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  1. Article: Involvement of neurons in the non-human primate anterior striatum in proactive inhibition.

    Yoshida, Atsushi / Hikosaka, Okihide

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Behaving as desired requires selecting the appropriate behavior and inhibiting the selection of inappropriate behavior. This inhibitory function involves multiple processes, such as reactive and proactive inhibition, instead of a single process. In this ... ...

    Abstract Behaving as desired requires selecting the appropriate behavior and inhibiting the selection of inappropriate behavior. This inhibitory function involves multiple processes, such as reactive and proactive inhibition, instead of a single process. In this study, macaque monkeys were required to perform a task in which they had to sequentially select (accept) or refuse (reject) a choice. Neural activity was recorded from the anterior striatum, which is considered to be involved in behavioral inhibition, focusing on the distinction between proactive and reactive inhibitions. We identified neurons with significant activity changes during the rejection of bad objects. Cluster analysis revealed three distinct groups, of which one showed obviously increased activity during object rejection, suggesting its involvement in proactive inhibition. This activity pattern was consistent irrespective of the rejection method, indicating a role beyond mere saccadic suppression. Furthermore, minimal activity changes during the fixation task indicated that these neurons were not primarily involved in reactive inhibition. In conclusion, these findings suggest that the anterior striatum plays a crucial role in cognitive control and orchestrates goal-directed behavior through proactive inhibition, which may be critical in understanding the mechanisms of behavioral inhibition dysfunction that occur in patients with basal ganglia disease.
    Language English
    Publishing date 2024-04-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.24.591009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Opposing functions of glutamatergic inputs between the globus pallidus external segment and substantia nigra pars reticulata.

    Yoshida, Atsushi / Hikosaka, Okihide

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The indirect pathway of the basal ganglia, including the subthalamic nucleus (STN) and globus pallidus external segment (GPe), is believed to play a crucial role in suppressing involuntary movements. However, recent evidence suggests the STN and GPe also ...

    Abstract The indirect pathway of the basal ganglia, including the subthalamic nucleus (STN) and globus pallidus external segment (GPe), is believed to play a crucial role in suppressing involuntary movements. However, recent evidence suggests the STN and GPe also facilitate voluntary movements. This study hypothesized that excitatory inputs from the STN to the GPe contribute to this facilitation, and that excitatory projections to the substantia nigra pars reticulata (SNr) are involved in the inhibition. To disrupt the STN-GPe or STN-SNr projections in monkeys during choice and fixation tasks, glutamate receptor inhibitors were injected into the GPe or SNr, which induced delayed saccade latencies toward good choices in the choice task (GPe) and caused frequent reflexive saccades to objects in the fixation task (SNr). Our findings suggest excitatory inputs to the GPe and SNr work in opposing manners, providing new insights that redefine our understanding of the functions of basal ganglia pathways.
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.25.550377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Implication of regional selectivity of dopamine deficits in impaired suppressing of involuntary movements in Parkinson's disease.

    Lee, Hyunchan / Kim, Hyoung F / Hikosaka, Okihide

    Neuroscience and biobehavioral reviews

    2024  Volume 162, Page(s) 105719

    Abstract: To improve the initiation and speed of intended action, one of the crucial mechanisms is suppressing unwanted movements that interfere with goal-directed behavior, which is observed relatively aberrant in Parkinson's disease patients. Recent research has ...

    Abstract To improve the initiation and speed of intended action, one of the crucial mechanisms is suppressing unwanted movements that interfere with goal-directed behavior, which is observed relatively aberrant in Parkinson's disease patients. Recent research has highlighted that dopamine deficits in Parkinson's disease predominantly occur in the caudal lateral part of the substantia nigra pars compacta (SNc) in human patients. We previously found two parallel circuits within the basal ganglia, primarily divided into circuits mediated by the rostral medial part and caudal lateral part of the SNc dopamine neurons. We have further discovered that the indirect pathway in caudal basal ganglia circuits, facilitated by the caudal lateral part of the SNc dopamine neurons, plays a critical role in suppressing unnecessary involuntary movements when animals perform voluntary goal-directed actions. We thus explored recent research in humans and non-human primates focusing on the distinct functions and networks of the caudal lateral part of the SNc dopamine neurons to elucidate the mechanisms involved in the impairment of suppressing involuntary movements in Parkinson's disease patients.
    Language English
    Publishing date 2024-05-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2024.105719
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Salience memories formed by value, novelty and aversiveness jointly shape object responses in the prefrontal cortex and basal ganglia

    Ali Ghazizadeh / Okihide Hikosaka

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 14

    Abstract: How object salience is encoded in the cortex and basal ganglia remains incompletely understood. Here, the authors show that individual prefrontal cortex neurons are jointly sensitive to the memory of value, aversiveness, novelty, and recency of objects, ... ...

    Abstract How object salience is encoded in the cortex and basal ganglia remains incompletely understood. Here, the authors show that individual prefrontal cortex neurons are jointly sensitive to the memory of value, aversiveness, novelty, and recency of objects, while the substantia nigra reticulata filters out novelty and recency signals but amplifies value and aversive memories.
    Keywords Science ; Q
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Conference proceedings: Dynamics of perception

    Hikosaka, Okihide

    (Biomedical research ; 14, Suppl. 4)

    1993  

    Event/congress International Symposium on Dynamics of Perception (3, 1993, Okazaki)
    Author's details Third International Symposium on "Dynamics of Perception", Okazaki, Japan, January 27 - 29, 1993. Ed.: O. Hikosaka
    Series title Biomedical research ; 14, Suppl. 4
    Collection
    Keywords Perception / congresses
    Language English
    Size 129 S. : Ill., graph. Darst.
    Publisher Biomed. Research Foundation
    Publishing place Tokyo
    Publishing country Japan
    Document type Book ; Conference proceedings
    HBZ-ID HT006501713
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1654 -14,Suppl.4- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Lateral habenula neurons signal step-by-step changes of reward prediction

    Hyunchan Lee / Okihide Hikosaka

    iScience, Vol 25, Iss 11, Pp 105440- (2022)

    2022  

    Abstract: ... the lateral habenula (LHb), which inhibit dopamine neurons (Matsumoto and Hikosaka, 2007). LHb neurons showed ...

    Abstract Summary: In real life, multiple objects of different values are mixed in a variety of environments. To survive, animals need to find rewarding objects that may be located but hidden in particular contexts (e.g., environments) with bad objects that are unassociated with reward. Then, animals and humans pay attention to the enriched environment so that they can find the rewarding object vigorously. How can the brain initiate such behavior based on the context? We thus created a behavioral task for monkeys in which multiple contextual events (environment, action cue) sequentially occurred before objects appeared. We then studied the lateral habenula (LHb), which inhibit dopamine neurons (Matsumoto and Hikosaka, 2007). LHb neurons showed phasic responses in each event step-by-step across the sequential events, whose direction (excitation or inhibition) corresponded to the immediate change of the predicted value. Moreover, LHb neurons sequentially compared detailed prediction errors based on their significance in multiple contexts.
    Keywords Biological sciences ; Neuroscience ; Behavioral neuroscience ; Science ; Q
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Lateral habenula neurons signal step-by-step changes of reward prediction.

    Lee, Hyunchan / Hikosaka, Okihide

    iScience

    2022  Volume 25, Issue 11, Page(s) 105440

    Abstract: ... the lateral habenula (LHb), which inhibit dopamine neurons (Matsumoto and Hikosaka, 2007). LHb neurons showed ...

    Abstract In real life, multiple objects of different values are mixed in a variety of environments. To survive, animals need to find rewarding objects that may be located but hidden in particular contexts (e.g., environments) with bad objects that are unassociated with reward. Then, animals and humans pay attention to the enriched environment so that they can find the rewarding object vigorously. How can the brain initiate such behavior based on the context? We thus created a behavioral task for monkeys in which multiple contextual events (environment, action cue) sequentially occurred before objects appeared. We then studied the lateral habenula (LHb), which inhibit dopamine neurons (Matsumoto and Hikosaka, 2007). LHb neurons showed phasic responses in each event step-by-step across the sequential events, whose direction (excitation or inhibition) corresponded to the immediate change of the predicted value. Moreover, LHb neurons sequentially compared detailed prediction errors based on their significance in multiple contexts.
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.105440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Lateral Habenula Responses During Eye Contact in a Reward Conditioning Task.

    Lee, Hyunchan / Hikosaka, Okihide

    Frontiers in behavioral neuroscience

    2022  Volume 16, Page(s) 815461

    Abstract: For many animals, social interaction may have intrinsic reward value over and above its utility as a means to the desired end. Eye contact is the starting point of interactions in many social animals, including primates, and abnormal patterns of eye ... ...

    Abstract For many animals, social interaction may have intrinsic reward value over and above its utility as a means to the desired end. Eye contact is the starting point of interactions in many social animals, including primates, and abnormal patterns of eye contact are present in many mental disorders. Whereas abundant previous studies have shown that negative emotions such as fear strongly affect eye contact behavior, modulation of eye contact by reward has received scant attention. Here we recorded eye movement patterns and neural activity in lateral habenula while monkeys viewed faces in the context of Pavlovian and instrumental conditioning tasks. Faces associated with larger rewards spontaneously elicited longer periods of eye contact from the monkeys, even though this behavior was not required or advantaged in the task. Concurrently, lateral habenula neurons were suppressed by faces signaling high value and excited by faces signaling low value. These results suggest that the reward signaling of lateral habenula may contribute to social behavior and disorders, presumably through its connections with the basal ganglia.
    Language English
    Publishing date 2022-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2022.815461
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  9. Article ; Online: Salience memories formed by value, novelty and aversiveness jointly shape object responses in the prefrontal cortex and basal ganglia.

    Ghazizadeh, Ali / Hikosaka, Okihide

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 6338

    Abstract: Ecological fitness depends on maintaining object histories to guide future interactions. Recent evidence shows that value memory changes passive visual responses to objects in ventrolateral prefrontal cortex (vlPFC) and substantia nigra reticulata (SNr). ...

    Abstract Ecological fitness depends on maintaining object histories to guide future interactions. Recent evidence shows that value memory changes passive visual responses to objects in ventrolateral prefrontal cortex (vlPFC) and substantia nigra reticulata (SNr). However, it is not known whether this effect is limited to reward history and if not how cross-domain representations are organized within the same or different neural populations in this corticobasal circuitry. To address this issue, visual responses of the same neurons across appetitive, aversive and novelty domains were recorded in vlPFC and SNr. Results showed that changes in visual responses across domains happened in the same rather than separate populations and were related to salience rather than valence of objects. Furthermore, while SNr preferentially encoded outcome related salience memory, vlPFC encoded salience memory across all domains in a correlated fashion, consistent with its role as an information hub to guide behavior.
    MeSH term(s) Basal Ganglia/physiology ; Prefrontal Cortex/physiology ; Reward ; Neurons/physiology ; Cerebral Cortex/physiology
    Language English
    Publishing date 2022-10-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-33514-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Conference proceedings: Prospects of the non-invasive approach to higher functions of the living organism

    Hikosaka, Okihide

    (Biomedical research ; 13, Suppl. 1)

    1992  

    Event/congress International Symposium on Studies on the Dynamics of Physiological Functions (1, 1991, Okazaki)
    Author's details First International Symposium on "Studies on the Dynamics of Physiological Functions" ... Okazaki, Japan, February 13 - 15, 1991. Ed.: O. Hikosaka
    Series title Biomedical research ; 13, Suppl. 1
    Collection
    Keywords Brain / physiology / congresses ; Magnetoencephalography / congresses ; Tomography, Emission-Computed / congresses
    Language English
    Size 87 S. : Ill., graph. Darst.
    Publisher Biomed. Research Foundation
    Publishing place Tokyo
    Publishing country Japan
    Document type Book ; Conference proceedings
    HBZ-ID HT006282504
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1654 -13,Suppl.1- verfügbar in Königswinter Königswinter

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