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  1. Buch ; Online ; Konferenzbeitrag: Proceedings of the 5th International Symposium on Biological Control of Arthropods

    Mason, Peter G. / Gillespie, David R. / Vincent, Charles

    Langkawi, Malaysia : September 11-15, 2017

    2017  

    Veranstaltung/Kongress International Symposium on Biological Control of Arthropods (5., 2017, Langkawi)
    Verfasserangabe edited by Peter G. Mason, David R. Gillespie and Charles Vincent
    Sprache Englisch
    Umfang 1 Online-Ressource (332 Seiten)
    Verlag CABI
    Erscheinungsort Wallingford ; Boston, MA
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch ; Online ; Konferenzbeitrag
    Anmerkung Open Access
    HBZ-ID HT020561781
    ISBN 9781786394118 ; 1786394111
    DOI 10.1079/9781786394118.0000
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Racial and Geographic Variation of Prenatal Care Coordination Receipt in the State of Wisconsin, 2010-2019.

    Mallinson, David C / Gillespie, Kate H

    Journal of community health

    2024  

    Abstract: Medicaid-funded obstetric care coordination programs supplement prenatal care with tailored services to improve birth outcomes. It is uncertain whether these programs reach populations with elevated risks of adverse birth outcomes-namely non-white, ... ...

    Abstract Medicaid-funded obstetric care coordination programs supplement prenatal care with tailored services to improve birth outcomes. It is uncertain whether these programs reach populations with elevated risks of adverse birth outcomes-namely non-white, highly rural, and highly urban populations. This study evaluates racial and geographic variation in the receipt of Wisconsin Medicaid's Prenatal Care Coordination (PNCC) program during 2010-2019. We sample 250,596 Medicaid-paid deliveries from a cohort of linked Wisconsin birth records and Medicaid claims. We measure PNCC receipt during pregnancy dichotomously (none; any) and categorically (none; assessment/care plan only; service receipt), and we stratify the sample on three maternal characteristics: race/ethnicity, urbanicity of residence county; and region of residence county. We examine annual trends in PNCC uptake and conduct logistic regressions to identify factors associated with assessment or service receipt. Statewide PNCC outreach decreased from 25% in 2010 to 14% in 2019, largely due to the decline in beneficiaries who only receive assessments/care plans. PNCC service receipt was greatest and persistent in Black and Hispanic populations and in urban areas. In contrast, PNCC service receipt was relatively low and shrinking in American Indian/Alaska Native, Asian/Pacific Islander, and white populations and in more rural areas. Additionally, being foreign-born was associated with an increased likelihood of getting a PNCC assessment in Asian/Pacific Islander and Hispanic populations, but we observed the opposite association in Black and white populations. Estimates signal a gap in PNCC receipt among some at-risk populations in Wisconsin, and findings may inform policy to enhance PNCC outreach.
    Sprache Englisch
    Erscheinungsdatum 2024-02-26
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 426631-6
    ISSN 1573-3610 ; 0094-5145
    ISSN (online) 1573-3610
    ISSN 0094-5145
    DOI 10.1007/s10900-024-01338-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: When more is less: heritable gain-of-function chk1 mutations impair human fertility.

    Gillespie, David A

    The FEBS journal

    2022  Band 290, Heft 7, Seite(n) 1719–1724

    Abstract: Heritable loss-of-function mutations in genes encoding key regulators of DNA repair and genome stability can result in degenerative progeroid and/or cancer predisposition syndromes; however, such mutations have never been found to affect the Chk1 protein ...

    Abstract Heritable loss-of-function mutations in genes encoding key regulators of DNA repair and genome stability can result in degenerative progeroid and/or cancer predisposition syndromes; however, such mutations have never been found to affect the Chk1 protein kinase, despite its central role in DNA damage signalling and checkpoint activation. Remarkably, two recent reports now demonstrate that heritable, gain-of-function mutations within the Chk1 C-terminal regulatory domain can cause female infertility in humans. In vitro, oocytes from individuals heterozygous for such mutant Chk1 alleles fail to undergo the first mitotic division after fertilization owing to arrest in G2 phase of the cell cycle. This arrest results from inhibition of the master regulator of mitosis, the cyclin-dependent kinase CDK1, through the same molecular mechanisms that are engaged by activated Chk1 to impose G2 checkpoint arrest in somatic cells bearing DNA damage. Remarkably, the failure of this first zygotic division in heterozygotes in vitro can be rescued through treatment with selective Chk1 inhibitor drugs, allowing development of apparently normal blastocysts and offering hope that a pharmacological solution to this cause of infertility may be possible.
    Mesh-Begriff(e) Female ; Humans ; Checkpoint Kinase 1/genetics ; Checkpoint Kinase 1/metabolism ; DNA Damage ; Fertility/genetics ; G2 Phase Cell Cycle Checkpoints/genetics ; Gain of Function Mutation ; Mutation ; Phosphorylation ; Protein Kinases/genetics ; Protein Kinases/metabolism
    Chemische Substanzen Checkpoint Kinase 1 (EC 2.7.11.1) ; Protein Kinases (EC 2.7.-) ; CHEK1 protein, human (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2022-03-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16415
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: When more is less: heritable gain‐of‐function chk1 mutations impair human fertility

    Gillespie, David A.

    The FEBS Journal. 2023 Apr., v. 290, no. 7 p.1719-1724

    2023  

    Abstract: Heritable loss‐of‐function mutations in genes encoding key regulators of DNA repair and genome stability can result in degenerative progeroid and/or cancer predisposition syndromes; however, such mutations have never been found to affect the Chk1 protein ...

    Abstract Heritable loss‐of‐function mutations in genes encoding key regulators of DNA repair and genome stability can result in degenerative progeroid and/or cancer predisposition syndromes; however, such mutations have never been found to affect the Chk1 protein kinase, despite its central role in DNA damage signalling and checkpoint activation. Remarkably, two recent reports now demonstrate that heritable, gain‐of‐function mutations within the Chk1 C‐terminal regulatory domain can cause female infertility in humans. In vitro, oocytes from individuals heterozygous for such mutant Chk1 alleles fail to undergo the first mitotic division after fertilization owing to arrest in G2 phase of the cell cycle. This arrest results from inhibition of the master regulator of mitosis, the cyclin‐dependent kinase CDK1, through the same molecular mechanisms that are engaged by activated Chk1 to impose G2 checkpoint arrest in somatic cells bearing DNA damage. Remarkably, the failure of this first zygotic division in heterozygotes in vitro can be rescued through treatment with selective Chk1 inhibitor drugs, allowing development of apparently normal blastocysts and offering hope that a pharmacological solution to this cause of infertility may be possible.
    Schlagwörter DNA damage ; DNA repair ; blastocyst ; cyclin-dependent kinase ; female fertility ; gain-of-function mutation ; genome ; heterozygosity ; human fertility ; interphase ; loss-of-function mutation ; mitosis ; mutants ; oocytes
    Sprache Englisch
    Erscheinungsverlauf 2023-04
    Umfang p. 1719-1724.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung REVIEW
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16415
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Buch ; Online ; Konferenzbeitrag: Proceedings of the 5th International Symposium on Biological Control of Arthropods

    Vincent, Charles / Gillespie, David R / Mason, Peter

    2017  

    Schlagwörter Pest control ; Insects (entomology) ; biological control agents ; nonindigenous species ; integrated control ; arthropods ; IPM ; rules ; exotic species ; Third World ; nontarget effects ; weeds ; animals ; pest control ; genotypic variation ; insect pests ; eukaryotes ; nonindigenous organisms ; integrated pest management ; genetic variation ; plant pests ; biocontrol agents ; biological control ; insects ; non-native species ; genetic analysis ; native species ; insect control ; parasitoids ; Developing Countries ; compatibility ; pest insects ; non-indigenous species ; non-native organisms ; genetic diversity ; pests ; species diversity ; weed control ; socioeconomic aspects ; augmentation ; forest pests ; social impact ; Underdeveloped Countries ; pesticides ; plants ; importation ; biocontrol ; pest arthropods ; introduction ; policy ; simulation models ; predators ; introduced organisms ; socioeconomics ; integrated plant protection ; economic impact ; genetic variability ; genotypic variability ; natural enemies ; biological control organisms ; Asia ; exotic organisms ; regulations ; arthropod pests ; parasites ; Hexapoda ; chemical control ; invertebrates ; introduced species ; non-indigenous organisms
    Sprache Englisch
    Umfang 1 electronic resource (332 pages)
    Verlag CABI
    Dokumenttyp Buch ; Online ; Konferenzbeitrag
    Anmerkung English
    HBZ-ID HT030379764
    ISBN 9781786394118 ; 1786394111
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  6. Buch ; Online ; E-Book: Gland-preserving salivary surgery

    Gillespie, M. Boyd / Walvekar, Rohan R. / Schaitkin, Barry M. / Eisele, David W.

    a problem-based approach

    2018  

    Verfasserangabe M. Boyd Gillespie, Rohan R. Walvekar, Barry M. Schaitkin, David W. Eisele editors
    Schlagwörter Medicine ; Otolaryngologic surgery ; Surgery
    Thema/Rubrik (Code) 617.5
    Sprache Englisch
    Umfang 1 Online-Ressource (xv, 267 Seiten), Illustrationen
    Verlag Springer
    Erscheinungsort Cham
    Erscheinungsland Schweiz
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019627995
    ISBN 978-3-319-58335-8 ; 9783319583334 ; 3-319-58335-2 ; 3319583336
    DOI 10.1007/978-3-319-58335-8
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  7. Artikel ; Online: Absolute indications and permanent inferior vena cava filters are best.

    Gillespie, David L

    Journal of vascular surgery. Venous and lymphatic disorders

    2020  Band 8, Heft 4, Seite(n) 593

    Mesh-Begriff(e) Anticoagulants ; Costs and Cost Analysis ; Humans ; Patients ; Pulmonary Embolism/diagnostic imaging ; Vena Cava Filters
    Chemische Substanzen Anticoagulants
    Sprache Englisch
    Erscheinungsdatum 2020-05-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ISSN 2213-3348
    ISSN (online) 2213-3348
    DOI 10.1016/j.jvsv.2020.04.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Failure of retrieval of inferior vena cava filters.

    Gillespie, David L

    Journal of vascular surgery. Venous and lymphatic disorders

    2019  Band 8, Heft 1, Seite(n) 53

    Mesh-Begriff(e) Device Removal ; Humans ; Pulmonary Embolism ; Vena Cava Filters
    Sprache Englisch
    Erscheinungsdatum 2019-12-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ISSN 2213-3348
    ISSN (online) 2213-3348
    DOI 10.1016/j.jvsv.2019.08.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: All-cause and Infection-attributable Mortality Amongst Adults With Bloodstream Infection-a Population-based Study.

    Underwood, Jonathan / Griffiths, Rowena / Gillespie, David / Akbari, Ashley / Ahmed, Haroon

    Open forum infectious diseases

    2024  Band 11, Heft 5, Seite(n) ofae126

    Abstract: Background: Bloodstream infections (BSIs) are common, life-threatening infections. However, it remains unclear whether deaths following BSIs are primarily from uncontrolled infection or underlying comorbidities. We aimed to determine the overall ... ...

    Abstract Background: Bloodstream infections (BSIs) are common, life-threatening infections. However, it remains unclear whether deaths following BSIs are primarily from uncontrolled infection or underlying comorbidities. We aimed to determine the overall mortality, infection-attributable mortality, and causes of death for four leading BSI pathogens.
    Methods: This retrospective cohort study was conducted within the Secure Anonymized Information Linkage Databank, containing anonymized population-scale electronic health record data for Wales, UK. We included adults with
    Results: We identified 35 691 adults with BSI (59.6%
    Conclusions: This population-level study challenges the assumption that most deaths following BSIs are directly attributable to uncontrolled infection, particularly subacutely more than 30 days from BSI. Our findings underscore the need for reevaluating clinical trial design and developing better preventive strategies for BSIs.
    Sprache Englisch
    Erscheinungsdatum 2024-03-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae126
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: The authors reply.

    Selewski, David T / Gillespie, Scott E / Gist, Katja M / Basu, Rajit K

    Critical care medicine

    2023  Band 51, Heft 8, Seite(n) e170–e172

    Sprache Englisch
    Erscheinungsdatum 2023-07-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005927
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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