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Artikel ; Online: Patient-Centered Clinical Decision Support-Where Are We and Where to Next?

Dullabh, Prashila / Leaphart, Desirae / Dhopeshwarkar, Rina / Heaney-Huls, Krysta / Desai, Priyanka

Studies in health technology and informatics

2024 Band 310, Seite(n) 444–448

Abstract: Patient-centered clinical decision support (PC CDS) includes digital health tools that support patients, caregivers, and care teams in healthcare decisions that incorporate patient-centered factors related to four components: knowledge, data, delivery, ... ...

Abstract	Patient-centered clinical decision support (PC CDS) includes digital health tools that support patients, caregivers, and care teams in healthcare decisions that incorporate patient-centered factors related to four components: knowledge, data, delivery, and use. This paper explores the current state of each factor and how each promotes patient-centeredness in healthcare. We conducted a literature review, reviewing 175 peer-reviewed and grey literature, and eighteen key informant interviews. Findings show a need for more research on how to incorporate patient input into the guideline selection and prioritization for PC CDS, development and implementation of PC CDS tools, technical challenges for capturing patient contributed data, and optimizing PC CDS across various settings to meet patient and caregiver needs. While progress is being made in each of the four components of PC CDS, critical gaps remain.
Mesh-Begriff(e)	Humans ; Decision Support Systems, Clinical ; Digital Health ; Expert Systems ; Health Facilities ; Patient-Centered Care
Sprache	Englisch
Erscheinungsdatum	2024-01-25
Erscheinungsland	Netherlands
Dokumenttyp	Review ; Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI231004
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Achieving the protection of high peak bone mass.

Heaney, R P

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

2016 Band 27, Heft 4, Seite(n) 1279–1280

Mesh-Begriff(e)	Bone Density/physiology ; Bone Development/physiology ; Exercise/physiology ; Humans ; Nutritional Physiological Phenomena/physiology ; Osteoporotic Fractures/prevention & control
Sprache	Englisch
Erscheinungsdatum	2016-04
Erscheinungsland	England
Dokumenttyp	Editorial
ZDB-ID	1064892-6
ISSN	1433-2965 ; 0937-941X
ISSN (online)	1433-2965
ISSN	0937-941X
DOI	10.1007/s00198-015-3467-5
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Toward a physiological referent for the vitamin D requirement.

Heaney, R P

Journal of endocrinological investigation

2014 Band 37, Heft 11, Seite(n) 1127–1130

Mesh-Begriff(e)	Animals ; Female ; Homeostasis/drug effects ; Homeostasis/physiology ; Humans ; Lactation/drug effects ; Lactation/metabolism ; Reference Values ; Vitamin D/metabolism ; Vitamin D/pharmacology ; Vitamin D/therapeutic use ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/metabolism
Chemische Substanzen	Vitamin D (1406-16-2)
Sprache	Englisch
Erscheinungsdatum	2014-10-12
Erscheinungsland	Italy
Dokumenttyp	Journal Article ; Review
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-014-0190-6
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The effect of vitamin D dose on bone mineral density.

Heaney, R P

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

2011 Band 23, Heft 2, Seite(n) 789–90; author reply 791

Mesh-Begriff(e)	Bone Density/drug effects ; Cholecalciferol/administration & dosage ; Dietary Supplements ; Female ; Humans ; Osteoporosis, Postmenopausal/drug therapy
Chemische Substanzen	Cholecalciferol (1C6V77QF41)
Sprache	Englisch
Erscheinungsdatum	2011-11-24
Erscheinungsland	England
Dokumenttyp	Letter ; Comment
ZDB-ID	1064892-6
ISSN	1433-2965 ; 0937-941X
ISSN (online)	1433-2965
ISSN	0937-941X
DOI	10.1007/s00198-011-1844-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Alfred R. Wallace's enduring influence on biogeographical studies of the Indo‐Australian archipelago

Ali, Jason R. / Heaney, Lawrence R.

Journal of Biogeography. 2023 Jan., v. 50, no. 1 p.32-40

2023

Abstract: To mark A.R. Wallace's 200th birthday, we review the direct and indirect contributions he made ...

Abstract	To mark A.R. Wallace's 200th birthday, we review the direct and indirect contributions he made to our understanding of the Indo‐Australian Archipelago's biogeography. He is widely known for his field research (1854–1862) and his 1863 boundary line separating the Oriental and Australasian faunal realms (between Bali and Lombok, Borneo and Sulawesi, and the Philippines and the Moluccas). Notably, though, he never accepted Huxley's ‘Wallace Line’ proposal (1868), whose northern part runs between the main Philippine islands and the Palawan Group to the west. Furthermore, in 1910, which was 3 years prior to his demise, he transferred Sulawesi's fauna to the Oriental realm. In 1924, Merrill introduced the ‘Wallacea’ transition zone. Although the label is today widely used to denote a sub‐region within the Indo‐Australian Archipelago between Wallace's 1863 line and Lydekker's 1896 line (first presented by Darlington in 1957), the western boundary was originally based on Huxley's line, and thus included the Philippine islands minus the Palawan group. Most biogeographers appear to be unaware of Merrill and his intention. Finally, recent attempts to define the faunal break have not led to a consensus view, despite the huge increase in primary data plus the application of modern analytical techniques. This reflects the complexities and diversity of the region's faunal distribution patterns, plus the differences in the ways that researchers choose to process their data.
Schlagwörter	Borneo ; Philippines ; biogeography ; fauna ; geographical distribution ; Indo-Australian Archipelago ; Indonesia
Sprache	Englisch
Erscheinungsverlauf	2023-01
Umfang	p. 32-40.
Erscheinungsort	John Wiley & Sons, Ltd
Dokumenttyp	Artikel ; Online
Anmerkung	JOURNAL ARTICLE
ZDB-ID	188963-1
ISSN	0305-0270
ISSN	0305-0270
DOI	10.1111/jbi.14470
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Impacts of Fine Particulate Matter From Wildfire Smoke on Respiratory and Cardiovascular Health in California.

Heaney, Alexandra / Stowell, Jennifer D / Liu, Jia Coco / Basu, Rupa / Marlier, Miriam / Kinney, Patrick

GeoHealth

2022 Band 6, Heft 6, Seite(n) e2021GH000578

Abstract: Increases in wildfire activity across the Western US pose a significant public health threat. While there is evidence that wildfire smoke is detrimental for respiratory health, the impacts on cardiovascular health remain unclear. This study evaluates the ...

Abstract	Increases in wildfire activity across the Western US pose a significant public health threat. While there is evidence that wildfire smoke is detrimental for respiratory health, the impacts on cardiovascular health remain unclear. This study evaluates the association between fine particulate matter (PM
Sprache	Englisch
Erscheinungsdatum	2022-06-03
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2471-1403
ISSN (online)	2471-1403
DOI	10.1029/2021GH000578
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Correction of vitamin D deficiency using sublingually administered vitamin D2 in a Crohn's disease patient with mal-absorption and a new ileostomy.

McCullough, Patrick / Heaney, Robert

The Journal of steroid biochemistry and molecular biology

2017 Band 173, Seite(n) 211–214

Abstract: Vitamin D deficiency has been shown to be associated with many adverse health problems. Studies have shown that patients with Crohn's disease who have low vitamin D levels have a poorer quality of life than those with more adequate levels. It has also ... ...

Abstract	Vitamin D deficiency has been shown to be associated with many adverse health problems. Studies have shown that patients with Crohn's disease who have low vitamin D levels have a poorer quality of life than those with more adequate levels. It has also been shown that patients with mal-absorption problems have a difficult time achieving normal vitamin D levels in spite of aggressive supplementation, and that exposure to UVB radiation may be the most effective treatment option for these patients. We present a case in which 25-hydroxyvitamin D levels were normalized within 2 weeks in a severely vitamin D deficient patient with Crohn's disease with mal-absorption and a new ileostomy, utilizing sublingually administered vitamin D2. A 58 year-old white female was admitted with a new ileostomy following partial bowel resection due to complications from Crohn's disease. She was found to be severely vitamin D deficient at the time of admission, with a level of 6.1ng/ml on hospital day 3. Her treatment with vitamin D was delayed for a few days. She was initially treated with 5000 units of vitamin D3 orally twice a day for 3days (days 7-10). After discussion with the patient and obtaining her consent, vitamin D3 was stopped, and she was then treated with a total of 8 doses of 50,000 units of vitamin D2 administered sublingually. She was given the first 3 doses on alternating days (days 11, 13, 15), and then 5 more doses on consecutive days (days 17-21). The rise in her 25-hydroxyvitamin D level in response to treatment with sublingual vitamin D2 was significant. On day 10, after receiving 3days of orally administered vitamin D3, her level was 9.8ng/ml. One week later, after receiving 3 sublingual doses of vitamin D2, it rose to 20.3ng/ml. It was then measured on alternating days twice over the next 4days, and it rose to 45.5ng/ml, and then to 47.4ng/ml on the day of discharge to home. The major finding of this study is that sublingual administration of vitamin D2 appears to work effectively when intestinal absorption is impaired. The optimal dosing regimen still needs to be determined for the average Crohn's disease patient.
Mesh-Begriff(e)	Crohn Disease/blood ; Crohn Disease/complications ; Crohn Disease/drug therapy ; Crohn Disease/physiopathology ; Ergocalciferols/administration & dosage ; Ergocalciferols/therapeutic use ; Female ; Humans ; Intestinal Absorption ; Middle Aged ; Quality of Life ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/physiopathology ; Vitamins/administration & dosage ; Vitamins/therapeutic use
Chemische Substanzen	Ergocalciferols ; Vitamins ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Sprache	Englisch
Erscheinungsdatum	2017
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2016.12.021
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Organic Chemical Contaminants in Water System Infrastructure Following Wildfire.

Draper, William M / Li, Na / Solomon, Gina M / Heaney, Yvonne C / Crenshaw, Reese B / Hinrichs, Richard L / Chandrasena, R Esala P

ACS ES&T water

2022 Band 2, Heft 2, Seite(n) 357–366

Abstract: Wildfires have destroyed multiple residential communities in California in recent years. After fires in 2017 and 2018, high concentrations of benzene and other volatile organic compounds (VOCs) were found in public drinking water systems in fire-affected ...

Abstract	Wildfires have destroyed multiple residential communities in California in recent years. After fires in 2017 and 2018, high concentrations of benzene and other volatile organic compounds (VOCs) were found in public drinking water systems in fire-affected areas. The sources of the contamination and appropriate remediation have been urgent matters for investigation. This study characterizes target and non-target VOCs and semi volatile organic compounds (SVOCs) in water from a highly contaminated service line after the 2018 Camp Fire (Paradise, CA). Ninety-five organic compounds were identified or tentatively identified in the service line. Laboratory combustion experiments with drinking water pipes made of polyvinyl chloride (PVC), cross-linked polyethylene (PEX) and high-density polyethylene (HDPE) and a review of the literature were used to evaluate potential sources of the detected chemicals. Among the service line contaminants were thirty-two compounds associated with PVC pyrolysis and twenty-eight organic compounds also associated with the pyrolysis of polyethylene. The service line sample also contained fifty-five compounds associated with uncontrolled burning of biomass and waste materials. The findings support hypotheses that wildfires can contaminate drinking water systems both by thermal damage to plastic pipes and intrusion of smoke. Residual chlorine disinfectant in the water system modifies the contaminant distribution observed.
Sprache	Englisch
Erscheinungsdatum	2022-02-01
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2690-0637
ISSN (online)	2690-0637
DOI	10.1021/acsestwater.1c00401
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The Glucocorticoid Toxicity Index-Metabolic Domains, an abridged version of the Glucocorticoid Toxicity Index: post-hoc analysis of data from the ADVOCATE trial.

Patel, Naomi J / Jayne, David R W / Merkel, Peter A / Bekker, Pirow / Zhang, Yuqing / McDowell, P Jane / Johal, Joslin / Heaney, Liam G / Murrell, Dedee / Stone, Martha N / Yue, Huibin / Stone, John H

The Lancet. Rheumatology

2023 Band 5, Heft 7, Seite(n) e413–e421

Abstract: ... p<0·0001). The corresponding correlation for the AIS was 0·73 (0·69-0·77, p<0·0001). The GTI-MD ... in the avacopan group than in the prednisone group, consistent with less toxicity (15·9 vs 23·0 at 13 weeks [p=0 ... 0010]; 26·7 vs 31·7 at 26 weeks [p=0·0092]). The GTI-MD AIS values were also consistent with less ...

Abstract	Background: Quantifying glucocorticoid toxicity is crucial to efforts to reduce it. The Glucocorticoid Toxicity Index (GTI) measures toxicity effectively in clinical trials by calculating two scores: the cumulative worsening score (CWS) and the aggregate improvement score (AIS). However, in clinical practice, high patient volumes limit the time available for standardised assessments. We aimed to compare the GTI with an abbreviated version of the GTI, the GTI-Metabolic Domains (GTI-MD), which could help to address this issue by using data that are collected easily at routine visits and do not require additional effort from clinicians. Methods: We did a post-hoc analysis of data from ADVOCATE, a randomised, double-blind, double-dummy, phase 3 trial in which avacopan replaced a standard prednisone taper in patients with antineutrophil cytoplasmic antibody-associated vasculitis. We calculated the cumulative worsening score (CWS) and aggregate improvement score (AIS) for each domain of the GTI-MD-comprising the BMI, glucose tolerance, blood pressure, and lipid metabolism domains of the GTI-to test its ability to differentiate the avacopan and prednisone groups by glucocorticoid toxicity. Data from two additional disease cohorts, one comprising patients with asthma and the other comprising patients with autoimmune blistering disease, constituted the validation set. Findings: Complete data were available for 321 (97%) of the 330 participants comprising the intention-to-treat population in the ADVOCATE trial at week 13, and 307 (93%) at week 26; data from these individuals were included in our post-hoc analysis. In ADVOCATE, 98 (59%) of 166 participants in the avacopan group were men and 68 (41%) were women, 88 (54%) of 164 in the prednisone group were men and 76 (46%) were women; the mean age of participants was 61·2 years [SD 14·6] in the avacopan group and 60·5 years [14·5] in the prednisone group. The validation cohort included 159 patients (89 with glucocorticoid-dependent asthma, of whom 40 [45%] were men and 49 [55%] were women, and 70 with autoimmune blistering disease of the skin, of whom 30 [43%] were men and 40 [57%] were women). The Spearman's rank correlation coefficient in ADVOCATE for the GTI-MD CWS with the GTI CWS for the treatment groups combined was 0·78 (95% CI 0·75-0·81; p<0·0001). The corresponding correlation for the AIS was 0·73 (0·69-0·77, p<0·0001). The GTI-MD distinguished the groups by glucocorticoid toxicity at both 13 weeks and 26 weeks. The mean GTI-MD CWS was lower in the avacopan group than in the prednisone group, consistent with less toxicity (15·9 vs 23·0 at 13 weeks [p=0·0010]; 26·7 vs 31·7 at 26 weeks [p=0·0092]). The GTI-MD AIS values were also consistent with less toxicity in the avacopan group (2·5 vs 13·0 at 13 weeks [p=0·0003], 4·4 vs 10·1 at 26 weeks [p=0·027]). A GTI-MD score of 0 corresponded to a low likelihood of toxicity in the other GTI domains. In the validation set, the Spearman's rank correlation coefficient for the GTI-MD CWS with the GTI CWS was 0·61 (95% CI 0·50-0·70; p<0·0001) and the corresponding correlation for the AIS was 0·58 (0·47-0·68; p<0·0001). Interpretation: The GTI-MD correlates well with the full GTI and could be incorporated readily into routine clinic workflows without additional input from the clinician. Using the GTI-MD on the background of electronic medical records systems could help clinicians to monitor glucocorticoid toxicity longitudinally, with the goals of preventing the burden of chronic, treatment-related harms and reducing long-term costs to health systems. Funding: ChemoCentryx.
Mesh-Begriff(e)	Female ; Humans ; Male ; Middle Aged ; Aniline Compounds ; Asthma ; Autoimmune Diseases ; Blister ; Glucocorticoids/adverse effects ; Nipecotic Acids ; Prednisone/adverse effects ; Double-Blind Method
Chemische Substanzen	Aniline Compounds ; avacopan (O880NM097T) ; Glucocorticoids ; Nipecotic Acids ; Prednisone (VB0R961HZT)
Sprache	Englisch
Erscheinungsdatum	2023-03-06
Erscheinungsland	England
Dokumenttyp	Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
ISSN	2665-9913
ISSN (online)	2665-9913
DOI	10.1016/S2665-9913(23)00131-5
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A re-assessment of diversity among Philippine gymnures (Mammalia: Erinaceidae: Podogymnura), with a new species from eastern Mindanao.

Balete, Danilo S / Heaney, Lawrence R / Rickart, Eric A / Quidlat, Roselyn S / Rowsey, Dakota M / Olson, Link E

Zootaxa

2023 Band 5228, Heft 3, Seite(n) 244–266

Abstract: ... previously only from the highlands of central Mindanao (P. truei truei and P. t. minima) and from two small ... islands off the northeast tip of Mindanao (P. aureospinula). Based on a combination ... of mitochondrial genetic and qualitative and quantitative morphological data, we recognize P. minima, formerly considered ...

Abstract	Podogymnura, a Philippine endemic genus of gymnures ("soft-furred hedgehogs"), has been known previously only from the highlands of central Mindanao (P. truei truei and P. t. minima) and from two small islands off the northeast tip of Mindanao (P. aureospinula). Based on a combination of mitochondrial genetic and qualitative and quantitative morphological data, we recognize P. minima, formerly considered a subspecies of P. truei, as a distinct species. We also recognize specimens from two little-studied montane regions of southeastern Mindanao, Mt. Hamiguitan and Mt. Kampalili, as a distinctive new species, P. intermedia n. sp. We estimate that dispersal of a common ancestor from Borneo to Mindanao ca. 1.9 to 3.5 Ma gave rise to Podogymnura, followed by speciation within Mindanao beginning 0.53 to 0.97 Ma. These results further increase the rich diversity of mammals on Mindanao, and underscore the importance of the eastern Mindanao highlands as a likely important but little-studied center of Philippine mammalian diversity.
Mesh-Begriff(e)	Animals ; Philippines ; Hedgehogs
Sprache	Englisch
Erscheinungsdatum	2023-01-13
Erscheinungsland	New Zealand
Dokumenttyp	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5228.3.2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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