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  1. Artikel ; Online: Q&A with Hao Gu.

    Gu, Hao

    Cell reports

    2024  Band 43, Heft 5, Seite(n) 114198

    Abstract: Hao Gu spoke with Cell Reports about his scientific journey, inspirations to become a scientist ...

    Abstract Hao Gu spoke with Cell Reports about his scientific journey, inspirations to become a scientist, and his work on molecular mechanisms driving the progression of tumors of the digestive system; in particular, he discussed his lab's recent work regarding the role of circDNA2v in colorectal cancer.
    Mesh-Begriff(e) Humans ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/genetics ; History, 21st Century
    Sprache Englisch
    Erscheinungsdatum 2024-04-30
    Erscheinungsland United States
    Dokumenttyp Interview ; Historical Article ; Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114198
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway.

    Chen, Hao / Ferguson, Cole J / Mitchell, Dylan C / Titus, Amanda / Paulo, Joao A / Hwang, Andrew / Lin, Tsen-Hsuan / Yano, Hiroko / Gu, Wei / Song, Sheng-Kwei / Yuede, Carla M / Gygi, Steven P / Bonni, Azad / Kim, Albert H

    bioRxiv : the preprint server for biology

    2024  

    Abstract: ... the Hao-Fountain syndrome (HAFOUS), characterized by developmental delay, intellectual disability, autism ...

    Abstract Precise control of protein ubiquitination is essential for brain development, and hence, disruption of ubiquitin signaling networks can lead to neurological disorders. Mutations of the deubiquitinase USP7 cause the Hao-Fountain syndrome (HAFOUS), characterized by developmental delay, intellectual disability, autism, and aggressive behavior. Here, we report that conditional deletion of USP7 in excitatory neurons in the mouse forebrain triggers diverse phenotypes including sensorimotor deficits, learning and memory impairment, and aggressive behavior, resembling clinical features of HAFOUS. USP7 deletion induces neuronal apoptosis in a manner dependent of the tumor suppressor p53. However, most behavioral abnormalities in USP7 conditional mice persist despite p53 loss. Strikingly, USP7 deletion in the brain perturbs the synaptic proteome and dendritic spine morphogenesis independently of p53. Integrated proteomics analysis reveals that the neuronal USP7 interactome is enriched for proteins implicated in neurodevelopmental disorders and specifically identifies the RNA splicing factor Ppil4 as a novel neuronal substrate of USP7. Knockdown of Ppil4 in cortical neurons impairs dendritic spine morphogenesis, phenocopying the effect of USP7 loss on dendritic spines. These findings reveal a novel USP7-Ppil4 ubiquitin signaling link that regulates neuronal connectivity in the developing brain, with implications for our understanding of the pathogenesis of HAFOUS and other neurodevelopmental disorders.
    Sprache Englisch
    Erscheinungsdatum 2024-01-13
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.10.24.563880
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Yin-Chen-Hao-Tang alleviates biliary obstructive cirrhosis in rats by inhibiting biliary epithelial cell proliferation and activation.

    Wang, Bing / Sun, Ming-Yu / Long, Ai-Hua / Cao, Hong-Yan / Ren, Shuang / Bian, Yan-Qin / Lu, Xiong / Gu, Hong-Tu / Liu, Cheng-Hai / Liu, Ping

    Pharmacognosy magazine

    2015  Band 11, Heft 42, Seite(n) 417–425

    Abstract: Background: Yin-Chen-Hao-Tang (YCHT) consists of three aqueous extracts from Artemisia capillaris ...

    Abstract Background: Yin-Chen-Hao-Tang (YCHT) consists of three aqueous extracts from Artemisia capillaris, Gardenia sp., and prepared Rheum rhabarbarum (rhubarb) (3:2:1). YCHT is characterized by its anti-inflammatory properties in liver regulation and relief of jaundice. We aimed to study the effects and mechanisms of action of YCHT on biliary obstructive cirrhosis.
    Materials and methods: Secondary biliary fibrosis was induced in rats by bile duct ligation (BDL) and scission. One week after BDL, rats were randomly divided into a saline-treated BDL or YCHT-treated BDL group for 4 weeks. Liver function and hepatic hydroxyproline (Hyp) content were assessed. Types I and IV collagen (Col-IV), laminin, fibronectin, alpha smooth muscle actin (α-SMA), and proliferating cell nuclear antigen protein and messenger ribonucleic acid (mRNA) expression were assessed with immunohistochemistry and real-time polymerase chain reaction.
    Results: In the YCHT-treated BDL group, serum total bilirubin, total bile acids, aspartate aminotransferase, alanine aminotransferase, and γ-glutamyl transferase were lower than those in the sham-operated BDL group. The proliferation of bile ducts in hepatic tissues and the Hyp content and Col deposition were also significantly lower than those in control rats. In addition, α-SMA and Col-IV staining was less obvious, and mRNA expression of Procol-α1 (IV), platelet derived growth factor subunit B (PDGF)-B, connective tissue growth factor, and transforming growth factor-beta in proliferative biliary epithelial cells (BECs) in the YCHT-treated BDL group was significantly lower than those in controls.
    Conclusions: YCHT effectively reduces the formation of biliary obstructive cirrhosis mainly via inhibition of BEC proliferation by down-regulation of PDGF-B mRNA expression, inhibition of BEC profibrogenic paracrines, and the epithelial-mesenchymal transition pathological process.
    Sprache Englisch
    Erscheinungsdatum 2015-01-29
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2274976-7
    ISSN 0976-4062 ; 0973-1296
    ISSN (online) 0976-4062
    ISSN 0973-1296
    DOI 10.4103/0973-1296.153098
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Buch: Shu fa hao ke bian

    Gu, Tinglong

    ming dai shu fa

    (Zhong guo mei shu quan ji : 中國美術全集 ; / Zhong guo mei shu quan ji bian ji wei yuan hui bian ; 58)

    2006  

    Verfasserangabe Gu ting long
    Serientitel Zhong guo mei shu quan ji : 中國美術全集
    / Zhong guo mei shu quan ji bian ji wei yuan hui bian ; 58
    Sprache Chinesisch
    Umfang 20, 197, 135 S, Ill
    Ausgabenhinweis Chong yin ban
    Verlag Shang hai ren min mei shu chu ban she
    Erscheinungsort Shang hai
    Dokumenttyp Buch
    ISBN 7805123306 ; 9787805123301
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  5. Buch: Shu fa hao ke bian

    Gu, Tinglong

    qing dai shu fa

    (Zhong guo mei shu quan ji : 中國美術全集 ; / Zhong guo mei shu quan ji bian ji wei yuan hui bian ; 59)

    2006  

    Verfasserangabe Gu ting long
    Serientitel Zhong guo mei shu quan ji : 中國美術全集
    / Zhong guo mei shu quan ji bian ji wei yuan hui bian ; 59
    Sprache Chinesisch
    Umfang 20, 198, 171 S, Ill
    Ausgabenhinweis Chong yin ban
    Verlag Shang hai ren min mei shu chu ban she
    Erscheinungsort Shang hai
    Dokumenttyp Buch
    ISBN 7805123462 ; 9787805123462
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  6. Artikel: UPLC-ESI-MS/MS-Based Analysis of Various Edible

    Ni, Ming / Chen, Junlei / Fu, Mao / Li, Huanyang / Bu, Shengqian / Hao, Xiaojiang / Gu, Wei

    Foods (Basel, Switzerland)

    2024  Band 13, Heft 5

    Abstract: ... The ... ...

    Abstract The genus
    Sprache Englisch
    Erscheinungsdatum 2024-03-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13050796
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Effect of Precursors and Their Regulators on the Biosynthesis of Antibiotics in

    Yan, Xu / Dong, Yao / Gu, Yawen / Cui, Hao

    Molecules (Basel, Switzerland)

    2024  Band 29, Heft 5

    Abstract: During the life activities of microorganisms, a variety of secondary metabolites are produced, including antimicrobials and antitumor drugs, which are widely used in clinical practice. In addition to exploring new antibiotics, this makes it one of the ... ...

    Abstract During the life activities of microorganisms, a variety of secondary metabolites are produced, including antimicrobials and antitumor drugs, which are widely used in clinical practice. In addition to exploring new antibiotics, this makes it one of the research priorities of
    Mesh-Begriff(e) Anti-Bacterial Agents/metabolism ; Actinobacteria/metabolism ; Actinomyces ; Secondary Metabolism
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2024-03-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29051132
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.MO 81: Hefte anzeigen

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  8. Artikel ; Online: Data-driven analytics for student reviews in China's higher vocational education MOOCs: A quality improvement perspective.

    Li, Hongbo / Gu, Huilin / Hao, Xue / Yan, Xin / Zhu, Qingkang

    PloS one

    2024  Band 19, Heft 3, Seite(n) e0298675

    Abstract: Higher vocational education is the core component of China's national education system and shoulders the mission of cultivating high-skilled and applied talents. The wide application of Massive Open Online Courses (MOOCs) has effectively improved the ... ...

    Abstract Higher vocational education is the core component of China's national education system and shoulders the mission of cultivating high-skilled and applied talents. The wide application of Massive Open Online Courses (MOOCs) has effectively improved the curriculum system of China's higher vocational education. In the meantime, some MOOCs suffer from poor course quality. Therefore, from the perspective of sustainable course quality improvement, we propose a data-driven framework for mining and analyzing student reviews in China's higher vocational education MOOCs. In our framework, we first mine multi-level student demands hidden in MOOC reviews by combining web crawlers and text mining. Then we use an artificial neural network and the KANO model to classify the extracted student demands, thereby designing effective and sustainable MOOC quality improvement strategies. Based on the real data from China's higher vocational education MOOCs, we validate the effectiveness of the proposed data-driven framework.
    Mesh-Begriff(e) Humans ; Vocational Education ; Quality Improvement ; Education, Distance ; Nigeria ; Students ; China
    Sprache Englisch
    Erscheinungsdatum 2024-03-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0298675
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: TEA: A Sequential Recommendation Framework via Temporally Evolving Aggregations.

    Li, Zijian / Cai, Ruichu / Wu, Fengzhu / Zhang, Sili / Gu, Hao / Hao, Yuexing / Yan, Yuguang

    IEEE transactions on neural networks and learning systems

    2024  Band 35, Heft 2, Seite(n) 2628–2639

    Abstract: Sequential recommendation aims to choose the most suitable items for a user at a specific timestamp given historical behaviors. Existing methods usually model the user behavior sequence based on transition-based methods such as Markov chain. However, ... ...

    Abstract Sequential recommendation aims to choose the most suitable items for a user at a specific timestamp given historical behaviors. Existing methods usually model the user behavior sequence based on transition-based methods such as Markov chain. However, these methods also implicitly assume that the users are independent of each other without considering the influence between users. In fact, this influence plays an important role in sequence recommendation since the behavior of a user is easily affected by others. Therefore, it is desirable to aggregate both user behaviors and the influence between users, which are evolved temporally and involved in the heterogeneous graph of users and items. In this article, we incorporate dynamic user-item heterogeneous graphs to propose a novel sequential recommendation framework. As a result, the historical behaviors as well as the influence between users can be taken into consideration. To achieve this, we first formalize sequential recommendation as a problem to estimate conditional probability given temporal dynamic heterogeneous graphs and user behavior sequences. After that, we exploit the conditional random field to aggregate the heterogeneous graphs and user behaviors for probability estimation and employ the pseudo-likelihood approach to derive a tractable objective function. Finally, we provide scalable and flexible implementations of the proposed framework. Experimental results on three real-world datasets not only demonstrate the effectiveness of our proposed method but also provide some insightful discoveries on the sequential recommendation.
    Sprache Englisch
    Erscheinungsdatum 2024-02-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2022.3190534
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7.

    Dai, Menghan / Li, Jie / Hao, Xiangwen / Li, Na / Zheng, Mingfang / He, Miao / Gu, Yu

    Neuroscience bulletin

    2024  

    Abstract: Abnormal visual experience during the critical period can cause deficits in visual function, such as amblyopia. High magnesium ( ... ...

    Abstract Abnormal visual experience during the critical period can cause deficits in visual function, such as amblyopia. High magnesium (Mg
    Sprache Englisch
    Erscheinungsdatum 2024-06-04
    Erscheinungsland Singapore
    Dokumenttyp Journal Article
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-024-01242-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6734: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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