LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 87

Suchoptionen

  1. Artikel ; Online: Using the operating microscope to improve ergonomics for thyroidectomy.

    Haigh, Philip I

    American journal of surgery

    2022  Band 225, Heft 4, Seite(n) 803–804

    Mesh-Begriff(e) Humans ; Thyroidectomy ; Ergonomics ; Microscopy ; Operating Rooms
    Sprache Englisch
    Erscheinungsdatum 2022-12-07
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2022.12.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Uk I Zs.42: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Lessons from the American Association of Endocrine Surgeons (AAES) ergonomics panel: Operating is a pain in the neck … and other places.

    Merrill, Andrea L / Haigh, Philip I / Lal, Geeta I

    American journal of surgery

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-02-23
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2024.02.038
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Uk I Zs.42: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Parathyroidectomy for nephrolithiasis in primary hyperparathyroidism: Beneficial but not a panacea.

    Huang, Siu-Yuan / Burchette, Raoul / Chung, Joanie / Haigh, Philip I

    Surgery

    2021  Band 171, Heft 1, Seite(n) 29–34

    Abstract: Background: Nephrolithiasis is a classic indication for parathyroidectomy in primary hyperparathyroidism patients; however, the effects of parathyroidectomy on nephrolithiasis recurrence are not well studied. The aim was to determine effect of ... ...

    Abstract Background: Nephrolithiasis is a classic indication for parathyroidectomy in primary hyperparathyroidism patients; however, the effects of parathyroidectomy on nephrolithiasis recurrence are not well studied. The aim was to determine effect of parathyroidectomy on time to first nephrolithiasis recurrence and recurrence rate per patient-years.
    Methods: A retrospective cohort study of patients diagnosed with primary hyperparathyroidism and at least one episode of nephrolithiasis was performed. The patients were divided into observation, presurgery, and postsurgery groups. Endpoints were time to first recurrence of nephrolithiasis and average recurrence rate per patient-years.
    Results: The cohort was comprised of 1,252 patients. In addition, 334 (27%) patients underwent parathyroidectomy and 918 (73%) were observed. The surgical and nonsurgical groups differed significantly in age, sex, Charlson, calcium, and primary hyperparathyroidism level. Overall recurrence rate was 31.3%. The 5-, 10-, and 15-year recurrence-free survival rates were 74.4%, 56.3%, 49.5%, respectively (presurgery), 82.4%, 70.9%, 62.8%, respectively (postsurgery; P < .0001), and 86.3%, 77.7%, and 70.6%, respectively (observation). The presurgery group had an increased risk of first recurrence compared with the observation group (hazard ratio 1.89; 95% confidence interval, 1.44-2.47). The average recurrence rates among all surgical patients who recurred were 1 event per 4.3 patient-years presurgery versus 1 event per 6.7 patient-years postsurgery (P = .0001).
    Conclusion: Recurrent nephrolithiasis is a significant problem in patients with primary hyperparathyroidism. Parathyroidectomy prolongs the time to first recurrence and decreases the number of re-recurrences over time but does not eliminate recurrences. Observation may also be a reasonable approach in selected patients.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Calcium/blood ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Hyperparathyroidism, Primary/blood ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/mortality ; Hyperparathyroidism, Primary/surgery ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Nephrolithiasis/blood ; Nephrolithiasis/etiology ; Nephrolithiasis/mortality ; Nephrolithiasis/surgery ; Parathyroid Hormone/blood ; Parathyroidectomy/statistics & numerical data ; Recurrence ; Retrospective Studies ; Secondary Prevention/methods ; Secondary Prevention/statistics & numerical data ; Time Factors ; Young Adult
    Chemische Substanzen Parathyroid Hormone ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2021-08-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2021.03.077
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Uk I Zs.129: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel ; Online: Long-term effects of primary hyperparathyroidism and parathyroidectomy on kidney function.

    Zhu, Catherine Y / Zhou, Hui X / Tseng, Chi-Hong / Fackelmayer, Oliver J / Haigh, Philip I / Adams, Annette L / Yeh, Michael W

    European journal of endocrinology

    2023  Band 189, Heft 1, Seite(n) 115–122

    Abstract: Importance: Limited evidence supports kidney dysfunction as an indication for parathyroidectomy in asymptomatic primary hyperparathyroidism (PHPT).: Objective: To investigate the natural history of kidney function in PHPT and whether ... ...

    Abstract Importance: Limited evidence supports kidney dysfunction as an indication for parathyroidectomy in asymptomatic primary hyperparathyroidism (PHPT).
    Objective: To investigate the natural history of kidney function in PHPT and whether parathyroidectomy alters renal outcomes.
    Design: Matched control study.
    Setting: A vertically integrated health care system serving 4.6 million patients in Southern California.
    Participants: 6058 subjects with PHPT and 16 388 matched controls, studied from 2000 to 2016.
    Exposures: Biochemically confirmed PHPT with varying serum calcium levels.
    Main outcomes: Estimated glomerular filtration rate (eGFR) trajectories were compared over 10 years, with cases subdivided by severity of hypercalcemia: serum calcium 2.62-2.74 mmol/L (10.5-11 mg/dL), 2.75-2.87 (11.1-11.5), 2.88-2.99 (11.6-12), and >2.99 (>12). Interrupted time series analysis was conducted among propensity-score-matched PHPT patients with and without parathyroidectomy to compare eGFR trajectories postoperatively.
    Results: Modest rates of eGFR decline were observed in PHPT patients with serum calcium 2.62-2.74 mmol/L (−1.0 mL/min/1.73 m2/year) and 2.75-2.87 mmol/L (−1.1 mL/min/1.73 m2/year), comprising 56% and 28% of cases, respectively. Compared with the control rate of −1.0 mL/min/1.73 m2/year, accelerated rates of eGFR decline were observed in patients with serum calcium 2.88-2.99 mmol/L (−1.5 mL/min/1.73 m2/year, P < .001) and >2.99 mmol/L (−2.1 mL/min/1.73 m2/year, P < .001), comprising 9% and 7% of cases, respectively. In the propensity score–matched population, patients with serum calcium >2.87 mmol/L exhibited mitigation of eGFR decline after parathyroidectomy (−2.0 [95% CI: −2.6 to −1.5] to −0.9 [95% CI: −1.5 to 0.4] mL/min/1.73 m2/year).
    Conclusions and relevance: Compared with matched controls, accelerated eGFR decline was observed in the minority of PHPT patients with serum calcium >2.87 mmol/L (11.5 mg/dL). Parathyroidectomy was associated with mitigation of eGFR decline in patients with serum calcium >2.87 mmol/L.
    Mesh-Begriff(e) Humans ; Hyperparathyroidism, Primary/surgery ; Calcium ; Parathyroidectomy ; Kidney ; Hypercalcemia/complications ; Parathyroid Hormone
    Chemische Substanzen Calcium (SY7Q814VUP) ; Parathyroid Hormone
    Sprache Englisch
    Erscheinungsdatum 2023-07-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1093/ejendo/lvad081
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Uh III Zs.147: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel ; Online: Hypocalcemia after Total Thyroidectomy in Graves Disease.

    Al Qubaisi, Malak / Haigh, Philip I

    The Permanente journal

    2019  Band 23

    Abstract: Context: Total thyroidectomy has been shown to provide a cost-effective and efficient method of permanently treating Graves disease; however, hypocalcemia can be a common complication.: Objective: To evaluate the risk of hypocalcemia after total ... ...

    Abstract Context: Total thyroidectomy has been shown to provide a cost-effective and efficient method of permanently treating Graves disease; however, hypocalcemia can be a common complication.
    Objective: To evaluate the risk of hypocalcemia after total thyroidectomy in patients with vs without Graves disease.
    Design: The 2016 American College of Surgeons National Surgical Quality Improvement Program participant use data files for procedure-targeted thyroidectomy and from 5871 patients were merged. This study included any patient who underwent total thyroidectomy.
    Main outcome measures: Whether symptomatic hypocalcemia developed anytime within 30 days after the thyroidectomy. A clinically severe hypocalcemic event was also evaluated as a secondary outcome measure.
    Results: Of the 2143 patients who underwent total thyroidectomy, 222 patients experienced hypocalcemia after surgery, 124 of whom had symptomatic hypocalcemia postoperatively. Among patients with hypocalcemia, 16.3% had Graves disease, whereas only 9.4% of patients without Graves disease experienced significant hypocalcemia. Multivariable logistic regression analysis revealed that women (odds ratio = 1.79; 95% confidence interval = 1.16-2.76; p = 0.009) and patients who underwent parathyroid autotransplantation (odds ratio = 1.91; 95% confidence interval = 1.30-2.81; p = 0.001) were at greater risk of development of hypocalcemia. Older patients were less likely to experience hypocalcemia postoperatively (odds ratio = 0.586; 95% confidence interval = 0.44-0.79; p = 0.0001).
    Conclusion: Patients with Graves disease are about twice as likely to experience hypocalcemia or clinically severe hypocalcemia postoperatively than are patients without the disease.
    Mesh-Begriff(e) Adult ; Aged ; Female ; Graves Disease/surgery ; Humans ; Hypocalcemia/epidemiology ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Risk ; Thyroidectomy
    Sprache Englisch
    Erscheinungsdatum 2019-05-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2062823-7
    ISSN 1552-5775 ; 1552-5767
    ISSN (online) 1552-5775
    ISSN 1552-5767
    DOI 10.7812/TPP/18-188
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel ; Online: Extent of thyroidectomy and survival in the SEER database: a case of citation amnesia.

    Haigh, Philip I

    Archives of otolaryngology--head & neck surgery

    2011  Band 137, Heft 8, Seite(n) 837; author reply 837–8

    Mesh-Begriff(e) Carcinoma, Papillary/surgery ; Female ; Humans ; Male ; Thyroid Neoplasms/surgery ; Thyroidectomy/methods
    Sprache Englisch
    Erscheinungsdatum 2011-08
    Erscheinungsland United States
    Dokumenttyp Comment ; Letter
    ZDB-ID 632721-7
    ISSN 1538-361X ; 0886-4470 ; 2168-6181
    ISSN (online) 1538-361X
    ISSN 0886-4470 ; 2168-6181
    DOI 10.1001/archoto.2011.133
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ul II Zs.87: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Artikel ; Online: IRB challenges in multisite studies: A case report and commentary from the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA).

    McCausland, Darren / Haigh, Margaret / McCallion, Philip / McCarron, Mary

    HRB open research

    2024  Band 7, Seite(n) 3

    Abstract: A shift from single to multi-site health studies enabled a range of research benefits including faster recruitment of larger and more diverse samples; increased statistical power, greater rigour, generalisability, and external reliability; and increased ... ...

    Abstract A shift from single to multi-site health studies enabled a range of research benefits including faster recruitment of larger and more diverse samples; increased statistical power, greater rigour, generalisability, and external reliability; and increased likelihood of impacting policy and clinical practice. However, ethical review of multi-site studies by Institutional Review Boards (IRBs) raises specific challenges compared with single site studies, with requirements to apply to multiple local IRBs increasing the burden on research, possibly endangering the integrity of the research process or inhibiting development of multi-site studies. The option of a single centralised IRB may offer a clearer, more consistent and efficient review process. This study presents a case report and commentary from 15 years engaging with IRBs in multiple sites in Ireland by the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA). It examines the ethics review process for IDS-TILDA through its first four waves. While the majority of 48 IRBs granted ethical approval within 13 weeks, six IRBs took 21-47 weeks to approve, leading to delays in data collection of up to 11 months. Despite additional review time, no changes were required to the study protocol. Therefore, a critical impact of the process was the delay in starting data collection within a small number of organisations, and reduced involvement in the study for one organisation. The ethical review process with multiple IRBs increased the degree of complexity of the process, with added bureaucracy and far greater communication required across 48 IRBs, substantially adding to the resource commitment for the review process. The relatively quick approval from the majority of IRBs was partially a result of the longitudinal study building relationships with organisations throughout multiple waves. That other health studies may not accrue this benefit supports calls for a single IRB system for multi-site health studies.
    Sprache Englisch
    Erscheinungsdatum 2024-02-12
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ISSN 2515-4826
    ISSN (online) 2515-4826
    DOI 10.12688/hrbopenres.13854.1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  8. Artikel ; Online: Influence of a negative sestamibi scan on the decision for parathyroid operation by the endocrinologist and surgeon.

    Wu, Susana / Hwang, Stephanie S / Haigh, Philip I

    Surgery

    2017  Band 161, Heft 1, Seite(n) 35–43

    Abstract: Background: It has been observed that negative sestamibi scans may impact practice patterns in patients with primary hyperparathyroidism. However, there are no published data on the issue. The objective was to elucidate the influence of negative ... ...

    Abstract Background: It has been observed that negative sestamibi scans may impact practice patterns in patients with primary hyperparathyroidism. However, there are no published data on the issue. The objective was to elucidate the influence of negative sestamibi scans on referrals by endocrinologists for parathyroidectomy and surgeon decision-making.
    Methods: All patients with primary hyperparathyroidism were identified within a region-wide health care system over a 2-year period. Data, including age, calcium, parathyroid hormone, renal function, bone density, and sestamibi scan results, were collected from the electronic medical record of all patients. The electronic referral system was used to track consultations with endocrinologists and surgeons. Multivariable logistic regression analysis was done to model factors involved in endocrinologist recommendations (referral or no referral to operation) and surgeon recommendations (parathyroidectomy or no parathyroidectomy).
    Results: A total of 539 patients with primary hyperparathyroidism were identified, and 452 were seen by endocrinologists. Of these, 260 patients had sestamibi scans done (120 negative and 140 positive), and 201 (77%) patients were referred to surgeons. Compared with positive sestamibi scans, negative sestamibi scans were independently associated with no referral to surgeons, after adjusting for presence of classic symptoms, age, fitness for operation, calcium, parathyroid hormone, glomerular filtration rate, and bone density (odds ratio = 0.36; 95% confidence interval 0.18-0.73). Surgeons saw an additional 54 patients referred from nonendocrinologists or primary care physicians and sestamibi scans were completed. Surgeons recommended parathyroidectomy in 236 of the 255 patients. Negative sestamibi scans were independently associated with no recommendation for operation (odds ratio = 0.32; 95% confidence interval 0.11-0.91). Surgeons initially scheduled and completed parathyroidectomies in 211/255 patients. Cure rate after operation was 98%, and this was not influenced by the sestamibi scan result.
    Conclusion: Negative sestamibi scans influence decision making in the management of patients with primary hyperparathyroidism. Endocrinologists commonly order sestamibi scans, and if negative, they are less likely to refer patients to surgeons. Surgeons are also influenced by sestamibi scans, and if negative, they are less likely to recommend parathyroidectomy. Cure rate in sestamibi-negative patients is excellent after operation.
    Mesh-Begriff(e) Adult ; Aged ; Clinical Decision-Making ; Cohort Studies ; Confidence Intervals ; Databases, Factual ; Endocrinologists ; Female ; Humans ; Hyperparathyroidism, Primary/diagnostic imaging ; Hyperparathyroidism, Primary/surgery ; Male ; Middle Aged ; Odds Ratio ; Parathyroidectomy/methods ; Preoperative Care/methods ; Radionuclide Imaging/methods ; Referral and Consultation ; Retrospective Studies ; Sensitivity and Specificity ; Severity of Illness Index ; Surgeons ; Technetium Tc 99m Sestamibi
    Chemische Substanzen Technetium Tc 99m Sestamibi (971Z4W1S09)
    Sprache Englisch
    Erscheinungsdatum 2017-01
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2016.05.048
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Uk I Zs.129: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  9. Artikel: BIOCHEMICAL DYNAMICS OF UNTREATED PRIMARY HYPERPARATHYROIDISM: AN OBSERVATIONAL STUDY.

    Yeh, Michael W / Zhou, Hui / Kuo, Eric J / Adams, Annette L / Li, Ning / Haigh, Philip I

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2019  Band 25, Heft 5, Seite(n) 470–476

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Calcium ; California ; Humans ; Hyperparathyroidism, Primary ; Parathyroid Hormone ; Parathyroidectomy ; Retrospective Studies
    Chemische Substanzen Parathyroid Hormone ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2019-01-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.4158/EP-2018-0489
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5034: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 508: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  10. Artikel ; Online: End-organ effects of primary hyperparathyroidism: A population-based study.

    Assadipour, Yasmine / Zhou, Hui / Kuo, Eric J / Haigh, Philip I / Adams, Annette L / Yeh, Michael W

    Surgery

    2018  Band 165, Heft 1, Seite(n) 99–104

    Abstract: Background: Patients with primary hyperparathyroidism are at risk for skeletal and renal end-organ damage.: Methods: We studied patients with biochemically confirmed primary hyperparathyroidism from 1995-2014 and quantified the frequency of ... ...

    Abstract Background: Patients with primary hyperparathyroidism are at risk for skeletal and renal end-organ damage.
    Methods: We studied patients with biochemically confirmed primary hyperparathyroidism from 1995-2014 and quantified the frequency of osteoporosis, nephrolithiasis, hypercalciuria, and decrease in renal function.
    Results: The cohort comprised 9,485 patients. In total, 3,303 (35%) had preexisting end-organ effects (osteoporosis, 24%; nephrolithiasis, 10%; hypercalciuria, 5%). Of 6,182 remaining patients, 1,769 (29%) exhibited progression to 1 or more end-organ effects over a median 3.7 years. Among patients with classic primary hyperparathyroidism (calcium and parathyroid hormone increased), progression was unrelated to the degree of hypercalcemia (calcium >11.5 mg/dL, hazard ratio 1.03, 95% confidence interval 0.85-1.25; 11.1-11.5 mg/dL, HR 1.07, 95% confidence interval 0.93-1.23; 10.5-11.0 mg/dL = reference). Patients with nonclassic primary hyperparathyroidism (calcium increased, parathyroid hormone 40-65 pg/mL) had a lesser risk of progression (calcium >11.5 mg/dL, hazard ratio 0.68, 95% confidence interval 0.50-0.94; 11.1-11.5 mg/dL, hazard ratio 0.68, 95% confidence interval 0.56-0.82; 10.5-11.0 mg/dL, hazard ratio 0.66, 95% confidence interval 0.59-0.74). End-organ damage developed before or within 5 years of diagnosis for 62% of patients.
    Conclusion: End-organ manifestations of primary hyperparathyroidism develop before biochemical diagnosis or within 5 years in most patients. End-organ damage occurred more frequently in patients with classic primary hyperparathyroidism versus nonclassic primary hyperparathyroidism, regardless of severity of hypercalcemia.
    Mesh-Begriff(e) Aged ; Calcium/blood ; Cohort Studies ; Disease Progression ; Female ; Glomerular Filtration Rate ; Humans ; Hypercalciuria/etiology ; Hyperparathyroidism, Primary/complications ; Male ; Middle Aged ; Nephrolithiasis/etiology ; Osteoporosis/etiology ; Severity of Illness Index
    Chemische Substanzen Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2018-11-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2018.04.088
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Uk I Zs.129: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang