LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 211

Suchoptionen

  1. Artikel: Interview with Scott B. Halstead, M.D.

    Halstead, Scott B

    Vector borne and zoonotic diseases (Larchmont, N.Y.)

    2007  Band 7, Heft 1, Seite(n) 99–105

    Mesh-Begriff(e) Aedes/virology ; Animals ; Dengue/prevention & control ; Dengue Vaccines/immunology ; Global Health ; Humans ; Mosquito Control ; Public Health
    Chemische Substanzen Dengue Vaccines
    Sprache Englisch
    Erscheinungsdatum 2007
    Erscheinungsland United States
    Dokumenttyp Interview
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2007.9998
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: Three Dengue Vaccines - What Now?

    Halstead, Scott B

    The New England journal of medicine

    2024  Band 390, Heft 5, Seite(n) 464–465

    Mesh-Begriff(e) Humans ; Dengue/prevention & control ; Dengue Vaccines/adverse effects ; Dengue Vaccines/therapeutic use ; Dengue Virus ; Vaccines, Attenuated/adverse effects ; Vaccines, Attenuated/therapeutic use
    Chemische Substanzen Dengue Vaccines ; Vaccines, Attenuated
    Sprache Englisch
    Erscheinungsdatum 2024-02-05
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2314240
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Buch: Dengue

    Halstead, Scott B.

    (Tropical medicine ; 5)

    2008  

    Verfasserangabe ed. by Scott B. Halstead
    Serientitel Tropical medicine ; 5
    Überordnung
    Schlagwörter Dengue ; Dengue Virus / pathogenicity
    Sprache Englisch
    Umfang XX, 485 S. : Ill., graph. Darst.
    Verlag Imperial College Press
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT015751309
    ISBN 1-84816-228-6 ; 978-1-84816-228-0
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: Is Dengue Vaccine Protection Possible?

    Halstead, Scott B

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Band 74, Heft 1, Seite(n) 156–160

    Abstract: In tropical and subtropical countries, 4 dengue viruses (DENVs) produce mild disease and a potentially fatal vascular permeability syndrome. Unique antigenic and biological properties of DENVs contribute to vaccine development delays. Three tissue ... ...

    Abstract In tropical and subtropical countries, 4 dengue viruses (DENVs) produce mild disease and a potentially fatal vascular permeability syndrome. Unique antigenic and biological properties of DENVs contribute to vaccine development delays. Three tissue culture-based tetravalent candidate dengue vaccines have advanced to phase 3 clinical testing. Sanofi-Pasteur's chimeric yellow fever tetravalent dengue vaccine, Dengvaxia, licensed in 19 dengue-endemic countries, Europe, and the United States, partially protects seropositives but sensitizes some seronegatives to severe hospitalized dengue. During 2 years of phase 3, Takeda's TAK-003, a chimeric DENV 2 tetravalent vaccine, protected against DENV 2 but was less protective against other DENVs. In seronegative adults, 1 dose of a tetravalent nonstructural deletion mutant vaccine in late phase developed by the US National Institutes of Health protected seronegative humans against challenge with DENVs 2 and 3. This experience suggests nearly whole DENV genomes are required to achieve balanced and sustained protective immunity.
    Mesh-Begriff(e) Adult ; Antibodies, Neutralizing ; Antibodies, Viral ; Dengue/prevention & control ; Dengue Vaccines ; Dengue Virus ; Humans ; Vaccines, Attenuated ; Yellow Fever
    Chemische Substanzen Antibodies, Neutralizing ; Antibodies, Viral ; Dengue Vaccines ; Vaccines, Attenuated
    Sprache Englisch
    Erscheinungsdatum 2021-03-31
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab282
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  5. Artikel ; Online: Vaccine-Associated Enhanced Viral Disease: Implications for Viral Vaccine Development.

    Halstead, Scott B

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

    2021  Band 35, Heft 5, Seite(n) 505–515

    Abstract: Vaccine-associated enhanced disease (VAED) is a serious barrier to attaining successful virus vaccines in human and veterinary medicine. VAED occurs as two different immunopathologies, antibody-dependent enhancement (ADE) and vaccine-associated ... ...

    Abstract Vaccine-associated enhanced disease (VAED) is a serious barrier to attaining successful virus vaccines in human and veterinary medicine. VAED occurs as two different immunopathologies, antibody-dependent enhancement (ADE) and vaccine-associated hypersensitivity (VAH). ADE contributes to the pathology of disease caused by four dengue viruses (DENV) through control of the intensity of cellular infection. Products of virus-infected cells are toxic. A partially protective yellow fever chimeric tetravalent DENV vaccine sensitized seronegative children to ADE breakthrough infections. A live-attenuated tetravalent whole virus vaccine in phase III testing appears to avoid ADE by providing durable protection against the four DENV. VAH sensitization by viral vaccines occurred historically. Children given formalin-inactivated measles or respiratory syncytial virus (RSV) vaccines experienced severe disease during breakthrough infections. Tissue responses demonstrated that VAH not ADE caused these vaccine safety problems. Subsequently, measles was successfully and safely contained by a live-attenuated virus vaccine. The difficulty in formulating a safe and effective RSV vaccine is troublesome evidence that avoiding VAH is a major research challenge. VAH-like tissue responses were observed during breakthrough homologous virus infections in monkeys given severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS) vaccines.
    Mesh-Begriff(e) Antibodies, Neutralizing ; Antibodies, Viral ; Dengue ; Dengue Vaccines ; Humans ; Viral Envelope Proteins ; Virus Diseases
    Chemische Substanzen Antibodies, Neutralizing ; Antibodies, Viral ; Dengue Vaccines ; Viral Envelope Proteins
    Sprache Englisch
    Erscheinungsdatum 2021-09-09
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1364202-9
    ISSN 1179-190X ; 1173-8804
    ISSN (online) 1179-190X
    ISSN 1173-8804
    DOI 10.1007/s40259-021-00495-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  6. Artikel ; Online: A Step in the Right Direction.

    Halstead, Scott B

    The Journal of infectious diseases

    2020  Band 222, Heft 5, Seite(n) 712–714

    Mesh-Begriff(e) Antibody-Dependent Enhancement ; Child ; Dengue ; Humans ; Viral Load ; Virus Diseases
    Sprache Englisch
    Erscheinungsdatum 2020-05-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiz619
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  7. Artikel ; Online: COVID-19: The Need for Immunoprevention at Industrial Scale.

    Halstead, Scott B

    The American journal of tropical medicine and hygiene

    2020  Band 102, Heft 6, Seite(n) 1151

    Mesh-Begriff(e) Antibodies, Monoclonal/biosynthesis ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Monoclonal/therapeutic use ; Antiviral Agents/chemical synthesis ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/pathogenicity ; COVID-19 ; COVID-19 Testing ; COVID-19 Vaccines ; Clinical Laboratory Techniques/statistics & numerical data ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Humans ; Immune Sera/chemistry ; Immune Sera/pharmacology ; Immunotherapy/methods ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; United States/epidemiology ; Viral Vaccines/biosynthesis ; Viral Vaccines/therapeutic use
    Chemische Substanzen Antibodies, Monoclonal ; Antiviral Agents ; COVID-19 Vaccines ; Immune Sera ; Viral Vaccines
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-10
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-0239
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  8. Artikel ; Online: An Urgent Need for "Common Cold Units" to Study COVID-19.

    Halstead, Scott B

    The American journal of tropical medicine and hygiene

    2020  Band 102, Heft 6, Seite(n) 1152–1153

    Mesh-Begriff(e) Antibodies, Monoclonal/biosynthesis ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Monoclonal/therapeutic use ; Antiviral Agents/chemical synthesis ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/pathogenicity ; COVID-19 ; COVID-19 Testing ; COVID-19 Vaccines ; Clinical Laboratory Techniques/statistics & numerical data ; Common Cold/diagnosis ; Common Cold/drug therapy ; Common Cold/epidemiology ; Common Cold/prevention & control ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Drug Repositioning/statistics & numerical data ; Humans ; Immune Sera/chemistry ; Immune Sera/pharmacology ; Immunotherapy/methods ; International Cooperation ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; United States/epidemiology ; Viral Vaccines/biosynthesis ; Viral Vaccines/therapeutic use
    Chemische Substanzen Antibodies, Monoclonal ; Antiviral Agents ; COVID-19 Vaccines ; Immune Sera ; Viral Vaccines
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-09
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-0246
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  9. Artikel ; Online: Travelling arboviruses: A historical perspective.

    Halstead, Scott B

    Travel medicine and infectious disease

    2019  Band 31, Seite(n) 101471

    Abstract: Chikungunya, dengue, yellow fever and Zika viruses share many attributes. All are complex and widespread zoonoses of subhuman primates that have made successful transitions to the urban Aedes aegypti transmission cycle. More important, they have an ... ...

    Abstract Chikungunya, dengue, yellow fever and Zika viruses share many attributes. All are complex and widespread zoonoses of subhuman primates that have made successful transitions to the urban Aedes aegypti transmission cycle. More important, they have an established record of travelling, having moved from their place of origin hundreds of years ago, sometimes repeatedly. Understanding their epidemiology requires a knowledge of past behaviors including unexplained restraints to their travel. This is a review of mechanisms that may contribute to invasiveness and pathogenicity of these important human pathogens.
    Mesh-Begriff(e) Arbovirus Infections/epidemiology ; Arbovirus Infections/history ; Arbovirus Infections/virology ; Arboviruses/physiology ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Travel-Related Illness
    Sprache Englisch
    Erscheinungsdatum 2019-08-28
    Erscheinungsland Netherlands
    Dokumenttyp Historical Article ; Journal Article ; Review
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2019.101471
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang