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  1. Artikel ; Online: The Usefulness of Rare Blood Group Systems in the Risk Determination for Severe COVID-19.

    Konstantinidis, Theocharis G / Iliadi, Valeria / Martinis, Georges / Panopoulou, Maria

    Pathophysiology : the official journal of the International Society for Pathophysiology

    2021  Band 28, Heft 4, Seite(n) 496–500

    Abstract: The newly identified human coronavirus was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on a detailed analysis of clinical manifestation. It was reported that blood type O individuals were less likely to become infected by ... ...

    Abstract The newly identified human coronavirus was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on a detailed analysis of clinical manifestation. It was reported that blood type O individuals were less likely to become infected by SARS-CoV, while blood type A individuals have an increased risk of severe illness. The Forssman antigen, or Forssman glycolipid synthase (FS), was first described in 1911 by John Frederick Forssman. Blood type A/B glycosyltransferases (AT/BTs) and Forssman glycolipid synthase (FS) are encoded by the evolutionarily related ABO (A/B alleles) and
    Sprache Englisch
    Erscheinungsdatum 2021-11-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1212740-1
    ISSN 1873-149X ; 0928-4680
    ISSN (online) 1873-149X
    ISSN 0928-4680
    DOI 10.3390/pathophysiology28040032
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  2. Artikel: The Emerging Role of the Gut Microbiome in Cardiovascular Disease: Current Knowledge and Perspectives.

    Papadopoulos, Panagiotis D / Tsigalou, Christina / Valsamaki, Pipitsa N / Konstantinidis, Theocharis G / Voidarou, Chrysoula / Bezirtzoglou, Eugenia

    Biomedicines

    2022  Band 10, Heft 5

    Abstract: The collection of normally non-pathogenic microorganisms that mainly inhabit our gut lumen shapes our health in many ways. Structural and functional perturbations in the gut microbial pool, known as "dysbiosis", have been proven to play a vital role in ... ...

    Abstract The collection of normally non-pathogenic microorganisms that mainly inhabit our gut lumen shapes our health in many ways. Structural and functional perturbations in the gut microbial pool, known as "dysbiosis", have been proven to play a vital role in the pathophysiology of several diseases, including cardiovascular disease (CVD). Although therapeutic regimes are available to treat this group of diseases, they have long been the main cause of mortality and morbidity worldwide. While age, sex, genetics, diet, tobacco use, and alcohol consumption are major contributors (World Health Organization, 2018), they cannot explain all of the consequences of CVD. In addition to the abovementioned traditional risk factors, the constant search for novel preventative and curative tools has shed light on the involvement of gut bacteria and their metabolites in the pathogenesis of CVD. In this narrative review, we will discuss the established interconnections between the gut microbiota and CVD, as well as the plausible therapeutic perspectives.
    Sprache Englisch
    Erscheinungsdatum 2022-04-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10050948
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  3. Artikel: Legionella pneumophila

    Iliadi, Valeria / Staykova, Jeni / Iliadis, Sergios / Konstantinidou, Ina / Sivykh, Polina / Romanidou, Gioulia / Vardikov, Daniil F / Cassimos, Dimitrios / Konstantinidis, Theocharis G

    Journal of clinical medicine

    2022  Band 11, Heft 20

    Abstract: An outbreak of a potentially fatal form of pneumonia in 1976 and in the annual convention of the American Legion was the first time ... ...

    Abstract An outbreak of a potentially fatal form of pneumonia in 1976 and in the annual convention of the American Legion was the first time that
    Sprache Englisch
    Erscheinungsdatum 2022-10-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11206126
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  4. Artikel ; Online: The Emerging Role of Neutrophils in the Pathogenesis of Thrombosis in COVID-19

    Valeria Iliadi / Ina Konstantinidou / Konstantina Aftzoglou / Sergios Iliadis / Theocharis G. Konstantinidis / Christina Tsigalou

    International Journal of Molecular Sciences, Vol 22, Iss 5368, p

    2021  Band 5368

    Abstract: Previous studies have shown that COVID-19 leads to thrombotic complications, which have been associated with high morbidity and mortality rates. Neutrophils are the largest population of white blood cells and play a pivotal role in innate immunity. ... ...

    Abstract Previous studies have shown that COVID-19 leads to thrombotic complications, which have been associated with high morbidity and mortality rates. Neutrophils are the largest population of white blood cells and play a pivotal role in innate immunity. During an infection, neutrophils migrate from circulation to the infection site, contributing to killing pathogens. This mechanism is regulated by chemokines such as IL-8. Moreover, it was shown that neutrophils play an important role in thromboinflammation. Through a diverse repertoire of mechanisms, neutrophils, apart from directly killing pathogens, are able to activate the formation of thrombi. In COVID-19 patients, neutrophil activation promotes neutrophil extracellular trap (NET) formation, platelet aggregation, and cell damage. Furthermore, neutrophils participate in the pathogenesis of endothelitis. Overall, this review summarizes recent progress in research on the pathogenesis of COVID-19, highlighting the role of the prothrombotic action of neutrophils in NET formation.
    Schlagwörter COVID-19 ; SARS CoV-2 ; NETs ; immunothrombosis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: The Emerging Role of Neutrophils in the Pathogenesis of Thrombosis in COVID-19.

    Iliadi, Valeria / Konstantinidou, Ina / Aftzoglou, Konstantina / Iliadis, Sergios / Konstantinidis, Theocharis G / Tsigalou, Christina

    International journal of molecular sciences

    2021  Band 22, Heft 10

    Abstract: Previous studies have shown that COVID-19 leads to thrombotic complications, which have been associated with high morbidity and mortality rates. Neutrophils are the largest population of white blood cells and play a pivotal role in innate immunity. ... ...

    Abstract Previous studies have shown that COVID-19 leads to thrombotic complications, which have been associated with high morbidity and mortality rates. Neutrophils are the largest population of white blood cells and play a pivotal role in innate immunity. During an infection, neutrophils migrate from circulation to the infection site, contributing to killing pathogens. This mechanism is regulated by chemokines such as IL-8. Moreover, it was shown that neutrophils play an important role in thromboinflammation. Through a diverse repertoire of mechanisms, neutrophils, apart from directly killing pathogens, are able to activate the formation of thrombi. In COVID-19 patients, neutrophil activation promotes neutrophil extracellular trap (NET) formation, platelet aggregation, and cell damage. Furthermore, neutrophils participate in the pathogenesis of endothelitis. Overall, this review summarizes recent progress in research on the pathogenesis of COVID-19, highlighting the role of the prothrombotic action of neutrophils in NET formation.
    Mesh-Begriff(e) COVID-19/complications ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/therapy ; Cytokine Release Syndrome/metabolism ; Cytokine Release Syndrome/virology ; Extracellular Traps/immunology ; Extracellular Traps/virology ; Humans ; Immunity, Innate ; Inflammation/immunology ; Inflammation/pathology ; Kidney/cytology ; Kidney/immunology ; Kidney/pathology ; Kidney/virology ; Lung/cytology ; Lung/immunology ; Lung/pathology ; Lung/virology ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/immunology ; Mucocutaneous Lymph Node Syndrome/virology ; Neutrophils/immunology ; SARS-CoV-2 ; Thrombosis/complications ; Thrombosis/immunology ; Thrombosis/pathology ; Thrombosis/virology
    Sprache Englisch
    Erscheinungsdatum 2021-05-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22105368
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  6. Artikel ; Online: The Emerging Role of the Gut Microbiome in Cardiovascular Disease

    Panagiotis D. Papadopoulos / Christina Tsigalou / Pipitsa N. Valsamaki / Theocharis G. Konstantinidis / Chrysoula Voidarou / Eugenia Bezirtzoglou

    Biomedicines, Vol 10, Iss 948, p

    Current Knowledge and Perspectives

    2022  Band 948

    Abstract: The collection of normally non-pathogenic microorganisms that mainly inhabit our gut lumen shapes our health in many ways. Structural and functional perturbations in the gut microbial pool, known as “dysbiosis”, have been proven to play a vital role in ... ...

    Abstract The collection of normally non-pathogenic microorganisms that mainly inhabit our gut lumen shapes our health in many ways. Structural and functional perturbations in the gut microbial pool, known as “dysbiosis”, have been proven to play a vital role in the pathophysiology of several diseases, including cardiovascular disease (CVD). Although therapeutic regimes are available to treat this group of diseases, they have long been the main cause of mortality and morbidity worldwide. While age, sex, genetics, diet, tobacco use, and alcohol consumption are major contributors (World Health Organization, 2018), they cannot explain all of the consequences of CVD. In addition to the abovementioned traditional risk factors, the constant search for novel preventative and curative tools has shed light on the involvement of gut bacteria and their metabolites in the pathogenesis of CVD. In this narrative review, we will discuss the established interconnections between the gut microbiota and CVD, as well as the plausible therapeutic perspectives.
    Schlagwörter microbiome ; cardiovascular disease ; gut dysbiosis ; CVD ; bacterial metabolites ; TMAO ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Legionella pneumophila

    Valeria Iliadi / Jeni Staykova / Sergios Iliadis / Ina Konstantinidou / Polina Sivykh / Gioulia Romanidou / Daniil F. Vardikov / Dimitrios Cassimos / Theocharis G. Konstantinidis

    Journal of Clinical Medicine, Vol 11, Iss 20, p

    The Journey from the Environment to the Blood

    2022  Band 6126

    Abstract: An outbreak of a potentially fatal form of pneumonia in 1976 and in the annual convention of the American Legion was the first time that Legionella spp. was identified. Thereafter, the term Legionnaires’ disease (LD) was established. The infection in ... ...

    Abstract An outbreak of a potentially fatal form of pneumonia in 1976 and in the annual convention of the American Legion was the first time that Legionella spp. was identified. Thereafter, the term Legionnaires’ disease (LD) was established. The infection in humans is transmitted by the inhalation of aerosols that contain the microorganisms that belong to the Legionellaceae family and the genus Legionella. The genus Legionella contains genetically heterogeneous species and serogroups. The Legionella pneumophila serogroup 1 (Lp1) is the most often detected strain in outbreaks of LD. The pathogenesis of LD infection initiates with the attachment of the bacterial cells to the host cells, and subsequent intracellular replication. Following invasion, Legionella spp. activates its virulence mechanisms: generation of specific compartments of Legionella-containing vacuole (LCV), and expression of genes that encode a type IV secretion system (T4SS) for the translocation of proteins. The ability of L. pneumophila to transmigrate across the lung’s epithelium barrier leads to bacteremia, spread, and invasion of many organs with subsequent manifestations, complications, and septic shock. The clinical manifestations of LD depend on the bacterial load in the aerosol, the virulence factors, and the immune status of the patient. The infection has two distinct forms: the non- pneumatic form or Pontiac fever, which is a milder febrile flu-like illness, and LD, a more severe form, which includes pneumonia. In addition, the extrapulmonary involvement of LD can include heart, brain, abdomen, and joints.
    Schlagwörter Legionella pneumophila ; bloodstream infection ; bacteremia ; Medicine ; R
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2022-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy.

    Romanidou, Gioulia / Konstantinidis, Theocharis G / Natsi, Anastasia-Maria / Kantartzi, Konstantia / Panopoulou, Maria / Kontomanolis, Emmanouil / Tsigalou, Christina / Lambropoulou, Maria / Gavriilaki, Eleni / Panagoutsos, Stylianos / Pasadakis, Ploumis / Mitroulis, Ioannis

    International journal of molecular sciences

    2023  Band 24, Heft 14

    Abstract: HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndrome is a life-threatening complication of pregnancy, which is often secondary to preeclampsia. To date, there is no biomarker in clinical use for the early stratification of women with ... ...

    Abstract HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndrome is a life-threatening complication of pregnancy, which is often secondary to preeclampsia. To date, there is no biomarker in clinical use for the early stratification of women with preeclampsia who are under increased risk of HELLP syndrome. Herein, we show that the levels of circulating developmental endothelial locus-1 (DEL-1), which is an extracellular immunomodulatory protein, are decreased in patients with HELLP syndrome compared to preeclampsia. DEL-1 levels are also negatively correlated with the circulating levels of kidney injury molecule-1 (KIM-1), which is a biomarker for disorders associated with kidney damage. Receiver-operating characteristic curve analysis for DEL-1 levels and the DEL-1 to KIM-1 ratio demonstrates that these values could be used as a potential biomarker that distinguishes patients with HELLP syndrome and preeclampsia. Finally, we show that placental endothelial cells are a source for DEL-1, and that the expression of this protein in placenta from patients with HELLP syndrome is minimal. Taken together, this study shows that DEL-1 is downregulated in HELLP syndrome both in the circulation and at the affected placental tissue, suggesting a potential role for this protein as a biomarker, which must be further evaluated.
    Mesh-Begriff(e) Pregnancy ; Female ; Humans ; HELLP Syndrome/metabolism ; Pre-Eclampsia/metabolism ; Placenta/metabolism ; Endothelial Cells/metabolism ; Thrombotic Microangiopathies/metabolism
    Sprache Englisch
    Erscheinungsdatum 2023-07-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411762
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  9. Artikel ; Online: Metformin in Esophageal Carcinoma: Exploring Molecular Mechanisms and Therapeutic Insights.

    Papadakos, Stavros P / Argyrou, Alexandra / Lekakis, Vasileios / Arvanitakis, Konstantinos / Kalisperati, Polyxeni / Stergiou, Ioanna E / Konstantinidis, Ippokratis / Schizas, Dimitrios / Koufakis, Theocharis / Germanidis, Georgios / Theocharis, Stamatios

    International journal of molecular sciences

    2024  Band 25, Heft 5

    Abstract: Esophageal cancer (EC) remains a formidable malignancy with limited treatment options and high mortality rates, necessitating the exploration of innovative therapeutic avenues. Through a systematic analysis of a multitude of studies, we synthesize the ... ...

    Abstract Esophageal cancer (EC) remains a formidable malignancy with limited treatment options and high mortality rates, necessitating the exploration of innovative therapeutic avenues. Through a systematic analysis of a multitude of studies, we synthesize the diverse findings related to metformin's influence on EC. This review comprehensively elucidates the intricate metabolic pathways and molecular mechanisms through which metformin may exert its anti-cancer effects. Key focus areas include its impact on insulin signaling, AMP-activated protein kinase (AMPK) activation, and the mTOR pathway, which collectively contribute to its role in mitigating esophageal cancer progression. This review critically examines the body of clinical and preclinical evidence surrounding the potential role of metformin, a widely prescribed anti-diabetic medication, in EC management. Our examination extends to the modulation of inflammation, oxidative stress and angiogenesis, revealing metformin's potential as a metabolic intervention in esophageal cancer pathogenesis. By consolidating epidemiological and clinical data, we assess the evidence that supports metformin's candidacy as an adjuvant therapy for esophageal cancer. By summarizing clinical and preclinical findings, our review aims to enhance our understanding of metformin's role in EC management, potentially improving patient care and outcomes.
    Mesh-Begriff(e) Humans ; Metformin/pharmacology ; Antineoplastic Agents/pharmacology ; AMP-Activated Protein Kinases/metabolism ; Esophageal Neoplasms/drug therapy ; Signal Transduction
    Chemische Substanzen Metformin (9100L32L2N) ; Antineoplastic Agents ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Sprache Englisch
    Erscheinungsdatum 2024-03-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052978
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  10. Artikel ; Online: Views and Attitudes of Blood Donors toward Blood Donation during the COVID-19 Pandemic in Thrace Region, Greece.

    Gkirtsou, Christina / Konstantinidis, Theocharis / Cassimos, Dimitrios / Konstantinidou, Eleni I / Kontekaki, Eftychia G / Rekari, Viki / Bezirtzoglou, Eugenia / Martinis, Georges / Stergiannis, Pantelis / For Thrace Study Group On Blood Donors' Attitude During The Covid-Pandemic

    International journal of environmental research and public health

    2022  Band 19, Heft 9

    Abstract: The COVID-19 pandemic has been going on for the last two years and it has affected our society and, amongst other things, has had a negative impact on blood donation, which has led to a significant reduction in blood supplies worldwide. The imposed ... ...

    Abstract The COVID-19 pandemic has been going on for the last two years and it has affected our society and, amongst other things, has had a negative impact on blood donation, which has led to a significant reduction in blood supplies worldwide. The imposed restrictions in terms of physical presence and transportation, and the fear of the unknown, have aggravated the situation. In Greece, after the first cases of COVID-19 were reported, the blood supplies at the blood transfusion units (BTUs) were dramatically reduced. Although the blood transfusions were lessened during the COVID-19 pandemic period, the blood stocks at all the BTUs of the country were also reduced.
    Mesh-Begriff(e) Attitude ; Blood Donors ; COVID-19/epidemiology ; Greece/epidemiology ; Humans ; Pandemics ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2022-04-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19094963
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