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  1. Artikel ; Online: 50 Years Ago in TheJournalofPediatrics: Multiple Lentigines Syndrome: Historical Perspective and Contributions of Dr David W. Smith.

    Sheppard, Sarah E / Krantz, Ian D

    The Journal of pediatrics

    2021  Band 233, Seite(n) 211

    Mesh-Begriff(e) History, 20th Century ; Humans ; LEOPARD Syndrome/history ; Pediatrics/history ; Periodicals as Topic/history
    Sprache Englisch
    Erscheinungsdatum 2021-05-24
    Erscheinungsland United States
    Dokumenttyp Historical Article ; Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2021.02.047
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  2. Artikel ; Online: 38th Annual David W. Smith Workshop on Malformations and Morphogenesis: Abstracts of the 2017 Annual Meeting.

    Stevens, Cathy A / Krantz, Ian

    American journal of medical genetics. Part A

    2018  , Seite(n) 1463–1536

    Abstract: The 38th Annual David W. Smith Workshop on Malformations and Morphogenesis occurred on August 26th ... the legacy of David W Smith, brought together clinicians and researchers interested in congenital ...

    Abstract The 38th Annual David W. Smith Workshop on Malformations and Morphogenesis occurred on August 26th - 29th, 2017 at the Stoweflake Resort and Conference Center in Stowe, VT. The Workshop, which honors the legacy of David W Smith, brought together clinicians and researchers interested in congenital malformations and their underlying mechanisms of morphogenesis. The Workshop highlighted four themes besides mechanisms of morphogenesis and new syndromes: Disorders of Transcriptional Regulation, Dysmorphology (Syndromes and Malformations) in Minority and Unique Populations, Syndromes and Isolated Birth Defects Involving Malformations of the Developing Foregut, and the Natural History of Syndromes. This Conference Report includes the abstracts presented at the 2017 Workshop.
    Sprache Englisch
    Erscheinungsdatum 2018-04-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2108614-X
    ISSN 1552-4833 ; 0148-7299 ; 1552-4825
    ISSN (online) 1552-4833
    ISSN 0148-7299 ; 1552-4825
    DOI 10.1002/ajmg.a.38698
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  3. Artikel ; Online: COP and the Cloth

    David Krantz

    Sci, Vol 3, Iss 24, p

    Quantitatively and Normatively Assessing Religious NGO Participation at the Conference of Parties to the United Nations Framework Convention on Climate Change

    2021  Band 24

    Abstract: How much is religion quantitatively involved in global climate politics? After assessing the role of the Conference of Parties to the United Nations Framework Convention on Climate Change from a normative perspective, this descriptive, transdisciplinary ... ...

    Abstract How much is religion quantitatively involved in global climate politics? After assessing the role of the Conference of Parties to the United Nations Framework Convention on Climate Change from a normative perspective, this descriptive, transdisciplinary and unconventional study offers the first comprehensive quantitative examination of religious nongovernmental organizations that formally participate in its annual meetings, the largest attempts to solve the climate crisis through global governance. This study finds that although their numbers are growing, only about 3 percent of registered nongovernmental organizations accredited to participate in the conference are overtly religious in nature—and that more than 80 percent of those faith-based groups are Christian. Additionally, this study finds that religious nongovernmental organizations that participate in the conference are mostly from the Global North. The results call for greater participation of religious institutions in the international climate negotiations in order for society to address the planetary emergency of climate change.
    Schlagwörter civil society ; climate politics ; environmental governance ; faith-based environmentalism ; faith-based nonprofits ; global governance ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter.

    Bonanno, Shivan L / Krantz, David E

    Translational psychiatry

    2023  Band 13, Heft 1, Seite(n) 226

    Abstract: The transcriptional effects of SSRIs and other serotonergic drugs remain unclear, in part due to the heterogeneity of postsynaptic cells, which may respond differently to changes in serotonergic signaling. Relatively simple model systems such as ... ...

    Abstract The transcriptional effects of SSRIs and other serotonergic drugs remain unclear, in part due to the heterogeneity of postsynaptic cells, which may respond differently to changes in serotonergic signaling. Relatively simple model systems such as Drosophila afford more tractable microcircuits in which to investigate these changes in specific cell types. Here, we focus on the mushroom body, an insect brain structure heavily innervated by serotonin and comprised of multiple different but related subtypes of Kenyon cells. We use fluorescence-activated cell sorting of Kenyon cells, followed by either bulk or single-cell RNA sequencing to explore the transcriptomic response of these cells to SERT inhibition. We compared the effects of two different Drosophila Serotonin Transporter (dSERT) mutant alleles as well as feeding the SSRI citalopram to adult flies. We find that the genetic architecture associated with one of the mutants contributed to significant artefactual changes in expression. Comparison of differential expression caused by loss of SERT during development versus aged, adult flies, suggests that changes in serotonergic signaling may have relatively stronger effects during development, consistent with behavioral studies in mice. Overall, our experiments revealed limited transcriptomic changes in Kenyon cells, but suggest that different subtypes may respond differently to SERT loss-of-function. Further work exploring the effects of SERT loss-of-function in other circuits may be used help to elucidate how SSRIs differentially affect a variety of different neuronal subtypes both during development and in adults.
    Mesh-Begriff(e) Animals ; Citalopram/pharmacology ; Drosophila/metabolism ; Neurons/metabolism ; Selective Serotonin Reuptake Inhibitors/pharmacology ; Serotonin Plasma Membrane Transport Proteins/genetics ; Serotonin Plasma Membrane Transport Proteins/metabolism
    Chemische Substanzen Citalopram (0DHU5B8D6V) ; Selective Serotonin Reuptake Inhibitors ; Serotonin Plasma Membrane Transport Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-06-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-023-02521-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter.

    Bonanno, Shivan L / Krantz, David E

    Research square

    2023  

    Abstract: The transcriptional effects of SSRIs and other serotonergic drugs remain unclear, in part due to the heterogeneity of postsynaptic cells, which may respond differently to changes in serotonergic signaling. Relatively simple model systems such as ... ...

    Abstract The transcriptional effects of SSRIs and other serotonergic drugs remain unclear, in part due to the heterogeneity of postsynaptic cells, which may respond differently to changes in serotonergic signaling. Relatively simple model systems such as Drosophila afford more tractable microcircuits in which to investigate these changes in specific cell types. Here, we focus on the mushroom body, an insect brain structure heavily innervated by serotonin and comprised of multiple different but related subtypes of Kenyon cells. We use fluorescence activated cell sorting of Kenyon cells, followed by either or bulk or single cell RNA sequencing to explore the transcriptomic response of these cells to SERT inhibition. We compared the effects of two different Drosophila Serotonin Transporter (dSERT) mutant alleles as well as feeding the SSRI citalapram to adult flies. We find that the genetic architecture associated with one of the mutants contributed to significant artefactual changes in expression. Comparison of differential expression caused by loss of SERT during development versus aged, adult flies, suggests that changes in serotonergic signaling may have relatively stronger effects during development, consistent with behavioral studies in mice. Overall, our experiments revealed limited transcriptomic changes in Kenyon cells, but suggest that different subtypes may respond differently to SERT loss-of-function. Further work exploring the effects of SERT loss-of-function in other Drosophila circuits may be used help to elucidate how SSRIs differentially affect a variety of different neuronal subtypes both during development and in adults.
    Sprache Englisch
    Erscheinungsdatum 2023-03-17
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.21203/rs.3.rs-2626506/v1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: The Interaction of Biology and Emotion: Uncovering a New Phenotype of Nonobstructive Coronary Artery Disease.

    Soufer, Robert / Krantz, David S

    Biological psychiatry

    2022  Band 91, Heft 7, Seite(n) 606–608

    Mesh-Begriff(e) Biology ; Coronary Artery Disease ; Emotions ; Humans ; Phenotype ; Risk Assessment ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2022-03-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2022.01.005
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  7. Buch: Prenatal screening and diagnosis

    Odibo, Anthony O. / Krantz, David A.

    (Clinics in laboratory medicine ; 30,3)

    2010  

    Verfasserangabe guest ed. Anthony O. Odibo ; David A. Krantz
    Serientitel Clinics in laboratory medicine ; 30,3
    Überordnung
    Sprache Englisch
    Umfang XVI S., S. 519 - 773 : Ill., graph. Darst.
    Verlag Saunders an imprint of Elsevier
    Erscheinungsort Philadelphia, Pa
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT016483339
    ISBN 978-1-4377-2462-2 ; 1-4377-2462-0
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Zs A 1695 -30,3- nicht ausleihbar Zeitschriften-Lesesaal

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  8. Artikel ; Online: Expression and potential regulatory functions of Drosophila octopamine receptors in the female reproductive tract.

    Rohrbach, Ethan W / Knapp, Elizabeth M / Deshpande, Sonali A / Krantz, David E

    G3 (Bethesda, Md.)

    2024  Band 14, Heft 3

    Abstract: Aminergic signaling is known to play a critical role in regulating female reproductive processes in both mammals and insects. In Drosophila, the ortholog of noradrenaline, octopamine, is required for ovulation as well as several other female reproductive ...

    Abstract Aminergic signaling is known to play a critical role in regulating female reproductive processes in both mammals and insects. In Drosophila, the ortholog of noradrenaline, octopamine, is required for ovulation as well as several other female reproductive processes. Two octopamine receptors have already been shown to be expressed in the Drosophila reproductive tract and to be required for egg-laying: OAMB and Octβ2R. The Drosophila genome contains 4 additional octopamine receptors-Octα2R, Octβ1R, Octβ3R, and Oct-TyrR-but their cellular patterns of expression in the reproductive tract and potential contribution(s) to egg-laying are not known. In addition, the mechanisms by which OAMB and Octβ2R regulate reproduction are incompletely understood. Using a panel of MiMIC Gal4 lines, we show that Octα2R, Octβ1R, Octβ3R, and Oct-TyrR receptors are not detectable in either epithelium or muscle but are clearly expressed in neurons within the female fly reproductive tract. Optogenetic activation of neurons that express at least 3 types of octopamine receptors stimulates contractions in the lateral oviduct. We also find that octopamine stimulates calcium transients in the sperm storage organs and that its effects in spermathecal, secretory cells, can be blocked by knock-down of OAMB. These data extend our understanding of the pathways by which octopamine regulates egg-laying in Drosophila and raise the possibility that multiple octopamine receptor subtypes could play a role in this process.
    Mesh-Begriff(e) Animals ; Female ; Male ; Drosophila/metabolism ; Drosophila melanogaster/metabolism ; Octopamine/metabolism ; Semen/metabolism ; Drosophila Proteins/metabolism ; Mammals ; Receptors, Biogenic Amine
    Chemische Substanzen norsynephrine receptor ; Octopamine (14O50WS8JD) ; Drosophila Proteins ; Receptors, Biogenic Amine
    Sprache Englisch
    Erscheinungsdatum 2024-01-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkae012
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  9. Artikel: Prospective Bidirectional Relations Between Depression and Metabolic Health: 30 Year Follow-up from the NHLBI CARDIA Study.

    Moorehead, Nicholas R / Goodie, Jeffrey L / Krantz, David S

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Objective: This study investigated prospective bidirectional relationships between depression and metabolic syndrome (MetS), and the moderating effects of race, sex, and health behaviors in a diverse cohort followed for 30 years.: Methods: Data were ... ...

    Abstract Objective: This study investigated prospective bidirectional relationships between depression and metabolic syndrome (MetS), and the moderating effects of race, sex, and health behaviors in a diverse cohort followed for 30 years.
    Methods: Data were analyzed from the NHLBI CARDIA study, a 30 year-prospective study of young adults (
    Results: There was a consistent, bi-directional relationship between depressive symptoms and MetS over time. Individuals with more CESD depressive symptoms were more likely to develop MetS over time compared to those reporting fewer symptoms (Wald Chi-Square = 7.09 (1),
    Conclusion: In a diverse young adult population prospectively followed into late middle age, MetS more consistently predicted depression over time than depression predicted MetS. The relation between MetS and depressive symptoms was moderated by race and sex, but not health behaviors.
    Sprache Englisch
    Erscheinungsdatum 2023-03-10
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.03.08.23286983
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Prospective bidirectional relations between depression and metabolic health: 30-year follow-up from the National Heart, Lung, and Blood Institute (NHLBI) Coronary Artery Disease in Young Adults (CARDIA) study.

    Moorehead, Nicholas R / Goodie, Jeffrey L / Krantz, David S

    Health psychology : official journal of the Division of Health Psychology, American Psychological Association

    2023  Band 43, Heft 4, Seite(n) 259–268

    Abstract: Objective: This study investigated prospective bidirectional relationships between depressive symptoms and metabolic syndrome (MetS) and the moderating effects of race, sex, and health behaviors in a diverse cohort followed for 30 years.: Method: ... ...

    Abstract Objective: This study investigated prospective bidirectional relationships between depressive symptoms and metabolic syndrome (MetS) and the moderating effects of race, sex, and health behaviors in a diverse cohort followed for 30 years.
    Method: Data were analyzed from the National Heart, Lung, and Blood Institute (NHLBI) Coronary Artery Disease in Young Adults (CARDIA) study, a 30-year prospective study of young adults (
    Results: There was a consistent, bidirectional relationship between depressive symptoms and MetS over time. Individuals with more CESD depressive symptoms were more likely to develop MetS over time compared to those reporting fewer symptoms, Wald χ²(1) = 7.09,
    Conclusion: In a diverse young adult population prospectively followed into late middle age, MetS more consistently predicted depressive symptoms over time than depressive symptoms predicted MetS. The relation between MetS and depressive symptoms was moderated by race and sex, but not health behaviors. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
    Mesh-Begriff(e) Female ; Middle Aged ; United States/epidemiology ; Humans ; Male ; Young Adult ; Adult ; Depression/psychology ; Prospective Studies ; National Heart, Lung, and Blood Institute (U.S.) ; Coronary Artery Disease/epidemiology ; Follow-Up Studies ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/psychology
    Sprache Englisch
    Erscheinungsdatum 2023-12-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 226369-5
    ISSN 1930-7810 ; 0278-6133
    ISSN (online) 1930-7810
    ISSN 0278-6133
    DOI 10.1037/hea0001339
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