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  1. Artikel: Werner Döring 75 Jahre alt

    Schmidt, Hartwig / Döring, Werner

    Uni HH : Berichte und Meinungen aus der Universität Hamburg Vol. 17, No. 5 , p. 80-81

    1986  Band 17, Heft 5, Seite(n) 80–81

    Verfasserangabe Hartwig Schmidt
    Erscheinungsort Hamburg
    Dokumenttyp Artikel
    ZDB-ID 221155-5
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  2. Buch: Schädel-Hirn-Trauma

    Wallesch, Claus-Werner / Kulke, Hartwig

    neurologische Rehabilitation und Neuropsychologie : eine Einführung für Ärzte, Psychologen, Therapeuten und Pflegende

    2017  

    Verfasserangabe Claus-W. Wallesch, Hartwig Kulke
    Schlagwörter Schädel-Hirn-Trauma ; Anschlussheilbehandlung
    Schlagwörter Anschlussheilverfahren ; Rehabilitation ; Nachbehandlung ; Heilverfahren ; Schädel-Hirn-Verletzung ; Schädelhirntrauma ; Schädeltrauma ; Schädelverletzung ; Hirntrauma ; Gehirntrauma ; Hirnverletzung ; Gehirnverletzung
    Sprache Deutsch
    Umfang 141 Seiten, Illustrationen, Diagramme
    Ausgabenhinweis 1. Auflage
    Verlag Verlag W. Kohlhammer
    Erscheinungsort Stuttgart
    Erscheinungsland Deutschland
    Dokumenttyp Buch
    HBZ-ID HT019388092
    ISBN 978-3-17-032023-9 ; 978317032026 ; 9783170320253 ; 9783170320260 ; 3-17-032023-8 ; 3170320262 ; 3170320254
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  3. Buch ; Dissertation / Habilitation: Adaptation und Ermüdung

    Hartwig, Werner

    Einflüsse auf die Biomechanik des Laufens im Hinblick auf die Prävention von Verletzungen des Kniegelenks

    1996  

    Verfasserangabe vorgelegt von Werner Hartwig
    Sprache Deutsch
    Umfang 127 S. : Ill., graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation München, Univ., Diss., 1996
    HBZ-ID HT007826024
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  4. Buch ; Online ; Dissertation / Habilitation: Die Therapie der postoperativen Lymphfistel nach Pankreaslinksresektionen

    Bidlingmaier, Elisabeth Carolin [Verfasser] / Hartwig, Werner [Akademischer Betreuer]

    2023  

    Verfasserangabe Elisabeth Carolin Bidlingmaier ; Betreuer: Werner Hartwig
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Universitätsbibliothek der Ludwig-Maximilians-Universität
    Erscheinungsort München
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  5. Artikel: 5‐Fluoruracil – Bestimmung von α‐Fluor‐β‐alanin in Urin mittels GC‐MS/MS : Biomonitoring Methods in German language, 2019

    Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe / Schierl, Rudolf / Fischer, Elke / Scherer, Gerhard / Hagedorn, Heinz Werner / Göen, Thomas / Hartwig, Andrea / MAK Commission

    The MAK collection for occupational health and safety, 4(1):337-352

    2019  

    Abstract: The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The method described hereinafter permits ... ...

    Körperschaft Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe
    Abstract The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The method described hereinafter permits the determination of α‐fluoro‐β‐alanine (FBAL), the main metabolite of 5‐fluorouracil, at low concentration levels and can be used for the biomonitoring of exposed individuals (manufacture, pharmacy, medicine). To this end, urine samples are spiked with 13C‐FBAL as internal standard (IS) and acidified with 0.1 M hydrochloric acid. The samples are then extracted and purified using a strong cation exchanger. After resuspension and derivatisation, FBAL is analysed using GC‐MS/MS in the MRM (Multiple Reaction Monitoring) mode and quantified with reference to the internal standard. Calibration standards are prepared in pooled urine and processed in the same way as the samples to be analysed.
    Schlagwörter 5-Fluoruracil ; Analysen in biologischem Material ; Biomonitoring ; Biomonitoring-Methoden ; Biomonitoring Methods ; GC-MS/MS ; Gaschromatographie-Massenspektrometrie ; Urin ; α-Fluor-β-alanin
    Sprache Deutsch
    Dokumenttyp Artikel
    DOI 10.4126/FRL01-006455588
    Datenquelle Fachrepositorium Lebenswissenschaften

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  6. Artikel: 5‐Fluorouracil – Determination of α‐fluoro‐β‐alanine in urine by GC‐MS/MS : Biomonitoring Methods, 2019

    Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe / Schierl, Rudolf / Fischer, Elke / Scherer, Gerhard / Hagedorn, Heinz Werner / Göen, Thomas / Hartwig, Andrea / MAK Commission

    The MAK collection for occupational health and safety, 4(1):303-316

    2019  

    Abstract: The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The method described hereinafter permits ... ...

    Körperschaft Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe
    Abstract The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The method described hereinafter permits the determination of α‐fluoro‐β‐alanine (FBAL), the main metabolite of 5‐fluorouracil, at low concentration levels and can be used for the biomonitoring of exposed individuals (manufacture, pharmacy, medicine). To this end, urine samples are spiked with 13C‐FBAL as internal standard (IS) and acidified with 0.1 M hydrochloric acid. The samples are then extracted and purified using a strong cation exchanger. After resuspension and derivatisation, FBAL is analysed using GC‐MS/MS in the MRM (Multiple Reaction Monitoring) mode and quantified with reference to the internal standard. Calibration standards are prepared in pooled urine and processed in the same way as the samples to be analysed.
    Schlagwörter 5-fluorouracil ; Analyses in Biological Materials ; Biomonitoring-Methoden ; Biomonitoring Methods ; GC-MS/MS ; biomonitoring ; gas chromatography mass spectrometry ; urine ; α-fluoro-β-alanine
    Sprache Englisch
    Dokumenttyp Artikel
    DOI 10.4126/FRL01-006455590
    Datenquelle Fachrepositorium Lebenswissenschaften

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  7. Artikel: Bitumen (Dampf und Aerosol bei der Heißverarbeitung) : MAK value documentation in German language, 2019 MAK value documentation in German language, 2019

    Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe / Nies, Eberhard / Brüning, Thomas / Steinhausen, M. / Welge, P. / Werner, S.C.M. / Pallapies, Dirk / Bartsch, Rüdiger / Brinkmann, Britta / Schriever‐Schwemmer, Gerlinde / Hartwig, Andrea / MAK Commission

    The MAK collection for occupational health and safety, 4(3):1253-1371

    2019  

    Abstract: The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the classification of bitumen [8052‐42‐4; 64741‐56‐6; 64742‐93‐4] in Carcinogen Category 2 considering all toxicological endpoints. New ... ...

    Körperschaft Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe
    Abstract The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the classification of bitumen [8052‐42‐4; 64741‐56‐6; 64742‐93‐4] in Carcinogen Category 2 considering all toxicological endpoints. New data allowed a separate assessment of the harmful properties of vapours and aerosols from high‐temperature processing of two bitumen groups. Straight‐Run and Air‐Rectified Bitumen For the derivation of a maximum concentration at the workplace (MAK value), a 2‐year inhalation study in rats exposed to vapours and aerosols from a mixture of straight‐run and air‐rectified bitumen is used. Due to an increased incidence of bronchioalveolar hyperplasia in the lungs and of inflammatory cells in the nasal epithelium, the study resulted in a NOAEC of 6 mg/m3. Taking into account the extrapolation from an animal study and the increased respiratory volume at the workplace compared with the exposure of the animals at rest, a MAK value of 1.5 mg/m3 (sum of vapour and inhalable fraction) is derived for straight‐run and air‐rectified bitumen based on bitumen condensate standard. The MAK value is one‐third of the mean concentration at which three out of 12 inflammation markers are elevated in the sputum of exposed workers. However, the clinical relevance of this finding is unclear and the margin to the MAK value is considered sufficient. The effects on the lung is the most sensitive endpoint, so vapours and aerosols of bitumen are assigned to Peak Limitation Category II with an excursion factor of 2. All in all, the investigated straight‐run and air‐rectified bitumens did not exhibit distinct genotoxic or carcinogenic properties. However, due to the wide range in the chemical composition, harmful emissions of carcinogenic and mutagenic substances during high‐temperature processing cannot be completely excluded. Therefore, vapours and aerosols of straight‐run and air‐rectified bitumens, as commonly used in road paving, are regarded as suspicious carcinogens and classified in Carcinogen Category 3 B. As no data are available for developmental toxicity they are assigned to Pregnancy Risk Group D. Skin contact may contribute significantly to systemic toxicity and the “H” notation is confirmed. Sensitization is not expected from the available data. Oxidized Bitumen There are no inhalation studies available for evaluation of the carcinogenicity of oxidized bitumen (“Roofing Bitumen”). The new animal studies published since 2001 and most of the previous studies show the carcinogenicity of condensates of vapours and aerosols of oxidized bitumens in skin painting studies in mice, so that a significant number of tested oxidized bitumens must be considered carcinogenic. The positive animal experiments on the carcinogenicity are consistent with the results of a genotoxicity study in roofing workers with increased DNA strand break rates. Vapours and aerosols of oxidized bitumen are classified in Carcinogen Category 2. A MAK value could not be derived. Mutations in bacteria and higher levels of benzo[a]pyrene in oxidized bitumen condensates compared to those of straight‐run and air‐rectified bitumen and the systemic availability of inhaled vapours and aerosols of oxidized bitumen support suspicion of germ cell mutagenicity. Therefore, vapours and aerosols of oxidized bitumen are classified in Category 3 B for germ cell mutagens. Skin contact may contribute significantly to systemic toxicity and the “H” notation is confirmed. Sensitization is not expected from the available data.
    Schlagwörter (sub)akute Toxizität ; (sub)chronische Toxizität ; Arbeitsstoff ; Bitumen ; Gefahrstoff ; Genotoxizität ; Destillationsbitumen ; Kanzerogenität ; Hautresorption ; Oxidationsbitumen ; MAK Value Documentations ; MAK-Begründungen ; MAK-Wert ; Metabolismus ; Spitzenbegrenzung ; Reizwirkung ; Reproduktionstoxizität ; Wirkungsmechanismus ; Toxikokinetik ; Toxizität ; fruchtschädigende Wirkung ; keimzellmutagene Wirkung ; krebserzeugende Wirkung ; maximale Arbeitsplatzkonzentration ; sensibilisierende Wirkung
    Sprache Deutsch
    Dokumenttyp Artikel
    DOI 10.4126/FRL01-006461022
    Datenquelle Fachrepositorium Lebenswissenschaften

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  8. Buch ; Online ; Dissertation / Habilitation: Die Rolle von LGR6 in der Genese des humanen duktalen Pankreaskarzinoms (PDAC)

    Härtwig, Daniel [Verfasser] / Werner, Jens [Akademischer Betreuer]

    2019  

    Verfasserangabe Daniel Härtwig ; Betreuer: Jens Werner
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Universitätsbibliothek der Ludwig-Maximilians-Universität
    Erscheinungsort München
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  9. Artikel ; Online: WNT enhancing signals in pancreatic cancer are transmitted by LGR6.

    Wang, Jing / Koch, Dominik T / Hofmann, Felix O / Härtwig, Daniel / Beirith, Iris / Janssen, Klaus Peter / Bazhin, Alexandr V / Niess, Hanno / Werner, Jens / Renz, Bernhard W / Ilmer, Matthias

    Aging

    2023  Band 15, Heft 20, Seite(n) 10897–10914

    Abstract: The G-protein-coupled receptor LGR6 associates with ligands of the R-Spondin (RSPO) family to potentiate preexisting signals of the canonical WNT pathway. However, its importance in pancreatic ductal adenocarcinoma (PDAC) remains unclear. Here, we show ... ...

    Abstract The G-protein-coupled receptor LGR6 associates with ligands of the R-Spondin (RSPO) family to potentiate preexisting signals of the canonical WNT pathway. However, its importance in pancreatic ductal adenocarcinoma (PDAC) remains unclear. Here, we show that LGR6 is differentially expressed in various PDAC cell lines of mesenchymal and epithelial phenotype, respectively, siding with the latter subsets. LGR6 expression is altered based upon the cells' WNT activation status. Furthermore, extrinsic enhancement of WNT pathway signaling increased LGR6 expression suggestive of a reinforcing self-regulatory loop in highly WNT susceptible cells. Downregulation of LGR6 on the other hand, seemed to tamper those effects. Last, downregulation of LGR6 reduced cancer stemness as determined by functional
    Mesh-Begriff(e) Humans ; Pancreatic Neoplasms/pathology ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Wnt Signaling Pathway/genetics ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Pancreatic Neoplasms
    Chemische Substanzen Receptors, G-Protein-Coupled ; LGR6 protein, human
    Sprache Englisch
    Erscheinungsdatum 2023-09-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205101
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Chronische Pankreatitis - Update Leitlinie: Eine Frage der richtigen Therapie zum richtigen Zeitpunkt.

    D'Haese, Jan G / Hartwig, Werner / Werner, Jens

    Zentralblatt fur Chirurgie

    2016  Band 141, Heft 2, Seite(n) 125–128

    Mesh-Begriff(e) Diagnosis, Differential ; Drainage ; Early Diagnosis ; Early Medical Intervention ; Guideline Adherence ; Humans ; Islets of Langerhans Transplantation ; Pain Measurement ; Pancreatectomy ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/surgery ; Pancreatic Pseudocyst/diagnosis ; Pancreatic Pseudocyst/surgery ; Pancreaticojejunostomy ; Pancreatitis, Chronic/complications ; Pancreatitis, Chronic/diagnosis ; Pancreatitis, Chronic/etiology ; Pancreatitis, Chronic/surgery ; Splenectomy
    Sprache Deutsch
    Erscheinungsdatum 2016-04
    Erscheinungsland Germany
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 200935-3
    ISSN 1438-9592 ; 0044-409X
    ISSN (online) 1438-9592
    ISSN 0044-409X
    DOI 10.1055/s-0036-1583222
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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