU="Pengermä, Pasi"
  32. AU="Cheung, Cherry Tin Yan"

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  1. Artikel ; Online: Coronavirus disease 2019 (COVID-19) and anti-rheumatic drugs.

    Georgiev, Tsvetoslav

    Rheumatology international

    2020  Band 40, Heft 5, Seite(n) 825–826

    Mesh-Begriff(e) Adrenal Cortex Hormones/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/immunology ; Betacoronavirus ; COVID-19 ; Chloroquine/therapeutic use ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Humans ; Interleukin-6/immunology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; Viral Load
    Chemische Substanzen Adrenal Cortex Hormones ; Antirheumatic Agents ; Interleukin-6 ; Chloroquine (886U3H6UFF)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-03-30
    Erscheinungsland Germany
    Dokumenttyp Letter
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-020-04570-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Clinical characteristics and disability in patients with knee osteoarthritis

    Tsvetoslav Georgiev

    Rheumatology, Vol 57, Iss 2, Pp 78-

    real world experience from Bulgaria

    2019  Band 84

    Schlagwörter quality of life ; disability ; self-esteem ; knee osteoarthritis ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2019-04-01T00:00:00Z
    Verlag Termedia Publishing House
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Multimodal approach to intraarticular drug delivery in knee osteoarthritis.

    Georgiev, Tsvetoslav

    Rheumatology international

    2020  Band 40, Heft 11, Seite(n) 1763–1769

    Abstract: The expectations from any future disease-modifying treatment for knee osteoarthritis (KOA) are extremely high as it has to impact the joint as a whole leading to favorable alterations of diverse tissues and functions. In this light, targeting the knee ... ...

    Abstract The expectations from any future disease-modifying treatment for knee osteoarthritis (KOA) are extremely high as it has to impact the joint as a whole leading to favorable alterations of diverse tissues and functions. In this light, targeting the knee only from the inside may not be biologically justified for the management of a whole joint disease such as KOA. Our hypothesis to test is whether any injectable therapeutic intervention alone can lead to disease modification of KOA which is viewed in the complexity of the modern concept of osteoarthritis (OA) as a whole joint disease. Therefore, we aimed at analyzing the intraarticular route to the KOA patient in an attempt to unveil its "biological" constraints. A comprehensive search through databases was carried out using specific keywords to add objectivity to the main messages. The literature analysis has shown that "cutting-edge" intraarticular therapies may offer a key to non-invasive symptomatic relief. Changing the course of KOA, however, may necessitate a multimodal approach towards the knee joint including a combination of intraarticular injections with interventions on multiple levels. Importantly, our understanding of OA has evolved redefining the concept of the disease, being in interaction with the human body as a whole. Any future conservative disease-modifying treatment of KOA should aim at a multimodal, holistic approach towards the knee joint including but not limited only to intraarticular injections. A combination with other interventions should be further researched.
    Mesh-Begriff(e) Arthroplasty, Replacement, Knee ; Genetic Therapy/methods ; Humans ; Hyaluronic Acid/administration & dosage ; Injections, Intra-Articular ; Mesenchymal Stem Cell Transplantation/methods ; Molecular Targeted Therapy ; Osteoarthritis, Knee/therapy ; Platelet-Rich Plasma ; Viscosupplements/administration & dosage
    Chemische Substanzen Viscosupplements ; Hyaluronic Acid (9004-61-9)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-16
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-020-04681-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Coronavirus disease 2019 (COVID-19) and anti-rheumatic drugs

    Georgiev, Tsvetoslav

    Rheumatology International

    2020  Band 40, Heft 5, Seite(n) 825–826

    Schlagwörter Immunology ; Immunology and Allergy ; Rheumatology ; covid19
    Sprache Englisch
    Verlag Springer Science and Business Media LLC
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-020-04570-z
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: Clinical characteristics and disability in patients with knee osteoarthritis: real world experience from Bulgaria.

    Georgiev, Tsvetoslav

    Reumatologia

    2019  Band 57, Heft 2, Seite(n) 78–84

    Abstract: Objectives: Although knee osteoarthritis (KOA) is a leading cause of impaired functioning among older adults globally, little is still known about the complex mechanisms of disability accumulation in these patients. The aim of the study was to analyze ... ...

    Abstract Objectives: Although knee osteoarthritis (KOA) is a leading cause of impaired functioning among older adults globally, little is still known about the complex mechanisms of disability accumulation in these patients. The aim of the study was to analyze the clinical parameters of patients with KOA in a Bulgarian population and to determine which of these clinical characteristics define disability to the greatest extent.
    Material and methods: Patients aged 40-80 years with symptomatic KOA were included. The assessment tools for pain, clinical disease severity, and disability were the pain visual analogue scale (VAS) and disease-specific questionnaires: Algofunctional Index of Lequesne, Western Ontario and McMaster Universities OA Index (WOMAC), and the Health Assessment Questionnaire-Disability Index (HAQ-DI), respectively. Radiographs of the knees were obtained and graded according to the Kellgren-Lawrence (KL) system.
    Results: One hundred and thirty-two patients (81% women) participated in the study. The median values of VAS (mm), WOMAC, Lequesne, and HAQ-DI scores were 52, 37.5, 11, 0.88, respectively. Men had milder disease, resulting in lower VAS, WOMAC, Lequesne, and HAQ-DI scores and less structural damage compared to women (
    Conclusions: Bulgarian patients with KOA had moderate disability which showed a strong relationship with physical function of WOMAC and disease severity. Multiple layers of causality coexist to determine the knee pain in Bulgarian patients with KOA.
    Sprache Englisch
    Erscheinungsdatum 2019-04-29
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 604151-6
    ISSN 0034-6233
    ISSN 0034-6233
    DOI 10.5114/reum.2019.84812
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Multimodal approach to intraarticular drug delivery in knee osteoarthritis

    Georgiev, Tsvetoslav

    Rheumatol.Int

    Abstract: The expectations from any future disease-modifying treatment for knee osteoarthritis (KOA) are extremely high as it has to impact the joint as a whole leading to favorable alterations of diverse tissues and functions. In this light, targeting the knee ... ...

    Abstract The expectations from any future disease-modifying treatment for knee osteoarthritis (KOA) are extremely high as it has to impact the joint as a whole leading to favorable alterations of diverse tissues and functions. In this light, targeting the knee only from the inside may not be biologically justified for the management of a whole joint disease such as KOA. Our hypothesis to test is whether any injectable therapeutic intervention alone can lead to disease modification of KOA which is viewed in the complexity of the modern concept of osteoarthritis (OA) as a whole joint disease. Therefore, we aimed at analyzing the intraarticular route to the KOA patient in an attempt to unveil its "biological" constraints. A comprehensive search through databases was carried out using specific keywords to add objectivity to the main messages. The literature analysis has shown that "cutting-edge" intraarticular therapies may offer a key to non-invasive symptomatic relief. Changing the course of KOA, however, may necessitate a multimodal approach towards the knee joint including a combination of intraarticular injections with interventions on multiple levels. Importantly, our understanding of OA has evolved redefining the concept of the disease, being in interaction with the human body as a whole. Any future conservative disease-modifying treatment of KOA should aim at a multimodal, holistic approach towards the knee joint including but not limited only to intraarticular injections. A combination with other interventions should be further researched.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #32803403
    Datenquelle COVID19

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  8. Artikel ; Online: Vascular effects of biologic and targeted synthetic antirheumatic drugs approved for rheumatoid arthritis: a systematic review.

    Gerganov, Georgi / Georgiev, Tsvetoslav / Dimova, Maria / Shivacheva, Tanya

    Clinical rheumatology

    2023  Band 42, Heft 10, Seite(n) 2651–2676

    Abstract: Background: Rheumatoid arthritis (RA) increases the risk of cardiovascular disease (CVD), with inflammation playing a key role. Biologic and targeted synthetic drugs used to treat RA can induce systemic immunomodulation and may have pleiotropic effects ... ...

    Abstract Background: Rheumatoid arthritis (RA) increases the risk of cardiovascular disease (CVD), with inflammation playing a key role. Biologic and targeted synthetic drugs used to treat RA can induce systemic immunomodulation and may have pleiotropic effects on vascular function, making it crucial to investigate their impact on CVD risk in RA patients.
    Methods: A systematic review of the literature was conducted to investigate the impact of biologic and targeted synthetic treatments approved for RA on various cardiovascular markers, including endothelial function, arterial stiffness, and subclinical atherosclerosis. Our analysis included a search of the MedLine (via PubMed) and Web of Science databases using a pre-determined search strategy. We conducted a narrative synthesis of the included studies due to heterogeneity in study design and outcome measures.
    Results: From an initial pool of 647 records, we excluded 327 studies based on their titles and abstracts, and we selected 182 studies for final examination. Ultimately, 58 articles met our inclusion criteria and were included in our systematic review. Our analysis of these studies revealed a positive effect of biologic and targeted synthetic therapies on vascular dysfunction associated with RA. However, the impact of these treatments on subclinical atherosclerosis was inconsistent.
    Conclusion: Overall, our systematic review provides important insights into the potential cardiovascular benefits of biologic and targeted synthetic treatments for RA by a still unknown mechanism. These findings can inform clinical practice and contribute to our understanding of their possible effects on early vascular pathology. Key Points • Great heterogeneity of methods are used to evaluate the endothelial function and arterial stiffness in patients with RA on biologic and targeted synthetic antirheumatic drugs. • Most studies have shown a considerable improvement in endothelial function and arterial stiffness with TNFi, despite some studies reporting only transient or no improvement. • Anakinra and tocilizumab may have a beneficial effect on vascular function and endothelial injury, as indicated by increased FMD, coronary flow reserve, and reduced levels of biomarkers of endothelial function, while the overall impact of JAKi and rituximab remains inconclusive based on the reviewed studies. • To fully comprehend the distinctions between biologic therapies, more long-term, well-designed clinical trials are necessary using a homogeneous methodology.
    Mesh-Begriff(e) Humans ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/complications ; Rituximab/therapeutic use ; Biological Products/therapeutic use ; Cardiovascular Diseases/complications
    Chemische Substanzen Antirheumatic Agents ; Rituximab (4F4X42SYQ6) ; Biological Products
    Sprache Englisch
    Erscheinungsdatum 2023-03-30
    Erscheinungsland Germany
    Dokumenttyp Systematic Review ; Journal Article ; Review
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-023-06587-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Takayasu arteritis associated with autoimmune/inflammatory syndrome induced by adjuvants: a case-based review.

    Simeonova, Desislava / Georgiev, Tsvetoslav / Shivacheva, Tanya

    Rheumatology international

    2023  Band 43, Heft 5, Seite(n) 975–981

    Abstract: Takayasu's arteritis (TA) is a chronic granulomatous vasculitis that predominantly affects the aorta and its major branches. Despite advancements in the understanding of the pathogenic pathways of vascular inflammation, the etiology and predisposing ... ...

    Abstract Takayasu's arteritis (TA) is a chronic granulomatous vasculitis that predominantly affects the aorta and its major branches. Despite advancements in the understanding of the pathogenic pathways of vascular inflammation, the etiology and predisposing factors of TA remain to be fully understood. In susceptible individuals, exposure to adjuvants may trigger, unlock or unmask an autoimmune disorder, presenting as non-specific constitutional symptoms or a fully developed autoimmune syndrome such as vasculitis. Here, we hypothesize that TA could be triggered by siliconosis, a subtype of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). ASIA, also known as Shoenfeld syndrome, encompasses a wide range of autoimmune and immune-mediated diseases resulting from dysregulation of the immune response after exposure to agents with adjuvant activity. This case report describes the development of large artery vasculitis, TA, in an individual one year following the placement of silicone breast implants. The patient initially presented with non-specific symptoms, and multiple imaging methods were employed, including ultrasound diagnostics, CT angiography, and 18-fluorodeoxyglucose positron emission tomography/CT. These techniques revealed vasculitic alterations in the carotid arteries and thoracic aorta. Initial treatment with glucocorticosteroids proved ineffective, prompting the addition of steroid-sparing immunosuppressive agents. Due to the distinct clinical symptoms, disease progression, implant-associated fibrosis, and resistance to therapy, the potential involvement of implants in the development of large-vessel vasculitis was considered, and a potential association with ASIA was postulated. Although there is limited evidence to support a direct link between adjuvants and the pathogenesis of TA, similarities in cellular immunity between the two conditions exist. The diagnosis of this complex and potentially debilitating condition requires a comprehensive clinical examination, laboratory evaluation, and instrumental assessment. This will aid in identifying potential contributing factors and ensuring successful treatment.
    Mesh-Begriff(e) Humans ; Takayasu Arteritis/complications ; Takayasu Arteritis/diagnosis ; Takayasu Arteritis/drug therapy ; Positron-Emission Tomography ; Aorta/pathology ; Carotid Arteries/pathology ; Immunosuppressive Agents/adverse effects ; Adjuvants, Immunologic
    Chemische Substanzen Immunosuppressive Agents ; Adjuvants, Immunologic
    Sprache Englisch
    Erscheinungsdatum 2023-03-15
    Erscheinungsland Germany
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-023-05309-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Meteorin-like Protein and Zonulin in Polycystic Ovary Syndrome: Exploring Associations with Obesity, Metabolic Parameters, and Inflammation.

    Kabakchieva, Plamena / Gateva, Antoaneta / Velikova, Tsvetelina / Georgiev, Tsvetoslav / Yamanishi, Kyosuke / Okamura, Haruki / Kamenov, Zdravko

    Biomedicines

    2024  Band 12, Heft 1

    Abstract: Objective: Polycystic ovary syndrome (PCOS) is a prevalent hormonal and metabolic disorder, wherein the adipose tissue and gut microbiome have been demonstrated to contribute to its pathogenesis. This study aims to assess the concentrations of the ... ...

    Abstract Objective: Polycystic ovary syndrome (PCOS) is a prevalent hormonal and metabolic disorder, wherein the adipose tissue and gut microbiome have been demonstrated to contribute to its pathogenesis. This study aims to assess the concentrations of the adipokine, meteorin-like protein (Metrnl) and the protein, zonulin, related to intestine permeability, in individuals with PCOS with a particular emphasis on their relationship with obesity, clinical manifestations, hormonal profiles, and metabolic parameters.
    Methods: A cohort comprising 58 women with PCOS, classified according to the Rotterdam criteria, was enrolled. The study also considered age, body mass index (BMI), and ethnicity-matched controls (
    Results: The Metrnl and zonulin levels exhibited no significant disparity between PCOS patients and controls. Nevertheless, within the entire participant cohort and the PCOS group exclusively, overweight/obese participants demonstrated higher Metrnl concentrations relative to their normal-weight counterparts (
    Conclusion: While Metrnl and zonulin levels do not serve as diagnostic indicators of PCOS, elevated Metrnl concentrations exhibited robust associations with proinflammatory and metabolic irregularities within the PCOS population.
    Sprache Englisch
    Erscheinungsdatum 2024-01-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12010222
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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