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  1. Artikel ; Online: Evaluation of the neutralizing antibody response against the omicron variant produced by heterologous or hybrid immunity: How does the fifth dose of COVID-19 vaccine affect the neutralizing antibody response?

    Bayhan, Gülsüm İclal / Güner, Rahmet / Yahşi, Aysun / Özkul, Aykut

    The Journal of infection

    2023  Band 87, Heft 3, Seite(n) e61–e62

    Mesh-Begriff(e) Humans ; COVID-19 Vaccines ; COVID-19/prevention & control ; SARS-CoV-2 ; Adaptive Immunity ; Antibodies, Neutralizing ; Antibodies, Viral ; Vaccination
    Chemische Substanzen COVID-19 Vaccines ; Antibodies, Neutralizing ; Antibodies, Viral
    Sprache Englisch
    Erscheinungsdatum 2023-07-04
    Erscheinungsland England
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.07.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: COVID-19 and the liver: A brief and core review.

    Kayaaslan, Bircan / Guner, Rahmet

    World journal of hepatology

    2022  Band 13, Heft 12, Seite(n) 2013–2023

    Abstract: Coronavirus disease 2019 has a wide range of clinical spectrum from asymptomatic infection to severe infection resulting in death within a short time. Currently, it is known that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) does not only ... ...

    Abstract Coronavirus disease 2019 has a wide range of clinical spectrum from asymptomatic infection to severe infection resulting in death within a short time. Currently, it is known that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) does not only cause a respiratory tract infection but a more complicated disease that can lead to multiple system involvement including the liver. Herein, we evaluate the epidemiology, the impact of liver injury/ dysfunction on disease prognosis, the pathophysiological mechanisms and management of liver injury. More than one-fourth of the patients have abnormal liver function tests, mostly a mild-to-moderate liver dysfunction. Liver injury is significantly associated with a poor clinical outcome. Direct cytotoxic effect of SARS-CoV-2, the immune response ("cytokine storm"), the complications related to the disease, and drugs used in the treatments are the pathophysiological mechanisms responsible for liver injury. However, the exact mechanism is not yet clearly explained. The binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 receptors and entering the hepatocyte and cholangiocytes can cause cytotoxic effects on the liver. Excessive immune response has an important role in disease progression and causes acute respiratory distress syndrome and multi-organ failures accompanied by liver injury. Treatment drugs, particularly lopinavir/ritonavir, remdesivir and antibiotics are a frequent reason for liver injury. The possible reasons should be meticulously investigated and resolved.
    Sprache Englisch
    Erscheinungsdatum 2022-01-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v13.i12.2013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Effectiveness of CoronaVac in preventing COVID-19 in healthcare workers.

    Bayhan, Gulsum Iclal / Guner, Rahmet

    Human vaccines & immunotherapeutics

    2022  Band 18, Heft 1, Seite(n) 2020017

    Abstract: The CoronaVac vaccine was found to be effective against symptomatic COVID-19 and protective against severe disease in phase 3 studies. However, there are little data about its effectiveness in real-world conditions. The aim of the current study was to ... ...

    Abstract The CoronaVac vaccine was found to be effective against symptomatic COVID-19 and protective against severe disease in phase 3 studies. However, there are little data about its effectiveness in real-world conditions. The aim of the current study was to investigate the protective effect of the CoronaVac vaccine in health-care workers (HCWs) in Turkey, a country where CoronaVac is widely used. The questionnaire was sent to all employees in the form of a survey link by using a telephone application. In the survey, HCWs were asked about demographic characteristics; CoronaVac vaccination status, history of a COVID-19 infection, whether COVID-19 infection was before or after the CoronaVac vaccination; the time between being vaccinated and the COVID-19 infection; the clinical pictures of COVID-19 infection. Those who experienced COVID-19 before vaccination were compared with the breakthrough cases in terms of demographic and clinical features. A total of 628 HCW agreed to participate in the study. A total of 536 (85.3%) volunteers had been vaccinated and 92 (14.6%) had not been vaccinated against COVID-19 with CoronaVac. There was a history of COVID-19 infection in 234 (37.2%) subjects and 188 (35%) had been vaccinated and 46 (50%) not vaccinated. The rate experiencing COVID-19 disease was significantly lower in the vaccinated than the unvaccinated volunteers. The rate of breakthrough cases after CoronaVac was found to be 7%. The hospitalization rate was similar in the breakthrough cases and those who had COVID-19 before CoronaVac vaccination. The results of our study indicate that CoronaVac provides protection against COVID-19.
    Mesh-Begriff(e) COVID-19/prevention & control ; COVID-19 Vaccines ; Health Personnel ; Humans ; SARS-CoV-2 ; Vaccines
    Chemische Substanzen COVID-19 Vaccines ; Vaccines
    Sprache Englisch
    Erscheinungsdatum 2022-02-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2021.2020017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Investigation of polypharmacy, antimicrobial-related potential drug-drug interactions in patients with hematological malignancies.

    Oktay, Zeynep / Güner, Rahmet / Kayaaslan, Bircan / Hasanoğlu, İmran / Kaya Kalem, Ayşe / Özet, Gülsüm

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

    2024  , Seite(n) 10781552241249419

    Abstract: Purpose: Drug-drug interactions (DDIs) occur when one drug interferes with the pharmacological activity of another and can lead to increased side effects. The purpose of this study was to examine potential interactions between antimicrobials and other ... ...

    Abstract Purpose: Drug-drug interactions (DDIs) occur when one drug interferes with the pharmacological activity of another and can lead to increased side effects. The purpose of this study was to examine potential interactions between antimicrobials and other drugs in patients with hematological malignancies (HMs).
    Method: The medications used by 233 patients with HMs before and during hospitalization in Ankara City Hospital Hematology Clinic services between January 2021 and July 2021 were examined. Potential DDIs (pDDIs) were identified through UptoDate, Drugs.com, and MedScape databases. The effects of major antimicrobial-related pDDIs on patients were examined. Agreement between the two interaction systems was judged based on the kappa test. SPSS R Version 4.0.2 was used in the statistical analysis of the data,
    Results: The prevalence of polypharmacy before hospitalization was determined as 22.7%. Diagnosed with acute leukemia and multiple myeloma, more antimicrobial-related pDDIs were detected during hospitalization (
    Conclusion: Interactions between antimicrobials and other drugs are undesirable problems. Further studies are required to evaluate the clinical and economic effects of the interactions on patients with HMs.
    Sprache Englisch
    Erscheinungsdatum 2024-04-26
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/10781552241249419
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Is there any evidence implying the use of a different criterion for protective anti-HBs titer after HBV vaccination in immunosuppressed patients?

    Hasanoğlu, İmran / Güner, Rahmet

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

    2020  Band 31, Heft 4, Seite(n) 346–347

    Mesh-Begriff(e) Consensus ; Hepatitis B/prevention & control ; Hepatitis B Antibodies ; Hepatitis B Surface Antigens ; Hepatitis B virus/immunology ; Humans ; Vaccination
    Chemische Substanzen Hepatitis B Antibodies ; Hepatitis B Surface Antigens
    Sprache Englisch
    Erscheinungsdatum 2020-05-15
    Erscheinungsland Turkey
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 1340275-4
    ISSN 2148-5607 ; 1300-4948
    ISSN (online) 2148-5607
    ISSN 1300-4948
    DOI 10.5152/tjg.2020.19040
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Antimicrobial stewardship in the intensive care unit.

    Ture, Zeynep / Güner, Rahmet / Alp, Emine

    Journal of intensive medicine

    2022  Band 3, Heft 3, Seite(n) 244–253

    Abstract: High resistance rates to antimicrobials continue to be a global health threat. The incidence of multidrug-resistant (MDR) microorganisms in intensive care units (ICUs) is quite high compared to in the community and other units in the hospital because ICU ...

    Abstract High resistance rates to antimicrobials continue to be a global health threat. The incidence of multidrug-resistant (MDR) microorganisms in intensive care units (ICUs) is quite high compared to in the community and other units in the hospital because ICU patients are generally older, have higher numbers of co-morbidities and immune-suppressed; moreover, the typically high rates of invasive procedures performed in the ICU increase the risk of infection by MDR microorganisms. Antimicrobial stewardship (AMS) refers to the implementation of coordinated interventions to improve and track the appropriate use of antibiotics while offering the best possible antibiotic prescription (according to dose, duration, and route of administration). Broad-spectrum antibiotics are frequently preferred in ICUs because of greater infection severity and colonization and infection by MDR microorganisms. For this reason, a number of studies on AMS in ICUs have increased in recent years. Reducing the use of broad-spectrum antibiotics forms the basis of AMS. For this purpose, parameters such as establishing an AMS team, limiting the use of broad-spectrum antimicrobials, terminating treatments early, using early warning systems, pursuing infection control, and providing education and feedback are used. In this review, current AMS practices in ICUs are discussed.
    Sprache Englisch
    Erscheinungsdatum 2022-11-15
    Erscheinungsland China
    Dokumenttyp Journal Article ; Review
    ISSN 2667-100X
    ISSN (online) 2667-100X
    DOI 10.1016/j.jointm.2022.10.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: A Subacute Thyroiditis Case After SARS-CoV-2 Infection

    Muge Ayhan / Rahmet Guner

    Haseki Tıp Bülteni, Vol 59, Iss 1, Pp 54-

    A Case Report and Current Literature Review

    2021  Band 56

    Abstract: Subacute thyroiditis (SAT), is a self-limiting inflammatory disorder which is linked to a viral infection. A few cases of SAT were reported after Severe Acute Respiratory syndrome Coronavirus-2 (SARS-CoV-2) infection. We here reported a case of SAT that ... ...

    Abstract Subacute thyroiditis (SAT), is a self-limiting inflammatory disorder which is linked to a viral infection. A few cases of SAT were reported after Severe Acute Respiratory syndrome Coronavirus-2 (SARS-CoV-2) infection. We here reported a case of SAT that occurred two weeks after SARS-CoV-2 infection. A thirty-nine-year-old male with no comorbid diseases applied to our outpatient clinic with the complaints of sore throat, fatigue and subfebrile fever. He had a contact history of his wife who has a positive SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) test. The nasopharyngeal swab was performed and his SARS-CoV-2 RT-PCR test was confirmed positive. He recovered from all symptoms in one week. On the second week of the first diagnosis, he developed neck pain, fatigue, muscle pains, palpitation and tremors. Because his thyroid palpation was painful and he was more symptomatic thyroid function tests were performed. Thyrotropin was suppressed (0.01 mIU/L), free triiodothyronine and free thyroxine levels were high as 11 ng/L and 3.72 ng/dL, respectively. His cervical ultrasound also revealed SAT. He was treated with prednisolone, ibuprofen and propranolol. Within one week, there was a progressive resolution of signs and symptoms. After the third week, his laboratory results returned to normal ranges.
    Schlagwörter subacute thyroiditis ; viral infection ; covid-19 ; endocrinology ; antiviral treatment ; Medicine ; R ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2021-06-01T00:00:00Z
    Verlag Galenos Yayinevi
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Iatrogenic botulism cases after gastric and axillary application of botulinum toxin and review of literature.

    Eser, Fatma / Hasanoğlu, İmran / Kayaaslan, Bircan / Kaya Kalem, Ayşe / Bilen, Şule / Orhan, Gürdal / Güner, Rahmet

    Journal of infection in developing countries

    2024  Band 18, Heft 3, Seite(n) 480–487

    Abstract: Introduction: Iatrogenic botulism is a rare, serious disease that progresses with descending paralysis and develops after cosmetic or therapeutic botulinum toxin-A (BoNT-A) application.: Case presentations: In this case series; six cases of ... ...

    Abstract Introduction: Iatrogenic botulism is a rare, serious disease that progresses with descending paralysis and develops after cosmetic or therapeutic botulinum toxin-A (BoNT-A) application.
    Case presentations: In this case series; six cases of iatrogenic botulism followed up in our center are presented. Four of these developed after gastric BoNT-A and two after axillary BoNT-A application.
    Results: The most important cause for the disease was the use of unlicensed products and high-dose toxin applications. The first symptoms were blurred vision, double vision, difficulty in swallowing, and hoarseness. Symptoms appeared within 4-10 days after the application of BoNT-A. Symptoms progressed in the course of descending paralysis in the following days with fatigue, weakness in extremities and respiratory distress. Diagnosis was based on patient history and clinical findings. The main principles of foodborne botulism therapy were applied in the treatment of iatrogenic botulism. If clinical worsening continued, regardless of the time elapsed after BoNT-A application, the use of botulinum antitoxin made a significant contribution to clinical improvement and was recommended.
    Conclusions: Routine and new indications for BoNT-A usage are increasing and, as a result, cases of iatrogenic botulism will be encountered more frequently. Physicians should be alert for iatrogenic botulism in the follow-up after BoNT-A applications and in the differential diagnosis of neurological diseases that are presented with similar findings.
    Mesh-Begriff(e) Humans ; Botulinum Toxins/therapeutic use ; Botulism/diagnosis ; Botulism/drug therapy ; Botulism/etiology ; Botulinum Antitoxin/therapeutic use ; Paralysis/complications ; Paralysis/drug therapy ; Iatrogenic Disease ; Clostridium botulinum ; Botulinum Toxins, Type A/adverse effects
    Chemische Substanzen Botulinum Toxins (EC 3.4.24.69) ; Botulinum Antitoxin ; Botulinum Toxins, Type A (EC 3.4.24.69)
    Sprache Englisch
    Erscheinungsdatum 2024-03-31
    Erscheinungsland Italy
    Dokumenttyp Review ; Journal Article
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.18868
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Point prevalence of antibiotic usage in major referral hospital in Turkey.

    Ayhan, Müge / Coşkun, Belgin / Kayaaslan, Bircan / Hasanoğlu, İmran / Kalem, Ayşe Kaya / Eser, Fatma / Bilir, Yeşim Aybar / Ünlü, Serpil / Güner, Rahmet

    PloS one

    2024  Band 19, Heft 1, Seite(n) e0296900

    Abstract: Introduction: The most important and undesirable consequence of inappropriate antibiotic use is the spread of antibiotic resistance, increased adverse effects, increased mortality and healthcare costs. We aimed to assess antibiotic usage characteristics ...

    Abstract Introduction: The most important and undesirable consequence of inappropriate antibiotic use is the spread of antibiotic resistance, increased adverse effects, increased mortality and healthcare costs. We aimed to assess antibiotic usage characteristics in inpatient setting in our center.
    Materials and methods: A one-day, single center point-prevalence study was carried out on June 9th 2021, in Ankara City Hospital in Turkey. Data of antibiotic consumption, appropriateness of usage and predictors of inappropriate use in adult patients were evaluated.
    Results: Out of 2640 adult patients, 893 (33.8%) were receiving at least one antibiotic. A total of 1212 antibiotic prescriptions with an average of 1.44±0.64 were found. Antibiotics were most commonly used for therapeutic purpose (84.7%), followed by surgical prophylaxis (11.6%). Majority of therapeutically used antibiotics were empirical (67.9%). Infectious diseases consultation was present in 68.3% with a compliance rate of 95.7%. Rate of inappropriate use was 20%. The most frequent cause of inappropriateness was unnecessary use (52.5%). Most commonly and most inappropriately used antibiotics were carbapenems (17.5%) and first generation cephalosporins (38.7%), respectively. Most of the inappropriateness observed in first-generation cephalosporins was due to inappropriate longer surgical prophylaxis. While age is an independent risk factor for inappropriate antibiotic use (p = 0.042), COVID-19 unit admission, use for therapeutic purpose and infectious diseases consultation were protective factors (p<0.001, p<0.001, p<0.001).
    Conclusion: Rate of inappropriate use was low, but inappropriate surgical prophylaxis remains an important problem in surgical units. There is a considerable need to implement an antimicrobial stewardship program that focuses on surgical prophylaxis practices.
    Mesh-Begriff(e) Adult ; Humans ; Anti-Bacterial Agents/adverse effects ; Turkey/epidemiology ; Prevalence ; Referral and Consultation ; Communicable Diseases/drug therapy ; Hospitals, Urban
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2024-01-31
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0296900
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Evaluating the efficiency of public policy measures against COVID-19

    Güner, Rahmet / Hasanoğlu, Imran / Aktaş, Firdevs

    Turkish journal of medical sciences

    2021  Band 51, Heft SI-1, Seite(n) 3229–3237

    Abstract: The World Health Organization (WHO) declared COVID-19 as a Public Health Emergency of international concern on January 30, 2020, and a pandemic on March 11, 2020. Afterward, it spread rapidly all over the world, causing almost 4 million deaths as of June ...

    Abstract The World Health Organization (WHO) declared COVID-19 as a Public Health Emergency of international concern on January 30, 2020, and a pandemic on March 11, 2020. Afterward, it spread rapidly all over the world, causing almost 4 million deaths as of June 2021. It is clear that effective preventive measures are needed in this devastating disease, which still has no cure. In addition to mask using, social distancing, and hygiene practices, which enter our lives as the most basic precautions, communities aim to reduce the effects of the COVID-19 pandemic. All over the world, the measures taken and activities performed in the COVID-19 pandemic are discussed, and information in this regard is shared. Mask usage, social distancing, hygiene, avoiding crowded and closed areas, contact tracing, rapid and accurate testing, increased indoor air quality, vaccination, and lockdown measures constitute the main preventive measures. This review summarizes the efficiency of public policy measures against COVID-19.
    Mesh-Begriff(e) COVID-19 ; Communicable Disease Control ; Humans ; Pandemics ; Public Policy ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-12-17
    Erscheinungsland Turkey
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-2106-301
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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