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Artikel ; Online: Donating blood on a regular basis reduces blood pressure (in hypertensives): appearances are not deceiving.

Kamhieh-Milz, Julian / Tauchmann, Yvonne / Kamhieh-Milz, Sundrela / Pruss, Axel / Doerffel, Yvonne / Michalsen, Andreas

2019 Band 59, Heft 4, Seite(n) 1405–1406

Mesh-Begriff(e)	Blood Donors ; Blood Pressure ; Humans ; Hypertension
Sprache	Englisch
Erscheinungsdatum	2019-04-05
Erscheinungsland	United States
Dokumenttyp	Letter ; Comment
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.15131
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Efficacy and safety of erythrocytapheresis and low-dose erythropoietin for treatment of hemochromatosis.

Brückl, Dorothea / Kamhieh-Milz, Sundrela / Kamhieh-Milz, Julian / Salama, Abdulgabar

Journal of clinical apheresis

2017 Band 32, Heft 3, Seite(n) 170–174

Abstract: Background: The aim of this study was to determine retrospectively the efficacy of combined therapy using erythropoietin (EPO) and erythrocytapheresis (EA) in patients with hereditary hemochromatosis (HH) who did not tolerate phlebotomy.: Patients and ...

Abstract	Background: The aim of this study was to determine retrospectively the efficacy of combined therapy using erythropoietin (EPO) and erythrocytapheresis (EA) in patients with hereditary hemochromatosis (HH) who did not tolerate phlebotomy. Patients and methods: Twenty patients (age range, 43-74 years) with genetically confirmed HH had received low-dose EPO (4,000 IU) in accordance to the patient's hemoglobin levels between each EA session. Laboratory parameters including hemoglobin, ferritin, transferrin, and iron were measured at regular intervals. Results: Anemia did not occur in a single patient and no serious side effects were observed. Combined treatment with EPO and EA was well tolerated, and all 18 patients who suffered from fatigue prior to therapy recovered. Median ferritin values were 678.5 ng/L before treatment and 145 ng/L after treatment. Conclusion: EA in combination with EPO is safe and effective in treating patients with HH. Prospective studies comparing this therapeutic option to phlebotomy are warranted. J. Clin. Apheresis 32:170-174, 2017. © 2016 Wiley Periodicals, Inc.
Sprache	Englisch
Erscheinungsdatum	2017-06
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	604912-6
ISSN	1098-1101 ; 0733-2459
ISSN (online)	1098-1101
ISSN	0733-2459
DOI	10.1002/jca.21477
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Borna disease virus: evidence of naturally-occurring infection in cats in Australia

KAMHIEH, SUNDRELA

APMIS. 2008 June., v. 116, suppl. 124

2008

Sprache	Englisch
Erscheinungsverlauf	2008-06
Umfang	p. 50-52.
Verlag	Blackwell Publishing Ltd
Erscheinungsort	Oxford, UK
Dokumenttyp	Artikel
ISSN	0108-0172 ; 0903-465X ; 0903-4641
ISSN	0108-0172 ; 0903-465X ; 0903-4641
DOI	10.1111/j.1600-0463.2008.000m7.x
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Letter to the Editor refuting "Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations" by Ralf Dürrwald, Jolanta Kolodziejek, Aemero Muluneh, Sibylle Herzog and Norbert Nowotny, Microbes and Infection 8 (2006) 917-929.

Flower, Robert / Kamhieh, Sundrela

Microbes and infection

2006 Band 8, Heft 5, Seite(n) 1419–20; author reply 1421–2

Mesh-Begriff(e)	Animals ; Borna Disease/epidemiology ; Borna Disease/virology ; Borna disease virus/classification ; Borna disease virus/genetics ; Cats ; Disease Reservoirs ; Dogs ; Genetic Variation ; Humans ; Molecular Sequence Data ; Phylogeny
Sprache	Englisch
Erscheinungsdatum	2006-04
Erscheinungsland	France
Dokumenttyp	Comment ; Letter
ZDB-ID	1465093-9
ISSN	1769-714X ; 1286-4579
ISSN (online)	1769-714X
ISSN	1286-4579
DOI	10.1016/j.micinf.2006.02.001
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Regular blood donation may help in the management of hypertension: an observational study on 292 blood donors.

Kamhieh-Milz, Sundrela / Kamhieh-Milz, Julian / Tauchmann, Yvonne / Ostermann, Thomas / Shah, Yatin / Kalus, Ulrich / Salama, Abdulgabar / Michalsen, Andreas

Transfusion

2015 Band 56, Heft 3, Seite(n) 637–644

Abstract: Background: Hypertension is one of the leading global risks for cardiovascular events worldwide. There is preliminary evidence that regular blood donation may be beneficial.: Study design and methods: Unselected blood donors were included in this ... ...

Abstract	Background: Hypertension is one of the leading global risks for cardiovascular events worldwide. There is preliminary evidence that regular blood donation may be beneficial. Study design and methods: Unselected blood donors were included in this observational study. Blood pressure (BP) was measured before and after blood donation, with participants donating between one and four occasions in a 1-year study period. Results: In this study, 292 donors were enrolled. At baseline, 146 had elevated BP (> 140/90 mmHg). In hypertensives, after four blood donations, systolic and diastolic blood pressure (SBP and DBP, respectively) decreased from a mean of 155.9 ± 13.0 to 143.7 ± 15.0 mmHg and from 91.4 ± 9.2 to 84.5 ± 9.3 mmHg, respectively (each p < 0.001). There was a clear dose effect with decreasing BP by the increasing number of blood donations. After at least four blood donations, donors with Stage II hypertensive baseline values (≥ 160 mmHg SBP and/or ≥ 100 mmHg DBP) were found to have the most marked reduction in BP, with 17.1 mmHg (95% confidence interval [CI], -23.2 to -11.0; p < 0.0001) and 11.7 mmHg (95% CI, -17.1 to -6.1; p = 0.0006) for SBP and DBP, respectively. The decrease in BP was not significantly associated with changes of blood count or variables of iron metabolism. Conclusions: Regular blood donation is associated with pronounced decreases of BP in hypertensives. This beneficial effect of blood donation may open a new door regarding community health care and cost reduction in the treatment of hypertension.
Mesh-Begriff(e)	Adult ; Aged ; Blood Donors/statistics & numerical data ; Blood Pressure/physiology ; Female ; Humans ; Hypertension/epidemiology ; Male ; Middle Aged ; Young Adult
Sprache	Englisch
Erscheinungsdatum	2015-12-08
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.13428
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Reduced antioxidant capacities in platelets from patients with autoimmune thrombocytopenia purpura (ITP).

Kamhieh-Milz, Julian / Bal, Gürkan / Sterzer, Viktor / Kamhieh-Milz, Sundrela / Arbach, Olga / Salama, Abdulgabar

Platelets

2012 Band 23, Heft 3, Seite(n) 184–194

Abstract: Autoimmune thrombocytopenic purpura (ITP) is characterized by an abnormally low platelet count and bleeding risks. The exact triggering event remains elusive. Oxidative stress may play a role in several autoimmune diseases. A direct link between ... ...

Abstract	Autoimmune thrombocytopenic purpura (ITP) is characterized by an abnormally low platelet count and bleeding risks. The exact triggering event remains elusive. Oxidative stress may play a role in several autoimmune diseases. A direct link between platelets in ITP and oxidative stress has not yet been addressed. The intracellular platelet antioxidant capacity (AOC) in ITP patients in the active phase (n = 24) and remission (n = 12), and 44 healthy controls were analysed with 2',7'-dichlorodihydrofluorescein diacetate, and in combination with hydrogen peroxide. Enzyme activities (EA) of serum glutathione peroxidase (GPx), glutathione reductase (GRed) and catalase (CAT) were investigated colourimetrically in patients and controls. The AOC of ITP patients in the active phase was drastically reduced, with significantly high mean fluorescence intensity values. Higher GPx activity was observed in both active phase and remission in comparison to healthy controls (p < 0.001), with greater activity observed in active ITP than remission (p = 0.001). However, GRed EA was not elevated indicating that reduced glutathione (GSH) is not comparably recovered as consumed, leading to a decreased bioavailability of GSH and increased oxidative stress. These results suggest that oxidative stress is implicated in active ITP and may play a crucial role in its pathophysiology.
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Antioxidants/metabolism ; Blood Platelets/metabolism ; Female ; Fluoresceins/chemistry ; Hemorrhage/blood ; Hemorrhage/etiology ; Hemorrhage/therapy ; Humans ; Hydrogen Peroxide/chemistry ; Male ; Middle Aged ; Oxidative Stress ; Oxidoreductases/blood ; Platelet Count ; Purpura, Thrombocytopenic, Idiopathic/blood ; Purpura, Thrombocytopenic, Idiopathic/complications ; Purpura, Thrombocytopenic, Idiopathic/therapy
Chemische Substanzen	2',7'-dichlorodihydrofluorescein diacetate ; Antioxidants ; Fluoresceins ; Hydrogen Peroxide (BBX060AN9V) ; Oxidoreductases (EC 1.-)
Sprache	Englisch
Erscheinungsdatum	2012
Erscheinungsland	England
Dokumenttyp	Clinical Trial ; Journal Article
ZDB-ID	1034283-7
ISSN	1369-1635 ; 0953-7104
ISSN (online)	1369-1635
ISSN	0953-7104
DOI	10.3109/09537104.2011.610909
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Differentially expressed microRNAs in maternal plasma for the noninvasive prenatal diagnosis of Down syndrome (trisomy 21).

Kamhieh-Milz, Julian / Moftah, Reham Fadl Hassan / Bal, Gürkan / Futschik, Matthias / Sterzer, Viktor / Khorramshahi, Omid / Burow, Martin / Thiel, Gundula / Stuke-Sontheimer, Annegret / Chaoui, Rabih / Kamhieh-Milz, Sundrela / Salama, Abdulgabar

BioMed research international

2014 Band 2014, Seite(n) 402475

Abstract: Objectives: Most developmental processes are under the control of small regulatory RNAs called microRNAs (miRNAs). We hypothesize that different fetal developmental processes might be reflected by extracellular miRNAs in maternal plasma and may be ... ...

Abstract	Objectives: Most developmental processes are under the control of small regulatory RNAs called microRNAs (miRNAs). We hypothesize that different fetal developmental processes might be reflected by extracellular miRNAs in maternal plasma and may be utilized as biomarkers for the noninvasive prenatal diagnosis of chromosomal aneuploidies. In this proof-of-concept study, we report on the identification of extracellular miRNAs in maternal plasma of Down syndrome (DS) pregnancies. Methods: Using high-throughput quantitative PCR (HT-qPCR), 1043 miRNAs were investigated in maternal plasma via comparison of seven DS pregnancies with age and fetal sex matched controls. Results: Six hundred and ninety-five miRNAs were identified. Thirty-six significantly differentially expressed mature miRNAs were identified as potential biomarkers. Hierarchical cluster analysis of these miRNAs resulted in the clear discrimination of DS from euploid pregnancies. Gene targets of the differentially expressed miRNAs were enriched in signaling pathways such as mucin type-O-glycans, ECM-receptor interactions, TGF-beta, and endocytosis, which have been previously associated with DS. Conclusions: miRNAs are promising and stable biomarkers for a broad range of diseases and may allow a reliable, cost-efficient diagnostic tool for the noninvasive prenatal diagnosis of DS.
Mesh-Begriff(e)	Adult ; Biomarkers/blood ; Down Syndrome/blood ; Down Syndrome/genetics ; Female ; Humans ; Male ; MicroRNAs/blood ; MicroRNAs/genetics ; Pregnancy ; Prenatal Diagnosis ; Transforming Growth Factor beta/genetics ; Trisomy
Chemische Substanzen	Biomarkers ; MicroRNAs ; Transforming Growth Factor beta
Sprache	Englisch
Erscheinungsdatum	2014-11-12
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2014/402475
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Differentially Expressed MicroRNAs in Maternal Plasma for the Noninvasive Prenatal Diagnosis of Down Syndrome (Trisomy 21)

Julian Kamhieh-Milz / Reham Fadl Hassan Moftah / Gürkan Bal / Matthias Futschik / Viktor Sterzer / Omid Khorramshahi / Martin Burow / Gundula Thiel / Annegret Stuke-Sontheimer / Rabih Chaoui / Sundrela Kamhieh-Milz / Abdulgabar Salama

BioMed Research International, Vol

2014 Band 2014

Abstract: Objectives. Most developmental processes are under the control of small regulatory RNAs called microRNAs (miRNAs). We hypothesize that different fetal developmental processes might be reflected by extracellular miRNAs in maternal plasma and may be ... ...

Abstract	Objectives. Most developmental processes are under the control of small regulatory RNAs called microRNAs (miRNAs). We hypothesize that different fetal developmental processes might be reflected by extracellular miRNAs in maternal plasma and may be utilized as biomarkers for the noninvasive prenatal diagnosis of chromosomal aneuploidies. In this proof-of-concept study, we report on the identification of extracellular miRNAs in maternal plasma of Down syndrome (DS) pregnancies. Methods. Using high-throughput quantitative PCR (HT-qPCR), 1043 miRNAs were investigated in maternal plasma via comparison of seven DS pregnancies with age and fetal sex matched controls. Results. Six hundred and ninety-five miRNAs were identified. Thirty-six significantly differentially expressed mature miRNAs were identified as potential biomarkers. Hierarchical cluster analysis of these miRNAs resulted in the clear discrimination of DS from euploid pregnancies. Gene targets of the differentially expressed miRNAs were enriched in signaling pathways such as mucin type-O-glycans, ECM-receptor interactions, TGF-beta, and endocytosis, which have been previously associated with DS. Conclusions. miRNAs are promising and stable biomarkers for a broad range of diseases and may allow a reliable, cost-efficient diagnostic tool for the noninvasive prenatal diagnosis of DS.
Schlagwörter	Medicine ; R
Thema/Rubrik (Code)	500 ; 610
Sprache	Englisch
Erscheinungsdatum	2014-01-01T00:00:00Z
Verlag	Hindawi Limited
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Proteomic profiling of secreted proteins for the hematopoietic support of interleukin-stimulated human umbilical vein endothelial cells.

Bal, Gürkan / Kamhieh-Milz, Julian / Sterzer, Viktor / Al-Samman, Muhammad / Debski, Janusz / Klein, Oliver / Kamhieh-Milz, Sundrela / Bhakdi, Sucharit / Salama, Abdulgabar

Cell transplantation

2013 Band 22, Heft 7, Seite(n) 1185–1199

Abstract: Human umbilical cord vein endothelial cells (HUVECs) secrete a number of factors that greatly impact the proliferation and differentiation of hematopoietic stem and progenitor cells (HSPCs). These factors remain largely unknown. Here, we report on the ... ...

Abstract	Human umbilical cord vein endothelial cells (HUVECs) secrete a number of factors that greatly impact the proliferation and differentiation of hematopoietic stem and progenitor cells (HSPCs). These factors remain largely unknown. Here, we report on the most comprehensive proteomic profiling of the HUVEC secretome and identified 827 different secreted proteins. Two hundred and thirty-one proteins were found in all conditions, whereas 369 proteins were identified only under proinflammatory conditions following IL-1β, IL-3, and IL-6 stimulation. Thirteen proteins including complement factor b (CFb) were identified only under IL-1β and IL-3 conditions and may potentially represent HSPC proliferation factors. The combination of bioinformatics and gene ontology annotations indicates the role of the complement system and its activation. Furthermore, CFb was found to be transcriptionally strongly upregulated. Addition of complement component 5b-9 (C5b-9) monoclonal antibody to the stem cell expansion assay was capable of significantly reducing their proliferation. This study suggests a complement-mediated cross-talk between endothelial cells and HSPCs under proinflammatory conditions.
Mesh-Begriff(e)	Antibodies, Monoclonal/pharmacology ; Antigens, CD34/metabolism ; Cell Proliferation/drug effects ; Complement C5b/immunology ; Complement System Proteins/metabolism ; Computational Biology ; Electrophoresis, Polyacrylamide Gel ; Flow Cytometry ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/drug effects ; Hematopoietic Stem Cells/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Interleukin-1beta/pharmacology ; Interleukin-3/pharmacology ; Interleukin-6/pharmacology ; Peptides/analysis ; Proteomics ; Spectrometry, Mass, Electrospray Ionization ; Up-Regulation
Chemische Substanzen	Antibodies, Monoclonal ; Antigens, CD34 ; Interleukin-1beta ; Interleukin-3 ; Interleukin-6 ; Peptides ; Complement C5b (80295-55-2) ; Complement System Proteins (9007-36-7)
Sprache	Englisch
Erscheinungsdatum	2013
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1135816-6
ISSN	1555-3892 ; 0963-6897
ISSN (online)	1555-3892
ISSN	0963-6897
DOI	10.3727/096368912X657288
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Borna disease virus: evidence of naturally-occurring infection in cats in Australia.

Kamhieh, Sundrela / Hodgson, Jennifer L / Bode, Liv / Ludwig, Hanns / Flower, Robert L P

APMIS. Supplementum

2008 , Heft 124, Seite(n) 50–52

Abstract: In Europe, Borna disease virus (BDV) infection has been linked with staggering disease. The aim of this study was serological investigation for BDV infection in Australian cats. De-identified sera were obtained from domestic cats presented at various ... ...

Abstract	In Europe, Borna disease virus (BDV) infection has been linked with staggering disease. The aim of this study was serological investigation for BDV infection in Australian cats. De-identified sera were obtained from domestic cats presented at various veterinary clinics. BDV antigen levels were measured by a monoclonal antibody-based ELISA. Antibody to BDV measured semiquantitatively by ELISA was detected in 0.8% of cats from South Australia and 3.2% of animals from NSW Confirmatory assays for ELISA positive samples included Western blot and immunofluorescence assay (IFA) with BDV-specific staining. Seven BDV-antigen positive sera (2.4%) were identified in sera from cats from New South Wales (NSW). In blinded testing, amongst a large number of negative results, repeat submissions over a seven-month period from a cat co-infected with Feline Immunodeficiency Virus (FIV) were BDV-antigen positive. Anti-BDV antibody detected in this cat by ELISA was confirmed by Western blot (p24/ p40/p56) and IFA. For 4 other anti-BDV ELISA-positive samples, specific reactions with BDV proteins were observed by Western blot. Ten other anti-BDV ELISA-positive samples were IFA positive. These data provide consistent serological evidence that, while horses in Australia are free of BDV infection, there may be a low rate of BDV infection in cats.
Mesh-Begriff(e)	Animals ; Antibodies, Viral/blood ; Antigens, Viral/blood ; Australia/epidemiology ; Blotting, Western ; Borna Disease/blood ; Borna Disease/epidemiology ; Borna disease virus/immunology ; Cat Diseases/blood ; Cat Diseases/epidemiology ; Cats ; Enzyme-Linked Immunosorbent Assay ; Fluorescent Antibody Technique, Indirect ; Seroepidemiologic Studies
Chemische Substanzen	Antibodies, Viral ; Antigens, Viral
Sprache	Englisch
Erscheinungsdatum	2008-09-03
Erscheinungsland	Denmark
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0903-465X
ISSN	0903-465X
DOI	10.1111/j.1600-0463.2008.000m7.x
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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