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  1. Artikel ; Online: Two Cases of

    Satolli, Sara / Invernizzi, Federica / Danti, Federica Rachele / Reale, Chiara / Panteghini, Celeste / Nardocci, Nardo / Garavaglia, Barbara / Zorzi, Giovanna

    Movement disorders clinical practice

    2023  Band 10, Heft 5, Seite(n) 842–844

    Sprache Englisch
    Erscheinungsdatum 2023-03-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13705
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  2. Artikel ; Online: The contribution of infection and the respiratory microbiome in acute exacerbations of idiopathic pulmonary fibrosis.

    Invernizzi, Rachele / Molyneaux, Philip L

    European respiratory review : an official journal of the European Respiratory Society

    2019  Band 28, Heft 152

    Abstract: Idiopathic pulmonary fibrosis (IPF) arises in genetically susceptible individuals as a result of an aberrant wound-healing response following repetitive alveolar injury. The clinical course of the disease remains both variable and unpredictable with ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF) arises in genetically susceptible individuals as a result of an aberrant wound-healing response following repetitive alveolar injury. The clinical course of the disease remains both variable and unpredictable with periods of more rapid decline, termed acute exacerbation of IPF (AE-IPF), often punctuating the disease trajectory. Exacerbations carry a significant morbidity and mortality, and their exact pathogenesis remains unclear. Given the emerging evidence that disruption and alteration in the lung microbiome plays a role in the pathogenesis and progression of IPF, this review discusses the current knowledge of the contribution of infection and the respiratory microbiome to AE-IPF.
    Mesh-Begriff(e) Animals ; Bacteria/pathogenicity ; Disease Progression ; Dysbiosis ; Host-Pathogen Interactions ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/microbiology ; Lung/microbiology ; Microbiota ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/microbiology
    Sprache Englisch
    Erscheinungsdatum 2019-07-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0045-2019
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Respiratory microbiome and epithelial interactions shape immunity in the lungs.

    Invernizzi, Rachele / Lloyd, Clare M / Molyneaux, Philip L

    Immunology

    2020  Band 160, Heft 2, Seite(n) 171–182

    Abstract: The airway epithelium represents a physical barrier to the external environment acting as the first line of defence against potentially harmful environmental stimuli including microbes and allergens. However, lung epithelial cells are increasingly ... ...

    Abstract The airway epithelium represents a physical barrier to the external environment acting as the first line of defence against potentially harmful environmental stimuli including microbes and allergens. However, lung epithelial cells are increasingly recognized as active effectors of microbial defence, contributing to both innate and adaptive immune function in the lower respiratory tract. These cells express an ample repertoire of pattern recognition receptors with specificity for conserved microbial and host motifs. Modern molecular techniques have uncovered the complexity of the lower respiratory tract microbiome. The interaction between the microbiota and the airway epithelium is key to understanding how stable immune homeostasis is maintained. Loss of epithelial integrity following exposure to infection can result in the onset of inflammation in susceptible individuals and may culminate in lung disease. Here we discuss the current knowledge regarding the molecular and cellular mechanisms by which the pulmonary epithelium interacts with the lung microbiome in shaping immunity in the lung. Specifically, we focus on the interactions between the lung microbiome and the cells of the conducting airways in modulating immune cell regulation, and how defects in barrier structure and function may culminate in lung disease. Understanding these interactions is fundamental in the search for more effective therapies for respiratory diseases.
    Mesh-Begriff(e) Adaptive Immunity ; Airway Remodeling/immunology ; Epithelial Cells/immunology ; Homeostasis/immunology ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Immunity, Mucosal ; Lung/cytology ; Lung/immunology ; Lung/microbiology ; Lung Diseases/immunology ; Lung Diseases/microbiology ; Microbiota/immunology ; Respiratory Mucosa/immunology ; Respiratory Mucosa/microbiology
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-14
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.13195
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  4. Artikel: Pediatric Paroxysmal Exercise-Induced Neurological Symptoms: Clinical Spectrum and Diagnostic Algorithm.

    Danti, Federica Rachele / Invernizzi, Federica / Moroni, Isabella / Garavaglia, Barbara / Nardocci, Nardo / Zorzi, Giovanna

    Frontiers in neurology

    2021  Band 12, Seite(n) 658178

    Abstract: Paroxysmal exercise-induced neurological symptoms (PENS) encompass a wide spectrum of clinical phenomena commonly presenting during childhood and characteristically elicited by physical exercise. Interestingly, few shared pathogenetic mechanisms have ... ...

    Abstract Paroxysmal exercise-induced neurological symptoms (PENS) encompass a wide spectrum of clinical phenomena commonly presenting during childhood and characteristically elicited by physical exercise. Interestingly, few shared pathogenetic mechanisms have been identified beyond the well-known entity of paroxysmal exercise-induced dyskinesia, PENS could be part of more complex phenotypes including neuromuscular, neurodegenerative, and neurometabolic disease, epilepsies, and psychogenetic disorders. The wide and partially overlapping phenotypes and the genetic heterogeneity make the differential diagnosis frequently difficult and delayed; however, since some of these disorders may be treatable, a prompt diagnosis is mandatory. Therefore, an accurate characterization of these symptoms is pivotal for orienting more targeted biochemical, radiological, neurophysiological, and genetic investigations and finally treatment. In this article, we review the clinical, genetic, pathophysiologic, and therapeutic landscape of paroxysmal exercise induced neurological symptoms, focusing on phenomenology and differential diagnosis.
    Sprache Englisch
    Erscheinungsdatum 2021-06-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.658178
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Autoantibodies are present in the bronchoalveolar lavage but not circulation in patients with fibrotic interstitial lung disease.

    Boustani, Karim / Ghai, Poonam / Invernizzi, Rachele / Hewitt, Richard J / Maher, Toby M / Li, Quan-Zhen / Molyneaux, Philip L / Harker, James A

    ERJ open research

    2022  Band 8, Heft 1

    Abstract: Background: Fibrotic interstitial lung disease (fILD) has previously been associated with the presence of autoantibody. While studies have focused on systemic autoimmunity, the role of local autoantibodies in the airways remains unknown. We therefore ... ...

    Abstract Background: Fibrotic interstitial lung disease (fILD) has previously been associated with the presence of autoantibody. While studies have focused on systemic autoimmunity, the role of local autoantibodies in the airways remains unknown. We therefore extensively characterised the airway and peripheral autoantibody profiles in patients with fILD, and assessed association with disease severity and outcome.
    Methods: Bronchoalveolar lavage (BAL) fluid was collected from a cohort of fILD patients and total BAL antibody concentrations were quantified. An autoantigen microarray was used to measure IgG and IgA autoantibodies against 122 autoantigens in BAL from 40 idiopathic pulmonary fibrosis (IPF), 20 chronic hypersensitivity pneumonitis (CHP), 20 connective tissue disease-associated ILD (CTD-ILD) patients and 20 controls.
    Results: A subset of patients with fILD but not healthy controls had a local autoimmune signature in their BAL that was not present systemically, regardless of disease. The proportion of patients with IPF with a local autoantibody signature was comparable to that of CTD-ILD, which has a known autoimmune pathology, identifying a potentially novel subset of patients. The presence of an airway autoimmune signature was not associated with reduced survival probability or changes in lung function in the cohort as a whole. Patients with IPF had increased BAL total IgA and IgG
    Conclusion: Airway autoantibodies that are not present systemically identify a group of patients with fILD and the mechanisms by which these autoantibodies contribute to disease requires further investigation.
    Sprache Englisch
    Erscheinungsdatum 2022-02-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00481-2021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Respiratory microbiome and epithelial interactions shape immunity in the lungs

    Invernizzi, Rachele / Lloyd, Clare M / Molyneaux, Philip L

    Immunology

    Abstract: The airway epithelium represents a physical barrier to the external environment acting as the first line of defence against potentially harmful environmental stimuli including microbes and allergens. However, lung epithelial cells are increasingly ... ...

    Abstract The airway epithelium represents a physical barrier to the external environment acting as the first line of defence against potentially harmful environmental stimuli including microbes and allergens. However, lung epithelial cells are increasingly recognized as active effectors of microbial defence, contributing to both innate and adaptive immune function in the lower respiratory tract. These cells express an ample repertoire of pattern recognition receptors with specificity for conserved microbial and host motifs. Modern molecular techniques have uncovered the complexity of the lower respiratory tract microbiome. The interaction between the microbiota and the airway epithelium is key to understanding how stable immune homeostasis is maintained. Loss of epithelial integrity following exposure to infection can result in the onset of inflammation in susceptible individuals and may culminate in lung disease. Here we discuss the current knowledge regarding the molecular and cellular mechanisms by which the pulmonary epithelium interacts with the lung microbiome in shaping immunity in the lung. Specifically, we focus on the interactions between the lung microbiome and the cells of the conducting airways in modulating immune cell regulation, and how defects in barrier structure and function may culminate in lung disease. Understanding these interactions is fundamental in the search for more effective therapies for respiratory diseases.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #11413
    Datenquelle COVID19

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  7. Artikel ; Online: Computational prediction and experimental validation of

    Demeter, Amanda / Jacomin, Anne-Claire / Gul, Lejla / Lister, Ashleigh / Lipscombe, James / Invernizzi, Rachele / Branchu, Priscilla / Macaulay, Iain / Nezis, Ioannis P / Kingsley, Robert A / Korcsmaros, Tamas / Hautefort, Isabelle

    Frontiers in cellular and infection microbiology

    2022  Band 12, Seite(n) 834895

    Abstract: Macroautophagy is a ubiquitous homeostasis and health-promoting recycling process of eukaryotic cells, targeting misfolded proteins, damaged organelles and intracellular infectious agents. Some intracellular pathogens such ... ...

    Abstract Macroautophagy is a ubiquitous homeostasis and health-promoting recycling process of eukaryotic cells, targeting misfolded proteins, damaged organelles and intracellular infectious agents. Some intracellular pathogens such as
    Mesh-Begriff(e) Autophagy/physiology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Epithelial Cells/metabolism ; Humans ; Salmonella Infections ; Salmonella typhimurium/genetics
    Chemische Substanzen Bacterial Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-08-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.834895
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Linking microbial genes to plasma and stool metabolites uncovers host-microbial interactions underlying ulcerative colitis disease course.

    Schirmer, Melanie / Stražar, Martin / Avila-Pacheco, Julian / Rojas-Tapias, Daniel F / Brown, Eric M / Temple, Emily / Deik, Amy / Bullock, Kevin / Jeanfavre, Sarah / Pierce, Kerry / Jin, Shen / Invernizzi, Rachele / Pust, Marie-Madlen / Costliow, Zach / Mack, David R / Griffiths, Anne M / Walters, Thomas / Boyle, Brendan M / Kugathasan, Subra /
    Vlamakis, Hera / Hyams, Jeffrey / Denson, Lee / Clish, Clary B / Xavier, Ramnik J

    Cell host & microbe

    2024  Band 32, Heft 2, Seite(n) 209–226.e7

    Abstract: Understanding the role of the microbiome in inflammatory diseases requires the identification of microbial effector molecules. We established an approach to link disease-associated microbes to microbial metabolites by integrating paired metagenomics, ... ...

    Abstract Understanding the role of the microbiome in inflammatory diseases requires the identification of microbial effector molecules. We established an approach to link disease-associated microbes to microbial metabolites by integrating paired metagenomics, stool and plasma metabolomics, and culturomics. We identified host-microbial interactions correlated with disease activity, inflammation, and the clinical course of ulcerative colitis (UC) in the Predicting Response to Standardized Colitis Therapy (PROTECT) pediatric inception cohort. In severe disease, metabolite changes included increased dipeptides and tauro-conjugated bile acids (BAs) and decreased amino-acid-conjugated BAs in stool, whereas in plasma polyamines (N-acetylputrescine and N1-acetylspermidine) increased. Using patient samples and Veillonella parvula as a model, we uncovered nitrate- and lactate-dependent metabolic pathways, experimentally linking V. parvula expansion to immunomodulatory tryptophan metabolite production. Additionally, V. parvula metabolizes immunosuppressive thiopurine drugs through xdhA xanthine dehydrogenase, potentially impairing the therapeutic response. Our findings demonstrate that the microbiome contributes to disease-associated metabolite changes, underscoring the importance of these interactions in disease pathology and treatment.
    Mesh-Begriff(e) Humans ; Child ; Colitis, Ulcerative/drug therapy ; Host Microbial Interactions ; Gastrointestinal Microbiome/genetics ; Disease Progression ; Genes, Microbial
    Sprache Englisch
    Erscheinungsdatum 2024-01-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2023.12.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Autoantibodies are present in the bronchoalveolar lavage but not circulation in patients with fibrotic interstitial lung disease

    Karim Boustani / Poonam Ghai / Rachele Invernizzi / Richard J. Hewitt / Toby M. Maher / Quan-Zhen Li / Philip L. Molyneaux / James A. Harker

    ERJ Open Research, Vol 8, Iss

    2022  Band 1

    Abstract: Background Fibrotic interstitial lung disease (fILD) has previously been associated with the presence of autoantibody. While studies have focused on systemic autoimmunity, the role of local autoantibodies in the airways remains unknown. We therefore ... ...

    Abstract Background Fibrotic interstitial lung disease (fILD) has previously been associated with the presence of autoantibody. While studies have focused on systemic autoimmunity, the role of local autoantibodies in the airways remains unknown. We therefore extensively characterised the airway and peripheral autoantibody profiles in patients with fILD, and assessed association with disease severity and outcome. Methods Bronchoalveolar lavage (BAL) fluid was collected from a cohort of fILD patients and total BAL antibody concentrations were quantified. An autoantigen microarray was used to measure IgG and IgA autoantibodies against 122 autoantigens in BAL from 40 idiopathic pulmonary fibrosis (IPF), 20 chronic hypersensitivity pneumonitis (CHP), 20 connective tissue disease-associated ILD (CTD-ILD) patients and 20 controls. Results A subset of patients with fILD but not healthy controls had a local autoimmune signature in their BAL that was not present systemically, regardless of disease. The proportion of patients with IPF with a local autoantibody signature was comparable to that of CTD-ILD, which has a known autoimmune pathology, identifying a potentially novel subset of patients. The presence of an airway autoimmune signature was not associated with reduced survival probability or changes in lung function in the cohort as a whole. Patients with IPF had increased BAL total IgA and IgG1 while subjects with CHP had increased BAL IgA, IgG1 and IgG4. In patients with CHP, increased BAL total IgA was associated with reduced survival probability. Conclusion Airway autoantibodies that are not present systemically identify a group of patients with fILD and the mechanisms by which these autoantibodies contribute to disease requires further investigation.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag European Respiratory Society
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: YY1-Related Dystonia: Clinical Aspects and Long-Term Response to Deep Brain Stimulation.

    Zorzi, Giovanna / Keller Sarmiento, Ignacio Juan / Danti, Federica Rachele / Bustos, Bernabe I / Invernizzi, Federica / Panteghini, Celeste / Reale, Chiara / Garavaglia, Barbara / Chiapparini, Luisa / Lubbe, Steven J / Nardocci, Nardo / Mencacci, Niccolò E

    Movement disorders : official journal of the Movement Disorder Society

    2021  Band 36, Heft 6, Seite(n) 1461–1462

    Mesh-Begriff(e) Adult ; Deep Brain Stimulation ; Dystonia/genetics ; Dystonia/therapy ; Dystonic Disorders/genetics ; Dystonic Disorders/therapy ; Globus Pallidus ; Humans ; Male ; Treatment Outcome ; YY1 Transcription Factor
    Chemische Substanzen YY1 Transcription Factor ; YY1 protein, human
    Sprache Englisch
    Erscheinungsdatum 2021-02-27
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28547
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