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  1. Article ; Online: Inhaled volatile β-caryophyllene is incorporated into the aortic wall and attenuates nicotine-induced aorta degeneration via a CB2 receptor-dependent pathway.

    Kishi, Chihiro / Higashihara, Mayo / Takemoto, Yuki / Kamei, Moeka / Yoshioka, Yuri / Matsumura, Shinichi / Yamada, Kazuya / Kobayashi, Takanori / Matahira, Yoshiharu / Moriyama, Tatsuya / Zaima, Nobuhiro

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 153, Page(s) 113423

    Abstract: β-caryophyllene (BCP) is a volatile bicyclic sesquiterpenoid found in essential oils obtained from several spices such as black pepper, oregano, basil, rosemary, cinnamon, and clove. BCP is a selective agonist of cannabinoid receptor 2 (CB2 receptor), ... ...

    Abstract β-caryophyllene (BCP) is a volatile bicyclic sesquiterpenoid found in essential oils obtained from several spices such as black pepper, oregano, basil, rosemary, cinnamon, and clove. BCP is a selective agonist of cannabinoid receptor 2 (CB2 receptor), and orally administered BCP exhibits various biological activities, including anti-inflammatory, antioxidant, and neuroprotective effects. However, it is still unclear how volatile BCP affects living organisms. We previously reported that inhaled BCP is transferred to sera and organs in mice; additionally, metabolomic analysis revealed inhaled BCP affect the dynamics of metabolites in the livers of mice. These data suggest that inhaled BCP may affect several biological activities by stimulating biological systems. In this study, we evaluated the effects of BCP inhalation on nicotine-induced degeneration of the aortic wall. In the group of mice which inhaled volatile BCP, nicotine-induced increases in elastic fiber degradation and matrix metalloproteinase-2 (MMP-2)-positive areas were attenuated. In addition, BCP improved the nicotine-induced stiffness of aortae and vulnerability to aortic rupture. In cultured aortae, the suppressive effects of BCP were inhibited by the CB2 receptor inhibitor AM630. These results suggest that inhaled BCP is incorporated into the aortic wall and prevents nicotine-induced degeneration of the aorta via a CB2 receptor-dependent pathway.
    MeSH term(s) Animals ; Aorta ; Matrix Metalloproteinase 2 ; Mice ; Nicotine ; Polycyclic Sesquiterpenes ; Receptor, Cannabinoid, CB2 ; Sesquiterpenes/pharmacology
    Chemical Substances Polycyclic Sesquiterpenes ; Receptor, Cannabinoid, CB2 ; Sesquiterpenes ; Nicotine (6M3C89ZY6R) ; caryophyllene (BHW853AU9H) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
    Language English
    Publishing date 2022-07-22
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.113423
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    Ud II Zs.198: Show issues Location:
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  2. Article ; Online: Severe hyponatremia due to inappropriate secretion of antidiuretic hormone following pleurodesis.

    Higashihara, Kazuya / Kimbara, Yoshiyuki / Suzuki, Yohei / Kawate, Eriko / Takahashi, Hideki

    Internal medicine (Tokyo, Japan)

    2009  Volume 48, Issue 12, Page(s) 1069–1071

    Abstract: A 69-year-old man was diagnosed as having syndrome of inappropriate secretion of antidiuretic hormone (SIADH) (serum sodium: 113 mEq/L) 13 days after a right upper lobectomy due to squamous cell carcinoma of the lung (pT1N0M0, stage IA) whereas the ... ...

    Abstract A 69-year-old man was diagnosed as having syndrome of inappropriate secretion of antidiuretic hormone (SIADH) (serum sodium: 113 mEq/L) 13 days after a right upper lobectomy due to squamous cell carcinoma of the lung (pT1N0M0, stage IA) whereas the preoperative serum sodium level was nearly normal. He had undergone pleurodesis by instillation of OK432 at 2 and 5 days after surgery for prolonged air leakage. Since other possible causes of SIADH, such as residue of lung cancer, pulmonary infections, brain disorders, or known causative drugs were ruled out, the SIADH in this patient was likely associated with pleurodesis by the use of OK-432. A review of similar cases reported suggests that it is important to be aware of the possibility of severe hyponatremia due to SIADH after chemical pleurodesis.
    MeSH term(s) Aged ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Carcinoma, Squamous Cell/surgery ; Combined Modality Therapy ; Humans ; Hyponatremia/diagnosis ; Hyponatremia/etiology ; Inappropriate ADH Syndrome/chemically induced ; Inappropriate ADH Syndrome/complications ; Lung Neoplasms/surgery ; Male ; Picibanil/administration & dosage ; Picibanil/adverse effects ; Pleurodesis/adverse effects ; Pleurodesis/methods ; Sodium/blood
    Chemical Substances Antineoplastic Agents ; Picibanil (39325-01-4) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2009-06-15
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.48.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Locally sulfonated poly(ether sulfone)s with highly sulfonated units as proton exchange membrane

    Matsumoto, Kazuya / Higashihara, Tomoya / Ueda, Mitsuru

    Journal of polymer science. Part A, Polymer chemistry. 2009 July 01, v. 47, no. 13

    2009  

    Abstract: Novel locally sulfonated poly(ether sulfone)s with highly sulfonated units were successfully synthesized for fuel cell applications. Poly(ether sulfone)s were prepared by the nucleophilic substitution of bis(4-fluorophenyl) sulfone with 1,2,4,5-tetrakis([ ...

    Abstract Novel locally sulfonated poly(ether sulfone)s with highly sulfonated units were successfully synthesized for fuel cell applications. Poly(ether sulfone)s were prepared by the nucleophilic substitution of bis(4-fluorophenyl) sulfone with 1,2,4,5-tetrakis([1,1'-biphenyl]-2-oxy)-3,6-bis(4-hydroxyphenoxy)benzene and bis(4-hydroxyphenyl) sulfide, followed by oxidation using m-chloroperoxybenzoic acid. The desired highly sulfonated units were easily introduced by postsulfonation and each one had ten sulfonic acid groups. The sulfonated polymers gave tough, flexible, and transparent membranes by solvent casting. The high contrast in polarity between highly sulfonated units and hydrophobic poly(ether sulfone) units enabled the formation of defined phase-separated structures and well-connected proton paths. The sulfonated polymers exhibited excellent proton conductivity over a wide range of relative humidities. The proton conductivity of the sulfonated polymer with an ion exchange capacity value of 2.38 mequiv/g was comparable to that of Nafion 117 even at 30% relative humidity.
    Language English
    Dates of publication 2009-0701
    Size p. 3444-3453.
    Publishing place Wiley Subscription Services, Inc., A Wiley Company
    Document type Article
    ISSN 0887-624X
    DOI 10.1002/pola.23403
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  4. Article: Sulfonated poly(ether sulfone)s with binaphthyl units as proton exchange membranes for fuel cell application

    Matsumoto, Kazuya / Nakagawa, Taijiro / Higashihara, Tomoya / Ueda, Mitsuru

    Journal of polymer science. Part A, Polymer chemistry. 2009 Nov. 01, v. 47, no. 21

    2009  

    Abstract: Sulfonated poly(ether sulfone)s containing binaphthyl units (BNSHs) were successfully prepared for fuel cell application. BNSHs, which have very simple structures, were easily synthesized by postsulfonation of poly(1,1'-dinaphthyl ether phenyl sulfone)s ... ...

    Abstract Sulfonated poly(ether sulfone)s containing binaphthyl units (BNSHs) were successfully prepared for fuel cell application. BNSHs, which have very simple structures, were easily synthesized by postsulfonation of poly(1,1'-dinaphthyl ether phenyl sulfone)s and gave tough, flexible, and transparent membranes by solvent casting. The BNSH membranes showed low water uptake compared to a typical sulfonated poly(ether ether sulfone) (BPSH-40) membrane with a similar ion exchange capacity (IEC) value and water insolubility, even with a high IEC values of 3.19 mequiv/g because of their rigid and bulky structures. The BNSH-100 membrane (IEC = 3.19 mequiv/g) exhibited excellent proton conductivity, which was comparable to or even higher than that of Nafion 117, over a range of 30-95% relative humidity (RH). The excellent proton conductivity, especially under low RH conditions, suggests that the BNSH-100 membrane has excellent proton paths because of its high IEC value, and water insolubility due to the high hydrophobicity of the binaphthyl structure.
    Language English
    Dates of publication 2009-1101
    Size p. 5827-5834.
    Publishing place Wiley Subscription Services, Inc., A Wiley Company
    Document type Article
    ISSN 0887-624X
    DOI 10.1002/pola.23627
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  5. Article: Influence of adjusted hydrophilic-hydrophobic lengths in sulfonated multiblock copoly(ether sulfone) membranes for fuel cell application

    Nakabayashi, Kazuhiro / Matsumoto, Kazuya / Higashihara, Tomoya / Ueda, Mitsuru

    Journal of polymer science. Part A, Polymer chemistry. 2008 Nov. 15, v. 46, no. 22

    2008  

    Abstract: Sulfonated multiblock copoly(ether sulfone)s applicable to proton exchange membrane fuel cells (PEMFCs) were synthesized by the coupling reaction of the hydroxyl-terminated hydrophilic and hydrophobic oligomers with different lengths in the presence of ... ...

    Abstract Sulfonated multiblock copoly(ether sulfone)s applicable to proton exchange membrane fuel cells (PEMFCs) were synthesized by the coupling reaction of the hydroxyl-terminated hydrophilic and hydrophobic oligomers with different lengths in the presence of highly reactive decafluorobiphenyl (DFB) as a chain extender to investigate the influence of each length on the membranes' properties, such as water uptake, proton conductivity, and morphology. Multiblock copolymers with high molecular weights (Mn > 50,000, Mw > 150,000) were obtained under mild reaction conditions. The resulting membranes demonstrated good oxidative stability for hot Fenton's reagent and maintained high water uptake (7.3-18.7 wt %) under a low relative humidity (50% RH). Proton conductivity of all membranes at 80 °C and 95% RH was higher than that of Nafion 117 membrane, and good proton conductivity of 7.0 x 10⁻³ S/cm was obtained at 80 °C and 50% RH by optimizing the oligomer lengths. The surface morphology of the membranes was investigated by tapping mode atomic force microscopy (AFM), which showed that the multiblock copolymer membranes had a clearer surface hydrophilic/hydrophobic-separated structure than that of the random copolymer, and contributed to good and effective proton conduction.
    Language English
    Dates of publication 2008-1115
    Size p. 7332-7341.
    Publishing place Wiley Subscription Services, Inc., A Wiley Company
    Document type Article
    ISSN 0887-624X
    DOI 10.1002/pola.23038
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  6. Article ; Online: Comparison of adherence and efficacy between inhaled salmeterol and transdermal tulobuterol patch in elderly patients with chronic obstructive pulmonary disorder.

    Sugawara, Tomonori / Nanjo, Yuta / Yamazaki, Mariko / Higashihara, Kazuya / Tsuda, Yasunari / Mochizuki, Hideaki / Noguchi, Toshiyuki / Takahashi, Hideki

    Journal of the American Geriatrics Society

    2009  Volume 57, Issue 5, Page(s) 919–920

    MeSH term(s) Administration, Cutaneous ; Administration, Inhalation ; Aged ; Albuterol/administration & dosage ; Albuterol/analogs & derivatives ; Bronchodilator Agents/administration & dosage ; Cross-Over Studies ; Female ; Humans ; Male ; Patient Compliance ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Salmeterol Xinafoate ; Terbutaline/administration & dosage ; Terbutaline/analogs & derivatives ; Treatment Outcome
    Chemical Substances Bronchodilator Agents ; tulobuterol (591I9SU0F7) ; Salmeterol Xinafoate (6EW8Q962A5) ; Terbutaline (N8ONU3L3PG) ; Albuterol (QF8SVZ843E)
    Language English
    Publishing date 2009-05
    Publishing country United States
    Document type Comparative Study ; Letter ; Randomized Controlled Trial
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/j.1532-5415.2009.02230.x
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    Ud II Zs.168: Show issues Location:
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