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  1. AU=Klestova Z S
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  1. Artikel: Anticoronavirus Activity of Water-Soluble Pristine C

    Hurmach, Vasyl / Platonov, Maxim / Prylutska, Svitlana / Klestova, Zinaida / Cherepanov, Vsevolod / Prylutskyy, Yuriy / Ritter, Uwe

    Advances in experimental medicine and biology

    2022  Band 1352, Seite(n) 159–172

    Abstract: Introduction: The emergence of a new member of the Coronaviridae family, which caused the 2020 pandemic, requires detailed research on the evolution of coronaviruses, their structure and properties, and interaction with cells. Modern nanobiotechnologies ...

    Abstract Introduction: The emergence of a new member of the Coronaviridae family, which caused the 2020 pandemic, requires detailed research on the evolution of coronaviruses, their structure and properties, and interaction with cells. Modern nanobiotechnologies can address the many clinical challenges posed by the COVID-19 pandemic. In particular, they offer new therapeutic approaches using biocompatible nanostructures with "specific" antiviral activity. Therefore, the nanosized spherical-like molecule (0.72 nm in diameter) composed of 60 carbon atoms, C
    Methods: The shape and size of the particles present in C
    Results: It was found that the maximum allowable cytotoxic concentration of C
    Conclusion: Pioneer in vitro study to identify the anticoronavirus activity of water-soluble pristine C
    Mesh-Begriff(e) Animals ; COVID-19 ; Fullerenes/pharmacology ; Humans ; Pandemics ; SARS-CoV-2 ; Swine ; Water
    Chemische Substanzen Fullerenes ; Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2022-02-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-85109-5_10
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Aspects of "antigen-antibody" interaction of chicken infectious bronchitis virus determined by surface plasmon resonance.

    Klestova, Z S / Voronina, A K / Yushchenko, A Yu / Vatlitsova, O S / Dorozinsky, G V / Ushenin, Yu V / Maslov, V P / Doroshenko, T P / Kravchenko, S A

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2021  Band 264, Seite(n) 120236

    Abstract: Authors performed investigation on "antigen-antibody" interaction of chicken infectious bronchitis coronavirus (IBV) by a method based on the surface plasmon resonance (SPR). Presence of space-size effect related to a difference between antigen and ... ...

    Abstract Authors performed investigation on "antigen-antibody" interaction of chicken infectious bronchitis coronavirus (IBV) by a method based on the surface plasmon resonance (SPR). Presence of space-size effect related to a difference between antigen and antibody particle sizes has been theoretically grounded and experimentally proven. Herewith, the difference between responses of the SPR-sensor to specific and non-specific interactions is considerably less (up to 6.3 times) than the expected one (8 - 11 times). An impact of functionalization of sensor's sensitive element surface, as well as acidity of buffer solution on the activity of antigen-antibody interaction was studied here. The difference between sensor's responses to specific and non-specific interactions increased two-fold from 200 to 432ang sec due to this treatment. When changing the acidity of analyzed solution from pH7.3 to pH6.8, the corresponding difference between sensor's responses increased by 6.3 times from 194 up to 1235ang.sec. Thus, an impact of space-size effect on interaction between IBV antigen and specific antibody can be considerably (almost in 3 times) decreased by reducing the acidity of used buffer solution. The results of our investigation can be successfully applied to develop new methods for detection of pathogens and specific antibodies using SPR.
    Mesh-Begriff(e) Animals ; Antibodies ; Chickens ; Coronavirus Infections/veterinary ; Infectious bronchitis virus ; Surface Plasmon Resonance
    Chemische Substanzen Antibodies
    Sprache Englisch
    Erscheinungsdatum 2021-07-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2021.120236
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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