Artikel ; Online: Renin-Angiotensin System: An Important Player in the Pathogenesis of Acute Respiratory Distress Syndrome.
International journal of molecular sciences
2020 Band 21, Heft 21
Abstract: Acute respiratory distress syndrome (ARDS) is characterized by massive inflammation, increased vascular permeability and pulmonary edema. Mortality due to ARDS remains very high and even in the case of survival, acute lung injury can lead to pulmonary ... ...
Abstract | Acute respiratory distress syndrome (ARDS) is characterized by massive inflammation, increased vascular permeability and pulmonary edema. Mortality due to ARDS remains very high and even in the case of survival, acute lung injury can lead to pulmonary fibrosis. The renin-angiotensin system (RAS) plays a significant role in these processes. The activities of RAS molecules are subject to dynamic changes in response to an injury. Initially, increased levels of angiotensin (Ang) II and des-Arg |
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Mesh-Begriff(e) | ADAM17 Protein/metabolism ; Angiotensin-Converting Enzyme 2 ; Animals ; Betacoronavirus ; COVID-19 ; Capillary Permeability/physiology ; Coronavirus Infections/pathology ; Humans ; Inflammation/pathology ; Lung/immunology ; Lung/pathology ; Mice ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/pathology ; Pulmonary Edema/pathology ; Rats ; Renin-Angiotensin System/physiology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/pathology ; Tumor Necrosis Factor-alpha/metabolism |
Chemische Substanzen | TNF protein, human ; Tumor Necrosis Factor-alpha ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Ace2 protein, mouse (EC 3.4.17.23) ; Ace2 protein, rat (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; ADAM17 Protein (EC 3.4.24.86) ; ADAM17 protein, human (EC 3.4.24.86) |
Schlagwörter | covid19 |
Sprache | Englisch |
Erscheinungsdatum | 2020-10-28 |
Erscheinungsland | Switzerland |
Dokumenttyp | Journal Article ; Review |
ZDB-ID | 2019364-6 |
ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
ISSN (online) | 1422-0067 |
ISSN | 1422-0067 ; 1661-6596 |
DOI | 10.3390/ijms21218038 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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