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  1. Artikel ; Online: Retreatment of symptomatic chronic bronchitis with bronchial rheoplasty.

    Klemm, Theresa / Krimsky, William / Welz, Kelly / Valipour, Arschang

    BMJ case reports

    2024  Band 17, Heft 2

    Abstract: A man in his early 70s with a long-standing history of chronic bronchitis presented to our department 3 years ago with debilitating chronic cough and excessive sputum production. He had no previous diagnosis of chronic obstructive pulmonary disease and ... ...

    Abstract A man in his early 70s with a long-standing history of chronic bronchitis presented to our department 3 years ago with debilitating chronic cough and excessive sputum production. He had no previous diagnosis of chronic obstructive pulmonary disease and without evidence of severe respiratory tract infections. Due to his symptom burden and impairments in daily activities, the patient was considered to be an appropriate candidate for bronchial rheoplasty, a novel endoscopic treatment for patients with chronic bronchitis. The patient responded well to bilateral treatment but then experienced symptom recurrence roughly 14 months after completing the initial treatment. In the absence of an alternative explanation for the return of these symptoms, he then underwent uneventful retreatment. The patient, again, reported significant symptom improvement and no adverse effects since retreatment. While further studies are necessary to assess the safety and efficacy of retreatment, the findings from this case are encouraging.
    Mesh-Begriff(e) Male ; Humans ; Bronchitis, Chronic/drug therapy ; Bronchitis, Chronic/surgery ; Pulmonary Disease, Chronic Obstructive ; Bronchi ; Retreatment ; Chronic Disease ; Bronchitis/complications ; Bronchitis/drug therapy ; Bronchitis/diagnosis
    Sprache Englisch
    Erscheinungsdatum 2024-02-17
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-256764
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Electrochemical CO

    Gawel, Alina / Jaster, Theresa / Siegmund, Daniel / Holzmann, Johannes / Lohmann, Heiko / Klemm, Elias / Apfel, Ulf-Peter

    iScience

    2022  Band 25, Heft 4, Seite(n) 104011

    Abstract: For the efficient electrochemical conversion of ... ...

    Abstract For the efficient electrochemical conversion of CO
    Sprache Englisch
    Erscheinungsdatum 2022-03-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.104011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Characterisation of the OTU domain deubiquitinase complement of

    Wilde, Mary-Louise / Ruparel, Ushma / Klemm, Theresa / Lee, V Vern / Calleja, Dale J / Komander, David / Tonkin, Christopher J

    Life science alliance

    2023  Band 6, Heft 6

    Abstract: The phylum Apicomplexa contains several parasitic species of medical and agricultural importance. The ubiquitination machinery remains, for the most part, uncharacterised in apicomplexan parasites, despite the important roles that it plays in eukaryotic ... ...

    Abstract The phylum Apicomplexa contains several parasitic species of medical and agricultural importance. The ubiquitination machinery remains, for the most part, uncharacterised in apicomplexan parasites, despite the important roles that it plays in eukaryotic biology. Bioinformatic analysis of the ubiquitination machinery in apicomplexan parasites revealed an expanded ovarian tumour domain-containing (OTU) deubiquitinase (DUB) family in
    Mesh-Begriff(e) Toxoplasma/genetics ; Toxoplasma/metabolism ; Ubiquitin/genetics ; Ubiquitin/metabolism ; Ubiquitination ; Plasmodium ; Deubiquitinating Enzymes/genetics ; Deubiquitinating Enzymes/metabolism
    Chemische Substanzen Ubiquitin ; Deubiquitinating Enzymes (EC 3.4.19.12)
    Sprache Englisch
    Erscheinungsdatum 2023-03-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202201710
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Electrochemical CO

    Jaster, Theresa / Gawel, Alina / Siegmund, Daniel / Holzmann, Johannes / Lohmann, Heiko / Klemm, Elias / Apfel, Ulf-Peter

    iScience

    2022  Band 25, Heft 4, Seite(n) 104010

    Abstract: Tackling climate change is one of the undoubtedly most important challenges at the present time. This review deals mainly with the chemical aspects of the current status for converting the greenhouse gas ... ...

    Abstract Tackling climate change is one of the undoubtedly most important challenges at the present time. This review deals mainly with the chemical aspects of the current status for converting the greenhouse gas CO
    Sprache Englisch
    Erscheinungsdatum 2022-03-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.104010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Electrochemical CO2 reduction toward multicarbon alcohols - The microscopic world of catalysts & process conditions

    Theresa Jaster / Alina Gawel / Daniel Siegmund / Johannes Holzmann / Heiko Lohmann / Elias Klemm / Ulf-Peter Apfel

    iScience, Vol 25, Iss 4, Pp 104010- (2022)

    2022  

    Abstract: Summary: Tackling climate change is one of the undoubtedly most important challenges at the present time. This review deals mainly with the chemical aspects of the current status for converting the greenhouse gas CO2 via electrochemical CO2 reduction ... ...

    Abstract Summary: Tackling climate change is one of the undoubtedly most important challenges at the present time. This review deals mainly with the chemical aspects of the current status for converting the greenhouse gas CO2 via electrochemical CO2 reduction reaction (CO2RR) to multicarbon alcohols as valuable products. Feasible reaction routes are presented, as well as catalyst synthesis methods such as electrodeposition, precipitation, or sputtering. In addition, a comprehensive overview of the currently achievable selectivities for multicarbon alcohols in CO2RR is given. It is also outlined to what extent, for example, modifications of the catalyst surfaces or the use of bifunctional compounds the product distribution is shifted. In addition, the influence of varying electrolyte, temperature, and pressure is described and discussed.
    Schlagwörter Catalysis ; Electrochemistry ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Electrochemical CO2 reduction - The macroscopic world of electrode design, reactor concepts & economic aspects

    Alina Gawel / Theresa Jaster / Daniel Siegmund / Johannes Holzmann / Heiko Lohmann / Elias Klemm / Ulf-Peter Apfel

    iScience, Vol 25, Iss 4, Pp 104011- (2022)

    2022  

    Abstract: Summary: For the efficient electrochemical conversion of CO2 into valuable chemical feedstocks, a well-coordinated interaction of all electrolyzer compartments is required. In addition to the catalyst, whose role is described in detail in the part “ ... ...

    Abstract Summary: For the efficient electrochemical conversion of CO2 into valuable chemical feedstocks, a well-coordinated interaction of all electrolyzer compartments is required. In addition to the catalyst, whose role is described in detail in the part “Electrochemical CO2 Reduction toward Multicarbon Alcohols - The Microscopic World of Catalysts & Process Conditions” of this divided review, the general cell setups, design and manufacture of the electrodes, membranes used, and process parameters must be optimally matched. The authors' goal is to provide a comprehensive review of the current literature on how these aspects affect the overall performance of CO2 electrolysis. To be economically competitive as an overall process, the framework conditions, i.e., CO2 supply and reaction product treatment must also be considered. If the key indicators for current density, selectivity, cell voltage, and lifetime of a CO2 electrolyzer mentioned in the techno-economic consideration of this review are met, electrochemical CO2 reduction can make a valuable contribution to the creation of closed carbon cycles and to a sustainable energy economy.
    Schlagwörter Catalysis ; Electrochemistry ; Economics ; Science ; Q
    Thema/Rubrik (Code) 660
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Konferenzbeitrag: Is student mentoring career-defining in surgical disciplines? A comparative survey among medical schools and medical students for mentoring programs

    Hertling, Stefan Ferdinand / Loos, Franziska / Back, David / Klemm, Theresa / Wildemann, Britt / Graul, Isabel

    2021  , Seite(n) AB66–1385

    Veranstaltung/Kongress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2021); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2021
    Schlagwörter Medizin, Gesundheit ; mentoring ; medical students ; gender ; career ; surgery
    Erscheinungsdatum 2021-10-26
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Konferenzbeitrag
    DOI 10.3205/21dkou409
    Datenquelle German Medical Science

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  8. Buch ; Online ; Dissertation / Habilitation: Minor differences cause major effects: How differential oligomerization regulates the activities of USP25 and USP28

    Klemm, Theresa Antonia [Verfasser] / Kisker, Caroline [Gutachter] / Buchberger, Alexander [Gutachter] / Popov, Nikita [Gutachter]

    2020  

    Verfasserangabe Theresa Antonia Klemm ; Gutachter: Caroline Kisker, Alexander Buchberger, Nikita Popov
    Schlagwörter Biowissenschaften, Biologie ; Life Science, Biology
    Thema/Rubrik (Code) sg570
    Sprache Englisch
    Verlag Universität Würzburg
    Erscheinungsort Würzburg
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  9. Buch ; Online: Electrochemical CO2 Reduction - The Macroscopic World of Electrode Design, Reactor Concepts & Economic Aspects

    Gawel, Alina / Jaster, Theresa / Siegmund, Daniel / Holzmann, Johannes / Lohmann, Heiko / Klemm, Elias / Apfel, Ulf-Peter

    2022  

    Abstract: Art. 104011, 36 S. ... For the efficient electrochemical conversion of CO2 into valuable chemical feedstocks, a well-coordinated interaction of all electrolyzer compartments is required. In addition to the catalyst, whose role is described in detail in the ...

    Abstract Art. 104011, 36 S.

    For the efficient electrochemical conversion of CO2 into valuable chemical feedstocks, a well-coordinated interaction of all electrolyzer compartments is required. In addition to the catalyst, whose role is described in detail in the part ""Electrochemical CO2 Reduction towards Multicarbon Alcohols - The Microscopic World of Catalysts & Process Conditions"" of this divided review, the general cell setups, design, and manufacture of the electrodes, membranes used, and process parameters must be optimally matched. The authors' goal is to provide a comprehensive review of the current literature on how these aspects affect the overall performance of CO2 electrolysis. To be economically competitive as an overall process, the framework conditions, i.e., CO2 supply and reaction product treatment, must also be considered. If the key indicators for current density, selectivity, cell voltage, and lifetime of a CO2 electrolyzer mentioned in the techno-economic consideration of this review are met, electrochemical CO2 reduction can make a valuable contribution to the creation of closed carbon cycles and to a sustainable energy economy.

    25

    Nr.4
    Schlagwörter membrane ; CO2 reduction ; process
    Thema/Rubrik (Code) 660
    Sprache Englisch
    Erscheinungsland de
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Smartphone-based screening for atrial fibrillation: a pragmatic randomized clinical trial.

    Rizas, Konstantinos D / Freyer, Luisa / Sappler, Nikolay / von Stülpnagel, Lukas / Spielbichler, Peter / Krasniqi, Aresa / Schreinlechner, Michael / Wenner, Felix N / Theurl, Fabian / Behroz, Amira / Eiffener, Elodie / Klemm, Mathias P / Schneidewind, Annika / Zens, Martin / Dolejsi, Theresa / Mansmann, Ulrich / Massberg, Steffen / Bauer, Axel

    Nature medicine

    2022  Band 28, Heft 9, Seite(n) 1823–1830

    Abstract: Digital smart devices have the capability of detecting atrial fibrillation (AF), but the efficacy of this type of digital screening has not been directly compared to usual care for detection of treatment-relevant AF. In the eBRAVE-AF trial ( NCT04250220 ) ...

    Abstract Digital smart devices have the capability of detecting atrial fibrillation (AF), but the efficacy of this type of digital screening has not been directly compared to usual care for detection of treatment-relevant AF. In the eBRAVE-AF trial ( NCT04250220 ), we randomly assigned 5,551 policyholders of a German health insurance company who were free of AF at baseline (age 65 years (median; interquartile range (11) years, 31% females)) to digital screening (n = 2,860) or usual care (n = 2,691). In this siteless trial, for digital screening, participants used a certified app on their own smartphones to screen for irregularities in their pulse waves. Abnormal findings were evaluated by 14-day external electrocardiogram (ECG) loop recorders. The primary endpoint was newly diagnosed AF within 6 months treated with oral anti-coagulation by an independent physician not involved in the study. After 6 months, participants were invited to cross-over for a second study phase with reverse assignment for secondary analyses. The primary endpoint of the trial was met, as digital screening more than doubled the detection rate of treatment-relevant AF in both phases of the trial, with odds ratios of 2.12 (95% confidence interval (CI), 1.19-3.76; P = 0.010) and 2.75 (95% CI, 1.42-5.34; P = 0.003) in the first and second phases, respectively. This digital screening technology provides substantial benefits in detecting AF compared to usual care and has the potential for broad applicability due to its wide availability on ordinary smartphones. Future studies are needed to test whether digital screening for AF leads to better treatment outcomes.
    Mesh-Begriff(e) Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Child ; Delivery of Health Care ; Electrocardiography ; Female ; Humans ; Male ; Mass Screening ; Smartphone
    Sprache Englisch
    Erscheinungsdatum 2022-08-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-01979-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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