Artikel ; Online: SARS-CoV-2 omicron sub-lineages differentially modulate interferon response in human lung epithelial cells.
2023 Band 332, Seite(n) 199134
Abstract: Although most of the attention was focused on the characterization of changes in the Spike protein among variants of SARS-CoV-2 virus, mutations outside the Spike region are likely to contribute to virus pathogenesis, virus adaptation and escape to the ... ...
Abstract | Although most of the attention was focused on the characterization of changes in the Spike protein among variants of SARS-CoV-2 virus, mutations outside the Spike region are likely to contribute to virus pathogenesis, virus adaptation and escape to the immune system. Phylogenetic analysis of SARS-CoV-2 Omicron strains reveals that several virus sub-lineages could be distinguished, from BA.1 up to BA.5. Regarding BA.1, BA.2 and BA.5, several mutations concern viral proteins with antagonistic activity to the innate immune system, such as NSP1 (S |
---|---|
Mesh-Begriff(e) | Humans ; Interferons ; SARS-CoV-2/genetics ; Phylogeny ; COVID-19 ; Epithelial Cells ; Interferon-beta/genetics ; Ataxia Telangiectasia Mutated Proteins ; Spike Glycoprotein, Coronavirus/genetics |
Chemische Substanzen | Interferons (9008-11-1) ; Interferon-beta (77238-31-4) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 |
Sprache | Englisch |
Erscheinungsdatum | 2023-05-17 |
Erscheinungsland | Netherlands |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 605780-9 |
ISSN | 1872-7492 ; 0168-1702 |
ISSN (online) | 1872-7492 |
ISSN | 0168-1702 |
DOI | 10.1016/j.virusres.2023.199134 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 1965: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.