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  1. Artikel ; Online: So long, and thanks for all the papers about fish (and other organisms too)

    Steven Kelly

    Biology Open, Vol 12, Iss

    2023  Band 6

    Schlagwörter Science ; Q ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag The Company of Biologists
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Ten years (and counting) of Biology Open.

    Kelly, Steven

    Biology open

    2022  Band 11, Heft 5

    Mesh-Begriff(e) Biology
    Sprache Englisch
    Erscheinungsdatum 2022-06-06
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 2632264-X
    ISSN 2046-6390 ; 2046-6390
    ISSN (online) 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.059370
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: The quest for more food.

    Kelly, Steven

    Science (New York, N.Y.)

    2022  Band 377, Heft 6604, Seite(n) 370–371

    Abstract: Rice yield is increased by boosting nitrogen uptake and photosynthesis. ...

    Abstract Rice yield is increased by boosting nitrogen uptake and photosynthesis.
    Mesh-Begriff(e) Crop Production/methods ; Nitrogen/metabolism ; Oryza/growth & development ; Oryza/metabolism ; Photosynthesis
    Chemische Substanzen Nitrogen (N762921K75)
    Sprache Englisch
    Erscheinungsdatum 2022-07-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.add3882
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Ten years (and counting) of Biology Open

    Steven Kelly

    Biology Open, Vol 11, Iss

    2022  Band 5

    Schlagwörter Science ; Q ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag The Company of Biologists
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Early-career researchers: answering the most important scientific questions of our time.

    Kelly, Steven

    Biology open

    2021  Band 10, Heft 11

    Mesh-Begriff(e) Biological Science Disciplines/trends ; Humans ; Intersectoral Collaboration ; Research Personnel/trends
    Sprache Englisch
    Erscheinungsdatum 2021-11-12
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 2632264-X
    ISSN 2046-6390 ; 2046-6390
    ISSN (online) 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.059061
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Early-career researchers

    Steven Kelly

    Biology Open, Vol 10, Iss

    answering the most important scientific questions of our time

    2021  Band 11

    Schlagwörter Science ; Q ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag The Company of Biologists
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: The economics of organellar gene loss and endosymbiotic gene transfer.

    Kelly, Steven

    Genome biology

    2021  Band 22, Heft 1, Seite(n) 345

    Abstract: Background: The endosymbiosis of the bacterial progenitors of the mitochondrion and the chloroplast are landmark events in the evolution of life on Earth. While both organelles have retained substantial proteomic and biochemical complexity, this ... ...

    Abstract Background: The endosymbiosis of the bacterial progenitors of the mitochondrion and the chloroplast are landmark events in the evolution of life on Earth. While both organelles have retained substantial proteomic and biochemical complexity, this complexity is not reflected in the content of their genomes. Instead, the organellar genomes encode fewer than 5% of the genes found in living relatives of their ancestors. While many of the 95% of missing organellar genes have been discarded, others have been transferred to the host nuclear genome through a process known as endosymbiotic gene transfer.
    Results: Here, we demonstrate that the difference in the per-cell copy number of the organellar and nuclear genomes presents an energetic incentive to the cell to either delete organellar genes or transfer them to the nuclear genome. We show that, for the majority of transferred organellar genes, the energy saved by nuclear transfer exceeds the costs incurred from importing the encoded protein into the organelle where it can provide its function. Finally, we show that the net energy saved by endosymbiotic gene transfer can constitute an appreciable proportion of total cellular energy budgets and is therefore sufficient to impart a selectable advantage to the cell.
    Conclusion: Thus, reduced cellular cost and improved energy efficiency likely played a role in the reductive evolution of mitochondrial and chloroplast genomes and the transfer of organellar genes to the nuclear genome.
    Mesh-Begriff(e) Arabidopsis/genetics ; Bacteria/genetics ; Cell Nucleus ; Chloroplasts ; Gene Transfer, Horizontal ; Genome, Chloroplast ; Genome, Mitochondrial ; Genome, Plant ; Host Microbial Interactions/genetics ; Mitochondria/genetics ; Proteomics ; Symbiosis/genetics
    Sprache Englisch
    Erscheinungsdatum 2021-12-20
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1474-760X
    ISSN (online) 1474-760X
    ISSN 1474-760X
    DOI 10.1186/s13059-021-02567-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: The economics of organellar gene loss and endosymbiotic gene transfer

    Steven Kelly

    Genome Biology, Vol 22, Iss 1, Pp 1-

    2021  Band 22

    Abstract: Abstract Background The endosymbiosis of the bacterial progenitors of the mitochondrion and the chloroplast are landmark events in the evolution of life on Earth. While both organelles have retained substantial proteomic and biochemical complexity, this ... ...

    Abstract Abstract Background The endosymbiosis of the bacterial progenitors of the mitochondrion and the chloroplast are landmark events in the evolution of life on Earth. While both organelles have retained substantial proteomic and biochemical complexity, this complexity is not reflected in the content of their genomes. Instead, the organellar genomes encode fewer than 5% of the genes found in living relatives of their ancestors. While many of the 95% of missing organellar genes have been discarded, others have been transferred to the host nuclear genome through a process known as endosymbiotic gene transfer. Results Here, we demonstrate that the difference in the per-cell copy number of the organellar and nuclear genomes presents an energetic incentive to the cell to either delete organellar genes or transfer them to the nuclear genome. We show that, for the majority of transferred organellar genes, the energy saved by nuclear transfer exceeds the costs incurred from importing the encoded protein into the organelle where it can provide its function. Finally, we show that the net energy saved by endosymbiotic gene transfer can constitute an appreciable proportion of total cellular energy budgets and is therefore sufficient to impart a selectable advantage to the cell. Conclusion Thus, reduced cellular cost and improved energy efficiency likely played a role in the reductive evolution of mitochondrial and chloroplast genomes and the transfer of organellar genes to the nuclear genome.
    Schlagwörter Endosymbiosis ; Gene loss endosymbiotic gene transfer ; Mitochondrion ; Chloroplast ; Organellar genome ; Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
    Thema/Rubrik (Code) 612
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: The Tumor Microenvironment and Immune Response in Breast Cancer.

    Monzavi-Karbassi, Behjatolah / Kelly, Thomas / Post, Steven R

    International journal of molecular sciences

    2024  Band 25, Heft 2

    Abstract: The complex interactions between cancer cells and their surrounding microenvironment are fundamental in determining tumor progression, response to therapy, and, ultimately, patient prognosis [ ... ]. ...

    Abstract The complex interactions between cancer cells and their surrounding microenvironment are fundamental in determining tumor progression, response to therapy, and, ultimately, patient prognosis [...].
    Mesh-Begriff(e) Humans ; Female ; Breast Neoplasms ; Tumor Microenvironment
    Sprache Englisch
    Erscheinungsdatum 2024-01-11
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020914
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Response to Tcherkez and Farquhar: Rubisco adaptation is more limited by phylogenetic constraint than by catalytic trade-off.

    Bouvier, Jacques W / Kelly, Steven

    Journal of plant physiology

    2023  Band 287, Seite(n) 154021

    Abstract: Rubisco is the primary entry point for carbon into the biosphere. It has been widely proposed that rubisco is highly constrained by catalytic trade-offs due to correlations between the enzyme's kinetic traits across species. In previous work, we have ... ...

    Abstract Rubisco is the primary entry point for carbon into the biosphere. It has been widely proposed that rubisco is highly constrained by catalytic trade-offs due to correlations between the enzyme's kinetic traits across species. In previous work, we have shown that the strength of these correlations, and thus the strength of catalytic trade-offs, have been overestimated due to the presence of phylogenetic signal in the kinetic trait data (Bouvier et al., 2021). We demonstrated that only the trade-offs between the Michaelis constant for CO
    Mesh-Begriff(e) Phylogeny ; Ribulose-Bisphosphate Carboxylase/genetics ; Ribulose-Bisphosphate Carboxylase/metabolism ; Carbon Dioxide ; Acclimatization ; Catalysis ; Kinetics
    Chemische Substanzen Ribulose-Bisphosphate Carboxylase (EC 4.1.1.39) ; Carbon Dioxide (142M471B3J)
    Sprache Englisch
    Erscheinungsdatum 2023-06-08
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 283647-6
    ISSN 1618-1328 ; 0176-1617
    ISSN (online) 1618-1328
    ISSN 0176-1617
    DOI 10.1016/j.jplph.2023.154021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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