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  1. Buch ; Dissertation / Habilitation: Darstellung von argyrophilen Nukleolus-Organisator-Regionen assoziierten Proteinen (AgNORs) nach feuchter Autoklavierung beim Mamma-Karzinom der Frau

    Heinrichs, Stefan

    Korrelation mit Tumorstadium und Überleben

    2002  

    Titelvarianten Darstellung von argyrophilen Nukleolus Organisator Regionen assoziierten Proteinen (AgNORs) nach feuchter Autoklavierung beim Mamma Karzinom der Frau
    Verfasserangabe vorgelegt von: Stefan Heinrichs
    Sprache Deutsch
    Umfang 66 Bl. : Ill., graph. Darst.
    Ausgabenhinweis [Mikrofiche-Ausg.]
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Münster (Westfalen), Univ., Diss., 2002
    HBZ-ID HT013670956
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    2002 MB 4996 bestellbar zur Ausleihe Magazin

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  2. Artikel ; Online: More resource efficient recycling of copper and copper alloys by using X-ray fluorescence sorting systems: An investigation on the metallic fraction of mixed foundry residues.

    Kölking, Max / Flamme, Sabine / Heinrichs, Stefan / Schmalbein, Nico / Jacob, Martin

    Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA

    2024  , Seite(n) 734242X241241601

    Abstract: According to the state of the art, most of the mixed copper and copper alloy scrap and residues are processed in a copper smelter. Despite the environmental and economic advantages relative to primary production, the recycling of copper and its alloying ... ...

    Abstract According to the state of the art, most of the mixed copper and copper alloy scrap and residues are processed in a copper smelter. Despite the environmental and economic advantages relative to primary production, the recycling of copper and its alloying elements (zinc, tin, lead, nickel, etc.) requires significantly more energy and cost than remelting unmixed or pure scrap fractions such as separate collected material or production scrap. To date, however, less attention has been given to the mechanical purification of mixed scrap. Therefore, sorting by alloy-specific components (SBASC) using an industrial X-ray fluorescence (XRF) sorting system was tested on the coarse metallic fraction (10-32 mm) of mixed foundry residues. The findings show that XRF-SBASC can recover higher-grade copper concentrates (reaching 98.3% Cu), leaded brass and complex alloys, such as aluminium bronze and red brass with high purities, for the use in the production of new materials. XRF-SBASC can therefore contribute to a more resource efficient metal recycling, mainly by reducing the energy consumption and loss levels in copper metallurgy.
    Sprache Englisch
    Erscheinungsdatum 2024-04-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1480483-9
    ISSN 1096-3669 ; 1399-3070 ; 0734-242X
    ISSN (online) 1096-3669 ; 1399-3070
    ISSN 0734-242X
    DOI 10.1177/0734242X241241601
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Herzinsuffizienz: Neue Therapien und Versorgungsstrukturen

    Heinrichs, Margarete / Frantz, Stefan

    Der Allgemeinarzt

    2019  Band 41, Heft 14, Seite(n) 54

    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 603653-3
    ISSN 0172-7249
    Datenquelle Current Contents Medizin

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  4. Artikel ; Online: Asthma self-management at work, asthma morbidity, and the subjective prognosis of gainful employment - the role of work engagement and overcommitment: a cross-sectional study.

    Heinrichs, Katherina / Schultz, Konrad / Hummel, Stefan / Jütjens, Olaf / Loerbroks, Adrian

    The Journal of asthma : official journal of the Association for the Care of Asthma

    2021  Band 59, Heft 4, Seite(n) 719–729

    Abstract: Objective: Work engagement is considered a constructive and satisfying state of mind promoting well-being, whereas overcommitment contributes to ill-health. We investigated if these psychosocial factors are related to asthma self-management at the ... ...

    Abstract Objective: Work engagement is considered a constructive and satisfying state of mind promoting well-being, whereas overcommitment contributes to ill-health. We investigated if these psychosocial factors are related to asthma self-management at the workplace (i.e. physical activity, trigger avoidance, acute symptom management, communication), asthma control, asthma-specific quality of life, and the subjective prognosis of gainful employment among employees with asthma.
    Methods: Questionnaires were distributed in three pulmonary rehabilitation clinics (10/2017-05/2018) in Germany. Work engagement was measured by three items from the Copenhagen Psychosocial Questionnaire and overcommitment by six items from the effort-reward imbalance questionnaire. Asthma self-management was mainly assessed by self-developed items, asthma morbidity by the Asthma Control Test and the Marks Asthma Quality of Life Questionnaire, and the subjective prognosis of gainful employment by a validated three-item scale. After dichotomization of all variables we ran Poisson regression analyses to calculate multivariable prevalence ratios with 95% confidence intervals.
    Results: The sample comprised 221 individuals with asthma. Low work engagement was related to physical inactivity. Low work engagement and high overcommitment were associated with inadequate trigger avoidance and acute symptom management, reduced asthma-specific quality of life, and a poor prognosis of gainful employment. No relationships were observed with communication or asthma control.
    Conclusions: Our findings highlight the potential contribution of high levels of work engagement to adequate asthma self-management, good quality of life, and a positive subjective prognosis of gainful employment among employees with asthma. Overcommitment shows associations with those outcomes in the opposite direction, which suggests a detrimental role in asthma.
    Mesh-Begriff(e) Asthma/epidemiology ; Asthma/therapy ; Cross-Sectional Studies ; Employment/psychology ; Humans ; Prevalence ; Prognosis ; Quality of Life ; Self-Management ; Stress, Psychological/epidemiology ; Surveys and Questionnaires ; Work Engagement
    Sprache Englisch
    Erscheinungsdatum 2021-03-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603816-5
    ISSN 1532-4303 ; 0277-0903
    ISSN (online) 1532-4303
    ISSN 0277-0903
    DOI 10.1080/02770903.2021.1892751
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Securing the Future Railway System

    Unger, Simon / Heinrichs, Markus / Scheuermann, Dirk / Katzenbeisser, Stefan / Schubert, Max / Hagemann, Leon / Iffländer, Lukas

    Technology Forecast, Security Measures, and Research Demands

    2023  

    Abstract: 1254 ... 1274 ... The railway industry - traditionally a conservative industry with low adaption speed for innovation - is currently entering its digitization phase. The sector faces a challenge in integrating new technologies and approaches into the ... ...

    Abstract 1254

    1274

    The railway industry - traditionally a conservative industry with low adaption speed for innovation - is currently entering its digitization phase. The sector faces a challenge in integrating new technologies and approaches into the employed - often safety-critical - systems. Keeping the systems secure while conforming to the demanding safety norms creates previously unknown problems. In the last decades, the number of attacks on the railway system has increased. Furthermore, with standardized digital technologies, the attack surface will keep growing. Therefore, in this work, we look into the foreseeable future of the railway system and present 21 likely use cases. We analyze these use cases regarding possible threats, rate the severity of these threats, and deduce and rate necessary countermeasures. To this end, we model these use cases and the corresponding threats and countermeasures using Attack Graphs. We use a graphical solution for the risk and security analysis due to advantages over other methods, i.e., table-based solutions, like simplified presentation and an easier understanding of relationships, dependencies, and interactions between various elements. From these Attack Graphs, we extracted 14 commonly recurring attack strategies. After analyzing 49 countermeasures regarding their current maturity and further research and standardization demands, we identified 21 in need of further investigation. This implies that 21 necessary countermeasures to secure these future use cases require further research to apply to railway systems or require standardization. These results will help researchers focus on the necessary research and standardization and railway operators to ensure the security of their systems.

    5

    4
    Thema/Rubrik (Code) 380 ; 303
    Sprache Englisch
    Erscheinungsland de
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for "Off-the-Shelf" Immunotherapy.

    Hoerster, Keven / Uhrberg, Markus / Wiek, Constanze / Horn, Peter A / Hanenberg, Helmut / Heinrichs, Stefan

    Frontiers in immunology

    2021  Band 11, Seite(n) 586168

    Abstract: Cellular immunotherapy using chimeric antigen receptors (CARs) so far has almost exclusively used autologous peripheral blood-derived T cells as immune effector cells. However, harvesting sufficient numbers of T cells is often challenging in heavily pre- ... ...

    Abstract Cellular immunotherapy using chimeric antigen receptors (CARs) so far has almost exclusively used autologous peripheral blood-derived T cells as immune effector cells. However, harvesting sufficient numbers of T cells is often challenging in heavily pre-treated patients with malignancies and perturbed hematopoiesis and perturbed hematopoiesis. Also, such a CAR product will always be specific for the individual patient. In contrast, NK cell infusions can be performed in non-HLA-matched settings due to the absence of alloreactivity of these innate immune cells. Still, the infused NK cells are subject to recognition and rejection by the patient's immune system, thereby limiting their life-span
    Mesh-Begriff(e) Allogeneic Cells/immunology ; Gene Editing/methods ; Gene Knockout Techniques/methods ; Histocompatibility Antigens Class I/immunology ; Humans ; Immunotherapy, Adoptive/methods ; Killer Cells, Natural/immunology ; Killer Cells, Natural/transplantation
    Chemische Substanzen Histocompatibility Antigens Class I
    Sprache Englisch
    Erscheinungsdatum 2021-01-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.586168
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Identification of a novel cardiac epitope triggering T-cell responses in patients with myocardial infarction.

    Hapke, Nils / Heinrichs, Margarete / Ashour, DiyaaElDin / Vogel, Elena / Hofmann, Ulrich / Frantz, Stefan / Campos Ramos, Gustavo

    Journal of molecular and cellular cardiology

    2022  Band 173, Seite(n) 25–29

    Abstract: T-cells contribute to pathophysiological processes in myocardial diseases, including myocardial infarction (MI) and heart failure (HF). Antigen-specificity is a hallmark of T-cell responses but the cardiac antigens that trigger heart-directed T-cell ... ...

    Abstract T-cells contribute to pathophysiological processes in myocardial diseases, including myocardial infarction (MI) and heart failure (HF). Antigen-specificity is a hallmark of T-cell responses but the cardiac antigens that trigger heart-directed T-cell responses in patients have not yet been uncovered, thus posing a roadblock to translation. In the present exploratory study, we identified a peptide fragment of the beta-1 adrenergic receptor (ADRB1) that elicits CD4
    Mesh-Begriff(e) Humans ; Epitopes ; CD4-Positive T-Lymphocytes ; Myocardial Infarction ; Heart
    Chemische Substanzen Epitopes
    Sprache Englisch
    Erscheinungsdatum 2022-09-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2022.09.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online ; Konferenzbeitrag: From Stem Cell Research to Three-Dimensional Organoids and Their Applications in Cancer Research: Meeting Report on the 9th International Meeting of the Stem Cell Network North Rhine Westphalia.

    Langer, Samantha / Horn, Peter A / Heinrichs, Stefan

    Cellular reprogramming

    2017  Band 19, Heft 5, Seite(n) 285–288

    Mesh-Begriff(e) Congresses as Topic ; Germany ; Humans ; Neoplasms/therapy ; Organoids/physiology ; Stem Cell Research
    Sprache Englisch
    Erscheinungsdatum 2017-09-07
    Erscheinungsland United States
    Dokumenttyp Congresses ; Research Support, Non-U.S. Gov't
    ZDB-ID 2542436-1
    ISSN 2152-4998 ; 1557-7457 ; 2152-4971
    ISSN (online) 2152-4998 ; 1557-7457
    ISSN 2152-4971
    DOI 10.1089/cell.2017.0037
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  9. Artikel ; Online: Regeneration of Nothofagus dombeyi (Mirb.) Ørst. in little to moderately disturbed southern beech forests in the Andes of Patagonia (Argentina)

    Zerbe, Stefan / Storz, Stefanie T. / Leitinger, Georg / Joelson, Natalia Zoe / Bava, José / Heinrichs, Steffi / Leuschner, Christoph / Loguercio, Gabriel / Simon, Alois / Urretavizcaya, María F. / Walentowski, Helge

    Forest Ecosystems. 2023 July 17, p.100126-

    2023  , Seite(n) 100126–

    Abstract: Natural forests and stands subjected to little to moderate human impact are continuously declining worldwide and with these, their biodiversity and ecosystem services. Many Nothofagus forests in the south of the South American continent are in a pristine ...

    Abstract Natural forests and stands subjected to little to moderate human impact are continuously declining worldwide and with these, their biodiversity and ecosystem services. Many Nothofagus forests in the south of the South American continent are in a pristine state or only moderately impacted by humans. Forest grazing by livestock, in the past and still today often practiced in a non-sustainable way is, however, increasingly under discussion to meet current environmental and socio-economic challenges. Accordingly, we investigate the regeneration of Nothofagus dombeyi, a keystone species of the Patagonian Andes, in secondary forests in Argentinian northern Patagonia, particularly addressing the role of disturbance through grazing by livestock at various intensities. We test the hypothesis that the regeneration of this tree species is favored by grazing impact and, thus, disturbance of the herb layer and soil surface. In support of our hypothesis, Nothofagus dombeyi regeneration was significantly higher in terms of individuals and height classes in moderately grazed forests. Multivariate analysis shows significant positive effects of moderate grazing pressure, herb layer cover, and the occurrence of bare soil on the regeneration of Nothofagus dombeyi. Our results show that an integration of livestock grazing and forest regeneration is possible and that agroforestry systems can be an adequate management option for stakeholders in the region. A grazing management can also be part of a forest fire prevention strategy. However, the regeneration success and grazing pressure should be continuously monitored.
    Schlagwörter Fagus ; Nothofagus dombeyi ; agroforestry ; anthropogenic activities ; biodiversity ; ecosystems ; fire prevention ; forest fires ; forest regeneration ; forests ; grazing intensity ; ground vegetation ; keystone species ; livestock ; multivariate analysis ; socioeconomics ; soil ; stakeholders ; trees ; Andes region ; Argentina ; Disturbance ; Fire management ; Forest grazing ; Forest management ; Plant traits
    Sprache Englisch
    Erscheinungsverlauf 2023-0717
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version
    ZDB-ID 2760380-5
    ISSN 2197-5620
    ISSN 2197-5620
    DOI 10.1016/j.fecs.2023.100126
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Regeneration of Nothofagus dombeyi (Mirb.) Ørst. in little to moderately disturbed southern beech forests in the Andes of Patagonia (Argentina)

    Stefan Zerbe / Stefanie T. Storz / Georg Leitinger / Natalia Zoe Joelson / José Bava / Steffi Heinrichs / Christoph Leuschner / Gabriel Loguercio / Alois Simon / María F. Urretavizcaya / Helge Walentowski

    Forest Ecosystems, Vol 10, Iss , Pp 100126- (2023)

    2023  

    Abstract: Natural forests and stands subjected to little to moderate human impact are continuously declining worldwide and with these, their biodiversity and ecosystem services. Many Nothofagus forests in the south of the South American continent are in a pristine ...

    Abstract Natural forests and stands subjected to little to moderate human impact are continuously declining worldwide and with these, their biodiversity and ecosystem services. Many Nothofagus forests in the south of the South American continent are in a pristine state or only moderately impacted by humans. Forest grazing by livestock, in the past and still today often practiced in a non-sustainable way is, however, increasingly under discussion to meet current environmental and socio-economic challenges. Accordingly, we investigate the regeneration of Nothofagus dombeyi, a keystone species of the Patagonian Andes, in secondary forests in Argentinian northern Patagonia, particularly addressing the role of disturbance through grazing by livestock at various intensities. We test the hypothesis that the regeneration of this tree species is favored by grazing impact and, thus, disturbance of the herb layer and soil surface. In support of our hypothesis, Nothofagus dombeyi regeneration was significantly higher in terms of individuals and height classes in moderately grazed forests. Multivariate analysis shows significant positive effects of moderate grazing pressure, herb layer cover, and the occurrence of bare soil on the regeneration of Nothofagus dombeyi. Our results show that an integration of livestock grazing and forest regeneration is possible and that agroforestry systems can be an adequate management option for stakeholders in the region. A grazing management can also be part of a forest fire prevention strategy. However, the regeneration success and grazing pressure should be continuously monitored.
    Schlagwörter Agroforestry ; Disturbance ; Fire management ; Forest grazing ; Forest management ; Plant traits ; Ecology ; QH540-549.5
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag KeAi Communications Co., Ltd.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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